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Cristina M. Furdui PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Molecular Medicine
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    Other Positions
    TitleCo-Director
    InstitutionWake Forest School of Medicine
    DepartmentCenter for Redox Biology & Medicine (CRBM)

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentBiochemistry

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentCancer Biology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kwok AT, Mohamed NS, Plate JF, Yammani RR, Rosas S, Bateman TA, Livingston E, Moore JE, Kerr BA, Lee J, Furdui CM, Tan L, Bouxsein ML, Ferguson VL, Stodieck LS, Zawieja DC, Delp MD, Mao XW, Willey JS. Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents. Sci Rep. 2021 May 18; 11(1):10469. PMID: 34006989.
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    2. Lipchick BC, Utley A, Han Z, Moparthy S, Yun DH, Bianchi-Smiraglia A, Wolff DW, Fink E, Liu L, Furdui CM, Lee J, Lee KP, Nikiforov MA. The fatty acid elongase ELOVL6 regulates bortezomib resistance in multiple myeloma. Blood Adv. 2021 04 13; 5(7):1933-1946. PMID: 33821992.
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    3. Su J, Song Q, Qasem S, O'Neill S, Lee J, Furdui CM, Pasche B, Metheny-Barlow L, Masters AH, Lo HW, Xing F, Watabe K, Miller LD, Tatter SB, Laxton AW, Whitlow CT, Chan MD, Soike MH, Ruiz J. Multi-Omics Analysis of Brain Metastasis Outcomes Following Craniotomy. Front Oncol. 2020; 10:615472. PMID: 33889540.
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    4. Holmila R, Wu H, Lee J, Tsang AW, Singh R, Furdui CM. Integrated Redox Proteomic Analysis Highlights New Mechanisms of Sensitivity to Silver Nanoparticles. Mol Cell Proteomics. 2021 Mar 20; 20:100073. PMID: 33757833.
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    5. Mainali R, Zabalawi M, Long D, Buechler N, Quillen E, Key CC, Zhu X, Parks JS, Furdui C, Stacpoole PW, Martinez J, McCall CE, Quinn MA. Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction. Elife. 2021 Feb 22; 10. PMID: 33616039.
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    6. Collins JA, Kapustina M, Bolduc JA, Pike JFW, Diekman BO, Mix K, Chubinskaya S, Eroglu E, Michel T, Poole LB, Furdui CM, Loeser RF. Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes. Free Radic Biol Med. 2021 Apr; 166:90-103. PMID: 33600943.
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    7. Turell L, Steglich M, Torres MJ, Deambrosi M, Antmann L, Furdui CM, Schopfer FJ, Alvarez B. Sulfenic acid in human serum albumin: Reaction with thiols, oxidation and spontaneous decay. Free Radic Biol Med. 2021 Mar; 165:254-264. PMID: 33515755.
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    8. Schipper S, Wu H, Furdui CM, Poole LB, Delahunty CM, Park R, Yates JR, Becker K, Przyborski JM. Identification of sulfenylation patterns in trophozoite stage Plasmodium falciparum using a non-dimedone based probe. Mol Biochem Parasitol. 2021 03; 242:111362. PMID: 33513391.
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    9. Yang W, Zhou X, Wang X, Lee J, Wu D, Sun P, Furdui CM, Ma T. Protein expression alteration in hippocampus upon genetic repression of AMPKa isoforms. Hippocampus. 2021 Apr; 31(4):353-361. PMID: 33492732.
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    10. Lewis JE, Forshaw TE, Boothman DA, Furdui CM, Kemp ML. Personalized Genome-Scale Metabolic Models Identify Targets of Redox Metabolism in Radiation-Resistant Tumors. Cell Syst. 2021 Jan 20; 12(1):68-81.e11. PMID: 33476554.
