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Simon A.Mahler MD, MS

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentEmergency Medicine
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentEpidemiology & Prevention (Public Health Sciences)

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentImplementation Science (Public Health Sciences)


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ashburn NP, Stopyra JP, Mahler SA. News From Lake Wobegon … Clinician Gestalt Debunked? Acad Emerg Med. 2020 01; 27(1):80-82. PMID: 31336399.
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    2. Levy PD, Mahler SA. Evaluating Suspected Acute MI in the Emergency Department: What Is and What Should Never Be. J Am Coll Cardiol. 2019 07 30; 74(4):495-497. PMID: 31345422.
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    3. Mahler SA, Lenoir KM, Wells BJ, Burke GL, Duncan PW, Case LD, Herrington DM, Diaz-Garelli JF, Futrell WM, Hiestand BC, Miller CD. Response by Mahler et al to Letter Regarding Article, "Safely Identifying Emergency Department Patients With Acute Chest Pain for Early Discharge: HEART Pathway Accelerated Diagnostic Protocol". Circulation. 2019 05 07; 139(19):e915-e916. PMID: 31059320.
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    4. Miller CD, Stopyra JP, Mahler SA, Case LD, Vasu S, Bell RA, Hundley WG. ACES (Accelerated Chest Pain Evaluation With Stress Imaging) Protocols Eliminate Testing Disparities in Patients With Chest Pain. Crit Pathw Cardiol. 2019 03; 18(1):5-9. PMID: 30747758.
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    5. Januzzi JL, Mahler SA, Christenson RH, Rymer J, Newby LK, Body R, Morrow DA, Jaffe AS. Recommendations for Institutions Transitioning to High-Sensitivity Troponin Testing: JACC Scientific Expert Panel. J Am Coll Cardiol. 2019 03 12; 73(9):1059-1077. PMID: 30798981.
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    6. Gesell SB, Golden SL, Limkakeng AT, Carr CM, Matuskowitz A, Smith LM, Mahler SA. Implementation of the HEART Pathway: Using the Consolidated Framework for Implementation Research. Crit Pathw Cardiol. 2018 12; 17(4):191-200. PMID: 30418249.
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    7. Mahler SA, Lenoir KM, Wells BJ, Burke GL, Duncan PW, Case LD, Herrington DM, Diaz-Garelli JF, Futrell WM, Hiestand BC, Miller CD. Safely Identifying Emergency Department Patients With Acute Chest Pain for Early Discharge. Circulation. 2018 11 27; 138(22):2456-2468. PMID: 30571347.
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    8. Stopyra JP, Riley RF, Hiestand BC, Russell GB, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Elliott SB, Herrington DM, Burke GL, Miller CD, Mahler SA. The HEART Pathway Randomized Controlled Trial One-year Outcomes. Acad Emerg Med. 2019 01; 26(1):41-50. PMID: 29920834.
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    9. Mahler SA, Register TC, Riley RF, D'Agostino RB, Stopyra JP, Miller CD. Monocyte Chemoattractant Protein-1 as a Predictor of Coronary Atherosclerosis in Patients Receiving Coronary Angiography. Crit Pathw Cardiol. 2018 06; 17(2):105-110. PMID: 29768320.
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    10. Riley RF, Miller CD, Russell GB, Soliman EZ, Hiestand BC, Herrington DM, Mahler SA. Usefulness of Serial 12-Lead Electrocardiograms in Predicting 30-Day Outcomes in Patients With Undifferentiated Chest Pain (the ASAP CATH Study). Am J Cardiol. 2018 08 01; 122(3):374-380. PMID: 30196932.
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    11. Alley WD, Burns C, Hartman ND, Askew K, Mahler SA. 3 for the Price of 1: Teaching Chest Pain Risk Stratification in a Multidisciplinary, Problem-based Learning Workshop. West J Emerg Med. 2018 May; 19(3):613-618. PMID: 29760864.
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    12. Stopyra JP, Harper WS, Higgins TJ, Prokesova JV, Winslow JE, Nelson RD, Alson RL, Davis CA, Russell GB, Miller CD, Mahler SA. Prehospital Modified HEART Score Predictive of 30-Day Adverse Cardiac Events. Prehosp Disaster Med. 2018 Feb; 33(1):58-62. PMID: 29316995.
