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Thomas D. DuBose MD

TitleProfessor Emeritus
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, General Internal Medicine
Address
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    Collapse Research 
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    K04AM001033     (DUBOSE, THOMAS D)Jul 1, 1981 - Jun 30, 1986
    NIH
    MECHANISMS OF RENAL ACID-BASE HOMEOSTASIS
    Role: Principal Investigator
    R01AM030603     (DUBOSE, THOMAS D)Jul 1, 1981 - Jun 30, 1987
    NIH
    MECHANISM OF RENAL ACID-BASE HOMEOSTASIS
    Role: Principal Investigator
    R01DK030603     (DUBOSE, THOMAS D)Jul 1, 1981 - Jul 31, 2009
    NIH
    Mechanism of Renal Acid- Base Homeostasis
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Frassetto LA, Sebastian A, DuBose TD. How metabolic acidosis and kidney disease may accelerate the aging process. Eur J Clin Nutr. 2020 08; 74(Suppl 1):27-32. PMID: 32873954.
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    2. Tucker BM, Pirkle JL, Stefi E, Sheikh-Hamad D, DuBose T. Iso-osmolar hyponatremia from polyethylene glycol. Clin Kidney J. 2021 Feb; 14(2):715-719. PMID: 33623696.
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    3. DuBose TD. Inadequate Dietary Potassium and Progression of CKD. Clin J Am Soc Nephrol. 2019 03 07; 14(3):319-320. PMID: 30765535.
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    4. West CA, Welling PA, West DA, Coleman RA, Cheng KY, Chen C, DuBose TD, Verlander JW, Baylis C, Gumz ML. Renal and colonic potassium transporters in the pregnant rat. Am J Physiol Renal Physiol. 2018 02 01; 314(2):F251-F259. PMID: 29046297.
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    5. DuBose TD. Regulation of Potassium Homeostasis in CKD. Adv Chronic Kidney Dis. 2017 09; 24(5):305-314. PMID: 29031357.
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    6. DuBose TD. Urine Ammonium and Preclinical Acidosis in CKD. J Am Soc Nephrol. 2017 08; 28(8):2258-2260. PMID: 28630230.
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    7. DuBose TD, deShazo RD. WILLIAM C. LITTLE, MD: 1950 - 2015. Trans Am Clin Climatol Assoc. 2016; 127:xcviii-c. PMID: 28066086.
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    8. Sun X, Stephens L, DuBose TD, Petrovic S. Adaptation by the collecting duct to an exogenous acid load is blunted by deletion of the proton-sensing receptor GPR4. Am J Physiol Renal Physiol. 2015 Jul 15; 309(2):F120-36. PMID: 25972512.
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    9. Maldonado ME, Fried ED, DuBose TD, Nelson C, Breida M. The role that graduate medical education must play in ensuring health equity and eliminating health care disparities. Ann Am Thorac Soc. 2014 May; 11(4):603-7. PMID: 24708150.
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    10. Petrovic S, Dubose TD. Missense mutations and proximal RTA. Have we reached a new threshold? Focus on "missense mutation T485S alters NBCe1-A electrogenicity causing proximal renal tubular acidosis". . 2013 Aug 15; 305(4):C373-4. PMID: 23720023.
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    11. Fisher KD, Codina J, Petrovic S, DuBose TD. Pyk2 regulates H+-ATPase-mediated proton secretion in the outer medullary collecting duct via an ERK1/2 signaling pathway. Am J Physiol Renal Physiol. 2012 Nov 01; 303(9):F1353-62. PMID: 22811489.
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    12. Saxena H, Deshpande DA, Tiegs BC, Yan H, Battafarano RJ, Burrows WM, Damera G, Panettieri RA, Dubose TD, An SS, Penn RB. The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH. Br J Pharmacol. 2012 Jun; 166(3):981-90. PMID: 22145625.
