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Reto H.Asmis PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Molecular Medicine
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    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentBiochemistry


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Polusani SR, Cortez V, Esparza J, Nguyen HN, Fan H, Velagaleti GVN, Butler MJ, Kinney MC, Oyajobi BO, Habib SL, Asmis R, Medina EA. Oxidatively modified low-density lipoproteins are potential mediators of proteasome inhibitor resistance in multiple myeloma. Int J Cancer. 2021 Jun 15; 148(12):3032-3040. PMID: 33521927.
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    2. Ahn YJ, Wang L, Foster S, Asmis R. Dietary 23-hydroxy ursolic acid protects against diet-induced weight gain and hyperglycemia by protecting monocytes and macrophages against nutrient stress-triggered reprogramming and dysfunction and preventing adipose tissue inflammation. J Nutr Biochem. 2020 12; 86:108483. PMID: 32860922.
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    3. Asmis R, Giordano-Mooga S. Sexual dimorphisms in redox biology. Redox Biol. 2020 04; 31:101533. PMID: 32279981.
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    4. Wang L, Ahn YJ, Asmis R. Sexual dimorphism in glutathione metabolism and glutathione-dependent responses. Redox Biol. 2020 04; 31:101410. PMID: 31883838.
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    5. Olivier M, Asmis R, Hawkins GA, Howard TD, Cox LA. The Need for Multi-Omics Biomarker Signatures in Precision Medicine. Int J Mol Sci. 2019 Sep 26; 20(19). PMID: 31561483.
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    6. Robinson RR, Dietz AK, Maroof AM, Asmis R, Forsthuber TG. The role of glial-neuronal metabolic cooperation in modulating progression of multiple sclerosis and neuropathic pain. Immunotherapy. 2019 02; 11(2):129-147. PMID: 30730270.
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    7. Nguyen HN, Ahn YJ, Medina EA, Asmis R. Dietary 23-hydroxy ursolic acid protects against atherosclerosis and obesity by preventing dyslipidemia-induced monocyte priming and dysfunction. Atherosclerosis. 2018 08; 275:333-341. PMID: 30015296.
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    8. Guo J, Kim HS, Asmis R, Ludueña RF. Interactions of ß tubulin isotypes with glutathione in differentiated neuroblastoma cells subject to oxidative stress. Cytoskeleton (Hoboken). 2018 07; 75(7):283-289. PMID: 29663696.
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    9. Akhtar F, Rouse CA, Catano G, Montalvo M, Ullevig SL, Asmis R, Kharbanda K, Maffi SK. Acute maternal oxidant exposure causes susceptibility of the fetal brain to inflammation and oxidative stress. J Neuroinflammation. 2017 Sep 30; 14(1):195. PMID: 28962577.
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    10. Short JD, Tavakoli S, Nguyen HN, Carrera A, Farnen C, Cox LA, Asmis R. Dyslipidemic Diet-Induced Monocyte "Priming" and Dysfunction in Non-Human Primates Is Triggered by Elevated Plasma Cholesterol and Accompanied by Altered Histone Acetylation. Front Immunol. 2017; 8:958. PMID: 28878765.
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    11. Tavakoli S, Downs K, Short JD, Nguyen HN, Lai Y, Jerabek PA, Goins B, Toczek J, Sadeghi MM, Asmis R. Characterization of Macrophage Polarization States Using Combined Measurement of 2-Deoxyglucose and Glutamine Accumulation: Implications for Imaging of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2017 10; 37(10):1840-1848. PMID: 28798141.
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    12. Jahrling JB, Lin AL, DeRosa N, Hussong SA, Van Skike CE, Girotti M, Javors M, Zhao Q, Maslin LA, Asmis R, Galvan V. mTOR drives cerebral blood flow and memory deficits in LDLR-/- mice modeling atherosclerosis and vascular cognitive impairment. J Cereb Blood Flow Metab. 2018 01; 38(1):58-74. PMID: 28511572.
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    13. Kim HS, Asmis R. Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype. Free Radic Biol Med. 2017 08; 109:75-83. PMID: 28330703.
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    14. Tavakoli S, Short JD, Downs K, Nguyen HN, Lai Y, Zhang W, Jerabek P, Goins B, Sadeghi MM, Asmis R. Differential Regulation of Macrophage Glucose Metabolism by Macrophage Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor: Implications for 18F FDG PET Imaging of Vessel Wall Inflammation. Radiology. 2017 04; 283(1):87-97. PMID: 27849433.
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    15. Kim HS, Tavakoli S, Piefer LA, Nguyen HN, Asmis R. Monocytic MKP-1 is a Sensor of the Metabolic Environment and Regulates Function and Phenotypic Fate of Monocyte-Derived Macrophages in Atherosclerosis. Sci Rep. 2016 09 27; 6:34223. PMID: 27670844.