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    13. Hartman ND, Harper EN, Leppert LM, Browning BM, Askew K, Manthey DE, Mahler SA. A Multidisciplinary Self-Directed Learning Module Improves Knowledge of a Quality Improvement Instrument: The HEART Pathway. J Healthc Qual. 2018 Jan/Feb; 40(1):e9-e14. PMID: 27442714.
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    14. Body R, Mahler S. Welcome to the Real World: Do the Conditions of FDA Approval Devalue High-sensitivity Troponin? Acad Emerg Med. 2017 10; 24(10):1278-1280. PMID: 28715149.
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    15. Stopyra JP, Miller CD, Hiestand BC, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Riley RF, Russell GB, Hoekstra JW, Mahler SA. Validation of the No Objective Testing Rule and Comparison to the HEART Pathway. Acad Emerg Med. 2017 09; 24(9):1165-1168. PMID: 28493646.
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    16. Stopyra JP, Miller CD, Mahler SA. In Reply. Acad Emerg Med. 2017 09; 24(9):1171-1172. PMID: 28608431.
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    17. Huis In 't Veld MA, Cullen L, Mahler SA, Backus BE, Dezman ZDW, Mattu A. The Fast and the Furious: Low-Risk Chest Pain and the Rapid Rule-Out Protocol. West J Emerg Med. 2017 Apr; 18(3):474-478. PMID: 28435499.
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    18. Mahler SA, Stopyra JP, Apple FS, Riley RF, Russell GB, Hiestand BC, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Herrington DM, Burke GL, Miller CD. Use of the HEART Pathway with high sensitivity cardiac troponins: A secondary analysis. Clin Biochem. 2017 May; 50(7-8):401-407. PMID: 28087371.
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    19. Baugh CW, Greenberg JO, Mahler SA, Kosowsky JM, Schuur JD, Parmar S, Ciociolo GR, Carr CW, Ghazinouri R, Scirica BM. Implementation of a Risk Stratification and Management Pathway for Acute Chest Pain in the Emergency Department. Crit Pathw Cardiol. 2016 12; 15(4):131-137. PMID: 27846004.
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    20. Mumma BE, Eggert J, Mahler SA, Kontos MC, Diercks DB. Association Between Hospital Practices and Door-in-door-out Time in ST-segment Elevation Myocardial Infarction. Crit Pathw Cardiol. 2016 12; 15(4):165-168. PMID: 27846009.
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    21. Cullen LA, Mills NL, Mahler S, Body R. Early Rule-Out and Rule-In Strategies for Myocardial Infarction. Clin Chem. 2017 Jan; 63(1):129-139. PMID: 28062616.
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    22. Riley RF, Miller CD, Russell GB, Harper EN, Hiestand BC, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Mahler SA. Cost analysis of the History, ECG, Age, Risk factors, and initial Troponin (HEART) Pathway randomized control trial. Am J Emerg Med. 2017 Jan; 35(1):77-81. PMID: 27765481.
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    23. Stopyra JP, Mahler SA. Ready for a Risk Stratification Robot? Acad Emerg Med. 2016 09; 23(9):1071-3. PMID: 27332776.
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    24. Stopyra JP, Miller CD, Hiestand BC, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Riley RF, Russell GB, Burke GL, Herrington D, Hoekstra JW, Mahler SA. Chest Pain Risk Stratification: A Comparison of the 2-Hour Accelerated Diagnostic Protocol (ADAPT) and the HEART Pathway. Crit Pathw Cardiol. 2016 06; 15(2):46-9. PMID: 27183253.
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    25. Sunwook K, Nussbaum MA, Quandt SA, Laurienti PJ, Arcury TA. Effects of Lifetime Occupational Pesticide Exposure on Postural Control Among Farmworkers and Non-Farmworkers. J Occup Environ Med. 2016 Feb; 58(2):133-9. PMID: 26720295.
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    26. Mahler SA, Burke GL, Duncan PW, Case LD, Herrington DM, Riley RF, Wells BJ, Hiestand BC, Miller CD. HEART Pathway Accelerated Diagnostic Protocol Implementation: Prospective Pre-Post Interrupted Time Series Design and Methods. JMIR Res Protoc. 2016 Jan 22; 5(1):e10. PMID: 26800789.
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    27. Stopyra JP, Miller CD, Hiestand BC, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Riley RF, Russell GB, Hoekstra JW, Mahler SA. Performance of the EDACS-accelerated Diagnostic Pathway in a Cohort of US Patients with Acute Chest Pain. Crit Pathw Cardiol. 2015 Dec; 14(4):134-8. PMID: 26569652.
