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Ryan T. Hughes MD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentRadiation Oncology
Address
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    Collapse Biography 
    Collapse education and training
    Wake Forest University, Winston Salem, NCBS05/2011Biology
    Wake Forest Baptist Medical Center, Winston Salem, NCMD06/2015Medicine
    Wake Forest Baptist Medical Center, Winston Salem, NC06/2016Medicine-Preliminary Intern
    Wake Forest Baptist Medical Center, Winston Salem, NCChief Resident06/2020Radiation Oncology

    Collapse Overview 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hughes RT, Tye KE, Ververs JD, O'Connell NS, Helis CA, Steber CR, Johnson AG, Chan MD, Farris MK. Virtual Radiation Oncology Peer Review is Associated with Decreased Engagement and Limited Case Discussion: Analysis of a Prospective Database Before and During the COVID-19 Pandemic. Int J Radiat Oncol Biol Phys. 2022 Apr 27. PMID: 35489631.
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    2. Johansson ED, Hughes RT, Meegalla NT, Porosnicu M, Patwa HS, Lack CM, Bunch PM. Neck Imaging Reporting and Data System Category 3 on Surveillance Computed Tomography: Incidence, Biopsy Rate, and Predictive Performance in Head and Neck Squamous Cell Carcinoma. Laryngoscope. 2022 Jan 19. PMID: 35043989.
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    3. Lanier CM, Lecompte M, Glenn C, Hughes RT, Isom S, Jenkins W, Cramer CK, Chan M, Tatter SB, Laxton AW. A Single-Institution Retrospective Study of Patients Treated With Laser-Interstitial Thermal Therapy for Radiation Necrosis of the Brain. Cureus. 2021 Nov; 13(11):e19967. PMID: 34984127.
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    4. Burcher KM, Lantz JW, Gavrila E, Abreu A, Burcher JT, Faucheux AT, Xie A, Jackson C, Song AH, Hughes RT, Lycan T, Bunch PM, Furdui CM, Topaloglu U, D'Agostino RB, Zhang W, Porosnicu M. Relationship between Tumor Mutational Burden, PD-L1, Patient Characteristics, and Response to Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2021 Nov 16; 13(22). PMID: 34830888.
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    5. Farris JC, Hughes RT, Steber CR, Craven TE, Frizzell BA. Patient assessment of lower urinary tract symptoms using the international prostate symptom score following low-dose-rate prostate brachytherapy. Brachytherapy. 2021 Nov-Dec; 20(6):1107-1113. PMID: 34353749.
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    6. Hughes RT, Porosnicu M, Levine BJ, Lycan TW, Shenker RF, Frizzell BA, Greven KM. Chemoradiotherapy with high-dose cisplatin compared with weekly cisplatin for locally advanced head and neck squamous cell carcinoma. J Med Imaging Radiat Oncol. 2021 Jul 26. PMID: 34309212.
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    7. Bunch PM, Meegalla NT, Abualruz AR, Frizzell BA, Patwa HS, Porosnicu M, Williams DW, Aiken AH, Hughes RT. Initial Referring Physician and Radiologist Experience with Neck Imaging Reporting and Data System. Laryngoscope. 2021 Jul 17. PMID: 34272871.
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    8. Johnson AG, Soike MH, Farris MK, Hughes RT. Efficacy and Survival after Palliative Radiotherapy for Malignant Pulmonary Obstruction. J Palliat Med. 2022 01; 25(1):46-53. PMID: 34255568.
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    9. Steber CR, Hughes RT, Urbanic J, Clark H, Petty WJ, Blackstock AW, Farris MK. Long-Term Outcomes from a Phase 2 Trial of Radiofrequency Ablation Combined with External Beam Radiation Therapy for Patients with Inoperable Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys. 2021 Apr 28. PMID: 33932531.
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    10. Steber CR, Ponnatapura J, Hughes RT, Farris MK. Rapid Development of Clinically Symptomatic Radiation Recall Pneumonitis Immediately Following COVID-19 Vaccination. Cureus. 2021 Apr 05; 13(4):e14303. PMID: 33968515.
