Donald Mcclain | Profiles RNS

Donald A. Mcclain MD, PhD

Title	Professor
Institution	Wake Forest School of Medicine
Department	Internal Medicine, Endocrinology & Metabolism
Address
vCard	Download vCard

Other Positions


Title	Director
Institution	Wake Forest School of Medicine
Department	Clinical and Translational Science Institute
Title	Director
Institution	Wake Forest School of Medicine
Department	Center for Diabetes, Obesity and Metabolism (CDOM)

Title	Professor
Institution	Wake Forest School of Medicine
Department	Internal Medicine, Molecular Medicine

Title	Director
Institution	Wake Forest School of Medicine
Department	Clinical and Translational Science Institute

Research

research activities and funding

T35DK007400 (MCCLAIN, DONALD A.)May 1, 1980 - Jun 30, 2021 NIH Wake Forest Short-term Research Training Program Role: Co-Principal Investigator

R29DK043526 (MCCLAIN, DONALD A.)Jun 1, 1990 - May 31, 1996 NIH ALTERNATE FORMS OF THE INSULIN RECEPTOR Role: Principal Investigator

R01DK043526 (MCCLAIN, DONALD A.)Jun 1, 1990 - Mar 30, 2015 NIH Hexosamines, Glucose Toxicity and Insulin Resistance Role: Principal Investigator

K30RR022962 (MCCLAIN, DONALD A)Sep 30, 2000 - Aug 31, 2010 NIH University of Utah Clinical Research Curriculum Award Role: Principal Investigator

R56DK059512 (MCCLAIN, DONALD A)Apr 1, 2001 - Jun 30, 2008 NIH Diabetes in Hemochromatosis: Prevalence and Mechanisms Role: Principal Investigator

U01HL070525 (MCCLAIN, DONALD A)Sep 30, 2001 - Aug 31, 2007 NIH ANIMAL MODELS OF DIABETIC CARDIOVASCULAR COMPLICATIONS Role: Principal Investigator

R01DK059512 (MCCLAIN, DONALD A)Mar 1, 2002 - Nov 30, 2007 NIH DIABETES IN HEMOCHROMATOSIS: PREVALENCE AND MECHANISMS Role: Principal Investigator

KL2RR025763 (MCCLAIN, DONALD A)May 19, 2008 - Apr 30, 2013 NIH University of Utah Center for Clinical and Translational Science-KL2 Role: Principal Investigator

TL1RR025762 (MCCLAIN, DONALD A)May 19, 2008 - Apr 30, 2013 NIH University of Utah Center for Clinical and Translational Science-TL1 Role: Principal Investigator

UL1RR025764 (MCCLAIN, DONALD A)May 19, 2008 - Apr 30, 2013 NIH University of Utah Center for Clinical and Translational Science-UL1 Role: Principal Investigator

KL2TR000104 (MCCLAIN, DONALD A.)May 19, 2008 - Oct 31, 2013 NIH University of Utah Center for Clinical and Translational Science-KL2 Role: Principal Investigator

TL1TR000103 (MCCLAIN, DONALD A.)May 19, 2008 - Oct 31, 2013 NIH University of Utah Center for Clinical and Translational Science-TL1 Role: Principal Investigator

UL1TR000105 (MCCLAIN, DONALD A.)May 19, 2008 - Oct 31, 2013 NIH University of Utah Center for Clinical and Translational Science-UL1 Role: Principal Investigator

R01DK081842 (MCCLAIN, DONALD A.)Jul 1, 2008 - Feb 28, 2019 NIH Iron And Metabolism: Altered Fuel Oxidation And Mitochondrial Dysfunction Role: Principal Investigator

I01BX001140 (MCCLAIN, DONALD A.)Apr 1, 2011 - Mar 31, 2020 NIH Iron, the circadian clock, and diabetes risk Role: Principal Investigator

T32DK091317 (FISHER, SIMON J)Jul 1, 2011 - Jun 30, 2021 NIH Interdisciplinary Training Program in Metabolism Role: Co-Principal Investigator

R21DK096288 (MCCLAIN, DONALD A.)Aug 7, 2012 - Dec 30, 2014 NIH Iron reduction by phlebotomy for the prevention and treatment of type 2 diabetes Role: Principal Investigator

UL1TR001067 (DERE, WILLARD H.)Sep 26, 2013 - Apr 30, 2018 NIH University of Utah Center for Clinical and Translational Science Role: Co-Principal Investigator