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    28. Alley W, Mahler SA. Clinical decision aids for chest pain in the emergency department: identifying low-risk patients. Open Access Emerg Med. 2015; 7:85-92. PMID: 27147894.
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    29. Mahler SA, Miller CD, Litt HI, Gatsonis CA, Snyder BS, Hollander JE. Performance of the 2-hour accelerated diagnostic protocol within the American College of Radiology Imaging Network PA 4005 cohort. Acad Emerg Med. 2015 Apr; 22(4):452-60. PMID: 25810343.
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    30. Mahler SA, Riley RF, Hiestand BC, Russell GB, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Elliott SB, Herrington DM, Burke GL, Miller CD. The HEART Pathway randomized trial: identifying emergency department patients with acute chest pain for early discharge. Circ Cardiovasc Qual Outcomes. 2015 Mar; 8(2):195-203. PMID: 25737484.
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    31. Nicks BA, Mahler S, Manthey D. Impact of a physician-in-triage process on resident education. West J Emerg Med. 2014 Nov; 15(7):902-7. PMID: 25493151.
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    32. Mahler SA. Ultrasound-guided peripheral intravenous access: a reply to Dr. Stone. J Emerg Med. 2014 Feb; 46(2):228-9. PMID: 24268894.
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    33. Mahler SA, Burke GL, Goff DC, Hiestand BC, Nicks BA, Hoekstra JW, Case LD, Miller CD. Avoidable utilization of the chest pain observation unit: evaluation of very-low-risk patients. Crit Pathw Cardiol. 2013 Jun; 12(2):59-64. PMID: 23680810.
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    34. Miller CD, Case LD, Little WC, Mahler SA, Burke GL, Harper EN, Lefebvre C, Hiestand B, Hoekstra JW, Hamilton CA, Hundley WG. Stress CMR reduces revascularization, hospital readmission, and recurrent cardiac testing in intermediate-risk patients with acute chest pain. JACC Cardiovasc Imaging. 2013 Jul; 6(7):785-94. PMID: 23664718.
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    35. Diercks DB, Mumma BE, Frank Peacock W, Hollander JE, Safdar B, Mahler SA, Miller CD, Counselman FL, Birkhahn R, Schrock J, Singer AJ, Nagurney JT. Incremental value of objective cardiac testing in addition to physician impression and serial contemporary troponin measurements in women. Acad Emerg Med. 2013 Mar; 20(3):265-70. PMID: 23517258.
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    36. Mahler SA, Hiestand BC, Nwanaji-Enwerem J, Goff DC, Burke GL, Douglas Case L, Nicks B, Miller CD. Reduction in observation unit length of stay with coronary computed tomography angiography depends on time of emergency department presentation. Acad Emerg Med. 2013 Mar; 20(3):231-9. PMID: 23517254.
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    37. Mahler SA, Miller CD, Hollander JE, Nagurney JT, Birkhahn R, Singer AJ, Shapiro NI, Glynn T, Nowak R, Safdar B, Peberdy M, Counselman FL, Chandra A, Kosowsky J, Neuenschwander J, Schrock JW, Plantholt S, Diercks DB, Peacock WF. Identifying patients for early discharge: performance of decision rules among patients with acute chest pain. Int J Cardiol. 2013 Sep 30; 168(2):795-802. PMID: 23117012.
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    38. Askew K, Manthey D, Mahler S. Clinical reasoning: are we testing what we are teaching? Med Educ. 2012 Jun; 46(6):540-2. PMID: 22626044.
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    39. Miller CD, Hoekstra JW, Lefebvre C, Blumstein H, Hamilton CA, Harper EN, Mahler S, Diercks DB, Neiberg R, Hundley WG. Provider-directed imaging stress testing reduces health care expenditures in lower-risk chest pain patients presenting to the emergency department. Circ Cardiovasc Imaging. 2012 Jan; 5(1):111-8. PMID: 22128195.
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    40. Wang H, Shi R, Mahler S, Gaspard J, Gorchynski J, D'Etienne J, Arnold T. Vascular pedicle width on chest radiograph as a measure of volume overload: meta-analysis. West J Emerg Med. 2011 Nov; 12(4):426-32. PMID: 22224132.
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    41. Mahler SA, Hiestand BC, Goff DC, Hoekstra JW, Miller CD. Can the HEART score safely reduce stress testing and cardiac imaging in patients at low risk for major adverse cardiac events? Crit Pathw Cardiol. 2011 Sep; 10(3):128-33. PMID: 21989033.
