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Xu Han

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentWake Forest Institute for Regenerative Medicine
Address
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    Collapse Biography 
    Collapse awards and honors
    2024Therapeutic Development Award, Department of Defense
    2022NIH Innovation Showcase Company, NIH
    2016University of Missouri Fast-Track Award, University of Missouri
    2016Outstanding Reviewer, Elsevier
    2018Coulter Translational Research Partnership Award, University of Missouri
    2014Faculty Innovation Award, University of Missouri
    2014Top Reviewer for the Journal of Cryobiology, Elsevier
    2003Computational Sciences Research Scholarship, University of Kentucky
    2022Idea Development Award of MBRP Burn Program , Department of Defense

    Collapse Research 
    Collapse research activities and funding
    R43OD020163     (HAN, XU)Jul 15, 2015 - Jan 14, 2017
    NIH
    An Ultra-fast Cooling Device for Vitrification and Cryopreservation of Cells and Tissues
    Role: Principal Investigator
    R44OD020163     (HAN, XU)Aug 16, 2015 - Aug 31, 2021
    NIH
    An Ultra-fast Cooling Device for Vitrification and Cryopreservation of Cells and Tissues
    Role: Principal Investigator
         (HAN, XU)Oct 1, 2015 - Feb 1, 2016
    Coulter Foundation
    A Novel Device for Corneal Cryopreservation
    Role: Principal Investigator
    2018-00489     (HAN, XU)Jun 1, 2018 - Feb 1, 2020
    NIFA
    A Highly Efficient Vitrification Device for Animal Embryos and Spermatozoa
    Role: Principal Investigator
         (HAN, XU)Aug 1, 2018 - Jan 1, 2020
    Coulter Foundation Translation Research Partnership
    Frozen Heart: Development of Novel Organ Storage Media for Cardiac Transplantation
    Role: Principal Investigator
    R43OD026279     (HAN, XU)Aug 3, 2018 - Jan 31, 2021
    NIH
    In-Situ Cryopreservation Without Cryoprotectants
    Role: Principal Investigator
    R43AI155070     (HAN, XU)May 12, 2020 - Apr 30, 2021
    NIH
    A Novel Cryopreservation Technology for Large Skin Grafts to Facilitate Tissue Banking and Allograft Transplantations
    Role: Principal Investigator
    R44EY033254     (HAN, XU)Sep 1, 2021 - Aug 31, 2023
    NIH
    Late-stage Preclinical Development and cGMP Production of a First-in-Class Cornea Cryopreservation Kit Based on FDA Feedback
    Role: Principal Investigator
    MB210106     (HAN, XU)Feb 1, 2022
    Idea Development Award of 2022 MBRP Burn Program
    Role: Principal Investigator
    R44AI170389     (HAN, XU)May 6, 2022 - Apr 30, 2025
    NIH
    Innovation of Skin Banking and Transplantation Based on a First-in-Class Biocompatible Cryopreservation Technology
    Role: Principal Investigator
    R44CA278579     (HAN, XU)Sep 15, 2022 - Aug 31, 2024
    NIH
    Innovation of Biobanking for Cellular Adoptive Immunotherapies Based on a First-in-Class Biocompatible Cryopreservation Technology for T and NK Cells and Their CAR-Engineered Products
    Role: Principal Investigator
         (HAN, XU)Jan 1, 2023 - Jan 1, 2025
    Mid-American Transplant Clinical Innovation Award
    Establishment of the First Limbal Tissue Bank Based on the First-in-Class Biocompatible Cryopreservation Technology
    Role: Principal Investigator
    R44OD035392     (HAN, XU)Sep 15, 2024 - Aug 31, 2026
    NIH
    Establishment of a First-in-Class Biocompatible and Efficient Cryopreservation Technology Platform for the Next Generation of Cell-Based Therapeutics in Regenerative Medicine and Drug Discovery
    Role: Principal Investigator
    HT9425-24-1-1099     (Xu Han)Dec 1, 2024 - Dec 1, 2027
    DoD
    Securing GMP Production and FDA Clearance for OdinSol as a First-in-Class Biocompatible Cryopreservation Technology to Innovate Blood Banking
    Role Description: Our first-in-class biocompatible cryopreservation medium has been modified to enhance the cryopreservation efficiency of red blood cells, eliminating the need for toxic cell-permeating cryoprotectants and the complicated operations required by traditional blood banking methods. This novel technology will offer cost-saving and efficient options for improved supply chain management in the biobanking of red blood cell units. In this project, we aim to obtain qualifications related to Good Manufacturing Practice (GMP) production, biocompatibility, safety, and efficacy testing, and secure 510(k) clearance to pave the path to commercialization.
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gedamke E, Conkling M, Goodman C, Han X, Pomponi S. . Novel Use of a -20°C Cryoprotectant Yields High Viability and Improved Aggregation of Marine Sponge Cells. In Vitro Cellular & Developmental Biology (Accepted). 2024; Online ahead of print.. View Publication.
    2. Xu Han; Ying-Bo Shui; R. Scott Duncan; Ying Liu; Andrew J W Huang; Peter Koulen. Efficient and Biocompatible Cryopreservation of Corneal Limbal Stem Cells and Bioartificial Retinal Pigment Epithelial Tissues Facilitates Novel Eye Banking Practices. Investigative Ophthalmology & Visual Science. 2024; (65):6173.
    3. Xu Han, Andrew Huang. PCT/US24/37990. 2024.
    4. Han X, Koulen P, Critser J.K . Japanese Patent No. 7512250. Issued. 2024.
    5. Ying Liu; Ying-Bo Shui; Andrew J W Huang; Xu Han. Novel Decellularization and Cryopreservation of Corneal Stroma for Lamellar Keratoplasty. Investigative Ophthalmology & Visual Science. 2024; (65):487.