KL2TR001065 (DERE, WILLARD H.)Sep 26, 2013 - Jun 30, 2018 NIH University of Utah Center for clinical and Translational Science Role: Co-Principal Investigator

TL1TR001066 (DERE, WILLARD H.)Sep 26, 2013 - Jun 30, 2018 NIH University of Utah Center for clinical and Translational Science Role: Co-Principal Investigator

UL1TR001420 (MCCLAIN, DONALD A.)Aug 13, 2015 - Jun 30, 2024 NIH Wake Forest Clinical and Translational Science Award Role: Co-Principal Investigator

R01DK119913 (MCCLAIN, DONALD A.)Jan 20, 2019 - Dec 31, 2023 NIH Iron Reduction for the Treatment of Diabetes and Nonalcoholic Fatty Liver Disease Role: Principal Investigator

P30DK124723 (MCCLAIN, DONALD A.)Apr 7, 2020 - Mar 31, 2025 NIH North Carolina Diabetes Research Center Role: Principal Investigator

I01BX005109 (MCCLAIN, DONALD A.)Oct 1, 2020 - Sep 30, 2024 NIH Mechanism of Integrative Metabolic Regulation by Iron and Hypoxia Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Conway RBN, Sudenga S, McClain D, Blot WJ. Diabetes and liver cancer risk: A stronger effect in Whites than Blacks? J Diabetes Complications. 2021 Mar; 35(3):107816. PMID: 33323327.

Citations:
Ahmadi S, Razazan A, Nagpal R, Jain S, Wang B, Mishra SP, Wang S, Justice J, Ding J, McClain DA, Kritchevsky SB, Kitzman D, Yadav H. Metformin Reduces Aging-Related Leaky Gut and Improves Cognitive Function by Beneficially Modulating Gut Microbiome/Goblet Cell/Mucin Axis. J Gerontol A Biol Sci Med Sci. 2020 06 18; 75(7):e9-e21. PMID: 32129462.

Citations:
Shah BN, Hassan TO, Zhang X, McClain DA, Gordeuk VR. Increased iron stores influence glucose metabolism in sickle cell anaemia. Br J Haematol. 2020 05; 189(4):e184-e187. PMID: 32232834.

Citations:
Daniels MC, McClain DA, Crook ED. Transcriptional Regulation of Transforming Growth Factor ß1 by Glucose: Investigation into the Role of the Hexosamine Biosynthesis Pathway. Am J Med Sci. 2020 02; 359(2):79-83. PMID: 32039769.

Citations:
Wang S, Ahmadi S, Nagpal R, Jain S, Mishra SP, Kavanagh K, Zhu X, Wang Z, McClain DA, Kritchevsky SB, Kitzman DW, Yadav H. Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice. Geroscience. 2020 02; 42(1):333-352. PMID: 31814084.

Citations:
Salaye L, Bychkova I, Sink S, Kovalic AJ, Bharadwaj MS, Lorenzo F, Jain S, Harrison AV, Davis AT, Turnbull K, Meegalla NT, Lee SH, Cooksey R, Donati GL, Kavanagh K, Bonkovsky HL, McClain DA. A Low Iron Diet Protects from Steatohepatitis in a Mouse Model. Nutrients. 2019 Sep 10; 11(9). PMID: 31510077.

Citations:
Kavanagh K, Day SM, Pait MC, Mortiz WR, Newgard CB, Ilkayeva O, Mcclain DA, Macauley SL. Type-2-Diabetes Alters CSF but Not Plasma Metabolomic and AD Risk Profiles in Vervet Monkeys. Front Neurosci. 2019; 13:843. PMID: 31555072.

Citations:
McGill JB, Johnson M, Hurst S, Cade WT, Yarasheski KE, Ostlund RE, Schechtman KB, Razani B, Kastan MB, McClain DA, de Las Fuentes L, Davila-Roman VG, Ory DS, Wickline SA, Semenkovich CF. Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness. Diabetol Metab Syndr. 2019; 11:61. PMID: 31384309.

Citations:
Mongraw-Chaffin M, Beavers DP, McClain DA. Hypoglycemic symptoms in the absence of diabetes: Pilot evidence of clinical hypoglycemia in young women. J Clin Transl Endocrinol. 2019 Dec; 18:100202. PMID: 31428564.