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    11. Bunch PM, Patwa HS, Hughes RT, Porosnicu M, Waltonen JD. Patient Selection for Transoral Robotic Surgery (TORS) in Oropharyngeal Squamous Cell Carcinoma: What the Surgeon Wants to Know. Top Magn Reson Imaging. 2021 Apr 01; 30(2):117-130. PMID: 33828063.
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    12. Hughes RT, Steber CR, Jacobson TJ, Farris MK. Impact of dose to lung outside the planning target volume on distant metastasis or progression after SBRT for early-stage non-small cell lung cancer. Radiother Oncol. 2021 Mar 09; 159:28-32. PMID: 33711410.
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    13. Bunch PM, Hughes RT, White EP, Sachs JR, Frizzell BA, Lack CM. The Pharyngolaryngeal Venous Plexus: A Potential Pitfall in Surveillance Imaging of the Neck. AJNR Am J Neuroradiol. 2021 May; 42(5):938-944. PMID: 33664114.
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    14. Steber CR, Hughes RT, Soike MH, Helis CA, Nieto K, Jacobson T, Nagatsuka M, McGinnis HS, Leyrer CM, Farris MK. Stereotactic body radiotherapy for synchronous early stage non-small cell lung cancer. Acta Oncol. 2021 May; 60(5):605-612. PMID: 33645424.
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    15. Shenker RF, May NH, Waltonen JD, Yang JP, O'Neill SS, Frizzell BA, Greven KM, Hughes RT. Comparing Outcomes for Patients with Human Papillomavirus (HPV) Type 16 versus Other High-Risk HPV Types in Oropharyngeal Squamous Cell Carcinoma. Head Neck Pathol. 2021 Feb 22. PMID: 33616854.
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    16. Hughes RT, Farris J, Steber C, Frizzell BA, Greven KM. Perineural Invasion As the Sole Pathologic Risk Factor After Surgical Resection for Head and Neck Squamous Cell Carcinoma. Cureus. 2021 Feb 03; 13(2):e13094. PMID: 33692913.
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    17. Steber C, Hughes RT, McTyre ER, Soike M, Farris M, Levine BJ, Pasche B, Levine E, Blackstock AW. Cisplatin/5-Fluorouracil (5-FU) Versus Carboplatin/Paclitaxel Chemoradiotherapy as Definitive or Pre-Operative Treatment of Esophageal Cancer. Cureus. 2021 Jan 08; 13(1):e12574. PMID: 33575139.
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    18. Burnett LR, Hughes RT, Rejeski AF, Moffatt LT, Shupp JW, Christy RJ, Winkfield KM. Review of the Terminology Describing Ionizing Radiation-Induced Skin Injury: A Case for Standardization. Technol Cancer Res Treat. 2021 Jan-Dec; 20:15330338211039681. PMID: 34613833.
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    19. Helis CA, Hughes RT, Chan MD. In Reply to the Letter to the Editor Regarding "Stereotactic Radiosurgery for Atypical and Anaplastic Meningiomas". World Neurosurg. 2020 12; 144:325. PMID: 33227867.
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    20. Steber C, Farris J, Hughes RT, Helis CA, Naal T, Kim-Shapiro JW, Jacobson T, Farris MK. Malignant Pericardial Mesothelioma Treated Using Volumetric Modulated Arc Therapy With a Simultaneous Integrated Boost. Adv Radiat Oncol. 2021 Jan-Feb; 6(1):100562. PMID: 33490725.
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    21. Steber CR, Hughes RT, Soike MH, Jacobson T, Helis CA, Farris JC, Farris MK. Five- Versus Ten-Fraction Regimens of Stereotactic Body Radiation Therapy for Primary and Metastatic NSCLC. Clin Lung Cancer. 2021 Jan; 22(1):e122-e131. PMID: 33046359.
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    22. Helis CA, Hughes RT, Cramer CK, Tatter SB, Laxton AW, Bourland JD, Munley MT, Chan MD. Stereotactic Radiosurgery for Atypical and Anaplastic Meningiomas. World Neurosurg. 2020 12; 144:e53-e61. PMID: 32758657.
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    23. Helis CA, Hughes RT, Nieto K, Ufondu A, Daugherty EC, Farris MK. Adrenal SBRT: a multi-institutional review of treatment outcomes and toxicity. Clin Exp Metastasis. 2020 10; 37(5):585-592. PMID: 32700208.
