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Ravi N. Singh PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentObstetrics and Gynecology, Maternal Fetal
Address
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentWake Forest Institute for Regenerative Medicine


    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MAB.A.06/1995Physics
    University College London, London, UKPh.D.05/2008Pharmaceutical Science
    Collapse awards and honors
    2011 - 2012Postdoctoral Fellow of the Year, Wake Forest University
    2011Fellowship to attend AACR/NCI Cancer Imaging Workshop , Wake Forest School of Medicine
    2010 - 2015NIH/NCI K99/R00 Howard Temin Pathway to Independence Award in Cancer Nanotechnology , Wake Forest School of Medicine
    2009Fellowship to attend AACR/NCI Pathobiology of Cancer Workshop
    2008 - 2010NIH/NCI T32 Postdoctoral Training Fellowship in Cancer Biology, Wake Forest School of Medicine
    2007Best Oral Presentation, University College London
    2006International Liposome Society Young Investigator Award, University College London

    Collapse Overview 
    Collapse overview
    My interdisciplinary background in biomedical nanotechnology, a field lying at the interface of biomedicine, chemistry, physics and materials science, brings together ideas and techniques from these disciplines. By studying and manipulating the bio-nano interface, I work to facilitate the translation of proof of principle experiments into clinical applications of well-defined materials for cancer therapy and diagnostic use. Most recently, my group showed that carbon nanotubes can be used to target breast and brain tumors, deliver genes and cancer therapeutics, and that appropriately functionalized carbon nanotubes are safe for blood born delivery. Additionally, we demonstrated that unmodified silver nanoparticles act as a self-therapeutic agent with a combination of selective cytotoxicity and radiation dose-enhancement effects toward triple negative breast cancer at doses that are nontoxic to noncancerous breast and other cells. I am dedicated to developing new tools to improve outcomes for cancer treatment and diagnosis.

    Collapse Research 
    Collapse research activities and funding
    K99/R00CA154006     (Ravi Singh)Aug 1, 2010 - Feb 28, 2015
    NIH/NCI
    Tumor Targeting and Diagnostic Applications of Glycosylated Nanotubes
    Role Description: The major goal of this project is to develop a carbon nanotube-based PET imaging agent targeted to glucose transporters for early detection of breast cancer.
    Role: PI
    K99CA154006     (SINGH, RAVI N)Aug 25, 2010 - Jul 31, 2012
    NIH
    Tumor Targeting and Diagnostic Applications of Glycosylated Nanotubes
    Role: Principal Investigator
    R00CA154006     (SINGH, RAVI N)Aug 25, 2010 - Jan 31, 2016
    NIH
    Tumor Targeting and Diagnostic Applications of Glycosylated Nanotubes
    Role: Principal Investigator
    Institutional Development Grant     (Nicole Levi-Polyachencko)Jun 1, 2015
    North Carolina Biotechnology Center
    Advanced instrumentation for pre-clinical evaluation of magnetic nanoparticle heating
    Role Description: This award is for a purchasing a DM100 Series Magnetic Hyperthermia Device for use to induce and thermally image of magnetic hyperthermia in vivo.
    Role: Co-I
    Wake Forest Innovations Ignition Funds     (Ulrich Bierbach)Jan 1, 2016 - Dec 31, 2016
    Wake Forest Innovations
    In vivo assessment of novel liposomal formulations of platinum-acridine chemotherapy
    Role Description: The objective is to determine the maximum tolerated dose, biodistribution and in vivo efficacy of nanoparticle formulations of new platinum-based chemotherapeutic agents for treatment of breast, lung and pancreatic cancer.
    Role: Co-I
    Brain Tumor SPORE Development Grant     (Ravi Singh)Apr 1, 2016 - Mar 31, 2017
    Comprehensive Cancer Center of Wake Forest University
    Image guided delivery of nanoparticles for drug delivery and enhanced photothermal therapy
    Role Description: The objective is to perform initial synthesis and in vivo testing of a multimodal, carbon nanotube platform for image-guided drug delivery and photothermal therapy of glioblastoma multiforme.
