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Rong Chen PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentTranslational Neuroscience
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Fitzpatrick MK, Szalanczy A, Beeson A, Vora A, Scott C, Grzybowski M, Klotz J, Der N, Chen R, Geurts AM, Solberg Woods LC. Protein-coding mutation in Adcy3 increases adiposity and alters emotional behaviors sex-dependently in rats. Obesity (Silver Spring). 2024 Dec 04. PMID: 39632398.
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    2. Neel AI, Wang Y, Sun H, Liontis KE, McCormack MC, Mayer JC, Cervera Juanes RP, Davenport AT, Grant KA, Daunais JD, Chen R. Differential regulation of G protein-coupled receptor-associated proteins in the caudate and the putamen of cynomolgus macaques following chronic ethanol drinking. J Neurochem. 2024 May 23. PMID: 38783749.
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    3. Walker NB, Tucker BR, Thomas LN, Tapp AE, Neel AI, Chen R, Jones SR, Drenan RM. ß2* nAChR sensitivity modulates acquisition of cocaine self-administration in male rats. Neuropharmacology. 2024 Jun 01; 250:109927. PMID: 38508306.
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    4. Chen R. Cholesterol modulation of interactions between psychostimulants and dopamine transporters. Adv Pharmacol. 2024; 99:35-59. PMID: 38467486.
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    5. Paliarin F, Duplantis C, Jones AF, Cucinello-Ragland J, Basavanhalli S, Blaze E, Doré E, Neel AI, Sun H, Chen R, Edwards S, Gilpin NW, Messing RO, Maiya R. A cre driver line for genetic targeting of kappa opioid receptor expressing cells. eNeuro. 2023 Jun 22. PMID: 37364995.
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    6. Estave PM, Sun H, Peck EG, Holleran KM, Chen R, Jones SR. Cocaine self-administration augments kappa opioid receptor system-mediated inhibition of dopamine activity in the mesolimbic dopamine system. IBRO Neurosci Rep. 2023 Jun; 14:129-137. PMID: 36748012.
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    7. Wang S, Neel AI, Adams KL, Sun H, Jones SR, Howlett AC, Chen R. Atorvastatin differentially regulates the interactions of cocaine and amphetamine with dopamine transporters. Neuropharmacology. 2023 Mar 01; 225:109387. PMID: 36567004.
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    8. Reid KZ, Lemezis BM, Hou TC, Chen R. Epigenetic Modulation of Opioid Receptors by Drugs of Abuse. Int J Mol Sci. 2022 Oct 05; 23(19). PMID: 36233105.
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    9. Wang S, Liu H, Roberts JB, Wiley AP, Marayati BF, Adams KL, Luessen DJ, Eldeeb K, Sun H, Zhang K, Chen R. Prolonged ethanol exposure modulates constitutive internalization and recycling of 5-HT1A receptors. J Neurochem. 2021 Dec 20. PMID: 34928513.
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    10. Oliver EE, Hughes EK, Puckett MK, Chen R, Lowther WT, Howlett AC. Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease. Biomolecules. 2020 11 27; 10(12). PMID: 33261012.
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    11. Burgos-Aguilar C, Ferris MJ, Sexton LL, Sun H, Xiao R, Chen R, Childers SR, Howlett AC. Metabotropic glutamate 2,3 receptor stimulation desensitizes agonist activation of G-protein signaling and alters transcription regulators in mesocorticolimbic brain regions. Synapse. 2021 Apr; 75(4):e22190. PMID: 33025628.
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    12. Sun H, Luessen DJ, Kind KO, Zhang K, Chen R. Cocaine Self-administration Regulates Transcription of Opioid Peptide Precursors and Opioid Receptors in Rat Caudate Putamen and Prefrontal Cortex. Neuroscience. 2020 09 01; 443:131-139. PMID: 32730947.
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    13. Chen R, Ferris MJ, Wang S. Dopamine D2 autoreceptor interactome: Targeting the receptor complex as a strategy for treatment of substance use disorder. Pharmacol Ther. 2020 09; 213:107583. PMID: 32473160.
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    14. Marayati BF, Tucker JF, Cerda DA, Hou TC, Chen R, Sugiyama T, Pease JB, Zhang K. The Catalytic-Dependent and -Independent Roles of Lsd1 and Lsd2 Lysine Demethylases in Heterochromatin Formation in Schizosaccharomyces pombe. Cells. 2020 04 13; 9(4). PMID: 32295063.
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    15. Martin TA, Smith HR, Luessen DJ, Chen R, Porrino LJ. Functional brain activity is globally elevated by dopamine D2 receptor knockdown in the ventral tegmental area. Brain Res. 2020 01 15; 1727:146552. PMID: 31726041.
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    16. Luessen DJ, Sun H, McGinnis MM, Hagstrom M, Marrs G, McCool BA, Chen R. Acute ethanol exposure reduces serotonin receptor 1A internalization by increasing ubiquitination and degradation of ß-arrestin2. J Biol Chem. 2019 09 20; 294(38):14068-14080. PMID: 31366729.