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    11. Kumar A, Kim S, Su Y, Sharma M, Kumar P, Singh S, Lee J, Furdui CM, Singh R, Hsu FC, Kim J, Whitlow CT, Nader MA, Deep G. Brain cell-derived exosomes in plasma serve as neurodegeneration biomarkers in male cynomolgus monkeys self-administrating oxycodone. EBioMedicine. 2021 Jan; 63:103192. PMID: 33418508.
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    12. Dushime R, Zhu Y, Wu H, Saez D, Shukla K, Brown-Harding H, Biavatti MW, Nelson KJ, Poole LB, Lowther WT, Jones PB, Furdui CM, Tsang AW. Discovery of Spilanthol Endoperoxide as a Redox Natural Compound Active against Mammalian Prx3 and Chlamydiatrachomatis Infection. Antioxidants (Basel). 2020 Dec 03; 9(12). PMID: 33287170.
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    13. Furdui CM, Sturla SJ, Carroll KS. Call for Papers for the Special Issue on Natural Products in Redox Toxicology. Chem Res Toxicol. 2020 11 16; 33(11):2687. PMID: 33190500.
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    14. Guo H, Deng N, Dou L, Ding H, Criswell T, Atala A, Furdui CM, Zhang Y. 3-D Human Renal Tubular Organoids Generated from Urine-Derived Stem Cells for Nephrotoxicity Screening. ACS Biomater Sci Eng. 2020 12 14; 6(12):6701-6709. PMID: 33320634.
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    15. Shukla K, Singh N, Lewis JE, Tsang AW, Boothman DA, Kemp ML, Furdui CM. MTHFD2 Blockade Enhances the Efficacy of ß-Lapachone Chemotherapy With Ionizing Radiation in Head and Neck Squamous Cell Cancer. Front Oncol. 2020; 10:536377. PMID: 33262939.
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    16. Quillen EE, Beavers DP, O'Brien Cox A, Furdui CM, Lee J, Miller RM, Wu H, Beavers KM. Use of Metabolomic Profiling to Understand Variability in Adiposity Changes Following an Intentional Weight Loss Intervention in Older Adults. Nutrients. 2020 Oct 19; 12(10). PMID: 33086512.
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    17. Zimmermann HR, Yang W, Kasica NP, Zhou X, Wang X, Beckelman BC, Lee J, Furdui CM, Keene CD, Ma T. Brain-specific repression of AMPKa1 alleviates pathophysiology in Alzheimer's model mice. J Clin Invest. 2020 07 01; 130(7):3511-3527. PMID: 32213711.
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    18. Bayne RS, Puckett S, Rodrigues LU, Cramer SD, Lee J, Furdui CM, Chou JW, Miller LD, Ornelles DA, Lyles DS. MAP3K7 and CHD1 Are Novel Mediators of Resistance to Oncolytic Vesicular Stomatitis Virus in Prostate Cancer Cells. Mol Ther Oncolytics. 2020 Jun 26; 17:496-507. PMID: 32529027.
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    19. Poole LB, Parsonage D, Sergeant S, Miller LR, Lee J, Furdui CM, Chilton FH. Acyl-lipid desaturases and Vipp1 cooperate in cyanobacteria to produce novel omega-3 PUFA-containing glycolipids. Biotechnol Biofuels. 2020; 13:83. PMID: 32399061.
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    20. Poole LB, Furdui CM, King SB. Introduction to approaches and tools for the evaluation of protein cysteine oxidation. Essays Biochem. 2020 02 17; 64(1):1-17. PMID: 32031597.
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    21. Holmila RJ, Vance SA, King SB, Tsang AW, Singh R, Furdui CM. Silver Nanoparticles Induce Mitochondrial Protein Oxidation in Lung Cells Impacting Cell Cycle and Proliferation. Antioxidants (Basel). 2019 Nov 14; 8(11). PMID: 31739476.