    R01CA207222     (SINGH, RAVI N)Apr 1, 2017 - Mar 31, 2022
    NIH
    Development of a novel therapeutic agent that exploits specific vulnerabilities in claudin low breast cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Xing F, Liu Y, Wu SY, Wu K, Sharma S, Mo YY, Feng J, Sanders S, Jin G, Singh R, Vidi PA, Tyagi A, Chan MD, Ruiz J, Debinski W, Pasche BC, Lo HW, Metheny-Barlow LJ, D'Agostino RB, Watabe K. Correction: Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis. Cancer Res. 2021 Nov 01; 81(21):5582. PMID: 34725134.
      Citations:    
    2. Rohde MM, Snyder CM, Sloop J, Solst SR, Donati GL, Spitz DR, Furdui CM, Singh R. The mechanism of cell death induced by silver nanoparticles is distinct from silver cations. Part Fibre Toxicol. 2021 10 14; 18(1):37. PMID: 34649580.
      Citations:    
    3. Wu K, Feng J, Lyu F, Xing F, Sharma S, Liu Y, Wu SY, Zhao D, Tyagi A, Deshpande RP, Pei X, Ruiz MG, Takahashi H, Tsuzuki S, Kimura T, Mo YY, Shiozawa Y, Singh R, Watabe K. Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer. Nat Commun. 2021 08 31; 12(1):5196. PMID: 34465793.
      Citations:    
    4. Snyder CM, Rohde MM, Fahrenholtz CD, Swanner J, Sloop J, Donati GL, Furdui CM, Singh R. Low Doses of Silver Nanoparticles Selectively Induce Lipid Peroxidation and Proteotoxic Stress in Mesenchymal Subtypes of Triple-Negative Breast Cancer. Cancers (Basel). 2021 Aug 22; 13(16). PMID: 34439373.
      Citations:    
    5. Holmila R, Wu H, Lee J, Tsang AW, Singh R, Furdui CM. Integrated Redox Proteomic Analysis Highlights New Mechanisms of Sensitivity to Silver Nanoparticles. Mol Cell Proteomics. 2021 Mar 20; 20:100073. PMID: 33757833.
      Citations:    
    6. Yao X, Lyu P, Yoo K, Yadav MK, Singh R, Atala A, Lu B. Engineered extracellular vesicles as versatile ribonucleoprotein delivery vehicles for efficient and safe CRISPR genome editing. J Extracell Vesicles. 2021 Mar; 10(5):e12076. PMID: 33747370.
      Citations:    
    7. Sears J, Swanner J, Fahrenholtz CD, Snyder C, Rohde M, Levi-Polyachenko N, Singh R. Combined Photothermal and Ionizing Radiation Sensitization of Triple-Negative Breast Cancer Using Triangular Silver Nanoparticles. Int J Nanomedicine. 2021; 16:851-865. PMID: 33574666.
      Citations:    
    8. McCarthy B, Cudykier A, Singh R, Levi-Polyachenko N, Soker S. Semiconducting polymer nanoparticles for photothermal ablation of colorectal cancer organoids. Sci Rep. 2021 Jan 15; 11(1):1532. PMID: 33452397.
      Citations:    
    9. Kumar A, Kim S, Su Y, Sharma M, Kumar P, Singh S, Lee J, Furdui CM, Singh R, Hsu FC, Kim J, Whitlow CT, Nader MA, Deep G. Brain cell-derived exosomes in plasma serve as neurodegeneration biomarkers in male cynomolgus monkeys self-administrating oxycodone. EBioMedicine. 2021 Jan; 63:103192. PMID: 33418508.
      Citations:    
    10. McCarthy B, Singh R, Levi-Polyachenko N. Oxaliplatin-resistant colorectal cancer models for nanoparticle hyperthermia. Int J Hyperthermia. 2021; 38(1):152-164. PMID: 33576281.