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    16. Asmis R. Monocytes and Macrophages: A Fresh Look at Functional and Phenotypic Diversity. Antioxid Redox Signal. 2016 11 10; 25(14):756-757. PMID: 27488399.
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    17. Moritz RJ, LeBaron RG, Phelix CF, Rupaimoole R, Kim HS, Tsin A, Asmis R. Macrophage TGF-ß1 and the Proapoptotic Extracellular Matrix Protein BIGH3 Induce Renal Cell Apoptosis in Prediabetic and Diabetic Conditions. Int J Clin Med. 2016 Jul; 7(7):496-510. PMID: 28149671.
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    18. Short JD, Downs K, Tavakoli S, Asmis R. Protein Thiol Redox Signaling in Monocytes and Macrophages. Antioxid Redox Signal. 2016 11 20; 25(15):816-835. PMID: 27288099.
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    19. Ullevig SL, Kim HS, Short JD, Tavakoli S, Weintraub ST, Downs K, Asmis R. Protein S-Glutathionylation Mediates Macrophage Responses to Metabolic Cues from the Extracellular Environment. Antioxid Redox Signal. 2016 11 20; 25(15):836-851. PMID: 26984580.
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    20. Halaney DL, Zahedivash A, Phipps JE, Wang T, Dwelle J, Saux CJ, Asmis R, Milner TE, Feldman MD. Differences in forward angular light scattering distributions between M1 and M2 macrophages. J Biomed Opt. 2015 Nov; 20(11):115002. PMID: 26538329.
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    21. Mondragon AA, Betts-Obregon BS, Moritz RJ, Parvathaneni K, Navarro MM, Kim HS, Lee CF, LeBaron RG, Asmis R, Tsin AT. BIGH3 protein and macrophages in retinal endothelial cell apoptosis. Apoptosis. 2015 Jan; 20(1):29-37. PMID: 25378215.
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    22. Phipps JE, Vela D, Hoyt T, Halaney DL, Mancuso JJ, Buja LM, Asmis R, Milner TE, Feldman MD. Macrophages and intravascular OCT bright spots: a quantitative study. JACC Cardiovasc Imaging. 2015 Jan; 8(1):63-72. PMID: 25499133.
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    23. Barman SA, Chen F, Su Y, Dimitropoulou C, Wang Y, Catravas JD, Han W, Orfi L, Szantai-Kis C, Keri G, Szabadkai I, Barabutis N, Rafikova O, Rafikov R, Black SM, Jonigk D, Giannis A, Asmis R, Stepp DW, Ramesh G, Fulton DJ. NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling. Arterioscler Thromb Vasc Biol. 2014 Aug; 34(8):1704-15. PMID: 24947524.
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    24. Kim HS, Ullevig SL, Nguyen HN, Vanegas D, Asmis R. Redox regulation of 14-3-3? controls monocyte migration. Arterioscler Thromb Vasc Biol. 2014 Jul; 34(7):1514-21. PMID: 24812321.
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    25. Ullevig SL, Kim HS, Nguyen HN, Hambright WS, Robles AJ, Tavakoli S, Asmis R. Ursolic acid protects monocytes against metabolic stress-induced priming and dysfunction by preventing the induction of Nox4. Redox Biol. 2014; 2:259-66. PMID: 24494201.
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    26. Tavakoli S, Zamora D, Ullevig S, Asmis R. Bioenergetic profiles diverge during macrophage polarization: implications for the interpretation of 18F-FDG PET imaging of atherosclerosis. J Nucl Med. 2013 Sep; 54(9):1661-7. PMID: 23886729.
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    27. Ullevig S, Kim HS, Asmis R. S-glutathionylation in monocyte and macrophage (dys)function. Int J Mol Sci. 2013 Jul 24; 14(8):15212-32. PMID: 23887649.
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    28. Lee CF, Ullevig S, Kim HS, Asmis R. Regulation of Monocyte Adhesion and Migration by Nox4. PLoS One. 2013; 8(6):e66964. PMID: 23825596.
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    29. Howard MA, Asmis R, Evans KK, Mustoe TA. Oxygen and wound care: a review of current therapeutic modalities and future direction. Wound Repair Regen. 2013 Jul-Aug; 21(4):503-11. PMID: 23756299.
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    30. Kim HS, Ullevig SL, Zamora D, Lee CF, Asmis R. Redox regulation of MAPK phosphatase 1 controls monocyte migration and macrophage recruitment. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):E2803-12. PMID: 22991462.
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    31. Jenkins JT, Halaney DL, Sokolov KV, Ma LL, Shipley HJ, Mahajan S, Louden CL, Asmis R, Milner TE, Johnston KP, Feldman MD. Excretion and toxicity of gold-iron nanoparticles. Nanomedicine. 2013 Apr; 9(3):356-65. PMID: 22960192.