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    13. Horvat SJ, Deshpande DA, Yan H, Panettieri RA, Codina J, DuBose TD, Xin W, Rich TC, Penn RB. A-kinase anchoring proteins regulate compartmentalized cAMP signaling in airway smooth muscle. FASEB J. 2012 Sep; 26(9):3670-9. PMID: 22649031.
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    14. Drafts BC, Sutton BJ, Dubose TD, Thohan V. Incessant ventricular tachycardia and cardiogenic shock: a common presentation of an uncommon diagnosis. Am J Med Sci. 2011 Dec; 342(6):527-9. PMID: 21817876.
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    15. Codina J, Opyd TS, Powell ZB, Furdui CM, Petrovic S, Penn RB, DuBose TD. pH-dependent regulation of the a-subunit of H+-K+-ATPase (HKa2). Am J Physiol Renal Physiol. 2011 Sep; 301(3):F536-43. PMID: 21653633.
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    16. Moossavi S, Wallace EL, Martin TJ, Dubose TD. Hepatitis C virus and cocaine-induced rhabdomyolysis. Am J Med. 2010 Dec; 123(12):e5-6. PMID: 20851367.
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    17. DuBose TD, Behrens MT, Berns A, Davis C, Goldfarb S, Hostetter T, Klotman P, Linas S, Owens S, Szczech L, Himmelfarb J. The patient-centered medical home and nephrology. J Am Soc Nephrol. 2009 Apr; 20(4):681-2. PMID: 19297553.
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    18. Saran AM, DuBose TD. Cardiovascular disease in chronic kidney disease. Ther Adv Cardiovasc Dis. 2008 Dec; 2(6):425-34. PMID: 19124439.
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    19. Freedman BI, Dubose TD. Chronic kidney disease: cause and consequence of cardiovascular disease. Arch Intern Med. 2007 Jun 11; 167(11):1113-5. PMID: 17563017.
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    20. Himmelfarb J, Henrich W, DuBose T. Anemia of kidney disease and clinical practice guidelines: quo vadis? Clin J Am Soc Nephrol. 2007 Mar; 2(2):213-4. PMID: 17699415.
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    21. Levey AS, Andreoli SP, DuBose T, Provenzano R, Collins AJ. Chronic kidney disease: common, harmful and treatable--World Kidney Day 2007. Am J Nephrol. 2007; 27(1):108-12. PMID: 17308371.
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    22. Levey AS, Andreoli SP, DuBose T, Provenzano R, Collins AJ. Chronic kidney disease: common, harmful, and treatable--World Kidney Day 2007. Clin J Am Soc Nephrol. 2007 Mar; 2(2):401-5. PMID: 17699441.
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    23. Levey AS, Andreoli SP, DuBose T, Provenzano R, Collins AJ. Chronic kidney disease: common, harmful and treatable--World Kidney Day 2007. Pediatr Nephrol. 2007 Mar; 22(3):321-5. PMID: 17256125.
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    24. Codina J, Liu J, Bleyer AJ, Penn RB, DuBose TD. Phosphorylation of S955 at the protein kinase A consensus promotes maturation of the alpha subunit of the colonic H+,K+ -ATPase. J Am Soc Nephrol. 2006 Jul; 17(7):1833-40. PMID: 16738016.
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    25. Wesson DE, King TE, Todd RF, Torres EA, Hellmann DB, Flack JM, Dubose TD, Schuster VL. Achieving diversity in academic internal medicine: recommendations for leaders. Am J Med. 2006 Jan; 119(1):76-81. PMID: 16431199.
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    26. Codina J, Li J, Dubose TD. CD63 interacts with the carboxy terminus of the colonic H+-K+-ATPase to decrease [corrected] plasma membrane localization and 86Rb+ uptake. . 2005 Jun; 288(6):C1279-86. PMID: 15647390.
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    27. Codina J, Li J, Dubose TD. A carboxy-terminus motif of HKalpha2 is necessary for assembly and function. Kidney Int. 2004 Dec; 66(6):2283-92. PMID: 15569317.