      Citations:    
    11. Sharma S, Pei X, Xing F, Wu SY, Wu K, Tyagi A, Zhao D, Deshpande R, Ruiz MG, Singh R, Lyu F, Watabe K. Regucalcin promotes dormancy of prostate cancer. Oncogene. 2021 Feb; 40(5):1012-1026. PMID: 33323968.
      Citations:    
    12. Holmila RJ, Vance SA, King SB, Tsang AW, Singh R, Furdui CM. Silver Nanoparticles Induce Mitochondrial Protein Oxidation in Lung Cells Impacting Cell Cycle and Proliferation. Antioxidants (Basel). 2019 Nov 14; 8(11). PMID: 31739476.
      Citations:    
    13. Peak TC, Panigrahi GK, Praharaj PP, Su Y, Shi L, Chyr J, Rivera-Chávez J, Flores-Bocanegra L, Singh R, Vander Griend DJ, Oberlies NH, Kerr BA, Hemal A, Bitting RL, Deep G. Syntaxin 6-mediated exosome secretion regulates enzalutamide resistance in prostate cancer. Mol Carcinog. 2020 01; 59(1):62-72. PMID: 31674708.
      Citations:    
    14. Swanner J, Fahrenholtz CD, Tenvooren I, Bernish BW, Sears JJ, Hooker A, Furdui CM, Alli E, Li W, Donati GL, Cook KL, Vidi PA, Singh R. Silver nanoparticles selectively treat triple-negative breast cancer cells without affecting non-malignant breast epithelial cells in vitro and in vivo. FASEB Bioadv. 2019 Oct; 1(10):639-660. PMID: 32123812.
      Citations:    
    15. Panigrahi GK, Praharaj PP, Kittaka H, Mridha AR, Black OM, Singh R, Mercer R, van Bokhoven A, Torkko KC, Agarwal C, Agarwal R, Abd Elmageed ZY, Yadav H, Mishra SK, Deep G. Exosome proteomic analyses identify inflammatory phenotype and novel biomarkers in African American prostate cancer patients. Cancer Med. 2019 03; 8(3):1110-1123. PMID: 30623593.
      Citations:    
    16. Yoo KW, Li N, Makani V, Singh RN, Atala A, Lu B. Large-Scale Preparation of Extracellular Vesicles Enriched with Specific microRNA. Tissue Eng Part C Methods. 2018 11; 24(11):637-644. PMID: 30306827.
      Citations:    
    17. Suo X, Eldridge BN, Zhang H, Mao C, Min Y, Singh R, Ming X. P-glycoprotein Targeted Photothermal Therapy of Drug Resistant Cancer Cells Using Antibody-conjugated Carbon Nanotubes. ACS Applied Materials & Interfaces. 2018; 39(10):33464-33473.
    18. Xing F, Liu Y, Wu SY, Wu K, Sharma S, Mo YY, Feng J, Sanders S, Jin G, Singh R, Vidi PA, Tyagi A, Chan MD, Ruiz J, Debinski W, Pasche BC, Lo HW, Metheny-Barlow LJ, D'Agostino RB, Watabe K. Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis. Cancer Res. 2018 08 01; 78(15):4316-4330. PMID: 30026327.
      Citations:    
    19. Holmila RJ, Vance SA, Chen X, Wu H, Shukla K, Bharadwaj MS, Mims J, Wary Z, Marrs G, Singh R, Molina AJ, Poole LB, King SB, Furdui CM. Mitochondria-targeted Probes for Imaging Protein Sulfenylation. Sci Rep. 2018 04 27; 8(1):6635. PMID: 29703899.
      Citations:    
    20. Panigrahi GK, Praharaj PP, Peak TC, Long J, Singh R, Rhim JS, Abd Elmageed ZY, Deep G. Author Correction: Hypoxia-induced exosome secretion promotes survival of African-American and Caucasian prostate cancer cells. Sci Rep. 2018 Apr 24; 8(1):6645. PMID: 29691455.