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    32. Liu M, Xiang R, Wilk SA, Zhang N, Sloane LB, Azarnoush K, Zhou L, Chen H, Xiang G, Walter CA, Austad SN, Musi N, DeFronzo RA, Asmis R, Scherer PE, Dong LQ, Liu F. Fat-specific DsbA-L overexpression promotes adiponectin multimerization and protects mice from diet-induced obesity and insulin resistance. Diabetes. 2012 Nov; 61(11):2776-86. PMID: 22807031.
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    33. Khandelwal AR, Hebert VY, Kleinedler JJ, Rogers LK, Ullevig SL, Asmis R, Shi R, Dugas TR. Resveratrol and quercetin interact to inhibit neointimal hyperplasia in mice with a carotid injury. J Nutr. 2012 Aug; 142(8):1487-94. PMID: 22718033.
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    34. Tavakoli S, Asmis R. Reactive oxygen species and thiol redox signaling in the macrophage biology of atherosclerosis. Antioxid Redox Signal. 2012 Dec 15; 17(12):1785-95. PMID: 22540532.
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    35. Wang T, Mancuso JJ, Sapozhnikova V, Dwelle J, Ma LL, Willsey B, Kazmi SM, Qiu J, Li X, Asmis R, Johnston KP, Feldman MD, Milner TE. Dual-wavelength multifrequency photothermal wave imaging combined with optical coherence tomography for macrophage and lipid detection in atherosclerotic plaques using gold nanoparticles. J Biomed Opt. 2012 Mar; 17(3):036009. PMID: 22502567.
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    36. Sapozhnikova V, Willsey B, Asmis R, Wang T, Jenkins JT, Mancuso J, Ma LL, Kuranov R, Milner TE, Johnston K, Feldman MD. Use of near-infrared luminescent gold nanoclusters for detection of macrophages. J Biomed Opt. 2012 Feb; 17(2):026006. PMID: 22463038.
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    37. Ullevig S, Zhao Q, Lee CF, Seok Kim H, Zamora D, Asmis R. NADPH oxidase 4 mediates monocyte priming and accelerated chemotaxis induced by metabolic stress. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):415-26. PMID: 22095986.
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    38. Ullevig SL, Zhao Q, Zamora D, Asmis R. Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis. Atherosclerosis. 2011 Dec; 219(2):409-16. PMID: 21752377.
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    39. Asmis R. "Topical" HDL for vein grafts: a new solution to an old problem? Atherosclerosis. 2011 Feb; 214(2):259-60. PMID: 21146819.
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    40. Asmis R, Qiao M, Zhao Q. Low flow oxygenation of full-excisional skin wounds on diabetic mice improves wound healing by accelerating wound closure and reepithelialization. Int Wound J. 2010 Oct; 7(5):349-57. PMID: 20659184.
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    41. Thompson JS, Asmis R, Tapp AA, Nelson B, Chu Y, Glass J, Moneyhon M, Brown SA. Pyrrolidine dithiocarbamate (PDTC) blocks apoptosis and promotes ionizing radiation-induced necrosis of freshly-isolated normal mouse spleen cells. Apoptosis. 2010 Jun; 15(6):705-14. PMID: 20333468.
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    42. Lee CF, Qiao M, Schröder K, Zhao Q, Asmis R. Nox4 is a novel inducible source of reactive oxygen species in monocytes and macrophages and mediates oxidized low density lipoprotein-induced macrophage death. Circ Res. 2010 May 14; 106(9):1489-97. PMID: 20360249.
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    43. Ma LL, Feldman MD, Tam JM, Paranjape AS, Cheruku KK, Larson TA, Tam JO, Ingram DR, Paramita V, Villard JW, Jenkins JT, Wang T, Clarke GD, Asmis R, Sokolov K, Chandrasekar B, Milner TE, Johnston KP. Small multifunctional nanoclusters (nanoroses) for targeted cellular imaging and therapy. ACS Nano. 2009 Sep 22; 3(9):2686-96. PMID: 19711944.
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    44. Qiao M, Zhao Q, Lee CF, Tannock LR, Smart EJ, LeBaron RG, Phelix CF, Rangel Y, Asmis R. Thiol oxidative stress induced by metabolic disorders amplifies macrophage chemotactic responses and accelerates atherogenesis and kidney injury in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1779-86. PMID: 19592463.
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    45. Zamilpa R, Rupaimoole R, Phelix CF, Somaraki-Cormier M, Haskins W, Asmis R, LeBaron RG. C-terminal fragment of transforming growth factor beta-induced protein (TGFBIp) is required for apoptosis in human osteosarcoma cells. Matrix Biol. 2009 Jul; 28(6):347-53. PMID: 19505574.
