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Nathaniel S. O'Connell PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentPHS-Biostatistics and Data Science (Public Health Sciences)
Address
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    Collapse Biography 
    Collapse education and training
    Medical University of South Carolina, Charleston, SCPhD05/2018Biostatistics
    Kennesaw State University, Kennesaw, GABS`05/3013Biology

    Collapse Overview 
    Collapse overview
    I see myself as a collaborative biostatistician that develops statistical methodology for problems encountered when working with collaborative teams. I am a faculty biostatistician a part of the Biostatistics, Epidemiology, and Research Design (BERD) group in the Wake Forest Clinical and Translational Science Institute. From my involvement in BERD and general collaboration with other researchers across WF and beyond, I work across a wide range of medical and public health disciplines, including: cancer, neurology, intensive care, pediatrics, telehealth, and more. My areas of applied statistical experience and expertise include, but are not limited to: design and analysis of clinical trials (particularly dose-finding trials), longitudinal/clustered data analysis, mixed models, analysis of EHR data, analysis of continuously monitored patient data, Bayesian methods, missing data, and prediction modeling using traditional and machine learning methods (e.g. Random Forests).

    My statistical methodology research interests stem from my collaborative work and include: design of dose-finding cancer trials, the development of composite toxicity burden scores in cancer patients, methods for handling missing data (particularly from daily patient diaries), and prediction modelling.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Weekes AJ, Hambright P, Trautmann A, Ali S, Pikus A, Wellinsky N, Shah S, O'Connell N. Low Stroke Volume Predicts Deterioration in Intermediate-Risk Pulmonary Embolism: Prospective Study. West J Emerg Med. 2024 Jul; 25(4):533-547. PMID: 39028239.
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    2. Mabudian L, Reding K, D'Agostino RB, Heiston EM, Bellissimo MP, Olson K, Ntim WO, Klepin HD, Dressler EV, Moore T, Jordan JH, O'Connell NS, Ladd A, Weaver KE, Ky B, Wagner LI, Hackney MH, Lesser GJ, Hundley WG. The relationship between body composition and left ventricular performance in women with breast, lymphoma, or sarcoma cancer. Cardiooncology. 2024 Jun 06; 10(1):34. PMID: 38845066.
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    3. Wells RE, O'Connell N, Minen MT. Mechanisms for mindfulness in migraine: Does catastrophizing matter? Headache. 2024 Jun; 64(6):609-611. PMID: 38842246.
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    4. Makhlin I, Demissei BG, D'Agostino R, Hundley WG, Baleanu-Gogonea C, Wilcox NS, Chen A, Smith AM, O'Connell NS, Januzzi JL, Lesser GJ, Scherrer-Crosbie M, Ibáñez B, Tang WHW, Ky B. Statins Do Not Significantly Affect Oxidative Nitrosative Stress Biomarkers in the PREVENT Randomized Clinical Trial. Clin Cancer Res. 2024 Jun 03; 30(11):2370-2376. PMID: 38573708.
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    5. O'Connell NS. Reply to S. Zhang et al and S. Selukar. J Clin Oncol. 2024 Jul 01; 42(19):2359-2360. PMID: 38657186.
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    6. Garg R, D'Agostino RB, O'Connell N, Lesser GJ, Salloum FN, Hines AL, Meléndez GC, Jordan JH, Ky B, Wagner LI, Sutton AL, Bottinor W, Olson KC, Ladd AC, Hundley WG. Hypertension Severity and Declines in Left Ventricular Ejection Fraction Among Women Receiving Adjuvant Chemotherapy for Breast Cancer (WF-97415 UPBEAT). Hypertension. 2024 Jun; 81(6):1365-1373. PMID: 38634292.
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    7. Weekes AJ, Trautmann A, Hambright PL, Ali S, Pikus AM, Wellinsky N, Goonan KL, Bradford S, O'Connell NS. Comparison of Treatment Approaches and Subsequent Outcomes within a Pulmonary Embolism Response Team Registry. Crit Care Res Pract. 2024; 2024:5590805. PMID: 38560480.
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    8. Peipert JD, Zhao F, Lee JW, Shen SE, Ip E, O'Connell N, Carlos RC, Graham N, Smith ML, Gareen IF, Raper PJ, Weiss M, Kumar SK, Rajkumar SV, Cella D, Gray R, Wagner LI. Patient-Reported Adverse Events and Early Treatment Discontinuation Among Patients With Multiple Myeloma. JAMA Netw Open. 2024 Mar 04; 7(3):e243854. PMID: 38536173.