Citations:
Gao Y, Liu J, Bai Z, Sink S, Zhao C, Lorenzo FR, McClain DA. Iron down-regulates leptin by suppressing protein O-GlcNAc modification in adipocytes, resulting in decreased levels of O-glycosylated CREB. J Biol Chem. 2019 04 05; 294(14):5487-5495. PMID: 30709903.

Citations:
Nagpal R, Wang S, Solberg Woods LC, Seshie O, Chung ST, Shively CA, Register TC, Craft S, McClain DA, Yadav H. Comparative Microbiome Signatures and Short-Chain Fatty Acids in Mouse, Rat, Non-human Primate, and Human Feces. Front Microbiol. 2018; 9:2897. PMID: 30555441.

Citations:
McClain DA, Sharma NK, Jain S, Harrison A, Salaye LN, Comeau ME, Langefeld CD, Lorenzo FR, Das SK. Adipose Tissue Transferrin and Insulin Resistance. J Clin Endocrinol Metab. 2018 11 01; 103(11):4197-4208. PMID: 30099506.

Citations:
Shannon C, Merovci A, Xiong J, Tripathy D, Lorenzo F, McClain D, Abdul-Ghani M, Norton L, DeFronzo RA. Effect of Chronic Hyperglycemia on Glucose Metabolism in Subjects With Normal Glucose Tolerance. Diabetes. 2018 12; 67(12):2507-2517. PMID: 30213826.

Citations:
Lamar ZS, Dothard A, Kennedy L, Isom S, Robinson M, Vaidya R, Hurd D, McClain D, Lesser G. Hyperglycemia during first-line R-CHOP or dose adjusted R-EPOCH chemotherapy for non-Hodgkin lymphoma is prevalent and associated with chemotherapy alteration - a retrospective study. Leuk Lymphoma. 2018 08; 59(8):1871-1877. PMID: 29252084.

Citations:
Nam H, Jones D, Cooksey RC, Gao Y, Sink S, Cox J, McClain DA. Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver. Diabetes. 2016 06; 65(6):1521-33. PMID: 26993063.

Citations:
Fernández-Real JM, McClain D, Manco M. Mechanisms Linking Glucose Homeostasis and Iron Metabolism Toward the Onset and Progression of Type 2 Diabetes. Diabetes Care. 2015 Nov; 38(11):2169-76. PMID: 26494808.

Citations:
Gao Y, Li Z, Gabrielsen JS, Simcox JA, Lee SH, Jones D, Cooksey B, Stoddard G, Cefalu WT, McClain DA. Adipocyte iron regulates leptin and food intake. J Clin Invest. 2015 Sep; 125(9):3681-91. PMID: 26301810.

Citations:
Ge RL, Simonson TS, Gordeuk V, Prchal JT, McClain DA. Metabolic aspects of high-altitude adaptation in Tibetans. Exp Physiol. 2015 Nov; 100(11):1247-55. PMID: 26053282.

Citations:
Zhang X, Zhang W, Saraf SL, Nouraie M, Han J, Gowhari M, Hassan J, Miasnikova G, Sergueeva A, Nekhai S, Kittles R, Machado RF, Garcia JG, Gladwin MT, Steinberg MH, Sebastiani P, McClain DA, Gordeuk VR. Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease. Hum Genet. 2015 Aug; 134(8):895-904. PMID: 26025476.

Citations:
Kwon OS, Tanner RE, Barrows KM, Runtsch M, Symons JD, Jalili T, Bikman BT, McClain DA, O'Connell RM, Drummond MJ. MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance. Am J Physiol Endocrinol Metab. 2015 Jul 01; 309(1):E11-21. PMID: 25968578.

Citations:
Bai Z, Wuren T, Liu S, Han S, Chen L, McClain D, Ge RL. Intermittent cold exposure results in visceral adipose tissue "browning" in the plateau pika (Ochotona curzoniae). Comp Biochem Physiol A Mol Integr Physiol. 2015 Jun; 184:171-8. PMID: 25662677.

Citations:
Simcox JA, Mitchell TC, Gao Y, Just SF, Cooksey R, Cox J, Ajioka R, Jones D, Lee SH, King D, Huang J, McClain DA. Dietary iron controls circadian hepatic glucose metabolism through heme synthesis. Diabetes. 2015 Apr; 64(4):1108-19. PMID: 25315005.

