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Brian J. Wells MD, PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentPHS-Biostatistics and Data Science (Public Health Sciences)
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentClinical and Translational Science Institute

    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentEpidemiology & Prevention (Public Health Sciences)

    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentFamily & Community Medicine


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    R21HS026803     (WELLS, BRIAN JAY)Apr 1, 2019 - Mar 31, 2021
    NIH
    A Direct-to-Patient Alert for Glycated Hemoglobin Screening Using Prediction Modeling and Mobile Health (mHealth)
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Diaz-Garelli F, Strowd R, Ahmed T, Lycan TW, Daley S, Wells BJ, Topaloglu U. What Oncologists Want: Identifying Challenges and Preferences on Diagnosis Data Entry to Reduce EHR-Induced Burden and Improve Clinical Data Quality. JCO Clin Cancer Inform. 2021 May; 5:527-540. PMID: 33989015.
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    2. Diaz-Garelli F, Lenoir KM, Wells BJ. Catch Me if You Can: Acute Events Hidden in Structured Chronic Disease Diagnosis Descriptions Show Detectable Recording Patterns in EHR. AMIA Annu Symp Proc. 2020; 2020:373-382. PMID: 33936410.
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    3. Weaver KE, Klepin HD, Wells BJ, Dressler EV, Winkfield KM, Lamar ZS, Avery TP, Pajewski NM, Hundley WG, Johnson A, Davidson EC, Lopetegui M, Foraker RE. Cardiovascular Assessment Tool for Breast Cancer Survivors and Oncology Providers: Usability Study. JMIR Cancer. 2021 Jan 21; 7(1):e18396. PMID: 33475511.
      Citations:    
    4. Smith AY, Kirk JK, Smith PF, Wells BJ. Mental Health and Benzodiazepine Use Among Patients on Chronic Opioid Therapy. J Am Board Fam Med. 2021 Jan-Feb; 34(1):99-104. PMID: 33452087.
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    5. Snavely AC, Hendley N, Stopyra JP, Lenoir KM, Wells BJ, Herrington DM, Hiestand BC, Miller CD, Mahler SA. Sex and race differences in safety and effectiveness of the HEART pathway accelerated diagnostic protocol for acute chest pain. Am Heart J. 2021 02; 232:125-136. PMID: 33160945.
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    6. Smith LM, Ashburn NP, Snavely AC, Stopyra JP, Lenoir KM, Wells BJ, Hiestand BC, Herrington DM, Miller CD, Mahler SA. Identification of very low-risk acute chest pain patients without troponin testing. Emerg Med J. 2020 Nov; 37(11):690-695. PMID: 32753395.
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    7. Wells BJ, Lenoir KM, Wagenknecht LE, Mayer-Davis EJ, Lawrence JM, Dabelea D, Pihoker C, Saydah S, Casanova R, Turley C, Liese AD, Standiford D, Kahn MG, Hamman R, Divers J. Detection of Diabetes Status and Type in Youth Using Electronic Health Records: The SEARCH for Diabetes in Youth Study. Diabetes Care. 2020 10; 43(10):2418-2425. PMID: 32737140.
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    8. Stopyra JP, Snavely AC, Lenoir KM, Wells BJ, Herrington DM, Hiestand BC, Miller CD, Mahler SA. HEART Pathway Implementation Safely Reduces Hospitalizations at One Year in Patients With Acute Chest Pain. Ann Emerg Med. 2020 11; 76(5):555-565. PMID: 32736933.
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    9. Diaz-Garelli F, Strowd R, Lawson VL, Mayorga ME, Wells BJ, Lycan TW, Topaloglu U. Workflow Differences Affect Data Accuracy in Oncologic EHRs: A First Step Toward Detangling the Diagnosis Data Babel. JCO Clin Cancer Inform. 2020 06; 4:529-538. PMID: 32543899.
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    10. Stopyra J, Snavely AC, Hiestand B, Wells BJ, Lenoir KM, Herrington D, Hendley N, Ashburn NP, Miller CD, Mahler SA. Comparison of accelerated diagnostic pathways for acute chest pain risk stratification. Heart. 2020 Jul; 106(13):977-984. PMID: 32269131.
