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Ellen E. Quillen PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Molecular Medicine
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    Collapse Affiliation 

    Collapse Biography 
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    University of Kansas, Lawrence, KSBS05/2005Biology, Genetics
    Pennsylvania State University, State College, PAPhD12/2010Anthropology, Genetics

    Collapse Overview 
    Collapse overview
    Dr. Quillen is a statistical and population geneticist. Her studies are focused on complex traits and include analyses of both normal variation like skin pigmentation and tanning response and disease traits such as bone fracture and osteoarthritis. Dr. Quillen is interested in applying integrated omic analyses to study age-related disorders and their molecular and physiological basis. Her work blends transcriptomic and epigenetic data with proteomics and metabolomics to better understand bone health and metabolic disease in non-human primate models.

    Collapse Research 
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    R01AR064244     (BREDBENNER, TODD L)Sep 18, 2013 - Aug 31, 2018
    NIH
    The Role of Bone Trait Covariation in Vertebral Fracture Resistance
    Role: Co-Investigator
    K01AG056663     (QUILLEN, ELLEN ELIZABETH)Sep 15, 2018 - Apr 30, 2021
    NIH
    Integrative multi-omic investigation of age-related changes in trabecular bone
    Role: Principal Investigator
         (Bethany Kerr)Dec 1, 2018 - Nov 30, 2019
    Elsa U. Pardee Foundation
    Profiling cell composition and methylation in bone pre-metastatic niche
    Role Description: Define alterations in bone marrow cellular composition with cancer and comorbidities; develop a methylation profile for cancerous and healthy bone marrow; Assess how changes in the bone microenvironment with arthritis or obesity alter cancer metastasis.
    Role: Co-PI
    UL1TR001102     (Quillen)Apr 1, 2019 - Mar 31, 2020
    NIH/NCATS
    Methylation analysis of bone cells to improve high-throughput evaluation of bone marrow composition and gene expression
    Role Description: This project will develop an algorithm to adjust for variation in bone marrow and trabecular bone tissue cell composition based on methylation profiling of individual cell types. Analyses will include human, non-human primate, and mouse bone to generate a panel of markers with broad applicability to expedite translation. This research will enable the methylation analysis of bulk bone tissue in future studies of cancer metastasis, radiation exposure, and osteoporosis.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mainali R, Zabalawi M, Long D, Buechler N, Quillen E, Key CC, Zhu X, Parks JS, Furdui C, Stacpoole PW, Martinez J, McCall CE, Quinn MA. Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction. Elife. 2021 Feb 22; 10. PMID: 33616039.
      Citations:    
    2. Housman G, Quillen EE, Stone AC. An evolutionary perspective of DNA methylation patterns in skeletal tissues using a baboon model of osteoarthritis. J Orthop Res. 2020 Dec 16. PMID: 33325553.
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    3. White JD, Indencleef K, Naqvi S, Eller RJ, Hoskens H, Roosenboom J, Lee MK, Li J, Mohammed J, Richmond S, Quillen EE, Norton HL, Feingold E, Swigut T, Marazita ML, Peeters H, Hens G, Shaffer JR, Wysocka J, Walsh S, Weinberg SM, Shriver MD, Claes P. Insights into the genetic architecture of the human face. Nat Genet. 2021 01; 53(1):45-53. PMID: 33288918.
      Citations:    
    4. Quillen EE, Beavers DP, O'Brien Cox A, Furdui CM, Lee J, Miller RM, Wu H, Beavers KM. Use of Metabolomic Profiling to Understand Variability in Adiposity Changes Following an Intentional Weight Loss Intervention in Older Adults. Nutrients. 2020 Oct 19; 12(10). PMID: 33086512.
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    5. Housman G, Quillen EE, Stone AC. Intraspecific and interspecific investigations of skeletal DNA methylation and femur morphology in primates. Am J Phys Anthropol. 2020 09; 173(1):34-49. PMID: 32170728.
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    6. Gokhman D, Nissim-Rafinia M, Agranat-Tamir L, Housman G, García-Pérez R, Lizano E, Cheronet O, Mallick S, Nieves-Colón MA, Li H, Alpaslan-Roodenberg S, Novak M, Gu H, Osinski JM, Ferrando-Bernal M, Gelabert P, Lipende I, Mjungu D, Kondova I, Bontrop R, Kullmer O, Weber G, Shahar T, Dvir-Ginzberg M, Faerman M, Quillen EE, Meissner A, Lahav Y, Kandel L, Liebergall M, Prada ME, Vidal JM, Gronostajski RM, Stone AC, Yakir B, Lalueza-Fox C, Pinhasi R, Reich D, Marques-Bonet T, Meshorer E, Carmel L. Differential DNA methylation of vocal and facial anatomy genes in modern humans. Nat Commun. 2020 03 04; 11(1):1189. PMID: 32132541.
