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Fei Xing PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentCancer Biology
Address
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    Collapse Biography 
    Collapse education and training
    Shandong UniversityB.S06/2007biotechnology
    Southern Illinois UniversityPh.D.05/2012molecular oncology

    Collapse Research 
    Collapse research activities and funding
    5R37CA230451-02     (fei xing)Aug 1, 2018 - Jul 30, 2023
    NCI
    Roles of neutrophils in c-Met mediated breast cancer brain metastases
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Su J, Song Q, Qasem S, O'Neill S, Lee J, Furdui CM, Pasche B, Metheny-Barlow L, Masters AH, Lo HW, Xing F, Watabe K, Miller LD, Tatter SB, Laxton AW, Whitlow CT, Chan MD, Soike MH, Ruiz J. Multi-Omics Analysis of Brain Metastasis Outcomes Following Craniotomy. Front Oncol. 2020; 10:615472. PMID: 33889540.
      Citations:    
    2. Sirkisoon SR, Carpenter RL, Rimkus T, Doheny D, Zhu D, Aguayo NR, Xing F, Chan M, Ruiz J, Metheny-Barlow LJ, Strowd R, Lin J, Regua AT, Arrigo A, Anguelov M, Pasche B, Debinski W, Watabe K, Lo HW. Correction: TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment. Oncogene. 2021 Mar; 40(12):2338. PMID: 33654200.
      Citations:    
    3. Tyagi A, Sharma S, Wu K, Wu SY, Xing F, Liu Y, Zhao D, Deshpande RP, D'Agostino RB, Watabe K. Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung. Nat Commun. 2021 01 20; 12(1):474. PMID: 33473115.
      Citations:    
    4. Xing F, Zhao D, Wu SY, Tyagi A, Wu K, Sharma S, Liu Y, Deshpande R, Wang Y, Cleary J, Miller LD, Chittiboyina AG, Yalamanchili C, Mo YY, Watabe K. Epigenetic and Posttranscriptional Modulation of SOS1 Can Promote Breast Cancer Metastasis through Obesity-Activated c-Met Signaling in African-American Women. Cancer Res. 2021 Jun 01; 81(11):3008-3021. PMID: 33446575.
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    5. Sharma S, Pei X, Xing F, Wu SY, Wu K, Tyagi A, Zhao D, Deshpande R, Ruiz MG, Singh R, Lyu F, Watabe K. Regucalcin promotes dormancy of prostate cancer. Oncogene. 2021 Feb; 40(5):1012-1026. PMID: 33323968.
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    6. Wu SY, Xing F, Sharma S, Wu K, Tyagi A, Liu Y, Zhao D, Deshpande RP, Shiozawa Y, Ahmed T, Zhang W, Chan M, Ruiz J, Lycan TW, Dothard A, Watabe K. Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function. J Exp Med. 2020 08 03; 217(8). PMID: 32496556.
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    7. Chen Y, Liu W, Zhang B, Suo Z, Xing F, Feng L. Sensitive and reversible perylene derivative-based fluorescent probe for acetylcholinesterase activity monitoring and its inhibitor. Anal Biochem. 2020 10 15; 607:113835. PMID: 32739347.
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    8. Helis CA, Hughes RT, Glenn CW, Lanier CM, Masters AH, Dohm A, Ahmed T, Ruiz J, Triozzi P, Gondal H, Cramer CK, Tatter SB, Laxton AW, Xing F, Lo HW, Su J, Watabe K, Wang G, Whitlow CT, Chan MD. Predictors of Adverse Radiation Effect in Brain Metastasis Patients Treated With Stereotactic Radiosurgery and Immune Checkpoint Inhibitor Therapy. Int J Radiat Oncol Biol Phys. 2020 09 01; 108(1):295-303. PMID: 32615262.
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    9. Sirkisoon SR, Carpenter RL, Rimkus T, Doheny D, Zhu D, Aguayo NR, Xing F, Chan M, Ruiz J, Metheny-Barlow LJ, Strowd R, Lin J, Regua AT, Arrigo A, Anguelov M, Pasche B, Debinski W, Watabe K, Lo HW. TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment. Oncogene. 2020 01; 39(1):64-78. PMID: 31462709.
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    10. Sharma S, Wu SY, Jimenez H, Xing F, Zhu D, Liu Y, Wu K, Tyagi A, Zhao D, Lo HW, Metheny-Barlow L, Sun P, Bourland JD, Chan MD, Thomas A, Barbault A, D'Agostino RB, Whitlow CT, Kirchner V, Blackman C, Pasche B, Watabe K. Ca2+ and CACNA1H mediate targeted suppression of breast cancer brain metastasis by AM RF EMF. EBioMedicine. 2019 Jun; 44:194-208. PMID: 31129098.