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    24. Helis CA, Hughes RT, Glenn CW, Lanier CM, Masters AH, Dohm A, Ahmed T, Ruiz J, Triozzi P, Gondal H, Cramer CK, Tatter SB, Laxton AW, Xing F, Lo HW, Su J, Watabe K, Wang G, Whitlow CT, Chan MD. Predictors of Adverse Radiation Effect in Brain Metastasis Patients Treated With Stereotactic Radiosurgery and Immune Checkpoint Inhibitor Therapy. Int J Radiat Oncol Biol Phys. 2020 09 01; 108(1):295-303. PMID: 32615262.
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    25. Helis CA, Hughes RT, Munley MT, Bourland JD, Jacobson T, Lucas JT, Cramer CK, Tatter SB, Laxton AW, Chan MD. Results of a third Gamma Knife radiosurgery for trigeminal neuralgia. J Neurosurg. 2020 Apr 24; 1-7. PMID: 32330887.
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    26. Farris MK, Helis CA, Hughes RT, LeCompte MC, Borg AM, Nieto K, Munley MT, Willey JS. Bench to Bedside: Animal Models of Radiation Induced Musculoskeletal Toxicity. Cancers (Basel). 2020 Feb 12; 12(2). PMID: 32059447.
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    27. LeCompte MC, Hughes RT, Farris M, Masters A, Soike MH, Lanier C, Glenn C, Cramer CK, Watabe K, Su J, Ruiz J, Whitlow CT, Wang G, Laxton AW, Tatter SB, Chan MD. Impact of brain metastasis velocity on neurologic death for brain metastasis patients experiencing distant brain failure after initial stereotactic radiosurgery. J Neurooncol. 2020 Jan; 146(2):285-292. PMID: 31894518.
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    28. Soike MH, Logue J, Qasem S, Hughes RT, McTyre E, Su J, Triozzi P, Bendandi M, Lo HW, Ahmed T, O'Neill SS, Debinski W, Pasche B, Watabe K, Miller LD, Chan MD, Ruiz J. CD138 plasma cells may predict brain metastasis recurrence following resection and stereotactic radiosurgery. Sci Rep. 2019 10 07; 9(1):14385. PMID: 31591443.
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    29. Hughes RT, Beuerlein WJ, O'Neill SS, Porosnicu M, Lycan TW, Waltonen JD, Frizzell BA, Greven KM. Human papillomavirus-associated squamous cell carcinoma of the larynx or hypopharynx: Clinical outcomes and implications for laryngeal preservation. Oral Oncol. 2019 11; 98:20-27. PMID: 31536842.
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    30. Hughes RT, McTyre ER, LeCompte M, Cramer CK, Munley MT, Laxton AW, Tatter SB, Ruiz J, Pasche B, Watabe K, Chan MD. Clinical Outcomes of Upfront Stereotactic Radiosurgery Alone for Patients With 5 to 15 Brain Metastases. Neurosurgery. 2019 08 01; 85(2):257-263. PMID: 29982831.
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    31. Rosas S, Hughes RT, Farris M, Lee H, McTyre ER, Plate JF, Shi L, Emory CL, Blackstock AW, Kerr BA, Willey JS. Cartilage oligomeric matrix protein in patients with osteoarthritis is independently associated with metastatic disease in prostate cancer. Oncotarget. 2019 Jul 30; 10(46):4776-4785. PMID: 31413818.
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    32. Farris MK, Wheless WH, Hughes RT, Soike MH, Masters AH, Helis CA, Chan MD, Cramer CK, Ruiz J, Lycan T, Petty WJ, Ahmed T, Leyrer CM, Blackstock AW. Limited-Stage Small Cell Lung Cancer: Is Prophylactic Cranial Irradiation Necessary? Pract Radiat Oncol. 2019 Nov; 9(6):e599-e607. PMID: 31271904.
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    33. Hughes RT, Helis CA, Soike MH, Levine BJ, Farris M, Blackstock AW. Moderately Hypofractionated Radiotherapy Alone for Stage I-IIB Non-small Cell Lung Cancer. Cureus. 2019 Jun 22; 11(6):e4969. PMID: 31453041.
