RNA-Induced Silencing Complex
"RNA-Induced Silencing Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the "guide strand" of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA).
| Descriptor ID |
D034743
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| MeSH Number(s) |
D08.811.277.352.355.350.810 D08.811.277.352.700.350.810 D12.776.157.725.500.906 D12.776.664.962.500.906
|
| Concept/Terms |
RNA-Induced Silencing Complex- RNA-Induced Silencing Complex
- Complex, RNA-Induced Silencing
- RNA Induced Silencing Complex
- Silencing Complex, RNA-Induced
- RISC Multicomponent Nuclease
- Multicomponent Nuclease, RISC
- Nuclease, RISC Multicomponent
|
Below are MeSH descriptors whose meaning is more general than "RNA-Induced Silencing Complex".
Below are MeSH descriptors whose meaning is more specific than "RNA-Induced Silencing Complex".
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