Citations:
Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin WG, Koivunen P, Prchal JT. A genetic mechanism for Tibetan high-altitude adaptation. Nat Genet. 2014 Sep; 46(9):951-6. PMID: 25129147.

Citations:
Carlin MB, Tanner RE, Agergaard J, Jalili T, McClain DA, Drummond MJ. Skeletal muscle Ras-related GTP binding B mRNA and protein expression is increased after essential amino acid ingestion in healthy humans. J Nutr. 2014 Sep; 144(9):1409-14. PMID: 25056691.

Citations:
Abbas MA, Abraham D, Kushner JP, McClain DA. Anti-obesity and pro-diabetic effects of hemochromatosis. Obesity (Silver Spring). 2014 Oct; 22(10):2120-2. PMID: 25044717.

Citations:
Drummond MJ, Addison O, Brunker L, Hopkins PN, McClain DA, LaStayo PC, Marcus RL. Downregulation of E3 ubiquitin ligases and mitophagy-related genes in skeletal muscle of physically inactive, frail older women: a cross-sectional comparison. J Gerontol A Biol Sci Med Sci. 2014 Aug; 69(8):1040-8. PMID: 24526667.

Citations:
Creighton Mitchell T, McClain DA. Diabetes and hemochromatosis. Curr Diab Rep. 2014; 14(5):488. PMID: 24682660.

Citations:
Zhu Y, Soto J, Anderson B, Riehle C, Zhang YC, Wende AR, Jones D, McClain DA, Abel ED. Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1a. . 2013 Jul 01; 305(1):H41-51. PMID: 23624629.

Citations:
Stapleton D, Nelson C, Parsawar K, Flores-Opazo M, McClain D, Parker G. The 3T3-L1 adipocyte glycogen proteome. Proteome Sci. 2013 Mar 22; 11(1):11. PMID: 23521774.

Citations:
Huang J, Simcox J, Mitchell TC, Jones D, Cox J, Luo B, Cooksey RC, Boros LG, McClain DA. Iron regulates glucose homeostasis in liver and muscle via AMP-activated protein kinase in mice. FASEB J. 2013 Jul; 27(7):2845-54. PMID: 23515442.

Citations:
Simcox JA, McClain DA. Iron and diabetes risk. Cell Metab. 2013 Mar 05; 17(3):329-41. PMID: 23473030.

Citations:
Lee SH, Jouihan HA, Cooksey RC, Jones D, Kim HJ, Winge DR, McClain DA. Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion. Endocrinology. 2013 Mar; 154(3):1029-38. PMID: 23372018.

Citations:
Byington CL, Savitz L, Varner M, McClain D. The Utah Center for Clinical and Translational Science: transformation through collaboration. Clin Transl Sci. 2012 Oct; 5(5):377-8. PMID: 23814914.

Citations:
McClain DA, Abuelgasim KA, Nouraie M, Salomon-Andonie J, Niu X, Miasnikova G, Polyakova LA, Sergueeva A, Okhotin DJ, Cherqaoui R, Okhotin D, Cox JE, Swierczek S, Song J, Simon MC, Huang J, Simcox JA, Yoon D, Prchal JT, Gordeuk VR. Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism. J Mol Med (Berl). 2013 Jan; 91(1):59-67. PMID: 23015148.

Citations:
Gabrielsen JS, Gao Y, Simcox JA, Huang J, Thorup D, Jones D, Cooksey RC, Gabrielsen D, Adams TD, Hunt SC, Hopkins PN, Cefalu WT, McClain DA. Adipocyte iron regulates adiponectin and insulin sensitivity. J Clin Invest. 2012 Oct; 122(10):3529-40. PMID: 22996660.

Citations:
Kusminski CM, Holland WL, Sun K, Park J, Spurgin SB, Lin Y, Askew GR, Simcox JA, McClain DA, Li C, Scherer PE. MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity. Nat Med. 2012 Oct; 18(10):1539-49. PMID: 22961109.

Citations:
Yang G, Jia Z, Aoyagi T, McClain D, Mortensen RM, Yang T. Systemic PPAR? deletion impairs circadian rhythms of behavior and metabolism. PLoS One. 2012; 7(8):e38117. PMID: 22899986.

Citations:
Underwood PC, Chamarthi B, Williams JS, Vaidya A, Garg R, Adler GK, Grotzke MP, Staskus G, Wadwekar D, Hopkins PN, Ferri C, McCall A, McClain D, Williams GH. Nonmodulation as the mechanism for salt sensitivity of blood pressure in individuals with hypertension and type 2 diabetes mellitus. J Clin Endocrinol Metab. 2012 Oct; 97(10):3775-82. PMID: 22865897.