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    34. Hughes RT, Masters AH, McTyre ER, Farris MK, Chung C, Page BR, Kleinberg LR, Hepel J, Contessa JN, Chiang V, Ruiz J, Watabe K, Su J, Fiveash JB, Braunstein S, Chao S, Attia A, Ayala-Peacock DN, Chan MD. Initial SRS for Patients With 5 to 15 Brain Metastases: Results of a Multi-Institutional Experience. Int J Radiat Oncol Biol Phys. 2019 08 01; 104(5):1091-1098. PMID: 30959122.
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    35. Masters AH, Hughes RT, Strowd L, Lamar Z, Winkfield KM. Efficacy of low-dose radiotherapy for refractory mycosis fungoides of the face. JAAD Case Rep. 2019 Apr; 5(4):348-351. PMID: 31008164.
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    36. Soike MH, Hughes RT, Farris M, McTyre ER, Cramer CK, Bourland JD, Chan MD. Does Stereotactic Radiosurgery Have a Role in the Management of Patients Presenting With 4 or More Brain Metastases? Neurosurgery. 2019 03 01; 84(3):558-566. PMID: 29860451.
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    37. Nagatsuka M, Hughes RT, Shenker RF, Frizzell BA, Greven KM. Omitting Elective Irradiation of the Contralateral Retropharyngeal Nodes in Oropharyngeal Squamous Cell Carcinoma Treated with Intensity-modulated Radiotherapy. Cureus. 2019 Jan 04; 11(1):e3825. PMID: 30868038.
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    38. Hughes RT, Soike MH, Prajapati S, Lin AQ, Ververs JD, Masters AH, Helis CA, Blackstock AW, Farris MK. Stereotactic body radiotherapy for an isolated splenic metastasis from ovarian carcinoma. J Radiosurg SBRT. 2019; 6(2):161-163. PMID: 31641553.
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    39. Farris M, Hughes RT, Lamar Z, Soike MH, Menke JR, Ohgami RS, Winkfield K. Histiocytic Sarcoma Associated With Follicular Lymphoma: Evidence for Dramatic Response With Rituximab and Bendamustine Alone and a Review of the Literature. Clin Lymphoma Myeloma Leuk. 2019 01; 19(1):e1-e8. PMID: 30396823.
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    40. Soike MH, McTyre ER, Hughes RT, Farris M, Cramer CK, LeCompte MC, Lanier CM, Ruiz J, Su J, Watabe K, Bourland JD, Munley MT, O'Neill S, Laxton AW, Tatter SB, Chan MD. Initial brain metastasis velocity: does the rate at which cancers first seed the brain affect outcomes? J Neurooncol. 2018 Sep; 139(2):461-467. PMID: 29740743.
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    41. LeCompte MC, McTyre ER, Strowd RE, Lanier C, Soike MH, Hughes RT, Masters AH, Cramer CK, Farris M, Ruiz J, Watabe K, Laxton AW, Tatter SB, Winkfield KM, Chan MD. Impact of diabetes mellitus on outcomes in patients with brain metastasis treated with stereotactic radiosurgery. J Radiosurg SBRT. 2018; 5(4):285-291. PMID: 30538889.
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    42. Shenker RF, Hughes RT, McTyre ER, Lanier C, Lo HW, Metheny-Barlow L, Su J, Thomas A, Brown DR, Avery T, Pasche B, Cramer CK, Laxton AW, Tatter SB, Watabe K, Chan MD. Potential prognostic markers for survival and neurologic death in patients with breast cancer brain metastases who receive upfront SRS alone. J Radiosurg SBRT. 2018; 5(4):277-283. PMID: 30538888.
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    43. Hughes RT, Black PJ, Page BR, Lucas JT, Qasem SA, Watabe K, Ruiz J, Laxton AW, Tatter SB, Debinski W, Chan MD. Local control of brain metastases after stereotactic radiosurgery: the impact of whole brain radiotherapy and treatment paradigm. J Radiosurg SBRT. 2016; 4(2):89-96. PMID: 29296433.
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    44. Black PJ, Page BR, Lucas JT, Hughes RT, Laxton AW, Tatter SB, Munley MT, Chan MD. Factors that determine local control with gamma knife radiosurgery: The role of primary histology. J Radiosurg SBRT. 2015; 3(4):281-286. PMID: 26478823.
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