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    9. Brouwer ECJ, Floyd WN, Jensen ET, O'Connell N, Shaltout HA, Washburn LK, South AM. Risk of Obesity and Unhealthy Central Adiposity in Adolescents Born Preterm With Very Low Birthweight Compared to Term-Born Peers. Child Obes. 2024 Feb 22. PMID: 38387005.
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    10. Hari K, O'Connell N, Taylor YJ, Moore JB, Bosworth H, Hanchate A, Pokharel Y. Patient Characteristics Associated with Telemedicine Use for Diabetes Mellitus Care: Experience of a University Health System. South Med J. 2024 Jan; 117(1):16-22. PMID: 38151246.
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    11. Alexander HB, Arnel M, O'Connell N, Munger Clary HM, Fanning J, Brubaker P, Fountain NB, Duncan P. A single-center survey on physical activity barriers, behaviors and preferences in adults with epilepsy. Epilepsy Behav. 2023 Dec; 149:109491. PMID: 37951132.
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    12. Thomas A, O'Connell NS, Douglas E, Hatcher S, Park CJ, Dent S, Ansley K, Klem I, Bansal R, Westbrook K, Hundley WG, Bottinor W, Hackney MH, Richardson KM, Sirkisoon SR, D'Agostino RB, Jordan JH. Cardiovascular impact of near complete estrogen deprivation in premenopausal women with breast cancer: The CROWN study. Am Heart J. 2024 Jan; 267:33-43. PMID: 37890547.
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    13. O'Connell NS, Zhao F, Lee JW, Ip EH, Peipert JD, Graham N, Smith ML, Gareen IF, Carlos RC, Obeng-Gyasi S, Sparano JA, Shanafelt TD, Thomas ML, Cella D, Wagner LI, Gray R. Importance of Low- and Moderate-Grade Adverse Events in Patients' Treatment Experience and Treatment Discontinuation: An Analysis of the E1912 Trial. J Clin Oncol. 2024 Jan 20; 42(3):266-272. PMID: 37801678.
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    14. Schiff AF, Deines D, Jensen ET, O'Connell N, Perry CJ, Shaltout HA, Washburn LK, South AM. Duration of Simultaneous Exposure to High-Risk and Lower-Risk Nephrotoxic Antimicrobials in the Neonatal Intensive Care Unit (NICU) and Future Adolescent Kidney Health. J Pediatr. 2024 Jan; 264:113730. PMID: 37722552.
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    15. Khanna AK, O'Connell NS, Ahuja S, Saha AK, Harris L, Cusson BD, Faris A, Huffman CS, Vallabhajosyula S, Clark CJ, Segal S, Wells BJ, Kirkendall ES, Sessler DI. Incidence, severity and detection of blood pressure and heart rate perturbations in postoperative ward patients after noncardiac surgery. J Clin Anesth. 2023 Jun 07; 89:111159. PMID: 37295123.
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    16. Weekes AJ, Raper JD, Esener D, Davison J, Boyd JS, Kelly C, Nomura JT, Thomas AM, Lupez K, Cox CA, Ockerse PM, Leech S, Johnson J, Abrams E, Murphy K, O'Connell NS. Comparing predictive performance of pulmonary embolism risk stratification tools for acute clinical deterioration. J Am Coll Emerg Physicians Open. 2023 Jun; 4(3):e12983. PMID: 37251351.
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    17. Gibbs KW, Forbes JL, Harrison KJ, Krall JT, Isenhart AA, Taylor SP, Martin RS, O'Connell NS, Bakhru RN, Palakshappa JA, Files DC. A Pragmatic Pilot Trial Comparing Patient-Triggered Adaptive Pressure Control to Patient-Triggered Volume Control Ventilation in Critically Ill Adults. Respir Care. 2023 Oct; 68(10):1331-1339. PMID: 36944477.
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    18. Bellissimo MP, Canada JM, Jordan JH, Ladd AC, Reding KW, Moore TL, Ntim WO, Heiston EM, Brubaker P, Mihalko SL, D'Agostino R, O'Connell N, Ky B, Wagner LI, Hackney MH, Weaver KE, Lesser GJ, Avis NE, Sutton AL, Lucas AR, Franco RL, Fuemmeler BF, Salloum FN, Hundley WG. Physical Activity During Breast Cancer Therapy Associates With Preserved Exercise Capacity and Cardiac Function (WF97415). JACC CardioOncol. 2023 Oct; 5(5):641-652. PMID: 37969655.