Citations:
Boudina S, Sena S, Sloan C, Tebbi A, Han YH, O'Neill BT, Cooksey RC, Jones D, Holland WL, McClain DA, Abel ED. Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity. Endocrinology. 2012 Jun; 153(6):2677-88. PMID: 22510273.

Citations:
Shamoon H, Center D, Davis P, Tuchman M, Ginsberg H, Califf R, Stephens D, Mellman T, Verbalis J, Nadler L, Shekhar A, Ford D, Rizza R, Shaker R, Brady K, Murphy B, Cronstein B, Hochman J, Greenland P, Orwoll E, Sinoway L, Greenberg H, Jackson R, Coller B, Topol E, Guay-Woodford L, Runge M, Clark R, McClain D, Selker H, Lowery C, Dubinett S, Berglund L, Cooper D, Firestein G, Johnston SC, Solway J, Heubi J, Sokol R, Nelson D, Tobacman L, Rosenthal G, Aaronson L, Barohn R, Kern P, Sullivan J, Shanley T, Blazar B, Larson R, FitzGerald G, Reis S, Pearson T, Buchanan T, McPherson D, Brasier A, Toto R, Disis M, Drezner M, Bernard G, Clore J, Evanoff B, Imperato-McGinley J, Sherwin R, Pulley J. Preparedness of the CTSA's structural and scientific assets to support the mission of the National Center for Advancing Translational Sciences (NCATS). Clin Transl Sci. 2012 Apr; 5(2):121-9. PMID: 22507116.

Citations:
Ge RL, Simonson TS, Cooksey RC, Tanna U, Qin G, Huff CD, Witherspoon DJ, Xing J, Zhengzhong B, Prchal JT, Jorde LB, McClain DA. Metabolic insight into mechanisms of high-altitude adaptation in Tibetans. Mol Genet Metab. 2012 Jun; 106(2):244-7. PMID: 22503288.

Citations:
Simonson TS, McClain DA, Jorde LB, Prchal JT. Genetic determinants of Tibetan high-altitude adaptation. Hum Genet. 2012 Apr; 131(4):527-33. PMID: 22068265.

Citations:
Soesanto Y, Luo B, Parker G, Jones D, Cooksey RC, McClain DA. Pleiotropic and age-dependent effects of decreased protein modification by O-linked N-acetylglucosamine on pancreatic ß-cell function and vascularization. J Biol Chem. 2011 Jul 22; 286(29):26118-26. PMID: 21622566.

Citations:
Flann KL, LaStayo PC, McClain DA, Hazel M, Lindstedt SL. Muscle damage and muscle remodeling: no pain, no gain? J Exp Biol. 2011 Feb 15; 214(Pt 4):674-9. PMID: 21270317.

Citations:
Huang J, Jones D, Luo B, Sanderson M, Soto J, Abel ED, Cooksey RC, McClain DA. Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. Diabetes. 2011 Jan; 60(1):80-7. PMID: 20876715.

Citations:
Cooksey RC, McClain DA. Increased hexosamine pathway flux and high fat feeding are not additive in inducing insulin resistance: evidence for a shared pathway. Amino Acids. 2011 Mar; 40(3):841-6. PMID: 20658157.

Citations:
Stapleton D, Nelson C, Parsawar K, McClain D, Gilbert-Wilson R, Barker E, Rudd B, Brown K, Hendrix W, O'Donnell P, Parker G. Analysis of hepatic glycogen-associated proteins. Proteomics. 2010 Jun; 10(12):2320-9. PMID: 20391537.

Citations:
Cooksey RC, Jones D, Gabrielsen S, Huang J, Simcox JA, Luo B, Soesanto Y, Rienhoff H, Abel ED, McClain DA. Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse. Am J Physiol Endocrinol Metab. 2010 Jun; 298(6):E1236-43. PMID: 20354157.

Citations:
McClain DA. Bridging the gap between basic and clinical investigation. Trends Biochem Sci. 2010 Apr; 35(4):187-8. PMID: 20172732.