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    11. Dohm A, Su J, McTyre ER, Taylor JM, Miller LD, Petty WJ, Xing F, Lo HW, Metheny-Barlow LJ, O'Neill S, Bellinger C, Dotson T, Pasche B, Watabe K, Chan MD, Ruiz J. Identification of CD37, cystatin A, and IL-23A gene expression in association with brain metastasis: analysis of a prospective trial. Int J Biol Markers. 2019 Mar; 34(1):90-97. PMID: 30854931.
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    12. Hu Z, Suo Z, Liu W, Zhao B, Xing F, Zhang Y, Feng L. DNA conformational polymorphism for biosensing applications. Biosens Bioelectron. 2019 Apr 15; 131:237-249. PMID: 30849723.
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    13. Liu Y, Pandey PR, Sharma S, Xing F, Wu K, Chittiboyina A, Wu SY, Tyagi A, Watabe K. ID2 and GJB2 promote early-stage breast cancer progression by regulating cancer stemness. Breast Cancer Res Treat. 2019 May; 175(1):77-90. PMID: 30725231.
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    14. Shenker RF, McTyre ER, Taksler GB, D'Agostino RB, Cramer CK, Ruiz J, Alphonse-Sullivan NK, Farris M, Watabe K, Xing F, Laxton AW, Tatter SB, Chan MD. Analysis of the drivers of cost of management when patients with brain metastases are treated with upfront radiosurgery. Clin Neurol Neurosurg. 2019 01; 176:10-14. PMID: 30468997.
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    15. Dohm AE, Hughes R, Wheless W, Lecompte M, Lanier C, Ruiz J, Watabe K, Xing F, Su J, Cramer C, Laxton A, Tatter S, Chan MD. Surgical resection and postoperative radiosurgery versus staged radiosurgery for large brain metastases. J Neurooncol. 2018 Dec; 140(3):749-756. PMID: 30367382.
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    16. Fu H, Xing F, Lv Y, Zeng B, You P, Liu J. ICBP90 mediates Notch signaling to facilitate human hepatocellular carcinoma growth. Tissue Cell. 2018 Oct; 54:65-71. PMID: 30309512.
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    17. Xing F, Liu Y, Wu SY, Wu K, Sharma S, Mo YY, Feng J, Sanders S, Jin G, Singh R, Vidi PA, Tyagi A, Chan MD, Ruiz J, Debinski W, Pasche BC, Lo HW, Metheny-Barlow LJ, D'Agostino RB, Watabe K. Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis. Cancer Res. 2018 08 01; 78(15):4316-4330. PMID: 30026327.
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    18. Xing F, Liu Y, Sharma S, Wu K, Chan MD, Lo HW, Carpenter RL, Metheny-Barlow LJ, Zhou X, Qasem SA, Pasche B, Watabe K. Activation of the c-Met Pathway Mobilizes an Inflammatory Network in the Brain Microenvironment to Promote Brain Metastasis of Breast Cancer. Cancer Res. 2016 09 01; 76(17):4970-80. PMID: 27364556.
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    19. Zeng C, Xing R, Liu J, Xing F. Role of CSL-dependent and independent Notch signaling pathways in cell apoptosis. Apoptosis. 2016 Jan; 21(1):1-12. PMID: 26496776.
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    20. Wu K, Fukuda K, Xing F, Zhang Y, Sharma S, Liu Y, Chan MD, Zhou X, Qasem SA, Pochampally R, Mo YY, Watabe K. Roles of the cyclooxygenase 2 matrix metalloproteinase 1 pathway in brain metastasis of breast cancer. J Biol Chem. 2015 Apr 10; 290(15):9842-54. PMID: 25691572.
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    21. Wang Y, Xing F, Ye S, Xiao J, Di J, Zeng S, Liu J. Jagged-1 signaling suppresses the IL-6 and TGF-ß treatment-induced Th17 cell differentiation via the reduction of ROR?t/IL-17A/IL-17F/IL-23a/IL-12rb1. Sci Rep. 2015 Feb 04; 5:8234. PMID: 25648768.
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    22. Xing F, Kobayashi A, Okuda H, Watabe M, Pai SK, Pandey PR, Hirota S, Wilber A, Mo YY, Moore BE, Liu W, Fukuda K, Iiizumi M, Sharma S, Liu Y, Wu K, Peralta E, Watabe K. Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain. EMBO Mol Med. 2013 Mar; 5(3):384-96. PMID: 23495140.
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    23. Okuda H, Xing F, Pandey PR, Sharma S, Watabe M, Pai SK, Mo YY, Iiizumi-Gairani M, Hirota S, Liu Y, Wu K, Pochampally R, Watabe K. miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4. Cancer Res. 2013 Feb 15; 73(4):1434-44. PMID: 23384942.