      Citations:    
    21. Peak TC, Praharaj PP, Panigrahi GK, Doyle M, Su Y, Schlaepfer IR, Singh R, Vander Griend DJ, Alickson J, Hemal A, Atala A, Deep G. Exosomes secreted by placental stem cells selectively inhibit growth of aggressive prostate cancer cells. Biochem Biophys Res Commun. 2018 05 23; 499(4):1004-1010. PMID: 29627574.
      Citations:    
    22. Panigrahi GK, Praharaj PP, Peak TC, Long J, Singh R, Rhim JS, Abd Elmageed ZY, Deep G. Hypoxia-induced exosome secretion promotes survival of African-American and Caucasian prostate cancer cells. Sci Rep. 2018 03 01; 8(1):3853. PMID: 29497081.
      Citations:    
    23. Swanner J, Singh R. Synthesis, Purification, Characterization, and Imaging of Cy3-Functionalized Fluorescent Silver Nanoparticles in 2D and 3D Tumor Models. Methods Mol Biol. 2018; 1790:209-218. PMID: 29858794.
      Citations:    
    24. Lu P, Li H, Li N, Singh RN, Bishop CE, Chen X, Lu B. MEX3C interacts with adaptor-related protein complex 2 and involves in miR-451a exosomal sorting. PLoS One. 2017; 12(10):e0185992. PMID: 28982131.
      Citations:    
    25. Fahrenholtz CD, Swanner J, Ramirez-Perez M, Singh RN. Heterogeneous Responses of Ovarian Cancer Cells to Silver Nanoparticles as a Single Agent and in Combination with Cisplatin. J Nanomater. 2017; 2017. PMID: 30034459.
      Citations:    
    26. Eldridge BN, Xing F, Fahrenholtz CD, Singh RN. Evaluation of multiwalled carbon nanotube cytotoxicity in cultures of human brain microvascular endothelial cells grown on plastic or basement membrane. Toxicol In Vitro. 2017 Jun; 41:223-231. PMID: 28285150.
      Citations:    
    27. Zheng Y, Fahrenholtz CD, Hackett CL, Ding S, Day CS, Dhall R, Marrs GS, Gross MD, Singh R, Bierbach U. Large-Pore Functionalized Mesoporous Silica Nanoparticles as Drug Delivery Vector for a Highly Cytotoxic Hybrid Platinum-Acridine Anticancer Agent. Chemistry. 2017 Mar 08; 23(14):3386-3397. PMID: 28122141.
      Citations:    
    28. Garg PK, Nazih R, Wu Y, Singh R, Garg S. 4-11C-Methoxy N-(2-Diethylaminoethyl) Benzamide: A Novel Probe to Selectively Target Melanoma. J Nucl Med. 2017 05; 58(5):827-832. PMID: 27980051.
      Citations:    
    29. Hu Y, Singh R, Deng Z, Mintz A, Hsu W. Liposome-protamine-DNA nanoparticle-mediated delivery of short hairpin RNA targeting brachyury inhibits chordoma cell growth. Journal of Biomedical Nanotechnology. 2016; 12(10):1952-1961. View Publication.
    30. Fahrenholtz CD, Ding S, Bernish BW, Wright ML, Zheng Y, Yang M, Yao X, Donati GL, Gross MD, Bierbach U, Singh R. Design and cellular studies of a carbon nanotube-based delivery system for a hybrid platinum-acridine anticancer agent. J Inorg Biochem. 2016 12; 165:170-180. PMID: 27496614.
      Citations:    
    31. Singh R, Gupta SC, Peng WX, Zhou N, Pochampally R, Atfi A, Watabe K, Lu Z, Mo YY. Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis. Cell Death Dis. 2016 06 09; 7(6):e2262. PMID: 27277684.
      Citations:    
    32. Eldridge BN, Bernish BW, Fahrenholtz CD, Singh R. Photothermal therapy of glioblastoma multiforme using multiwalled carbon nanotubes optimized for diffusion in extracellular space. ACS Biomater Sci Eng. 2016 Jun 13; 2(6):963-976. PMID: 27795996.