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    22. Swanner J, Fahrenholtz CD, Tenvooren I, Bernish BW, Sears JJ, Hooker A, Furdui CM, Alli E, Li W, Donati GL, Cook KL, Vidi PA, Singh R. Silver nanoparticles selectively treat triple-negative breast cancer cells without affecting non-malignant breast epithelial cells in vitro and in vivo. FASEB Bioadv. 2019 Oct; 1(10):639-660. PMID: 32123812.
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    23. Atkins HM, Bharadwaj MS, O'Brien Cox A, Furdui CM, Appt SE, Caudell DL. Endometrium and endometriosis tissue mitochondrial energy metabolism in a nonhuman primate model. Reprod Biol Endocrinol. 2019 Aug 24; 17(1):70. PMID: 31445519.
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    24. Tesfay L, Paul BT, Konstorum A, Deng Z, Cox AO, Lee J, Furdui CM, Hegde P, Torti FM, Torti SV. Stearoyl-CoA Desaturase 1 Protects Ovarian Cancer Cells from Ferroptotic Cell Death. Cancer Res. 2019 10 15; 79(20):5355-5366. PMID: 31270077.
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    25. Xiong G, Tang W, Zhang D, He D, Wei G, Atala A, Liang XJ, Bleyer AJ, Bleyer ME, Yu J, Aloi JA, Ma JX, Furdui CM, Zhang Y. Impaired Regeneration Potential in Urinary Stem Cells Diagnosed from the Patients with Diabetic Nephropathy. Theranostics. 2019; 9(14):4221-4232. PMID: 31281543.
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    26. Solingapuram Sai KK, Bashetti N, Chen X, Norman S, Hines JW, Meka O, Kumar JVS, Devanathan S, Deep G, Furdui CM, Mintz A. Initial biological evaluations of 18F-KS1, a novel ascorbate derivative to image oxidative stress in cancer. EJNMMI Res. 2019 May 17; 9(1):43. PMID: 31101996.
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    27. Kwok AT, Moore JE, Rosas S, Kerr BA, Andrews RN, Nguyen CM, Lee J, Furdui CM, Collins BE, Munley MT, Willey JS. Knee and Hip Joint Cartilage Damage from Combined Spaceflight Hazards of Low-Dose Radiation Less than 1 Gy and Prolonged Hindlimb Unloading. Radiat Res. 2019 06; 191(6):497-506. PMID: 30925135.
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    28. Li Z, Forshaw TE, Holmila RJ, Vance SA, Wu H, Poole LB, Furdui CM, King SB. Triphenylphosphonium-Derived Protein Sulfenic Acid Trapping Agents: Synthesis, Reactivity, and Effect on Mitochondrial Function. Chem Res Toxicol. 2019 03 18; 32(3):526-534. PMID: 30784263.
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    29. Wang X, Buechler NL, Long DL, Furdui CM, Yoza BK, McCall CE, Vachharajani V. Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis. Inflammation. 2019 Feb; 42(1):156-169. PMID: 30203196.
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    30. Collins JA, Wood ST, Bolduc JA, Nurmalasari NPD, Chubinskaya S, Poole LB, Furdui CM, Nelson KJ, Loeser RF. Differential peroxiredoxin hyperoxidation regulates MAP kinase signaling in human articular chondrocytes. Free Radic Biol Med. 2019 04; 134:139-152. PMID: 30639614.
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    31. Chen X, Lee J, Wu H, Tsang AW, Furdui CM. Mass Spectrometry in Advancement of Redox Precision Medicine. Adv Exp Med Biol. 2019; 1140:327-358. PMID: 31347057.
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    32. Saez D, Dushime R, Wu H, Ramos Cordova LB, Shukla K, Brown-Harding H, Furdui CM, Tsang AW. Sulforaphane promotes chlamydial infection by suppressing mitochondrial protein oxidation and activation of complement C3. Protein Sci. 2019 01; 28(1):216-227. PMID: 30367535.
