"Aflatoxin M1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).
| Descriptor ID |
D016607
|
| MeSH Number(s) |
D03.438.150.119.100 D03.830.219.119.100 D23.946.587.142.100
|
| Concept/Terms |
Aflatoxin M1- Aflatoxin M1
- 4-Hydroxyaflatoxin B1
- 4 Hydroxyaflatoxin B1
|
Below are MeSH descriptors whose meaning is more general than "Aflatoxin M1".
Below are MeSH descriptors whose meaning is more specific than "Aflatoxin M1".
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