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    11. Brooks AK, Miller DP, Fanning JT, Suftin EL, Reid MC, Wells BJ, Leng X, Hurley RW. A Pain eHealth Platform for Engaging Obese, Older Adults with Chronic Low Back Pain in Nonpharmacological Pain Treatments: Protocol for a Pilot Feasibility Study. JMIR Res Protoc. 2020 Jan 02; 9(1):e14525. PMID: 31895042.
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    12. Pajewski NM, Lenoir K, Wells BJ, Williamson JD, Callahan KE. Frailty Screening Using the Electronic Health Record Within a Medicare Accountable Care Organization. J Gerontol A Biol Sci Med Sci. 2019 10 04; 74(11):1771-1777. PMID: 30668637.
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    13. Diaz-Garelli JF, Strowd R, Ahmed T, Wells BJ, Merrill R, Laurini J, Pasche B, Topaloglu U. A tale of three subspecialties: Diagnosis recording patterns are internally consistent but Specialty-Dependent. JAMIA Open. 2019 Oct; 2(3):369-377. PMID: 31984369.
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    14. Lenchik L, Lenoir KM, Tan J, Boutin RD, Callahan KE, Kritchevsky SB, Wells BJ. Opportunistic Measurement of Skeletal Muscle Size and Muscle Attenuation on Computed Tomography Predicts 1-Year Mortality in Medicare Patients. J Gerontol A Biol Sci Med Sci. 2019 06 18; 74(7):1063-1069. PMID: 30124775.
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    15. Dharod A, Wells BJ, Lenoir K, Willeford WG, Milks MW, Atkinson HH. Holiday Discharges Are Associated with Higher 30-Day General Internal Medicine Hospital Readmissions at an Academic Medical Center. South Med J. 2019 06; 112(6):338-343. PMID: 31158889.
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    16. Mahler SA, Lenoir KM, Wells BJ, Burke GL, Duncan PW, Case LD, Herrington DM, Diaz-Garelli JF, Futrell WM, Hiestand BC, Miller CD. Response by Mahler et al to Letter Regarding Article, "Safely Identifying Emergency Department Patients With Acute Chest Pain for Early Discharge: HEART Pathway Accelerated Diagnostic Protocol". Circulation. 2019 05 07; 139(19):e915-e916. PMID: 31059320.
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    17. Diaz-Garelli JF, Strowd R, Wells BJ, Ahmed T, Merrill R, Topaloglu U. Lost in Translation: Diagnosis Records Show More Inaccuracies After Biopsy in Oncology Care EHRs. AMIA Jt Summits Transl Sci Proc. 2019; 2019:325-334. PMID: 31258985.
      Citations:    
    18. Mahler SA, Lenoir KM, Wells BJ, Burke GL, Duncan PW, Case LD, Herrington DM, Diaz-Garelli JF, Futrell WM, Hiestand BC, Miller CD. Safely Identifying Emergency Department Patients With Acute Chest Pain for Early Discharge. Circulation. 2018 11 27; 138(22):2456-2468. PMID: 30571347.
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    19. Sabaté J, Burkholder-Cooley NM, Segovia-Siapco G, Oda K, Wells B, Orlich MJ, Fraser GE. Unscrambling the relations of egg and meat consumption with type 2 diabetes risk. Am J Clin Nutr. 2018 11 01; 108(5):1121-1128. PMID: 30329007.
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    20. Wells BJ, Lenoir KM, Diaz-Garelli JF, Futrell W, Lockerman E, Pantalone KM, Kattan MW. Predicting Current Glycated Hemoglobin Values in Adults: Development of an Algorithm From the Electronic Health Record. JMIR Med Inform. 2018 Oct 22; 6(4):e10780. PMID: 30348631.
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    21. Diaz-Garelli JF, Wells BJ, Yelton C, Strowd R, Topaloglu U. Biopsy Records Do Not Reduce Diagnosis Variability in Cancer Patient EHRs: Are We More Uncertain After Knowing? AMIA Jt Summits Transl Sci Proc. 2018; 2017:72-80. PMID: 29888044.
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    22. Mercer MB, Rose SL, Talerico C, Wells BJ, Manne M, Vakharia N, Jolly S, Milinovich A, Bauman J, Kattan MW. Use of Visual Decision Aids in Physician-Patient Communication: A Pilot Investigation. J Patient Exp. 2018 Sep; 5(3):167-176. PMID: 30214921.