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    33. Forshaw TE, Holmila R, Nelson KJ, Lewis JE, Kemp ML, Tsang AW, Poole LB, Lowther WT, Furdui CM. Peroxiredoxins in Cancer and Response to Radiation Therapies. Antioxidants (Basel). 2019 Jan 01; 8(1). PMID: 30609657.
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    34. Lewis JE, Singh N, Holmila RJ, Sumer BD, Williams NS, Furdui CM, Kemp ML, Boothman DA. Targeting NAD+ Metabolism to Enhance Radiation Therapy Responses. Semin Radiat Oncol. 2019 01; 29(1):6-15. PMID: 30573185.
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    35. Rodrigues ACZ, Messi ML, Wang ZM, Abba MC, Pereyra A, Birbrair A, Zhang T, O'Meara M, Kwan P, Lopez EIS, Willis MS, Mintz A, Files DC, Furdui C, Oppenheim RW, Delbono O. The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability. Acta Physiol (Oxf). 2019 03; 225(3):e13195. PMID: 30269419.
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    36. Qiao H, Zhang Y, Lin W, Wang YF, Furdui CM, Jiang Q, Li X, Long T, Wang Y, Qin DN. Decreased expression of pigment epithelium-derived factor within the penile tissues contributes to erectile dysfunction in diabetic rats. Clin Sci (Lond). 2018 10 31; 132(20):2175-2188. PMID: 30232174.
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    37. Nelson KJ, Bolduc JA, Wu H, Collins JA, Burke EA, Reisz JA, Klomsiri C, Wood ST, Yammani RR, Poole LB, Furdui CM, Loeser RF. H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes. J Biol Chem. 2018 10 19; 293(42):16376-16389. PMID: 30190325.
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    38. Hoth JJ, Smith LM, Furdui CM, Wells JD, Yoza BK, McCall CE. Antioxidant treatment after injury suppresses second hit immune priming. J Trauma Acute Care Surg. 2018 08; 85(2):367-374. PMID: 30080782.
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    39. Yang M, Wu H, Chu J, Gabriel LA, Kim Y, Anderson KS, Furdui CM, Bierbach U. Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent. Chem Commun (Camb). 2018 Jul 11; 54(54):7479-7482. PMID: 29915817.
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    40. Bolduc JA, Nelson KJ, Haynes AC, Lee J, Reisz JA, Graff AH, Clodfelter JE, Parsonage D, Poole LB, Furdui CM, Lowther WT. Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins. J Biol Chem. 2018 07 27; 293(30):11901-11912. PMID: 29884768.
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    41. Holmila RJ, Vance SA, Chen X, Wu H, Shukla K, Bharadwaj MS, Mims J, Wary Z, Marrs G, Singh R, Molina AJ, Poole LB, King SB, Furdui CM. Mitochondria-targeted Probes for Imaging Protein Sulfenylation. Sci Rep. 2018 04 27; 8(1):6635. PMID: 29703899.
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    42. Chen X, Mims J, Huang X, Singh N, Motea E, Planchon SM, Beg M, Tsang AW, Porosnicu M, Kemp ML, Boothman DA, Furdui CM. Modulators of Redox Metabolism in Head and Neck Cancer. Antioxid Redox Signal. 2018 12 01; 29(16):1660-1690. PMID: 29113454.
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    43. Lewis JE, Costantini F, Mims J, Chen X, Furdui CM, Boothman DA, Kemp ML. Genome-Scale Modeling of NADPH-Driven ß-Lapachone Sensitization in Head and Neck Squamous Cell Carcinoma. Antioxid Redox Signal. 2018 10 01; 29(10):937-952. PMID: 28762750.
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    44. Long D, Wu H, Tsang AW, Poole LB, Yoza BK, Wang X, Vachharajani V, Furdui CM, McCall CE. The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat. Sci Rep. 2017 09 08; 7(1):11005. PMID: 28887543.