Citations:
Tabbi-Anneni I, Cooksey R, Gunda V, Liu S, Mueller A, Song G, McClain DA, Wang L. Overexpression of nuclear receptor SHP in adipose tissues affects diet-induced obesity and adaptive thermogenesis. Am J Physiol Endocrinol Metab. 2010 05; 298(5):E961-70. PMID: 20124506.

Citations:
Symons JD, McMillin SL, Riehle C, Tanner J, Palionyte M, Hillas E, Jones D, Cooksey RC, Birnbaum MJ, McClain DA, Zhang QJ, Gale D, Wilson LJ, Abel ED. Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure. Circ Res. 2009 May 08; 104(9):1085-94. PMID: 19342603.

Citations:
Shakya A, Cooksey R, Cox JE, Wang V, McClain DA, Tantin D. Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity. Nat Cell Biol. 2009 Mar; 11(3):320-7. PMID: 19219035.

Citations:
Marcus RL, Lastayo PC, Dibble LE, Hill L, McClain DA. Increased strength and physical performance with eccentric training in women with impaired glucose tolerance: a pilot study. J Womens Health (Larchmt). 2009 Feb; 18(2):253-60. PMID: 19183097.

Citations:
Yang S, Liu A, Weidenhammer A, Cooksey RC, McClain D, Kim MK, Aguilera G, Abel ED, Chung JH. The role of mPer2 clock gene in glucocorticoid and feeding rhythms. Endocrinology. 2009 May; 150(5):2153-60. PMID: 19179447.

Citations:
Taylor RP, Geisler TS, Chambers JH, McClain DA. Up-regulation of O-GlcNAc transferase with glucose deprivation in HepG2 cells is mediated by decreased hexosamine pathway flux. J Biol Chem. 2009 Feb 06; 284(6):3425-32. PMID: 19073609.

Citations:
McClain DA. Introduction to a mini-forum on "glyconutrients". Glycobiology. 2008 Sep; 18(9):651. PMID: 18710891.

Citations:
Soesanto YA, Luo B, Jones D, Taylor R, Gabrielsen JS, Parker G, McClain DA. Regulation of Akt signaling by O-GlcNAc in euglycemia. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E974-80. PMID: 18728220.

Citations:
Ruddock MW, Stein A, Landaker E, Park J, Cooksey RC, McClain D, Patti ME. Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling. J Biochem. 2008 Nov; 144(5):599-607. PMID: 18713797.

Citations:
Jouihan HA, Cobine PA, Cooksey RC, Hoagland EA, Boudina S, Abel ED, Winge DR, McClain DA. Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis. Mol Med. 2008 Mar-Apr; 14(3-4):98-108. PMID: 18317567.

Citations:
Taylor RP, Parker GJ, Hazel MW, Soesanto Y, Fuller W, Yazzie MJ, McClain DA. Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase. J Biol Chem. 2008 Mar 07; 283(10):6050-7. PMID: 18174169.

Citations:
Luo B, Soesanto Y, McClain DA. Protein modification by O-linked GlcNAc reduces angiogenesis by inhibiting Akt activity in endothelial cells. Arterioscler Thromb Vasc Biol. 2008 Apr; 28(4):651-7. PMID: 18174452.

Citations:
Young ME, Yan J, Razeghi P, Cooksey RC, Guthrie PH, Stepkowski SM, McClain DA, Tian R, Taegtmeyer H. Proposed regulation of gene expression by glucose in rodent heart. Gene Regul Syst Bio. 2007 Nov 05; 1:251-62. PMID: 19936093.

Citations:
Huang J, Gabrielsen JS, Cooksey RC, Luo B, Boros LG, Jones DL, Jouihan HA, Soesanto Y, Knecht L, Hazel MW, Kushner JP, McClain DA. Increased glucose disposal and AMP-dependent kinase signaling in a mouse model of hemochromatosis. J Biol Chem. 2007 Dec 28; 282(52):37501-7. PMID: 17971451.

Citations:
Wende AR, Schaeffer PJ, Parker GJ, Zechner C, Han DH, Chen MM, Hancock CR, Lehman JJ, Huss JM, McClain DA, Holloszy JO, Kelly DP. A role for the transcriptional coactivator PGC-1alpha in muscle refueling. J Biol Chem. 2007 Dec 14; 282(50):36642-51. PMID: 17932032.

Citations:
Hao HX, Cardon CM, Swiatek W, Cooksey RC, Smith TL, Wilde J, Boudina S, Abel ED, McClain DA, Rutter J. PAS kinase is required for normal cellular energy balance. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15466-71. PMID: 17878307.