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    24. Yu C, Xing F, Tang Z, Bronner C, Lu X, Di J, Zeng S, Liu J. Anisomycin suppresses Jurkat T cell growth by the cell cycle-regulating proteins. Pharmacol Rep. 2013; 65(2):435-44. PMID: 23744428.
      Citations:    
    25. Liu W, Xing F, Iiizumi-Gairani M, Okuda H, Watabe M, Pai SK, Pandey PR, Hirota S, Kobayashi A, Mo YY, Fukuda K, Li Y, Watabe K. N-myc downstream regulated gene 1 modulates Wnt-ß-catenin signalling and pleiotropically suppresses metastasis. EMBO Mol Med. 2012 Feb; 4(2):93-108. PMID: 22246988.
      Citations:    
    26. Kobayashi A, Okuda H, Xing F, Pandey PR, Watabe M, Hirota S, Pai SK, Liu W, Fukuda K, Chambers C, Wilber A, Watabe K. Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone. J Exp Med. 2011 Dec 19; 208(13):2641-55. PMID: 22124112.
      Citations:    
    27. Xing F, Okuda H, Watabe M, Kobayashi A, Pai SK, Liu W, Pandey PR, Fukuda K, Hirota S, Sugai T, Wakabayshi G, Koeda K, Kashiwaba M, Suzuki K, Chiba T, Endo M, Mo YY, Watabe K. Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells. Oncogene. 2011 Sep 29; 30(39):4075-86. PMID: 21499308.
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    28. Wang YF, Cai DH, Chen H, Mo YY, Yi N, Xing FY. [An infrared imaging system for detecting electrophoretic mobility shift of DNA-protein complexes]. Nan Fang Yi Ke Da Xue Xue Bao. 2009 Feb; 29(2):289-91. PMID: 19246302.
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    29. Fang ZY, Xing FY, Guo ZF, Chen L. [Effect of Jagged-1 on the cytokine expression of murine myeloid-derived dendritic cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Feb; 25(2):100-3. PMID: 19174003.
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    30. Wang JK, Hu MQ, Xing FY. [Effect of Jagged1 on the morphology of DC differentiation observed by atomic force microscopy]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Oct; 24(10):969-71. PMID: 18845081.
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    31. Xing F, Liu J, Mo Y, Liu Z, Qin Q, Wang J, Fan Z, Long Y, Liu N, Zhao K, Jiang Y. Lysophosphatidylcholine up-regulates human endothelial nitric oxide synthase gene transactivity by c-Jun N-terminal kinase signalling pathway. J Cell Mol Med. 2009 Jun; 13(6):1136-48. PMID: 18624763.
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    32. Xing FY, Yu Z, Liu J, Ji YH. [Effect of a soluble Jagged 1/Fc chimera protein on the activation, proliferation and cell cycle of lymphocytes in mice]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Jan; 24(1):6-9. PMID: 18177607.
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    33. Xing F, Jiang Y, Liu J, Zhao K, Mo Y, Liu Z, Zeng Y. Downregulation of human endothelial nitric oxide synthase promoter activity by p38 mitogen-activated protein kinase activation. Biochem Cell Biol. 2006 Oct; 84(5):780-8. PMID: 17167542.
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    34. Xing F, Jiang Y, Liu J, Zhao K, Mo Y, Qin Q, Wang J, Ouyang J, Zeng Y. Role of AP1 element in the activation of human eNOS promoter by lysophosphatidylcholine. J Cell Biochem. 2006 Jul 01; 98(4):872-84. PMID: 16453281.
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    35. Shangguan G, Xing F, Qu X, Mao J, Zhao D, Zhao X, Ren J. DNA binding specificity and cytotoxicity of novel antitumor agent Ge132 derivatives. Bioorg Med Chem Lett. 2005 Jun 15; 15(12):2962-5. PMID: 15914003.
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    36. Zhang LH, Jia YH, Sun XG, Xing FY, Liu ZF, Song G, Jiang Y. [Effect of total Panax notoginseng saponins on the activity of human endothelial nitric oxide synthase gene promoter]. Di Yi Jun Yi Da Xue Xue Bao. 2004 Oct; 24(10):1113-6. PMID: 15485778.
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    37. Mo YY, Xing FY, Zhang B, Hen Y, Jiang Y. [Effect of astrocyte-conditioned medium on tert-butyl hydroperoxide-induced apoptosis of PC12 cells]. Di Yi Jun Yi Da Xue Xue Bao. 2004 Sep; 24(9):999-1000. PMID: 15447845.
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