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    45. Chen X, Wu H, Park CM, Poole TH, Keceli G, Devarie-Baez NO, Tsang AW, Lowther WT, Poole LB, King SB, Xian M, Furdui CM. Discovery of Heteroaromatic Sulfones As a New Class of Biologically Compatible Thiol-Selective Reagents. ACS Chem Biol. 2017 08 18; 12(8):2201-2208. PMID: 28687042.
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    46. Dean TC, Yang M, Liu M, Grayson JM, DeMartino AW, Day CS, Lee J, Furdui CM, Bierbach U. Human Serum Albumin-Delivered [Au(PEt3)]+ Is a Potent Inhibitor of T Cell Proliferation. ACS Med Chem Lett. 2017 May 11; 8(5):572-576. PMID: 28523113.
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    47. Mauney CH, Rogers LC, Harris RS, Daniel LW, Devarie-Baez NO, Wu H, Furdui CM, Poole LB, Perrino FW, Hollis T. The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch. Antioxid Redox Signal. 2017 Dec 01; 27(16):1317-1331. PMID: 28398823.
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    48. Xu Z, Feng X, Dong J, Wang ZM, Lee J, Furdui C, Files DC, Beavers KM, Kritchevsky S, Milligan C, Jin JP, Delbono O, Zhang T. Cardiac troponin T and fast skeletal muscle denervation in ageing. J Cachexia Sarcopenia Muscle. 2017 Oct; 8(5):808-823. PMID: 28419739.
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    49. Lee Y, Furdui C, Beamer LJ. Data on the phosphorylation state of the catalytic serine of enzymes in the a-D-phosphohexomutase superfamily. Data Brief. 2017 Feb; 10:398-405. PMID: 28050582.
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    50. Peloso A, Urbani L, Cravedi P, Katari R, Maghsoudlou P, Fallas ME, Sordi V, Citro A, Purroy C, Niu G, McQuilling JP, Sittadjody S, Farney AC, Iskandar SS, Zambon JP, Rogers J, Stratta RJ, Opara EC, Piemonti L, Furdui CM, Soker S, De Coppi P, Orlando G. The Human Pancreas as a Source of Protolerogenic Extracellular Matrix Scaffold for a New-generation Bioartificial Endocrine Pancreas. Ann Surg. 2016 07; 264(1):169-79. PMID: 26649588.
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    51. Wajih N, Liu X, Shetty P, Basu S, Wu H, Hogg N, Patel RP, Furdui CM, Kim-Shapiro DB. The role of red blood cell S-nitrosation in nitrite bioactivation and its modulation by leucine and glucose. Redox Biol. 2016 08; 8:415-21. PMID: 27156251.
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    52. Zhang T, Pereyra AS, Wang ZM, Birbrair A, Reisz JA, Files DC, Purcell L, Feng X, Messi ML, Feng H, Chalovich J, Jin JP, Furdui C, Delbono O. Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice. Aging Cell. 2016 06; 15(3):488-98. PMID: 26892246.
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    53. Collins JA, Wood ST, Nelson KJ, Rowe MA, Carlson CS, Chubinskaya S, Poole LB, Furdui CM, Loeser RF. Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes. J Biol Chem. 2016 Mar 25; 291(13):6641-54. PMID: 26797130.
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    54. Wood ST, Long DL, Reisz JA, Yammani RR, Burke EA, Klomsiri C, Poole LB, Furdui CM, Loeser RF. Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments. Arthritis Rheumatol. 2016 Jan; 68(1):117-26. PMID: 26314228.
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    55. Ritchie MK, Johnson LC, Clodfelter JE, Pemble CW, Fulp BE, Furdui CM, Kridel SJ, Lowther WT. Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE. J Biol Chem. 2016 Feb 12; 291(7):3520-30. PMID: 26663084.