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    46. Asmis LM, Asmis R, Sulzer I, Furlan M, Lämmle B. Contact system activation in human sepsis - 47kD HK, a marker of sepsis severity? Swiss Med Wkly. 2008 Mar 08; 138(9-10):142-9. PMID: 18330734.
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    47. Rutkute K, Asmis RH, Nikolova-Karakashian MN. Regulation of neutral sphingomyelinase-2 by GSH: a new insight to the role of oxidative stress in aging-associated inflammation. J Lipid Res. 2007 Nov; 48(11):2443-52. PMID: 17693623.
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    48. Qiao M, Kisgati M, Cholewa JM, Zhu W, Smart EJ, Sulistio MS, Asmis R. Increased expression of glutathione reductase in macrophages decreases atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1375-82. PMID: 17363688.
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    49. Kisgati M, Asmis R. Generation of retroviruses for the overexpression of cytosolic and mitochondrial glutathione reductase in macrophages in vivo. Cytotechnology. 2007 May; 54(1):5-14. PMID: 19003013.
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    50. Fanti P, Asmis R, Stephenson TJ, Sawaya BP, Franke AA. Positive effect of dietary soy in ESRD patients with systemic inflammation--correlation between blood levels of the soy isoflavones and the acute-phase reactants. Nephrol Dial Transplant. 2006 Aug; 21(8):2239-46. PMID: 16766544.
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    51. Wang Y, Qiao M, Mieyal JJ, Asmis LM, Asmis R. Molecular mechanism of glutathione-mediated protection from oxidized low-density lipoprotein-induced cell injury in human macrophages: role of glutathione reductase and glutaredoxin. Free Radic Biol Med. 2006 Sep 01; 41(5):775-85. PMID: 16895798.
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    52. Asmis R, Qiao M, Rossi RR, Cholewa J, Xu L, Asmis LM. Adriamycin promotes macrophage dysfunction in mice. Free Radic Biol Med. 2006 Jul 01; 41(1):165-74. PMID: 16781464.
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    53. Li XA, Guo L, Asmis R, Nikolova-Karakashian M, Smart EJ. Scavenger receptor BI prevents nitric oxide-induced cytotoxicity and endotoxin-induced death. Circ Res. 2006 Apr 14; 98(7):e60-5. PMID: 16574909.
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    54. Thompson JS, Asmis R, Glass J, Liu H, Wilson C, Nelson B, Brown SA, Stromberg AJ. P53 status influences regulation of HSPs and ribosomal proteins by PDTC and radiation. Biochem Biophys Res Commun. 2006 May 05; 343(2):435-42. PMID: 16546138.
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    55. Asmis R, Wang Y, Xu L, Kisgati M, Begley JG, Mieyal JJ. A novel thiol oxidation-based mechanism for adriamycin-induced cell injury in human macrophages. FASEB J. 2005 Nov; 19(13):1866-8. PMID: 16160061.
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    56. Asmis R, Begley JG, Jelk J, Everson WV. Lipoprotein aggregation protects human monocyte-derived macrophages from OxLDL-induced cytotoxicity. J Lipid Res. 2005 Jun; 46(6):1124-32. PMID: 15772426.
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    57. Li XA, Guo L, Dressman JL, Asmis R, Smart EJ. A novel ligand-independent apoptotic pathway induced by scavenger receptor class B, type I and suppressed by endothelial nitric-oxide synthase and high density lipoprotein. J Biol Chem. 2005 May 13; 280(19):19087-96. PMID: 15749707.
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    58. Zhao Z, de Beer MC, Cai L, Asmis R, de Beer FC, de Villiers WJ, van der Westhuyzen DR. Low-density lipoprotein from apolipoprotein E-deficient mice induces macrophage lipid accumulation in a CD36 and scavenger receptor class A-dependent manner. Arterioscler Thromb Vasc Biol. 2005 Jan; 25(1):168-73. PMID: 15514202.
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    59. Romerio SC, Linder L, Nyfeler J, Wenk M, Litynsky P, Asmis R, Haefeli WE. Acute hyperhomocysteinemia decreases NO bioavailability in healthy adults. Atherosclerosis. 2004 Oct; 176(2):337-44. PMID: 15380457.
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    60. Asmis R, Begley JG. Oxidized LDL promotes peroxide-mediated mitochondrial dysfunction and cell death in human macrophages: a caspase-3-independent pathway. Circ Res. 2003 Jan 10; 92(1):e20-9. PMID: 12522131.
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    61. Hojo Y, Saito Y, Tanimoto T, Hoefen RJ, Baines CP, Yamamoto K, Haendeler J, Asmis R, Berk BC. Fluid shear stress attenuates hydrogen peroxide-induced c-Jun NH2-terminal kinase activation via a glutathione reductase-mediated mechanism. Circ Res. 2002 Oct 18; 91(8):712-8. PMID: 12386148.
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