"Factor XIIa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
| Descriptor ID |
D015956
|
| MeSH Number(s) |
D08.811.277.656.300.760.324 D08.811.277.656.959.350.324 D12.776.124.125.450.324 D23.119.450.324
|
| Concept/Terms |
Factor XIIa- Factor XIIa
- Factor XII, Activated
- Coagulation Factor XIIa
- Factor XIIa, Coagulation
- XIIa, Coagulation Factor
- Prekallikrein Activator
- Activator, Prekallikrein
- Activated Factor XII
- Blood Coagulation Factor XII, Activated
|
Below are MeSH descriptors whose meaning is more general than "Factor XIIa".
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