The chorion layer of fetal membranes is prematurely destroyed in women with preterm premature rupture of the membranes.
Canzoneri BJ, Feng L, Grotegut CA, Bentley RC, Heine RP, Murtha AP. The chorion layer of fetal membranes is prematurely destroyed in women with preterm premature rupture of the membranes. Reprod Sci. 2013 Oct; 20(10):1246-54.