      Citations:    
    33. Stuart CH, Singh R, Smith TL, D'Agostino R, Caudell D, Balaji KC, Gmeiner WH. Prostate-specific membrane antigen-targeted liposomes specifically deliver the Zn(2+) chelator TPEN inducing oxidative stress in prostate cancer cells. Nanomedicine (Lond). 2016 05; 11(10):1207-22. PMID: 27077564.
      Citations:    
    34. Eldridge BN, Bernish BW, Fahrenholtz CD, Singh R. Photothermal therapy of glioblastoma multiforme using multiwalled carbon nanotubes optimized for diffusion in extracellular space. American Chemical Society: Biomaterials and Interfaces. 2016; 6(2):963-976. View Publication.
    35. Fahrenholtz CD, Hadimani M, King SB, Torti SV, Singh R. Targeting breast cancer with sugar-coated carbon nanotubes. Nanomedicine (Lond). 2015; 10(16):2481-97. PMID: 26296098.
      Citations:    
    36. Swanner J, Mims J, Carroll DL, Akman SA, Furdui CM, Torti SV, Singh RN. Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells. Int J Nanomedicine. 2015; 10:3937-53. PMID: 26185437.
      Citations:    
    37. Chapman S, Dobrovolskaia M, Farahani K, Goodwin A, Joshi A, Lee H, Meade T, Pomper M, Ptak K, Rao J, Singh R, Sridhar S, Stern S, Wang A, Weaver JB, Woloschak G, Yang L. Nanoparticles for cancer imaging: The good, the bad, and the promise. Nano Today. 2013 Oct; 8(5):454-460. PMID: 25419228.
      Citations:    
    38. Singh R, Torti SV. Carbon nanotubes in hyperthermia therapy. Adv Drug Deliv Rev. 2013 Dec; 65(15):2045-60. PMID: 23933617.
      Citations:    
    39. Neal RE, Rossmeisl JH, Robertson JL, Arena CB, Davis EM, Singh RN, Stallings J, Davalos RV. Improved local and systemic anti-tumor efficacy for irreversible electroporation in immunocompetent versus immunodeficient mice. PLoS One. 2013; 8(5):e64559. PMID: 23717630.
      Citations:    
    40. Singh R, Alexander P, Burke A, Torti FM, Torti SV . In SH Cho and S Krishnan, Cancer Nanotechnology: Principles and Applications in Radiation Oncology. Carbon Nanotubes for Thermal Therapy. 2013.
    41. Xie B, Singh R, Torti FM, Keblinski P, Torti S. Heat localization for targeted tumor treatment with nanoscale near-infrared radiation absorbers. Phys Med Biol. 2012 Sep 21; 57(18):5765-75. PMID: 22948207.
      Citations:    
    42. Burke AR, Singh RN, Carroll DL, Torti FM, Torti SV. Targeting Cancer Stem Cells with Nanoparticle-Enabled Therapies. J Mol Biomark Diagn. 2012 Jul 02; Suppl 8. PMID: 24383043.
      Citations:    
    43. Burke AR, Singh RN, Carroll DL, Wood JC, D'Agostino RB, Ajayan PM, Torti FM, Torti SV. The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy. Biomaterials. 2012 Apr; 33(10):2961-70. PMID: 22245557.
      Citations:    
    44. Burke AR, Singh RN, Carroll DL, Owen JD, Kock ND, D'Agostino R, Torti FM, Torti SV. Determinants of the thrombogenic potential of multiwalled carbon nanotubes. Biomaterials. 2011 Sep; 32(26):5970-8. PMID: 21663954.
      Citations:    
    45. Singh RP, Farney AC, Rogers J, Gautreaux M, Reeves-Daniel A, Hartmann E, Doares W, Iskandar S, Adams P, Stratta RJ. Hypertension in standard criteria deceased donors is associated with inferior outcomes following kidney transplantation. Clin Transplant. 2011 Jul-Aug; 25(4):E437-46. PMID: 21517998.
