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Raghunatha Yammani PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Molecular Medicine
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentOrthopedic Surgery


    Collapse Research 
    Collapse research activities and funding
    R03AR061050     (YAMMANI, RAGHUNATHA R)Apr 1, 2011 - Jun 30, 2014
    NIH
    Invivo role of S100A4 in OA pathophysiology
    Role: Principal Investigator
    R21AR063835     (YAMMANI, RAGHUNATHA R)Jul 25, 2013 - Jun 30, 2017
    NIH
    ER Stress: Role in OA
    Role: Principal Investigator
    R01AR066105     (YAMMANI, RAGHUNATHA R)Jun 1, 2014 - May 31, 2020
    NIH
    Diet , ER stress and OA
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kwok AT, Mohamed NS, Plate JF, Yammani RR, Rosas S, Bateman TA, Livingston E, Moore JE, Kerr BA, Lee J, Furdui CM, Tan L, Bouxsein ML, Ferguson VL, Stodieck LS, Zawieja DC, Delp MD, Mao XW, Willey JS. Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents. Sci Rep. 2021 May 18; 11(1):10469. PMID: 34006989.
      Citations:    
    2. Tan L, Harper LR, Armstrong A, Carlson CS, Yammani RR. Dietary saturated fatty acid palmitate promotes cartilage lesions and activates the unfolded protein response pathway in mouse knee joints. PLoS One. 2021; 16(2):e0247237. PMID: 33617553.
      Citations:    
    3. Tan L, Register TC, Yammani RR. Age-Related Decline in Expression of Molecular Chaperones Induces Endoplasmic Reticulum Stress and Chondrocyte Apoptosis in Articular Cartilage. Aging Dis. 2020 Oct; 11(5):1091-1102. PMID: 33014525.
      Citations:    
    4. Stone AV, Loeser RF, Callahan MF, McNulty MA, Long DL, Yammani RR, Bean S, Vanderman K, Chubinskaya S, Ferguson CM. Role of the Hypoxia-Inducible Factor Pathway in Normal and Osteoarthritic Meniscus and in Mice after Destabilization of the Medial Meniscus. Cartilage. 2020 Sep 17; 1947603520958143. PMID: 32940061.
      Citations:    
    5. Tan L, Harper L, McNulty MA, Carlson CS, Yammani RR. High-fat diet induces endoplasmic reticulum stress to promote chondrocyte apoptosis in mouse knee joints. FASEB J. 2020 04; 34(4):5818-5826. PMID: 32124494.
      Citations:    
    6. Tan L, Yammani RR. Nupr1 regulates palmitate-induced apoptosis in human articular chondrocytes. Biosci Rep. 2019 02 28; 39(2). PMID: 30674641.
      Citations:    
    7. Nelson KJ, Bolduc JA, Wu H, Collins JA, Burke EA, Reisz JA, Klomsiri C, Wood ST, Yammani RR, Poole LB, Furdui CM, Loeser RF. H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes. J Biol Chem. 2018 10 19; 293(42):16376-16389. PMID: 30190325.
      Citations:    
    8. Mallik A, Yammani RR. Saturated fatty acid palmitate negatively regulates autophagy by promoting ATG5 protein degradation in meniscus cells. Biochem Biophys Res Commun. 2018 07 20; 502(3):370-374. PMID: 29852167.
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    9. Wood ST, Long DL, Reisz JA, Yammani RR, Burke EA, Klomsiri C, Poole LB, Furdui CM, Loeser RF. Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments. Arthritis Rheumatol. 2016 Jan; 68(1):117-26. PMID: 26314228.
      Citations:    
    10. Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O. Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Sci Transl Med. 2015 Mar 11; 7(278):278ra32. PMID: 25761888.
      Citations:    
    11. Yammani RR, Loeser RF. Brief report: stress-inducible nuclear protein 1 regulates matrix metalloproteinase 13 expression in human articular chondrocytes. Arthritis Rheumatol. 2014 May; 66(5):1266-71. PMID: 24497499.
      Citations:    
    12. Yammani RR, Loeser RF. Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes. Arthritis Res Ther. 2012 Jan 30; 14(1):R23. PMID: 22289259.
      Citations:    
    13. Yammani RR. S100 proteins in cartilage: role in arthritis. Biochim Biophys Acta. 2012 Apr; 1822(4):600-6. PMID: 22266138.
      Citations:    
    14. Miranda KJ, Loeser RF, Yammani RR. Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13. J Biol Chem. 2010 Oct 08; 285(41):31517-24. PMID: 20685652.
      Citations:    
    15. Yammani RR, Long D, Loeser RF. Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes. Arthritis Rheum. 2009 Mar; 60(3):792-800. PMID: 19248116.
      Citations:    
    16. Cravero JD, Carlson CS, Im HJ, Yammani RR, Long D, Loeser RF. Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis. Arthritis Rheum. 2009 Feb; 60(2):492-500. PMID: 19180501.
      Citations:    
    17. Ahuja R, Yammani R, Bauer JA, Kalra S, Seetharam S, Seetharam B. Interactions of cubilin with megalin and the product of the amnionless gene (AMN): effect on its stability. Biochem J. 2008 Mar 01; 410(2):301-8. PMID: 17990981.
      Citations:    
    18. Bose S, Kalra S, Yammani RR, Ahuja R, Seetharam B. Plasma membrane delivery, endocytosis and turnover of transcobalamin receptor in polarized human intestinal epithelial cells. J Physiol. 2007 Jun 01; 581(Pt 2):457-66. PMID: 17347267.
      Citations:    
    19. Yammani RR, Carlson CS, Bresnick AR, Loeser RF. Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products. Arthritis Rheum. 2006 Sep; 54(9):2901-11. PMID: 16948116.
      Citations:    
    20. Loeser RF, Yammani RR, Carlson CS, Chen H, Cole A, Im HJ, Bursch LS, Yan SD. Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis. Arthritis Rheum. 2005 Aug; 52(8):2376-85. PMID: 16052547.
      Citations:    
    21. Kalra S, Li N, Yammani RR, Seetharam S, Seetharam B. Cobalamin (vitamin B12) binding, phylogeny, and synteny of human transcobalamin. Arch Biochem Biophys. 2004 Nov 15; 431(2):189-96. PMID: 15488467.
      Citations:    
    22. Kalra S, Seetharam S, Yammani RR, Seetharam B. Rat transcobalamin: cloning and regulation of mRNA expression. J Physiol. 2004 Apr 15; 556(Pt 2):623-35. PMID: 14724191.
      Citations:    
    23. Seetharam B, Yammani RR. Cobalamin transport proteins and their cell-surface receptors. Expert Rev Mol Med. 2003 Jun 13; 5(18):1-18. PMID: 14585166.
      Citations:    
    24. Vanamala SK, Seetharam S, Yammani RR, Seetharam B. Human transcobalamin II receptor binds to Staphylococcus aureus protein A: implications as to its structure and function. Arch Biochem Biophys. 2003 Mar 15; 411(2):204-14. PMID: 12623069.
      Citations:    
    25. Yammani RR, Sharma M, Seetharam S, Moulder JE, Dahms NM, Seetharam B. Loss of albumin and megalin binding to renal cubilin in rats results in albuminuria after total body irradiation. . 2002 Aug; 283(2):R339-46. PMID: 12121845.
      Citations:    
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