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    19. Weekes AJ, Davison J, Lupez K, Raper JD, Thomas AM, Cox CA, Esener D, Boyd JS, Nomura JT, Murphy K, Ockerse PM, Leech S, Johnson J, Abrams E, Kelly C, O'Connell NS. Quality of life 1?month after acute pulmonary embolism in emergency department patients. Acad Emerg Med. 2023 Aug; 30(8):819-831. PMID: 36786661.
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    20. Estave PM, Margol C, Beeghly S, Anderson R, Shakir M, Coffield A, Byrnes J, O'Connell N, Seng E, Gardiner P, Wells RE. Mechanisms of mindfulness in patients with migraine: Results of a qualitative study. Headache. 2023 Mar; 63(3):390-409. PMID: 36853655.
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    21. O'Connell NS, Wages NA, Garrett-Mayer E. Quasi-partial order continual reassessment method: Applying toxicity scores to cancer dose-finding drug combination trials. Contemp Clin Trials. 2023 Feb; 125:107050. PMID: 36529437.
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    22. Casacchia NJ, Rosenthal GE, O'Connell NS, Bundy R, Witek L, Wells BJ, Palakshappa D. Characteristics of Adult Primary Care Patients Who Use the Patient Portal: A Cross-Sectional Analysis. Appl Clin Inform. 2022 Oct; 13(5):1053-1062. PMID: 36167336.
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    23. Hundley WG, D'Agostino R, Crotts T, Craver K, Hackney MH, Jordan JH, Ky B, Wagner LI, Herrington DM, Yeboah J, Reding KW, Ladd AC, Rapp SR, Russo S, O'Connell N, Weaver KE, Dressler EV, Ge Y, Melin SA, Gudena V, Lesser GJ. Statins and Left Ventricular Ejection Fraction Following Doxorubicin Treatment. NEJM Evid. 2022 Sep; 1(9). PMID: 36908314.
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    24. Weekes AJ, Raper JD, Thomas AM, Lupez K, Cox CA, Esener D, Boyd JS, Nomura JT, Davison J, Ockerse PM, Leech S, Abrams E, Kelly C, O'Connell NS. Electrocardiographic findings associated with early clinical deterioration in acute pulmonary embolism. Acad Emerg Med. 2022 Oct; 29(10):1185-1196. PMID: 35748352.
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    25. Weekes AJ, Fraga DN, Belyshev V, Bost W, Gardner CA, O'Connell NS. Intermediate-risk pulmonary embolism: echocardiography predictors of clinical deterioration. Crit Care. 2022 06 04; 26(1):160. PMID: 35659340.
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    26. Gibbs KW, Forbes JL, O'Connell NS, Martin RS, Bakhru RN, Palakshappa JA, Files DC. Excess Tidal Volume Ventilation in Critically Ill Adults Receiving Adaptive Pressure Control: A Cohort Study. Ann Am Thorac Soc. 2022 May 27. PMID: 35622413.
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    27. Hughes RT, Tye KE, Ververs JD, O'Connell NS, Helis CA, Steber CR, Johnson AG, Chan MD, Farris MK. Virtual Radiation Oncology Peer Review is Associated with Decreased Engagement and Limited Case Discussion: Analysis of a Prospective Database Before and During the COVID-19 Pandemic. Int J Radiat Oncol Biol Phys. 2022 Apr 27. PMID: 35489631.
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    28. Raper JD, Thomas AM, Lupez K, Cox CA, Esener D, Boyd JS, Nomura JT, Davison J, Ockerse PM, Leech S, Johnson J, Abrams E, Murphy K, Kelly C, O'Connell NS, Weekes AJ. Can right ventricular assessments improve triaging of low risk pulmonary embolism? Acad Emerg Med. 2022 Jul; 29(7):835-850. PMID: 35289978.
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    29. Obeng-Gyasi S, Graham N, Kumar S, Lee JW, Jacobus S, Weiss M, Cella D, Zhao F, Ip EH, O'Connell N, Hong F, Peipert DJ, Gareen IF, Timsina LR, Gray R, Wagner LI, Carlos RC. Examining allostatic load, neighborhood socioeconomic status, symptom burden and mortality in multiple myeloma patients. Blood Cancer J. 2022 Apr 01; 12(4):53. PMID: 35365604.
