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Getting to the crux of the matter: IL-23 and Th17 cell accumulation in the CNS.
IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition.
Th17 and Th1 responses directed against the immunizing epitope, as opposed to secondary epitopes, dominate the autoimmune repertoire during relapses of experimental autoimmune encephalomyelitis.
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Getting to the crux of the matter: IL-23 and Th17 cell accumulation in the CNS.
Segal BM. Getting to the crux of the matter: IL-23 and Th17 cell accumulation in the CNS. Eur J Immunol. 2009 Jul; 39(7):1713-5.
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PubMed
subject areas
Animals
CD4-Positive T-Lymphocytes
Central Nervous System
Encephalomyelitis, Autoimmune, Experimental
Interleukin-17
Interleukin-23
Mice
Mice, Inbred C57BL
Mice, Knockout
Receptors, Interleukin
Receptors, Interleukin-12
T-Lymphocytes, Helper-Inducer
T-Lymphocytes, Regulatory
authors with profiles
B. Scott Segal MD, MHCM