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    56. Weckerle A, Snipes JA, Cheng D, Gebre AK, Reisz JA, Murea M, Shelness GS, Hawkins GA, Furdui CM, Freedman BI, Parks JS, Ma L. Characterization of circulating APOL1 protein complexes in African Americans. J Lipid Res. 2016 Jan; 57(1):120-30. PMID: 26586272.
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    57. Devarie-Baez NO, Silva Lopez EI, Furdui CM. Biological chemistry and functionality of protein sulfenic acids and related thiol modifications. Free Radic Res. 2016; 50(2):172-94. PMID: 26340608.
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    58. Swanner J, Mims J, Carroll DL, Akman SA, Furdui CM, Torti SV, Singh RN. Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells. Int J Nanomedicine. 2015; 10:3937-53. PMID: 26185437.
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    59. Mims J, Bansal N, Bharadwaj MS, Chen X, Molina AJ, Tsang AW, Furdui CM. Energy metabolism in a matched model of radiation resistance for head and neck squamous cell cancer. Radiat Res. 2015 Mar; 183(3):291-304. PMID: 25738895.
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    60. Parsonage D, Nelson KJ, Ferrer-Sueta G, Alley S, Karplus PA, Furdui CM, Poole LB. Dissecting peroxiredoxin catalysis: separating binding, peroxidation, and resolution for a bacterial AhpC. Biochemistry. 2015 Feb 24; 54(7):1567-75. PMID: 25633283.
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    61. Chen X, Liu L, Mims J, Punska EC, Williams KE, Zhao W, Arcaro KF, Tsang AW, Zhou X, Furdui CM. Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors. Epigenetics. 2015; 10(6):545-61. PMID: 25961636.
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    62. Patel AL, Chen X, Wood ST, Stuart ES, Arcaro KF, Molina DP, Petrovic S, Furdui CM, Tsang AW. Activation of epidermal growth factor receptor is required for Chlamydia trachomatis development. BMC Microbiol. 2014 Dec 04; 14:277. PMID: 25471819.
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    63. Baez NO, Reisz JA, Furdui CM. Mass spectrometry in studies of protein thiol chemistry and signaling: opportunities and caveats. Free Radic Biol Med. 2015 Mar; 80:191-211. PMID: 25261734.
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    64. Furdui CM. Ionizing radiation: mechanisms and therapeutics. Antioxid Redox Signal. 2014 Jul 10; 21(2):218-20. PMID: 24702164.
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    65. Poole TH, Reisz JA, Zhao W, Poole LB, Furdui CM, King SB. Strained cycloalkynes as new protein sulfenic acid traps. J Am Chem Soc. 2014 Apr 30; 136(17):6167-70. PMID: 24724926.
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    66. Bansal N, Mims J, Kuremsky JG, Olex AL, Zhao W, Yin L, Wani R, Qian J, Center B, Marrs GS, Porosnicu M, Fetrow JS, Tsang AW, Furdui CM. Broad phenotypic changes associated with gain of radiation resistance in head and neck squamous cell cancer. Antioxid Redox Signal. 2014 Jul 10; 21(2):221-36. PMID: 24597745.
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    67. Reisz JA, Bansal N, Qian J, Zhao W, Furdui CM. Effects of ionizing radiation on biological molecules--mechanisms of damage and emerging methods of detection. Antioxid Redox Signal. 2014 Jul 10; 21(2):260-92. PMID: 24382094.
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    68. Reisz JA, Bechtold E, King SB, Poole LB, Furdui CM. Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids. FEBS J. 2013 Dec; 280(23):6150-61. PMID: 24103186.
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    69. Furdui CM, Poole LB. Chemical approaches to detect and analyze protein sulfenic acids. Mass Spectrom Rev. 2014 Mar-Apr; 33(2):126-46. PMID: 24105931.
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    70. Haynes AC, Qian J, Reisz JA, Furdui CM, Lowther WT. Molecular basis for the resistance of human mitochondrial 2-Cys peroxiredoxin 3 to hyperoxidation. J Biol Chem. 2013 Oct 11; 288(41):29714-23. PMID: 24003226.