Citations:
Abraham D, Sharma PK, Bentz J, Gault PM, Neumayer L, McClain DA. Utility of ultrasound-guided fine-needle aspiration of parathyroid adenomas for localization before minimally invasive parathyroidectomy. Endocr Pract. 2007 Jul-Aug; 13(4):333-7. PMID: 17669707.

Citations:
Hsueh W, Abel ED, Breslow JL, Maeda N, Davis RC, Fisher EA, Dansky H, McClain DA, McIndoe R, Wassef MK, Rabadán-Diehl C, Goldberg IJ. Recipes for creating animal models of diabetic cardiovascular disease. Circ Res. 2007 May 25; 100(10):1415-27. PMID: 17525381.

Citations:
Luo B, Parker GJ, Cooksey RC, Soesanto Y, Evans M, Jones D, McClain DA. Chronic hexosamine flux stimulates fatty acid oxidation by activating AMP-activated protein kinase in adipocytes. J Biol Chem. 2007 Mar 09; 282(10):7172-80. PMID: 17227772.

Citations:
Cooksey RC, Pusuluri S, Hazel M, McClain DA. Hexosamines regulate sensitivity of glucose-stimulated insulin secretion in beta-cells. Am J Physiol Endocrinol Metab. 2006 Feb; 290(2):E334-40. PMID: 16188910.

Citations:
McClain DA, Hazel M, Parker G, Cooksey RC. Adipocytes with increased hexosamine flux exhibit insulin resistance, increased glucose uptake, and increased synthesis and storage of lipid. Am J Physiol Endocrinol Metab. 2005 May; 288(5):E973-9. PMID: 15613679.

Citations:
Donthi RV, Ye G, Wu C, McClain DA, Lange AJ, Epstein PN. Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity. J Biol Chem. 2004 Nov 12; 279(46):48085-90. PMID: 15331593.

Citations:
Cooksey RC, Jouihan HA, Ajioka RS, Hazel MW, Jones DL, Kushner JP, McClain DA. Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis. Endocrinology. 2004 Nov; 145(11):5305-12. PMID: 15308612.

Citations:
Parker G, Taylor R, Jones D, McClain D. Hyperglycemia and inhibition of glycogen synthase in streptozotocin-treated mice: role of O-linked N-acetylglucosamine. J Biol Chem. 2004 May 14; 279(20):20636-42. PMID: 15014073.

Citations:
Hazel M, Cooksey RC, Jones D, Parker G, Neidigh JL, Witherbee B, Gulve EA, McClain DA. Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance. Endocrinology. 2004 May; 145(5):2118-28. PMID: 14684615.

Citations:
Parker GJ, Lund KC, Taylor RP, McClain DA. Insulin resistance of glycogen synthase mediated by o-linked N-acetylglucosamine. J Biol Chem. 2003 Mar 21; 278(12):10022-7. PMID: 12510058.

Citations:
McClain DA, Lubas WA, Cooksey RC, Hazel M, Parker GJ, Love DC, Hanover JA. Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10695-9. PMID: 12136128.

Citations:
Cooksey RC, McClain DA. Transgenic mice overexpressing the rate-limiting enzyme for hexosamine synthesis in skeletal muscle or adipose tissue exhibit total body insulin resistance. Ann N Y Acad Sci. 2002 Jun; 967:102-11. PMID: 12079840.

Citations:
Belke DD, Betuing S, Tuttle MJ, Graveleau C, Young ME, Pham M, Zhang D, Cooksey RC, McClain DA, Litwin SE, Taegtmeyer H, Severson D, Kahn CR, Abel ED. Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest. 2002 Mar; 109(5):629-39. PMID: 11877471.

Citations:
McClain DA. Hexosamines as mediators of nutrient sensing and regulation in diabetes. J Diabetes Complications. 2002 Jan-Feb; 16(1):72-80. PMID: 11872372.

Citations:

Year	Publications
2002	4
2003	2
2004	4
2005	1
2007	7
2008	7
2009	4
2010	6
2011	3
2012	9
2013	5
2014	6
2015	6
2016	1
2017	1
2018	3
2019	6
2020	4

Mcclain's Networks

Click the

Explore

buttons for more information and interactive visualizations!

Concepts (400)

Explore

Co-Authors (15)

Explore

Similar People (51)

Explore

Same Department

Explore

Physical Neighbors