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    28. Li J, Codina J, Petroske E, Werle MJ, Willingham MC, DuBose TD. The effect of beta-subunit assembly on function and localization of the colonic H+,K+-ATPase alpha-subunit. Kidney Int. 2004 Sep; 66(3):1068-75. PMID: 15327400.
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    29. Li J, Codina J, Petroske E, Werle MJ, DuBose TD. The carboxy terminus of the colonic H(+), K(+)-ATPase alpha-subunit is required for stable beta subunit assembly and function. Kidney Int. 2004 Apr; 65(4):1301-10. PMID: 15086469.
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    30. King TE, Dickinson TA, DuBose TD, Flack JM, Hellmann DB, Pamies RJ, Todd RF, Torres EA, Wesson DE. The case for diversity in academic internal medicine. Am J Med. 2004 Feb 15; 116(4):284-9. PMID: 14969662.
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    31. Codina J, Li J, Hong Y, DuBose TD. The gamma-Na+,K+-ATPase subunit assembles selectively with alpha1/beta1-Na+,K+-ATPase but not with the colonic H+,K+-ATPase. Kidney Int. 2002 Mar; 61(3):967-74. PMID: 11849451.
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    32. Codina J, Cardwell J, Gitomer JJ, Cui Y, Kone BC, Dubose TD. Sch-28080 depletes intracellular ATP selectively in mIMCD-3 cells. . 2000 Nov; 279(5):C1319-26. PMID: 11029278.
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    33. Codina J, Pressley TA, DuBose TD. The colonic H+,K+-ATPase functions as a Na+-dependent K+(NH4+)-ATPase in apical membranes from rat distal colon. J Biol Chem. 1999 Jul 09; 274(28):19693-8. PMID: 10391909.
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    34. Codina J, Gurich R, Dubose TD. Peptides derived from the human transferrin receptor stimulate endosomal acidification via a Gi-type protein. Kidney Int. 1999 Jun; 55(6):2376-82. PMID: 10354285.
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    35. Wall SM, Mehta P, DuBose TD. Dietary K+ restriction upregulates total and Sch-28080-sensitive bicarbonate absorption in rat tIMCD. Am J Physiol. 1998 10; 275(4):F543-9. PMID: 9755126.
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    36. Codina J, Delmas-Mata JT, DuBose TD. Expression of HKalpha2 protein is increased selectively in renal medulla by chronic hypokalemia. Am J Physiol. 1998 09; 275(3):F433-40. PMID: 9729517.
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    37. Codina J, Delmas-Mata JT, DuBose TD. The alpha-subunit of the colonic H+,K+-ATPase assembles with beta1-Na+,K+-ATPase in kidney and distal colon. J Biol Chem. 1998 Apr 03; 273(14):7894-9. PMID: 9525884.
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    38. Guntupalli J, Onuigbo M, Wall S, Alpern RJ, DuBose TD. Adaptation to low-K+ media increases H(+)-K(+)-ATPase but not H(+)-ATPase-mediated pHi recovery in OMCD1 cells. Am J Physiol. 1997 Aug; 273(2 Pt 1):C558-71. PMID: 9277353.
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    39. Codina J, Pressley TA, DuBose TD. Effect of chronic hypokalemia on H(+)-K(+)-ATPase expression in rat colon. Am J Physiol. 1997 Jan; 272(1 Pt 2):F22-30. PMID: 9039045.
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    40. Codina J, Kone BC, Delmas-Mata JT, DuBose TD. Functional expression of the colonic H+,K+-ATPase alpha-subunit. Pharmacologic properties and assembly with X+,K+-ATPase beta-subunits. J Biol Chem. 1996 Nov 22; 271(47):29759-63. PMID: 8939912.
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    41. Wall SM, Truong AV, DuBose TD. H(+)-K(+)-ATPase mediates net acid secretion in rat terminal inner medullary collecting duct. Am J Physiol. 1996 Nov; 271(5 Pt 2):F1037-44. PMID: 8945998.