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    30. Huffman C, O'Connell N, Burns M, Blakely M, Gilliland W. Out and about: Factors associated with nurses' use of COVID-19 personal protective behaviors when not at work. Nurs Forum. 2022 Mar; 57(2):234-243. PMID: 34748227.
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    31. Ip EH, Saldana S, Miller KD, Carlos RC, Gareen IF, Sparano JA, Graham N, Zhao F, Lee JW, O'Connell NS, Cella D, Peipert JD, Gray RJ, Wagner LI. Tolerability of bevacizumab and chemotherapy in a phase 3 clinical trial with human epidermal growth factor receptor 2-negative breast cancer: A trajectory analysis of adverse events. Cancer. 2021 Nov 02. PMID: 34726788.
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    32. Meadows AD, Swanson SA, Galligan TM, Naidenko OV, O'Connell N, Perrone-Gray S, Leiba NS. Packaged Foods Labeled as Organic Have a More Healthful Profile Than Their Conventional Counterparts, According to Analysis of Products Sold in the U.S. in 2019-2020. Nutrients. 2021 Aug 29; 13(9). PMID: 34578899.
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    33. Jordan JH, D'Agostino RB, Ansley K, Douglas E, Melin S, Sorscher S, Vasu S, Park S, Kotak A, Romitti PA, O'Connell NS, Hundley WG, Thomas A. Myocardial Function in Premenopausal Women Treated With Ovarian Function Suppression and an Aromatase Inhibitor. JNCI Cancer Spectr. 2021 Aug; 5(4). PMID: 34476341.
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    34. Estave PM, Beeghly S, Anderson R, Margol C, Shakir M, George G, Berger A, O'Connell N, Burch R, Haas N, Powers SW, Seng E, Buse DC, Lipton RB, Wells RE. Learning the full impact of migraine through patient voices: A qualitative study. Headache. 2021 Jul; 61(7):1004-1020. PMID: 34081779.
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    35. Reding KW, O'Connell NS, D'Agostino RB, Hundley W, Lucas AR, Ladd AC, Jordan JH, Heiston EM, Ge Y, Hundley WG. Both intermuscular fat and LVEF decline promote heart failure symptoms in cancer survivors. Cardiooncology. 2021 May 08; 7(1):16. PMID: 33964981.
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    36. Farris SR, Grazzi L, Holley M, Dorsett A, Xing K, Pierce CR, Estave PM, O'Connell N, Wells RE. Online Mindfulness May Target Psychological Distress and Mental Health during COVID-19. Glob Adv Health Med. 2021; 10:21649561211002461. PMID: 34497735.
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    37. Semelka CT, Ornelles DA, O'Connell NS, Parsons EC, Blevins MW, Ivey LE, Bischoff WE. Detection of Environmental Spread of SARS-CoV-2 and Associated Patient Characteristics. Open Forum Infect Dis. 2021 Jun; 8(6):ofab107. PMID: 34183976.
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    38. Wells RE, O'Connell N, Pierce CR, Estave P, Penzien DB, Loder E, Zeidan F, Houle TT. Effectiveness of Mindfulness Meditation vs Headache Education for Adults With Migraine: A Randomized Clinical Trial. JAMA Intern Med. 2021 Mar 01; 181(3):317-328. PMID: 33315046.
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    39. Ghoshal S, O'Connell N, Tegeler C, Freedman BI. Cerebral hemodynamics in peritoneal dialysis versus intermittent hemodialysis: A transcranial Doppler pilot study. Perit Dial Int. 2020 Sep 10; 896860820953712. PMID: 32909931.
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    40. Neitzke DJ, Bowers JS, Andrijauskaite K, O'Connell NS, Garrett-Mayer E, Wrangle J, Li Z, Paulos CM, Cole DJ, Rubinstein MP. Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis. Cancer Immunol Immunother. 2017 Jun; 66(6):737-751. PMID: 28280853.
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    41. O'Connell NS, Dai L, Jiang Y, Speiser JL, Ward R, Wei W, Carroll R, Gebregziabher M. Methods for Analysis of Pre-Post Data in Clinical Research: A Comparison of Five Common Methods. J Biom Biostat. 2017 Feb 24; 8(1):1-8. PMID: 30555734.
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    42. Welch BM, O'Connell NS, Qanungo S, Halbert-Hughes C, Schiffman JD. Collecting Family Health History using an Online Social Network: a Nationwide Survey among Potential Users. AMIA Annu Symp Proc. 2015; 2015:1316-25. PMID: 26958272.
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