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Nicklaus P. Ashburn MD, MS

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentEmergency Medicine
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    Collapse Biography 
    Collapse education and training
    Wake Forest University School of MedicineMD05/2018Medicine
    Wake Forest University School of Medicine06/2021Emergency Medicine
    Wake Forest UniversityMS09/2022Translational and Health System Science
    Wake Forest UniversityBS05/2014Biology
    Wake Forest University School of Medicine06/2022Cardiovascular Disease Epidemiology and Prevention

    Collapse Research 
    Collapse research activities and funding
    R01HS029017     (MAHLER, SIMON A)Apr 1, 2023 - Jan 31, 2028
    NIH
    Testing a Cardiovascular Ambulatory Rapid Evaluation for Patients with Chest Pain (CARE-CP)
    Role: Co-Investigator
    K23HL169929     (ASHBURN, NICKLAUS)Apr 1, 2024 - Mar 31, 2029
    NIH
    Initiating Preventive Care for Hyperlipidemia in the Emergency Department: The EMERALD Trial
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Millard MJ, Ashburn NP, Snavely AC, Hashemian T, Supples M, Allen B, Christenson R, Madsen T, McCord J, Mumma B, Stopyra J, Wilkerson RG, Mahler SA. European Society of Cardiology 0/1-hour algorithm (high-sensitivity cardiac troponin T) performance across distinct age groups. Heart. 2024 May 23; 110(12):838-845. PMID: 38471727.
      Citations:    
    2. George TS, Ashburn NP, Snavely AC, Beaver BP, Chado MA, Cannon H, Costa CG, Winslow JE, Nelson RD, Stopyra JP, Mahler SA. Does Single Dose Epinephrine Improve Outcomes for Patients with Out-of-Hospital Cardiac Arrest and Bystander CPR or a Shockable Rhythm? Prehosp Emerg Care. 2024 May 21; 1-9. PMID: 38713769.
      Citations:    
    3. Mahler SA, Ashburn NP, Supples MW, Hashemian T, Snavely AC. Validation of the ACC Expert Consensus Decision Pathway for Patients With Chest Pain. J Am Coll Cardiol. 2024 Apr 02; 83(13):1181-1190. PMID: 38538196.
      Citations:    
    4. Ashburn NP, Snavely AC, Allen BR, Christenson RH, Madsen T, McCord JK, Mumma BE, Hashemian T, Stopyra JP, Wilkerson RG, Mahler SA. Performance of the European Society of Cardiology 0/1-hour algorithm with high-sensitivity cardiac troponin T at 90 days among patients with known coronary artery disease. Am J Emerg Med. 2024 May; 79:111-115. PMID: 38417221.
      Citations:    
    5. Supples MW, Snavely AC, Ashburn NP, Allen BR, Mahler SA. Response to "troponin thresholds for MI risk stratification" by Dr. Pickering. Acad Emerg Med. 2024 Mar; 31(3):306-307. PMID: 38381470.
      Citations:    
    6. Mahler SA, Ashburn NP, Paradee BE, Stopyra JP, O'Neill JC, Snavely AC. Safety and Effectiveness of the High-Sensitivity Cardiac Troponin HEART Pathway in Patients With Possible Acute Coronary Syndrome. Circ Cardiovasc Qual Outcomes. 2024 Mar; 17(3):e010270. PMID: 38328912.
      Citations:    
    7. Stopyra JP, Snavely AC, Ashburn NP, Supples MW, Brown WM, Miller CD, Mahler SA. Rural EMS STEMI Patients - Why the Delay to PCI? Prehosp Emerg Care. 2024 Jan 18; 1-8. PMID: 38235978.
      Citations:    
    8. Supples MW, Snavely AC, Ashburn NP, Allen BR, Christenson RH, Nowak R, Wilkerson RG, Mumma BE, Madsen T, Stopyra JP, Mahler SA. Performance of the 0/2-hour high-sensitivity cardiac troponin?T diagnostic protocol in a multisite United States cohort. Acad Emerg Med. 2024 Mar; 31(3):239-248. PMID: 37925594.