      Citations:    
    46. Ding X, Singh R, Burke A, Hatcher H, Olson J, Kraft RA, Schmid M, Carroll D, Bourland JD, Akman S, Torti FM, Torti SV. Development of iron-containing multiwalled carbon nanotubes for MR-guided laser-induced thermotherapy. Nanomedicine (Lond). 2011 Oct; 6(8):1341-52. PMID: 21506687.
      Citations:    
    47. Neal RE, Singh R, Hatcher HC, Kock ND, Torti SV, Davalos RV. Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode. Breast Cancer Res Treat. 2010 Aug; 123(1):295-301. PMID: 20191380.
      Citations:    
    48. Hatcher HC, Singh RN, Torti FM, Torti SV. Synthetic and natural iron chelators: therapeutic potential and clinical use. Future Med Chem. 2009 Dec; 1(9):1643-70. PMID: 21425984.
      Citations:    
    49. Burke A, Ding X, Singh R, Kraft RA, Levi-Polyachenko N, Rylander MN, Szot C, Buchanan C, Whitney J, Fisher J, Hatcher HC, D'Agostino R, Kock ND, Ajayan PM, Carroll DL, Akman S, Torti FM, Torti SV. Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12897-902. PMID: 19620717.
      Citations:    
    50. Singh R, Kostarelos K. Designer adenoviruses for nanomedicine and nanodiagnostics. Trends Biotechnol. 2009 Apr; 27(4):220-9. PMID: 19251331.
      Citations:    
    51. Singh R, Tian B, Kostarelos K. Artificial envelopment of nonenveloped viruses: enhancing adenovirus tumor targeting in vivo. FASEB J. 2008 Sep; 22(9):3389-402. PMID: 18556649.
      Citations:    
    52. Singh R, Al-Jamal KT, Lacerda L, Kostarelos K. Nanoengineering artificial lipid envelopes around adenovirus by self-assembly. ACS Nano. 2008 May; 2(5):1040-50. PMID: 19206502.
      Citations:    
    53. Lacerda L, Soundararajan A, Singh R, Pastorin G, Al-Jamal KT, et al. . Dynamic Imaging of functionalized multi-walled carbon nanotube systemic circulation and urinary excretion. Advanced Materials. 2007; 2(20):225-230. View Publication.
    54. Singh R, Pantarotto D, Lacerda L, Pastorin G, Klumpp C, Prato M, Bianco A, Kostarelos K. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3357-62. PMID: 16492781.
      Citations:    
    55. Singh R, Pantarotto D, McCarthy D, Chaloin O, Hoebeke J, Partidos CD, Briand JP, Prato M, Bianco A, Kostarelos K. Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: toward the construction of nanotube-based gene delivery vectors. J Am Chem Soc. 2005 Mar 30; 127(12):4388-96. PMID: 15783221.
      Citations:    
    56. Singh R, McCarthy D, Kostarelos K. . Surface modification of adenovirus by zwitterionic (DMPC:Chol) liposomes can up- or down-regulate adenoviral gene transfer efficiency in vitro. Journal of drug delivery science and technology. 2005; 15(4):289-294.
    57. Pantarotto D, Singh R, McCarthy D, Erhardt M, Briand JP, Prato M, Kostarelos K, Bianco A. Functionalized carbon nanotubes for plasmid DNA gene delivery. Angew Chem Int Ed Engl. 2004 Oct 04; 43(39):5242-6. PMID: 15455428.
      Citations:    
    58. Worgall S, Kikuchi T, Singh R, Martushova K, Lande L, Crystal RG. Protection against pulmonary infection with Pseudomonas aeruginosa following immunization with P. aeruginosa-pulsed dendritic cells. Infect Immun. 2001 Jul; 69(7):4521-7. PMID: 11401995.
      Citations:    
    59. Kikuchi T, Worgall S, Singh R, Moore MA, Crystal RG. Dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can initiate antigen-specific humoral immunity independent of CD4+ T cells. Nat Med. 2000 Oct; 6(10):1154-9. PMID: 11017148.