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    7. Norton HL, Quillen EE, Bigham AW, Pearson LN, Dunsworth HM. Human Races Are Not Like Dog Breeds: Refuting a Racist Analogy. Evolution: Education and Outreach. 2019; 17(12).
    8. Quillen EE, Norton HL, Parra EJ, Lona-Durazo F, Ang KC, Illiescu FM, Pearson LN, Shriver MD, Lasisi T, Gokcumen O, Starr I, Lin YL, Martin AR, Jablonski NG. Shades of complexity: New perspectives on the evolution and genetic architecture of human skin. Am J Phys Anthropol. 2019 01; 168 Suppl 67:4-26. PMID: 30408154.
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    9. Housman G, Havill LM, Quillen EE, Comuzzie AG, Stone AC. Assessment of DNA Methylation Patterns in the Bone and Cartilage of a Nonhuman Primate Model of Osteoarthritis. Cartilage. 2019 07; 10(3):335-345. PMID: 29457464.
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    10. Quillen EE, Blangero J, Almasy L. A variance component method for integrated pathway analysis of gene expression data. BMC Proc. 2016; 10(Suppl 7):337-342. PMID: 27980659.
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    11. Quillen EE. The Evolution of Tanning Needs Its Day in the Sun. Hum Biol. 2015 Oct; 87(4):352-360. PMID: 27737586.
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    12. Quillen EE, Voruganti VS, Chittoor G, Rubicz R, Peralta JM, Almeida MA, Kent JW, Diego VP, Dyer TD, Comuzzie AG, Göring HH, Duggirala R, Almasy L, Blangero J. Evaluation of estimated genetic values and their application to genome-wide investigation of systolic blood pressure. BMC Proc. 2014; 8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S66. PMID: 25519398.
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    13. Claes P, Liberton DK, Daniels K, Rosana KM, Quillen EE, Pearson LN, McEvoy B, Bauchet M, Zaidi AA, Yao W, Tang H, Barsh GS, Absher DM, Puts DA, Rocha J, Beleza S, Pereira RW, Baynam G, Suetens P, Vandermeulen D, Wagner JK, Boster JS, Shriver MD. Modeling 3D facial shape from DNA. PLoS Genet. 2014 Mar; 10(3):e1004224. PMID: 24651127.
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    14. Quillen EE, Chen XD, Almasy L, Yang F, He H, Li X, Wang XY, Liu TQ, Hao W, Deng HW, Kranzler HR, Gelernter J. ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample. . 2014 Mar; 165B(2):103-10. PMID: 24277619.
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    15. Quillen EE, Rainwater DL, Dyer TD, Carless MA, Curran JE, Johnson MP, Göring HH, Cole SA, Rutherford S, Maccluer JW, Moses EK, Blangero J, Almasy L, Mahaney MC. Novel associations of nonstructural Loci with paraoxonase activity. J Lipids. 2012; 2012:189681. PMID: 22577559.
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    16. Quillen EE, Bauchet M, Bigham AW, Delgado-Burbano ME, Faust FX, Klimentidis YC, Mao X, Stoneking M, Shriver MD. OPRM1 and EGFR contribute to skin pigmentation differences between Indigenous Americans and Europeans. Hum Genet. 2012 Jul; 131(7):1073-80. PMID: 22198722.
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    17. Quillen EE, Shriver MD. Unpacking human evolution to find the genetic determinants of human skin pigmentation. J Invest Dermatol. 2011 Nov 17; 131(E1):E5-7. PMID: 22094403.
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    18. Quillen EE, Guiltinan JS, Beleza S, Rocha J, Pereira RW, Shriver MD. Iris texture traits show associations with iris color and genomic ancestry. Am J Hum Biol. 2011 Jul-Aug; 23(4):567-9. PMID: 21630365.
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    19. Quillen EE, Shriver MD. SLC24A5: exchanging genetic and biochemical knowledge. Pigment Cell Melanoma Res. 2008 Jun; 21(3):344-5. PMID: 18397209.
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    20. Bauchet M, McEvoy B, Pearson LN, Quillen EE, Sarkisian T, Hovhannesyan K, Deka R, Bradley DG, Shriver MD. Measuring European population stratification with microarray genotype data. Am J Hum Genet. 2007 May; 80(5):948-56. PMID: 17436249.
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    21. Quillen EE, Haslam GC, Samra HS, Amani-Taleshi D, Knight JA, Wyatt DE, Bishop SC, Colvert KK, Richter ML, Kitos PA. Ectoadenylate kinase and plasma membrane ATP synthase activities of human vascular endothelial cells. J Biol Chem. 2006 Jul 28; 281(30):20728-20737. PMID: 16714292.
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