      Citations:    
    9. Ashburn NP, McCord JK, Snavely AC, Christenson RH, Apple FS, Nowak RM, Peacock WF, deFilippi CR, Mahler SA. Navigating the Observation Zone: Do Risk Scores Help Stratify Patients With Indeterminate High-Sensitivity Cardiac Troponins? Circulation. 2024 Jan 02; 149(1):70-72. PMID: 38153992.
      Citations:    
    10. Supples MW, Snavely AC, O'Neill JC, Ashburn NP, Allen BR, Christenson RH, Nowak R, Wilkerson RG, Mumma BE, Madsen T, Stopyra JP, Mahler SA. Sex and race differences in the performance of the European Society of Cardiology 0/1-h algorithm with high-sensitivity troponin T. Clin Cardiol. 2024 Feb; 47(2):e24199. PMID: 38088463.
      Citations:    
    11. Ashburn NP, Snavely AC, Rikhi R, Shapiro MD, Chado MA, Stopyra JP, Mahler SA. Preventive Cardiovascular Care for Hypercholesterolemia in US Emergency Departments: A National Missed Opportunity. Crit Pathw Cardiol. 2023 Dec 01; 22(4):110-113. PMID: 37831464.
      Citations:    
    12. Stopyra JP, Snavely AC, Ashburn NP, Supples MW, Miller CD, Mahler SA. Delayed first medical contact to reperfusion time increases mortality in rural emergency medical services patients with ST-elevation myocardial infarction. Acad Emerg Med. 2023 Aug 11. PMID: 37567785.
      Citations:    
    13. Ashburn NP, Snavely AC, Stanek LS, Shapiro MD, Rikhi RR, Chado MA, Stopyra JP, Mahler SA. Emergency Department Observation Unit Patients Want Evaluation and Treatment for Hypercholesterolemia: A Health Belief Model Study. Crit Pathw Cardiol. 2023 Sep 01; 22(3):91-94. PMID: 37418345.
      Citations:    
    14. Popp LM, Ashburn NP, Snavely AC, Allen BR, Christenson RH, Madsen T, Mumma BE, Nowak R, Stopyra JP, Wilkerson RG, Mahler SA. Race differences in cardiac testing rates for patients with chest pain in a multisite cohort. Acad Emerg Med. 2023 Jun 12. PMID: 37306075.
      Citations:    
    15. Ashburn NP, Snavely AC, Rikhi R, Shapiro MD, Chado MA, Ambrosini AP, Biglari AA, Kitchen ST, Millard MJ, Stopyra JP, Mahler SA. Rarely tested or treated but highly prevalent: Hypercholesterolemia in ED observation unit patients with chest pain. Am J Emerg Med. 2023 Sep; 71:47-53. PMID: 37329876.
      Citations:    
    16. Ashburn NP, Snavely AC, O'Neill JC, Allen BR, Christenson RH, Madsen T, Massoomi MR, McCord JK, Mumma BE, Nowak R, Stopyra JP, In't Veld MH, Wilkerson RG, Mahler SA. Performance of the European Society of Cardiology 0/1-Hour Algorithm With High-Sensitivity Cardiac Troponin T Among Patients With Known Coronary Artery Disease. JAMA Cardiol. 2023 Apr 01; 8(4):347-356. PMID: 36857071.
      Citations:    
    17. Ashburn NP, Snavely AC, Rikhi RR, Chado MA, Colbaugh WB, Noe GR, Kinney IJ, Morgan RJ, Stopyra JP, Mahler SA. Chest pain observation unit: A missed opportunity to initiate smoking cessation therapy. Am J Emerg Med. 2023 Jun; 68:17-21. PMID: 36905881.
      Citations:    
    18. O'Neill JC, Ashburn NP, Paradee BE, Snavely AC, Stopyra JP, Noe G, Mahler SA. Rural and socioeconomic differences in the effectiveness of the HEART Pathway accelerated diagnostic protocol. Acad Emerg Med. 2023 Feb; 30(2):110-123. PMID: 36527333.
      Citations:    
    19. Ashburn NP, Snavely AC, Mahler SA, Stopyra JP. Response by Ashburn et al. to Letter "Caveat Cum CARES". Prehosp Emerg Care. 2023; 27(2):279. PMID: 36369675.