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    71. Lee Y, Mehra-Chaudhary R, Furdui C, Beamer LJ. Identification of an essential active-site residue in the a-D-phosphohexomutase enzyme superfamily. FEBS J. 2013 Jun; 280(11):2622-32. PMID: 23517223.
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    72. Lang BS, Gorren AC, Oberdorfer G, Wenzl MV, Furdui CM, Poole LB, Mayer B, Gruber K. Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry. J Biol Chem. 2012 Nov 02; 287(45):38124-34. PMID: 22988236.
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    73. Lee Y, Mick J, Furdui C, Beamer LJ. A coevolutionary residue network at the site of a functionally important conformational change in a phosphohexomutase enzyme family. PLoS One. 2012; 7(6):e38114. PMID: 22685552.
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    74. Feng X, Zhang T, Xu Z, Choi SJ, Qian J, Furdui CM, Register TC, Delbono O. Myosin heavy chain isoform expression in the Vastus Lateralis muscle of aging African green vervet monkeys. Exp Gerontol. 2012 Aug; 47(8):601-7. PMID: 22617406.
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    75. Qian J, Wani R, Klomsiri C, Poole LB, Tsang AW, Furdui CM. A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of ß-ketoesters as cleavable probes. Chem Commun (Camb). 2012 Apr 28; 48(34):4091-3. PMID: 22430672.
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    76. Wani R, Bharathi NS, Field J, Tsang AW, Furdui CM. Oxidation of Akt2 kinase promotes cell migration and regulates G1-S transition in the cell cycle. . 2011 Oct 01; 10(19):3263-8. PMID: 21957489.
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    77. Qian J, Klomsiri C, Wright MW, King SB, Tsang AW, Poole LB, Furdui CM. Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins. Chem Commun (Camb). 2011 Aug 28; 47(32):9203-5. PMID: 21738918.
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    78. Wani R, Qian J, Yin L, Bechtold E, King SB, Poole LB, Paek E, Tsang AW, Furdui CM. Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species. Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10550-5. PMID: 21670275.
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    79. Codina J, Opyd TS, Powell ZB, Furdui CM, Petrovic S, Penn RB, DuBose TD. pH-dependent regulation of the a-subunit of H+-K+-ATPase (HKa2). Am J Physiol Renal Physiol. 2011 Sep; 301(3):F536-43. PMID: 21653633.
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    80. Roberts A, Furdui C, Anderson KS. Observation of a chemically labile, noncovalent enzyme intermediate in the reaction of metal-dependent Aquifex pyrophilus KDO8PS by time-resolved mass spectrometry. Rapid Commun Mass Spectrom. 2010 Jul 15; 24(13):1919-24. PMID: 20533322.
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    81. Schramm AM, Karr D, Mehra-Chaudhary R, Van Doren SR, Furdui CM, Beamer LJ. Breaking the covalent connection: Chain connectivity and the catalytic reaction of PMM/PGM. Protein Sci. 2010 Jun; 19(6):1235-42. PMID: 20512975.
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    82. Bechtold E, Reisz JA, Klomsiri C, Tsang AW, Wright MW, Poole LB, Furdui CM, King SB. Water-soluble triarylphosphines as biomarkers for protein S-nitrosation. ACS Chem Biol. 2010 Apr 16; 5(4):405-14. PMID: 20146502.
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    83. Klomsiri C, Nelson KJ, Bechtold E, Soito L, Johnson LC, Lowther WT, Ryu SE, King SB, Furdui CM, Poole LB. Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins. Methods Enzymol. 2010; 473:77-94. PMID: 20513472.
      Citations:    
    84. Wallen JR, Mallett TC, Boles W, Parsonage D, Furdui CM, Karplus PA, Claiborne A. Crystal structure and catalytic properties of Bacillus anthracis CoADR-RHD: implications for flavin-linked sulfur trafficking. Biochemistry. 2009 Oct 13; 48(40):9650-67. PMID: 19725515.