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    17. Severino AL, Chen R, Hayashida K, Aschenbrenner CA, Sun H, Peters CM, Gutierrez S, Pan B, Eisenach JC. Plasticity and Function of Spinal Oxytocin and Vasopressin Signaling during Recovery from Surgery with Nerve Injury. Anesthesiology. 2018 09; 129(3):544-556. PMID: 29912007.
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    18. Chen R, McIntosh S, Hemby SE, Sun H, Sexton T, Martin TJ, Childers SR. High and low doses of cocaine intake are differentially regulated by dopamine D2 receptors in the ventral tegmental area and the nucleus accumbens. Neurosci Lett. 2018 04 03; 671:133-139. PMID: 29454035.
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    19. Siciliano CA, Saha K, Calipari ES, Fordahl SC, Chen R, Khoshbouei H, Jones SR. Amphetamine Reverses Escalated Cocaine Intake via Restoration of Dopamine Transporter Conformation. J Neurosci. 2018 01 10; 38(2):484-497. PMID: 29175958.
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    20. Luessen DJ, Sun H, McGinnis MM, McCool BA, Chen R. Chronic intermittent ethanol exposure selectively alters the expression of Ga subunit isoforms and RGS subtypes in rat prefrontal cortex. Brain Res. 2017 Oct 01; 1672:106-112. PMID: 28736108.
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    21. Blume LC, Leone-Kabler S, Luessen DJ, Marrs GS, Lyons E, Bass CE, Chen R, Selley DE, Howlett AC. Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner. J Neurochem. 2016 11; 139(3):396-407. PMID: 27513693.
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    22. Luessen DJ, Hinshaw TP, Sun H, Howlett AC, Marrs G, McCool BA, Chen R. RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells. Neuropharmacology. 2016 11; 110(Pt A):297-307. PMID: 27528587.
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    23. Rose JH, Karkhanis AN, Chen R, Gioia D, Lopez MF, Becker HC, McCool BA, Jones SR. Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens. Int J Neuropsychopharmacol. 2016 05; 19(5). PMID: 26625893.
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    24. Luessen DJ, Chen R. Journal of Biomolecular Research & Therapeutics. Psychostimulants, brain membrane lipids and dopamine transmission. 2016; (5):143.
    25. Sun H, Calipari ES, Beveridge TJ, Jones SR, Chen R. The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration. Neuroscience. 2015 Oct 29; 307:253-61. PMID: 26321241.
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    26. Li X, Li S, Zheng W, Pan J, Huang K, Chen R, Pan T, Liao G, Chen Z, Zhou D, Shen W, Zhou W, Liu Y. Environmental enrichment and abstinence attenuate ketamine-induced cardiac and renal toxicity. Sci Rep. 2015 Jun 26; 5:11611. PMID: 26112338.
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    27. Ferris MJ, Calipari ES, Rose JH, Siciliano CA, Sun H, Chen R, Jones SR. A Single Amphetamine Infusion Reverses Deficits in Dopamine Nerve-Terminal Function Caused by a History of Cocaine Self-Administration. Neuropsychopharmacology. 2015 Jul; 40(8):1826-36. PMID: 25689882.
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    28. Luderman KD, Chen R, Ferris MJ, Jones SR, Gnegy ME. Protein kinase C beta regulates the D2-like dopamine autoreceptor. Neuropharmacology. 2015 Feb; 89:335-41. PMID: 25446677.
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    29. Ferris MJ, España RA, Locke JL, Konstantopoulos JK, Rose JH, Chen R, Jones SR. Dopamine transporters govern diurnal variation in extracellular dopamine tone. Proc Natl Acad Sci U S A. 2014 Jul 01; 111(26):E2751-9. PMID: 24979798.
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    30. Calipari ES, Sun H, Eldeeb K, Luessen DJ, Feng X, Howlett AC, Jones SR, Chen R. Amphetamine self-administration attenuates dopamine D2 autoreceptor function. Neuropsychopharmacology. 2014 Jul; 39(8):1833-42. PMID: 24513972.
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    31. Chen R, Hemby SE. Journal of Addiction and Prevention. Dysregulation of RGS proteins by psychostimulants. 2014; (2):1-7.
    32. Chen R, Daining CP, Sun H, Fraser R, Stokes SL, Leitges M, Gnegy ME. Protein kinase Cß is a modulator of the dopamine D2 autoreceptor-activated trafficking of the dopamine transporter. J Neurochem. 2013 Jun; 125(5):663-72. PMID: 23458603.
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    33. Kaur K, Parra S, Chen R, Charbeneau RA, Wade SM, Jay PY, Neubig RR. Gai2 signaling: friend or foe in cardiac injury and heart failure? Naunyn Schmiedebergs Arch Pharmacol. 2012 May; 385(5):443-53. PMID: 22411356.
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    34. Perry ML, Leinninger GM, Chen R, Luderman KD, Yang H, Gnegy ME, Myers MG, Kennedy RT. Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats. J Neurochem. 2010 Aug; 114(3):666-74. PMID: 20412389.
