The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators.
Tseng CC, Baillie G, Donvito G, Mustafa MA, Juola SE, Zanato C, Massarenti C, Dall'Angelo S, Harrison WTA, Lichtman AH, Ross RA, Zanda M, Greig IR. The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators. J Med Chem. 2019 05 23; 62(10):5049-5062.