      Citations:    
    20. Popp LM, Ashburn NP, Paradee BE, Snavely AC, O'Neill JC, Boyer KM, Body R, Mahler SA, Stopyra JP. Prehospital Comparison of the HEAR and HE-MACS Scores for 30-Day Adverse Cardiac Events. Prehosp Emerg Care. 2022 Nov 29; 1-7. PMID: 36322910.
      Citations:    
    21. Snavely AC, Paradee BE, Ashburn NP, Allen BR, Christenson R, O'Neill JC, Nowak R, Wilkerson RG, Mumma BE, Madsen T, Stopyra JP, Mahler SA. Derivation and validation of a high sensitivity troponin-T HEART pathway. Am Heart J. 2023 Feb; 256:148-157. PMID: 36400184.
      Citations:    
    22. Ashburn NP, Beaver BP, Snavely AC, Nazir N, Winslow JT, Nelson RD, Mahler SA, Stopyra JP. One and Done Epinephrine in Out-of-Hospital Cardiac Arrest? Outcomes in a Multiagency United States Study. Prehosp Emerg Care. 2022 Aug 30; 1-13. PMID: 36041188.
      Citations:    
    23. Stopyra JP, Crowe RP, Snavely AC, Supples MW, Page N, Smith Z, Ashburn NP, Foley K, Miller CD, Mahler SA. Prehospital Time Disparities for Rural Patients with Suspected STEMI. Prehosp Emerg Care. 2022 Apr 27; 1-8. PMID: 35380911.
      Citations:    
    24. Ashburn NP, Snavely AC, Paradee BE, O'Neill JC, Stopyra JP, Mahler SA. Age differences in the safety and effectiveness of the HEART Pathway accelerated diagnostic protocol for acute chest pain. J Am Geriatr Soc. 2022 Apr 05. PMID: 35383887.
      Citations:    
    25. Stopyra JP, Snavely AC, Ashburn NP, O'Neill J, Paradee BE, Hehl B, Vorrie J, Wells M, Nelson RD, Hendley NW, Miller CD, Mahler SA. Performance of Prehospital Use of Chest Pain Risk Stratification Tools: The RESCUE Study. Prehosp Emerg Care. 2022 Feb 17; 1-6. PMID: 35103569.
      Citations:    
    26. McGinnis HD, Ashburn NP, Paradee BE, O'Neill JC, Snavely AC, Stopyra JP, Mahler SA. Major adverse cardiac event rates in moderate-risk patients: Does prior coronary disease matter? Acad Emerg Med. 2022 Feb 15. PMID: 35166427.
      Citations:    
    27. Snavely AC, Mahler SA, Hendley NW, Ashburn NP, Hehl B, Vorrie J, Wells M, Nelson RD, Miller CD, Stopyra JP. Prehospital Translation of Chest Pain Tools (RESCUE Study): Completion Rate and Inter-rater Reliability. West J Emerg Med. 2022 Jan 18; 23(2):222-228. PMID: 35302456.
      Citations:    
    28. Stopyra JP, Ashburn NP, Mahler SA. A Methodological Appraisal of the HEART Score and Its Variants Response. Ann Emerg Med. 2022 01; 79(1):84-85. PMID: 34949411.
      Citations:    
    29. Ashburn NP, O'Neill JC, Stopyra JP, Mahler SA. Scoring systems for the triage and assessment of short-term cardiovascular risk in patients with acute chest pain. Rev Cardiovasc Med. 2021 Dec 22; 22(4):1393-1403. PMID: 34957779.
      Citations:    
    30. Ashburn NP, Snavely AC, Allen BR, Christenson RH, Herrington DM, Hiestand BC, Miller CD, Stopyra JP, Mahler SA. Monocyte chemoattractant protein-1 is not predictive of cardiac events in patients with non-low-risk chest pain. Emerg Med J. 2021 Dec 21. PMID: 34933919.
      Citations:    
    31. Ashburn NP, Snavely AC, Angi RM, Scheidler JF, Crowe RP, McGinnis HD, Hiestand BC, Miller CD, Mahler SA, Stopyra JP. Prehospital time for patients with acute cardiac complaints: A rural health disparity. Am J Emerg Med. 2022 Feb; 52:64-68. PMID: 34871845.