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    35. Chen R, Furman CA, Gnegy ME. Dopamine transporter trafficking: rapid response on demand. Future Neurol. 2010 Jan 01; 5(1):123. PMID: 20174452.
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    36. Zarcone TJ, Chen R, Fowler SC. Effects of differing response-force requirements on food-maintained responding in C57Bl/6J mice. J Exp Anal Behav. 2009 Sep; 92(2):257-74. PMID: 20354603.
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    37. Furman CA, Chen R, Guptaroy B, Zhang M, Holz RW, Gnegy M. Dopamine and amphetamine rapidly increase dopamine transporter trafficking to the surface: live-cell imaging using total internal reflection fluorescence microscopy. J Neurosci. 2009 Mar 11; 29(10):3328-36. PMID: 19279270.
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    38. Chen R, Furman CA, Zhang M, Kim MN, Gereau RW, Leitges M, Gnegy ME. Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. J Pharmacol Exp Ther. 2009 Mar; 328(3):912-20. PMID: 19098163.
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    39. Zarcone TJ, Chen R, Fowler SC. Effects of differing response-force requirements on food-maintained responding in CD-1 mice. J Exp Anal Behav. 2007 Nov; 88(3):381-93. PMID: 18047228.
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    40. Chen R, Zhang M, Park S, Gnegy ME. C57BL/6J mice show greater amphetamine-induced locomotor activation and dopamine efflux in the striatum than 129S2/SvHsd mice. Pharmacol Biochem Behav. 2007 May; 87(1):158-63. PMID: 17524461.
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    41. Chen R, Wei H, Hill ER, Chen L, Jiang L, Han DD, Gu HH. Direct evidence that two cysteines in the dopamine transporter form a disulfide bond. Mol Cell Biochem. 2007 Apr; 298(1-2):41-8. PMID: 17131045.
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    42. Chen R, Tilley MR, Wei H, Zhou F, Zhou FM, Ching S, Quan N, Stephens RL, Hill ER, Nottoli T, Han DD, Gu HH. Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9333-8. PMID: 16754872.
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    43. Han DD, Chen R, Hill ER, Tilley MR, Gu HH. Cause and solutions to the polymerase chain reaction smear problem in genotyping. Anal Biochem. 2006 Jun 15; 353(2):296-8. PMID: 16626617.
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    44. Chen R, Wu X, Wei H, Han DD, Gu HH. Molecular cloning and functional characterization of the dopamine transporter from Eloria noyesi, a caterpillar pest of cocaine-rich coca plants. Gene. 2006 Jan 17; 366(1):152-60. PMID: 16310975.
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    45. Chen R, Han DD, Gu HH. A triple mutation in the second transmembrane domain of mouse dopamine transporter markedly decreases sensitivity to cocaine and methylphenidate. J Neurochem. 2005 Jul; 94(2):352-9. PMID: 15998286.
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    46. Zarcone TJ, Chen R, Fowler SC. Differential acquisition of food-reinforced disk pressing by CD-1, BALB/cJ and C57BL/6J mice. Behav Brain Res. 2004 Jun 04; 152(1):1-9. PMID: 15135964.
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    47. Chen R, Osterhaus G, McKerchar T, Fowler SC. The role of exogenous testosterone in cocaine-induced behavioral sensitization and plasmalemmal or vesicular dopamine uptake in castrated rats. Neurosci Lett. 2003 Nov 20; 351(3):161-4. PMID: 14623131.
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    48. Chen R, Wei J, Fowler SC, Wu JY. Demonstration of functional coupling between dopamine synthesis and its packaging into synaptic vesicles. J Biomed Sci. 2003 Nov-Dec; 10(6 Pt 2):774-81. PMID: 14631117.
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    49. Fowler SC, Birkestrand B, Chen R, Vorontsova E, Zarcone T. Behavioral sensitization to amphetamine in rats: changes in the rhythm of head movements during focused stereotypies. Psychopharmacology (Berl). 2003 Nov; 170(2):167-77. PMID: 12827349.
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    50. Fowler SC, Zarcone TJ, Vorontsova E, Chen R. Motor and associative deficits in D2 dopamine receptor knockout mice. Int J Dev Neurosci. 2002 Jun-Aug; 20(3-5):309-21. PMID: 12175868.
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    51. Fowler SC, Zarcone TJ, Chen R, Taylor MD, Wright DE. Low grip strength, impaired tongue force and hyperactivity induced by overexpression of neurotrophin-3 in mouse skeletal muscle. Int J Dev Neurosci. 2002 Jun-Aug; 20(3-5):303-8. PMID: 12175867.
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    52. Moss SJ, Wang G, Chen R, Pal R, Fowler SC. 3-acetylpyridine reduces tongue protrusion force but does not abolish lick rhythm in the rat. Brain Res. 2001 Nov 30; 920(1-2):1-9. PMID: 11716805.
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    53. Fowler SC, Birkestrand BR, Chen R, Moss SJ, Vorontsova E, Wang G, Zarcone TJ. A force-plate actometer for quantitating rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor. J Neurosci Methods. 2001 May 30; 107(1-2):107-24. PMID: 11389948.
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