      Citations:    
    85. Lew ED, Furdui CM, Anderson KS, Schlessinger J. The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations. Sci Signal. 2009 Feb 17; 2(58):ra6. PMID: 19224897.
      Citations:    
    86. Schramm AM, Mehra-Chaudhary R, Furdui CM, Beamer LJ. Backbone flexibility, conformational change, and catalysis in a phosphohexomutase from Pseudomonas aeruginosa. Biochemistry. 2008 Sep 02; 47(35):9154-62. PMID: 18690721.
      Citations:    
    87. Jönsson TJ, Tsang AW, Lowther WT, Furdui CM. Identification of intact protein thiosulfinate intermediate in the reduction of cysteine sulfinic acid in peroxiredoxin by human sulfiredoxin. J Biol Chem. 2008 Aug 22; 283(34):22890-4. PMID: 18593714.
      Citations:    
    88. Poole LB, Klomsiri C, Knaggs SA, Furdui CM, Nelson KJ, Thomas MJ, Fetrow JS, Daniel LW, King SB. Fluorescent and affinity-based tools to detect cysteine sulfenic acid formation in proteins. Bioconjug Chem. 2007 Nov-Dec; 18(6):2004-17. PMID: 18030992.
      Citations:    
    89. Mansoorabadi SO, Seravalli J, Furdui C, Krymov V, Gerfen GJ, Begley TP, Melnick J, Ragsdale SW, Reed GH. EPR spectroscopic and computational characterization of the hydroxyethylidene-thiamine pyrophosphate radical intermediate of pyruvate:ferredoxin oxidoreductase. Biochemistry. 2006 Jun 13; 45(23):7122-31. PMID: 16752902.
      Citations:    
    90. Furdui CM, Lew ED, Schlessinger J, Anderson KS. Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction. Mol Cell. 2006 Mar 03; 21(5):711-7. PMID: 16507368.
      Citations:    
    91. Li Z, Sau AK, Furdui CM, Anderson KS. Probing the role of tightly bound phosphoenolpyruvate in Escherichia coli 3-deoxy-d-manno-octulosonate 8-phosphate synthase catalysis using quantitative time-resolved electrospray ionization mass spectrometry in the millisecond time range. Anal Biochem. 2005 Aug 01; 343(1):35-47. PMID: 15979047.
      Citations:    
    92. Furdui CM, Sau AK, Yaniv O, Belakhov V, Woodard RW, Baasov T, Anderson KS. The use of (E)- and (Z)-phosphoenol-3-fluoropyruvate as mechanistic probes reveals significant differences between the active sites of KDO8P and DAHP synthases. Biochemistry. 2005 May 17; 44(19):7326-35. PMID: 15882071.
      Citations:    
    93. Furdui C, Zhou L, Woodard RW, Anderson KS. Insights into the mechanism of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (Phe) from Escherichia coli using a transient kinetic analysis. J Biol Chem. 2004 Oct 29; 279(44):45618-25. PMID: 15326172.
      Citations:    
    94. Shulami S, Furdui C, Adir N, Shoham Y, Anderson KS, Baasov T. A reciprocal single mutation affects the metal requirement of 3-deoxy-D-manno-2-octulosonate-8-phosphate (KDO8P) synthases from Aquifex pyrophilus and Escherichia coli. J Biol Chem. 2004 Oct 22; 279(43):45110-20. PMID: 15308670.
      Citations:    
    95. Furdui C, Ragsdale SW. The roles of coenzyme A in the pyruvate:ferredoxin oxidoreductase reaction mechanism: rate enhancement of electron transfer from a radical intermediate to an iron-sulfur cluster. Biochemistry. 2002 Aug 06; 41(31):9921-37. PMID: 12146957.
      Citations:    
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