      Citations:    
    32. Popp LM, Lowell LM, Ashburn NP, Stopyra JP. Adverse events after prehospital nitroglycerin administration in a nationwide registry analysis. Am J Emerg Med. 2021 Dec; 50:196-201. PMID: 34390902.
      Citations:    
    33. Popp LM, Ashburn NP, McGinnis HD, Stopyra JP. Prehospital Cross-Sectional Study of Drowning Patients Across the United States. Wilderness Environ Med. 2021 09; 32(3):271-277. PMID: 34183233.
      Citations:    
    34. Stopyra JP, Snavely AC, Ashburn NP, Nelson RD, McMurray EL, Hunt MR, Miller CD, Mahler SA. EMS blood collection from patients with acute chest pain reduces emergency department length of stay. Am J Emerg Med. 2021 Apr 26; 47:248-252. PMID: 33964547.
      Citations:    
    35. Hendley NW, Moskop J, Ashburn NP, Mahler SA, Stopyra JP. The ethical dilemma of emergency department patients with low-risk chest pain. Emerg Med J. 2021 Mar 09. PMID: 33687992.
      Citations:    
    36. Stopyra JP, Snavely AC, Smith LM, Harris RD, Nelson RD, Winslow JE, Alson RL, Pomper GJ, Riley RF, Ashburn NP, Hendley NW, Gaddy J, Woodrum T, Fornage L, Conner D, Alvarez M, Pflum A, Koehler LE, Miller CD, Mahler SA. Prehospital use of a modified HEART Pathway and point-of-care troponin to predict cardiovascular events. PLoS One. 2020; 15(10):e0239460. PMID: 33027260.
      Citations:    
    37. Ashburn NP, Smith ZP, Hunter KJ, Hendley NW, Mahler SA, Hiestand BC, Stopyra JP. The disutility of stress testing in low-risk HEART Pathway patients. Am J Emerg Med. 2020 Aug 15. PMID: 33041122.
      Citations:    
    38. Smith LM, Ashburn NP, Snavely AC, Stopyra JP, Lenoir KM, Wells BJ, Hiestand BC, Herrington DM, Miller CD, Mahler SA. Identification of very low-risk acute chest pain patients without troponin testing. Emerg Med J. 2020 Nov; 37(11):690-695. PMID: 32753395.
      Citations:    
    39. Stopyra J, Snavely AC, Hiestand B, Wells BJ, Lenoir KM, Herrington D, Hendley N, Ashburn NP, Miller CD, Mahler SA. Comparison of accelerated diagnostic pathways for acute chest pain risk stratification. Heart. 2020 Jul; 106(13):977-984. PMID: 32269131.
      Citations:    
    40. Stopyra JP, Snavely AC, Scheidler JF, Smith LM, Nelson RD, Winslow JE, Pomper GJ, Ashburn NP, Hendley NW, Riley RF, Koehler LE, Miller CD, Mahler SA. Point-of-Care Troponin Testing during Ambulance Transport to Detect Acute Myocardial Infarction. Prehosp Emerg Care. 2020 Nov-Dec; 24(6):751-759. PMID: 31985326.
      Citations:    
    41. Ashburn NP, Hendley NW, Angi RM, Starnes AB, Nelson RD, McGinnis HD, Winslow JE, Cline DM, Hiestand BC, Stopyra JP. Prehospital Trauma Scene and Transport Times for Pediatric and Adult Patients. West J Emerg Med. 2020 Feb 21; 21(2):455-462. PMID: 32191204.
      Citations:    
    42. Ashburn NP, Ryder CW, Angi RM, Snavely AC, Nelson RD, Bozeman WP, McGinnis HD, Winslow JT, Stopyra JP. One-Year Mortality and Associated Factors in Patients Receiving Out-of-Hospital Naloxone for Presumed Opioid Overdose. Ann Emerg Med. 2020 05; 75(5):559-567. PMID: 31983499.
      Citations:    
    43. Ashburn NP, Stopyra JP, Mahler SA. News From Lake Wobegon … Clinician Gestalt Debunked? Acad Emerg Med. 2020 01; 27(1):80-82. PMID: 31336399.
      Citations:    
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