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    42. Ono S, Guntupalli J, DuBose TD. Role of H(+)-K(+)-ATPase in pHi regulation in inner medullary collecting duct cells in culture. Am J Physiol. 1996 May; 270(5 Pt 2):F852-61. PMID: 8928848.
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    43. DuBose TD, Good DW. Effects of chronic Cl depletion alkalosis on proximal tubule transport and renal production of ammonium. Am J Physiol. 1995 Oct; 269(4 Pt 2):F508-14. PMID: 7485535.
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    44. DuBose TD, Codina J, Burges A, Pressley TA. Regulation of H(+)-K(+)-ATPase expression in kidney. Am J Physiol. 1995 Oct; 269(4 Pt 2):F500-7. PMID: 7485534.
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    45. Ono S, Mougouris T, DuBose TD, Sansom SC. ATP and calcium modulation of nonselective cation channels in IMCD cells. Am J Physiol. 1994 Oct; 267(4 Pt 2):F558-65. PMID: 7524357.
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    46. Sansom SC, Mougouris T, Ono S, DuBose TD. ATP-sensitive K(+)-selective channels of inner medullary collecting duct cells. Am J Physiol. 1994 Sep; 267(3 Pt 2):F489-96. PMID: 8092263.
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    47. Guntupalli J, DuBose TD. Effects of endothelin on rat renal proximal tubule Na(+)-Pi cotransport and Na+/H+ exchange. Am J Physiol. 1994 Apr; 266(4 Pt 2):F658-66. PMID: 8184900.
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    48. DuBose TD, Good DW. Chronic hyperkalemia impairs ammonium transport and accumulation in the inner medulla of the rat. J Clin Invest. 1992 Oct; 90(4):1443-9. PMID: 1401077.
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    49. DuBose TD, Good DW. Effects of chronic hyperkalemia on renal production and proximal tubule transport of ammonium in rats. Am J Physiol. 1991 May; 260(5 Pt 2):F680-7. PMID: 2035655.
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    50. Gurich RW, Codina J, DuBose TD. A potential role for guanine nucleotide-binding protein in the regulation of endosomal proton transport. J Clin Invest. 1991 May; 87(5):1547-52. PMID: 1850757.
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    51. Beach RE, DuBose TD. Adrenergic regulation of (Na+, K+)-ATPase activity in proximal tubules of spontaneously hypertensive rats. Kidney Int. 1990 Sep; 38(3):402-8. PMID: 2172614.
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    52. Gurich RW, DuBose TD. Heterogeneity of cAMP effect on endosomal proton transport. Am J Physiol. 1989 Nov; 257(5 Pt 2):F777-84. PMID: 2556037.
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    53. Bidani A, Brown SE, Heming TA, Gurich R, Dubose TD. Cytoplasmic pH in pulmonary macrophages: recovery from acid load is Na+ independent and NEM sensitive. Am J Physiol. 1989 Jul; 257(1 Pt 1):C65-76. PMID: 2526587.
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    54. DuBose TD, Caflisch CR. Effect of selective aldosterone deficiency on acidification in nephron segments of the rat inner medulla. J Clin Invest. 1988 Nov; 82(5):1624-32. PMID: 3183058.
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    55. DuBose TD, Bidani A. Kinetics of CO2 exchange in the kidney. Annu Rev Physiol. 1988; 50:653-67. PMID: 3132080.
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    56. Good DW, DuBose TD. Ammonia transport by early and late proximal convoluted tubule of the rat. J Clin Invest. 1987 Mar; 79(3):684-91. PMID: 3818944.
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    57. Good DW, Caflisch CR, DuBose TD. Transepithelial ammonia concentration gradients in inner medulla of the rat. Am J Physiol. 1987 Mar; 252(3 Pt 2):F491-500. PMID: 3826390.
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    58. DuBose TD, Caflisch CR. Validation of the difference in urine and blood carbon dioxide tension during bicarbonate loading as an index of distal nephron acidification in experimental models of distal renal tubular acidosis. J Clin Invest. 1985 Apr; 75(4):1116-23. PMID: 3921566.
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