      Citations:    
    60. Kaner RJ, Ladetto JV, Singh R, Fukuda N, Matthay MA, Crystal RG. Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema. Am J Respir Cell Mol Biol. 2000 Jun; 22(6):657-64. PMID: 10837361.
      Citations:    
    61. Worgall S, Worgall TS, Kostarelos K, Singh R, Leopold PL, Hackett NR, Crystal RG. Free cholesterol enhances adenoviral vector gene transfer and expression in CAR-deficient cells. Mol Ther. 2000 Jan; 1(1):39-48. PMID: 10933910.
      Citations:    
    62. Worgall S, Bezdicek P, Kim MK, Park JG, Singh R, Christofidou-Solomidou M, Prince A, Kovesdi I, Schreiber AD, Crystal RG. Augmentation of pulmonary host defense against Pseudomonas by FcgammaRIIA cDNA transfer to the respiratory epithelium. J Clin Invest. 1999 Aug; 104(4):409-18. PMID: 10449433.
      Citations:    
    63. Worgall S, Connor R, Kaner RJ, Fenamore E, Sheridan K, Singh R, Crystal RG. Expression and use of human immunodeficiency virus type 1 coreceptors by human alveolar macrophages. J Virol. 1999 Jul; 73(7):5865-74. PMID: 10364338.
      Citations:    
    64. Kaner RJ, Worgall S, Leopold PL, Stolze E, Milano E, Hidaka C, Ramalingam R, Hackett NR, Singh R, Bergelson J, Finberg R, Falck-Pedersen E, Crystal RG. Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie/adenovirus receptor. Am J Respir Cell Mol Biol. 1999 Mar; 20(3):361-70. PMID: 10030833.
      Citations:    
    65. Worgall S, Singh R, Leopold PL, Kaner RJ, Hackett NR, Topf N, Moore MA, Crystal RG. Selective expansion of alveolar macrophages in vivo by adenovirus-mediated transfer of the murine granulocyte-macrophage colony-stimulating factor cDNA. Blood. 1999 Jan 15; 93(2):655-66. PMID: 9885228.
      Citations:    
    66. Suzuki M, Singh R, Moore MA, Song WR, Crystal RG. Similarity of strain- and route-dependent murine responses to an adenovirus vector using the homologous thrombopoietin cDNA as the reporter genes. Hum Gene Ther. 1998 May 20; 9(8):1223-31. PMID: 9625262.
      Citations:    
    67. Suzuki M, Singh RN, Crystal RG. Pharmacological expression in rat hepatocytes of a gene transferred by an adenovirus vector enabled by a chimeric promoter containing multiple cyclic adenosine monophosphate response elements. Hepatology. 1998 Jan; 27(1):160-5. PMID: 9425932.
      Citations:    
    68. Suzuki M, Singh RN, Crystal RG. Ability of a chimeric cAMP-responsive promoter to confer pharmacologic control of CFTR cDNA expression and cAMP-mediated Cl- secretion. Gene Ther. 1997 Nov; 4(11):1195-201. PMID: 9425443.
      Citations:    
    69. Cannizzo SJ, Frey BM, Raffi S, Moore MA, Eaton D, Suzuki M, Singh R, Mack CA, Crystal RG. Augmentation of blood platelet levels by intratracheal administration of an adenovirus vector encoding human thrombopoietin cDNA. Nat Biotechnol. 1997 Jun; 15(6):570-3. PMID: 9181581.
      Citations:    
    70. Suzuki M, Singh RN, Crystal RG. Regulatable promoters for use in gene therapy applications: modification of the 5'-flanking region of the CFTR gene with multiple cAMP response elements to support basal, low-level gene expression that can be upregulated by exogenous agents that raise intracellular levels of cAMP. Hum Gene Ther. 1996 Oct 01; 7(15):1883-93. PMID: 8894680.
      Citations:    
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