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    42. Mahler SA, Massey G, Meskill L, Wang H, Arnold TC. Can we make the basilic vein larger? maneuvers to facilitate ultrasound guided peripheral intravenous access: a prospective cross-sectional study. Int J Emerg Med. 2011 Aug 25; 4:53. PMID: 21867495.
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    43. Mahler SA, Swoboda TK, Wang H, Arnold TC. Dedicated emergency department ultrasound rotation improves residents' ultrasound knowledge and interpretation skills. J Emerg Med. 2012 Jul; 43(1):129-33. PMID: 21550756.
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    44. Mahler SA, McCartney JR, Swoboda TK, Yorek L, Arnold TC. The impact of emergency department overcrowding on resident education. J Emerg Med. 2012 Jan; 42(1):69-73. PMID: 21536400.
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    45. Mahler SA, Wolcott CJ, Swoboda TK, Wang H, Arnold TC. Techniques for teaching electrocardiogram interpretation: self-directed learning is less effective than a workshop or lecture. Med Educ. 2011 Apr; 45(4):347-53. PMID: 21401682.
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    46. Wang H, Zhou H, Mahler S, Chervenak R, Wolcott M. Alcohol affects the late differentiation of progenitor B cells. Alcohol Alcohol. 2011 Jan-Feb; 46(1):26-32. PMID: 21098503.
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    47. Mahler SA, Wang H, Lester C, Skinner J, Arnold TC, Conrad SA. Short- vs long-axis approach to ultrasound-guided peripheral intravenous access: a prospective randomized study. Am J Emerg Med. 2011 Nov; 29(9):1194-7. PMID: 20951527.
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    48. Locascio EJ, Mahler SA, Arnold TC. Intestinal angioedema misdiagnosed as recurrent episodes of gastroenteritis. West J Emerg Med. 2010 Sep; 11(4):391-4. PMID: 21079716.
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    49. Mahler SA, Chan HY, Carden DL, Wolcott C, Conrad SA. Emergency Department Activation of Interventional Cardiology to Reduce Door-to-Balloon Time. West J Emerg Med. 2010 Sep; 11(4):363-6. PMID: 21079710.
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    50. Wang H, Hollingsworth J, Mahler S, Arnold T. Diffuse ST segment depression from hypothermia. Int J Emerg Med. 2010 Aug 21; 3(4):451-4. PMID: 21373321.
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    51. Mahler SA, Conrad SA, Wang H, Arnold TC. Resuscitation with balanced electrolyte solution prevents hyperchloremic metabolic acidosis in patients with diabetic ketoacidosis. Am J Emerg Med. 2011 Jul; 29(6):670-4. PMID: 20825879.
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    52. Mahler SA, Pattani S, Standifer J, Caldito G, Conrad SA, Arnold TC. Clinical sobriety assessment by emergency physicians in blunt trauma patients with acute alcohol exposure. J Emerg Med. 2010 Nov; 39(5):685-90. PMID: 19615845.
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    53. Mahler SA, Wang H, Lester C, Conrad SA. Ultrasound-guided peripheral intravenous access in the emergency department using a modified Seldinger technique. J Emerg Med. 2010 Sep; 39(3):325-9. PMID: 19303241.
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    54. Mahler SA, Thoma T. Commentary: speaking up and reaching out. Ann Emerg Med. 2008 Aug; 52(2):166-7. PMID: 18655921.
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    55. Mahler SA, Wagner MJ, Church A, Sokolosky M, Cline DM. Importance of residency program web sites to emergency medicine applicants. J Emerg Med. 2009 Jan; 36(1):83-8. PMID: 18439790.
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    56. Mahler SA, Manthey DE. Diagnosis of a preputial cavity abscess with bedside ultrasound in the emergency department. J Emerg Med. 2008 Oct; 35(3):273-6. PMID: 17976780.
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    57. Rich PB, Douillet CD, Mahler SA, Husain SA, Boucher RC. Adenosine triphosphate is released during injurious mechanical ventilation and contributes to lung edema. J Trauma. 2003 Aug; 55(2):290-7. PMID: 12913640.
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    58. Reickert CA, Rich PB, Crotti S, Mahler SA, Awad SS, Lynch WR, Johnson KJ, Hirschl RB. Partial liquid ventilation and positive end-expiratory pressure reduce ventilator-induced lung injury in an ovine model of acute respiratory failure. Crit Care Med. 2002 Jan; 30(1):182-9. PMID: 11902260.
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