    6. Han X, White H, Koulen P. US Patent 11,937,596. Issued. 2024.
    7. Wenxuan Zhou, Chen Wang, Yao Shi, Yi Pan, Xiaduo Meng, Xunlei Kang and Xu Han. Novel cryopreservation medium for enhanced stability of T cells at -80 °C. Frontiers in Hematology. 2024; 3(16):346627.
    8. Han X, White H, Koulen P. Japanese Patent 7398434. Issued. 2024.
    9. Han X, White H, Koulen P. Indian Patent 454620. Issued. 2024.
    10. Han X, Koulen P, Critser J.K . Chinese Patent ZL2019800559191 Issued. 2024.
    11. Han X, Koulen P, Critser J.K. . Indian Patent 453069. Issued. 2023.
    12. Han X, White H, Koulen P. . Chinese Patent ZL201980037064.X. Issued. 2023.
    13. Corcoran JA, Han X. Improved cryopreservation media formulation reduces costs of maintenance while preserving function of genetically modified insect cells. In Vitro Cell Dev Biol Anim. 2022 Dec; 58(10):867-876. PMID: 36515806.
      Citations:    
    14. Han X, White H, Koulen P. PCT/USA63/170673. 2022.
    15. Han X, White H, Koulen P . PCT/US2019/26162. 2019.
    16. Han X, Koulen P, Critser J. PCT/US2019/048986. 2019.
    17. Mao Y, Zhang Y, Han X . Cryoprotective Mechanism of Using Ficoll for Cell Cryopreservation at Non-Cryogenic Temperatures: A Molecular Dynamics Study. International Journal of Heat and Mass Transfer. 2018; 127:319-325.
    18. Han X, Yuan Y, and Roberts R.M. . PCT/US2017/032606. 2017.
    19. Yuan Y, Yang Y, Tian Y, Park J, Dai A, Roberts RM, Liu Y, Han X. Efficient long-term cryopreservation of pluripotent stem cells at -80?°C. Sci Rep. 2016 Oct 03; 6:34476. PMID: 27694817.
      Citations:    
    20. Han X. Direct Microscale Measurement of Mouse Oocyte Membrane Permeability to Water and Ethylene Glycol at Subzero Temperatures Using Cryomicroscopy. Cryo Letters. 2016; 37(6):394-400. PMID: 28072425.
      Citations:    
    21. Han X, Critser JK. A Theoretical and Experimental Investigation of Mechanical Damage to Rodent Sperm Generated by Microscale Ice Formation. Cryo Letters. 2016; 37(6):388-393. PMID: 28072424.
      Citations:    
    22. Su F, Ma H, Han X, Chen HH, Tian B. Ultra-high cooling rate utilizing thin film evaporation. Appl Phys Lett. 2012 Sep 10; 101(11):113702. PMID: 23093807.
      Citations:    
    23. Wu Y, Han X, Benson JD, Almasri M. Micromachined Coulter counter for dynamic impedance study of time sensitive cells. Biomed Microdevices. 2012 Aug; 14(4):739-50. PMID: 22526683.
      Citations:    
    24. Benson JD, Bagchi A, Han X, Critser JK, Woods EJ. Melting point equations for the ternary system water/sodium chloride/ethylene glycol revisited. Cryobiology. 2010 Dec; 61(3):352-6. PMID: 20955693.
      Citations:    
    25. Han X, Liu Y, Critser JK. Determination of the quaternary phase diagram of the water-ethylene glycol-sucrose-NaCl system and a comparison between two theoretical methods for synthetic phase diagrams. Cryobiology. 2010 Aug; 61(1):52-7. PMID: 20447385.
      Citations:    
    26. Han X, Critser JK. Measurement of the size of intracellular ice crystals in mouse oocytes using a melting point depression method and the influence of intracellular solute concentrations. Cryobiology. 2009 Dec; 59(3):302-7. PMID: 19729005.
      Citations:    
    27. Han X, Ma L, Benson J, Brown A, Critser JK. Measurement of the apparent diffusivity of ethylene glycol in mouse ovaries through rapid MRI and theoretical investigation of cryoprotectant perfusion procedures. Cryobiology. 2009 Jun; 58(3):298-302. PMID: 19248776.
      Citations:    
    28. Han X, Ma H, Jiao A, Critser JK. Investigations on the heat transport capability of a cryogenic oscillating heat pipe and its application in achieving ultra-fast cooling rates for cell vitrification cryopreservation. Cryobiology. 2008 Jun; 56(3):195-203. PMID: 18430413.
      Citations:    
    29. Han X, Ma H.B, Wilson C, Critser J.K . . Effects of nanoparticles on the nucleation and devitrification temperatures of cryoprotectant solutions. Microfluidics and Nanofluidics. 2008; 4:357-361..
    30. Han X, Luo D, Cui X, Heimfeild S, Gao D . A modified differential scanning calorimetry method for determining water transport properties in biological cells during the freezing process. Cell Preservation Technology. 2007; 5:182-189.
    31. Jiao A, Han X, Critser JK, Ma H. Numerical investigations of transient heat transfer characteristics and vitrification tendencies in ultra-fast cell cooling processes. Cryobiology. 2006 Jun; 52(3):386-92. PMID: 16616118.
      Citations:    
    32. Han X, Gao D, Luo D, Yu C, Lu C. C . Numerical simulation of the microwave rewarming process of cryopreserved organs. Microwave and optical technology letters. 2005; 5:201-205..
    33. Luo D, Han X, He L, Cui X, Cheng S, Lu C, Liu J, Gao D. A modified differential scanning calorimetry for determination of cell volumetric change during the freezing process. Cryo Letters. 2002; 23(4):229-36. PMID: 12391483.
      Citations:    
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