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    23. Pantalone KM, Misra-Hebert AD, Hobbs TM, Wells BJ, Kong SX, Chagin K, Dey T, Milinovich A, Weng W, Bauman JM, Burguera B, Zimmerman RS, Kattan MW. Effect of glycemic control on the Diabetes Complications Severity Index score and development of complications in people with newly diagnosed type 2 diabetes. J Diabetes. 2018 Mar; 10(3):192-199. PMID: 28976724.
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    24. Pantalone KM, Hobbs TM, Chagin KM, Kong SX, Wells BJ, Kattan MW, Bouchard J, Sakurada B, Milinovich A, Weng W, Bauman J, Misra-Hebert AD, Zimmerman RS, Burguera B. Prevalence and recognition of obesity and its associated comorbidities: cross-sectional analysis of electronic health record data from a large US integrated health system. BMJ Open. 2017 Nov 16; 7(11):e017583. PMID: 29150468.
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    25. Hatipoglu U, Wells BJ, Chagin K, Joshi D, Milinovich A, Rothberg MB. Predicting 30-Day All-Cause Readmission Risk for Subjects Admitted With Pneumonia at the Point of Care. Respir Care. 2018 Jan; 63(1):43-49. PMID: 29066584.
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    26. Stone AV, Jinnah A, Wells BJ, Atkinson H, Miller AN, Futrell WM, Lenoir K, Emory CL. Nutritional markers may identify patients with greater risk of re-admission after geriatric hip fractures. Int Orthop. 2018 02; 42(2):231-238. PMID: 28988402.
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    27. Zimmerman RS, Hobbs TM, Wells BJ, Kong SX, Kattan MW, Bouchard J, Chagin KM, Yu C, Sakurada B, Milinovich A, Weng W, Bauman JM, Pantalone KM. Association of glucagon-like peptide-1 receptor agonist use and rates of acute myocardial infarction, stroke and overall mortality in patients with type 2 diabetes mellitus in a large integrated health system. Diabetes Obes Metab. 2017 11; 19(11):1555-1561. PMID: 28407414.
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    28. Applegate RL, Dorotta IL, Wells B, Juma D, Applegate PM. The Relationship Between Oxygen Reserve Index and Arterial Partial Pressure of Oxygen During Surgery. Anesth Analg. 2016 09; 123(3):626-33. PMID: 27007078.
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    29. Pantalone KM, Wells BJ, Chagin KM, Ejzykowicz F, Yu C, Milinovich A, Bauman JM, Kattan MW, Rajpathak S, Zimmerman RS. Intensification of Diabetes Therapy and Time Until A1C Goal Attainment Among Patients With Newly Diagnosed Type 2 Diabetes Who Fail Metformin Monotherapy Within a Large Integrated Health System. Diabetes Care. 2016 Sep; 39(9):1527-34. PMID: 27519447.
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    30. Pantalone KM, Hobbs TM, Wells BJ, Kong SX, Kattan MW, Bouchard J, Chagin KM, Yu C, Sakurada B, Milinovich A, Weng W, Bauman JM, Zimmerman RS. Changes in Characteristics and Treatment Patterns of Patients with Newly Diagnosed Type 2 Diabetes in a Large United States Integrated Health System between 2008 and 2013. Clin Med Insights Endocrinol Diabetes. 2016; 9:23-30. PMID: 27398040.
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    31. Mahler SA, Burke GL, Duncan PW, Case LD, Herrington DM, Riley RF, Wells BJ, Hiestand BC, Miller CD. HEART Pathway Accelerated Diagnostic Protocol Implementation: Prospective Pre-Post Interrupted Time Series Design and Methods. JMIR Res Protoc. 2016 Jan 22; 5(1):e10. PMID: 26800789.
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    32. Derakhshan A, Miller J, Lubelski D, Nowacki AS, Wells BJ, Milinovich A, Benzel EC, Mroz TE, Steinmetz MP. The Impact of Socioeconomic Status on the Utilization of Spinal Imaging. Neurosurgery. 2015 Nov; 77(5):746-53; discussion 753-4. PMID: 26214318.
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    33. Pantalone KM, Hobbs TM, Wells BJ, Kong SX, Kattan MW, Bouchard J, Yu C, Sakurada B, Milinovich A, Weng W, Bauman JM, Zimmerman RS. Clinical characteristics, complications, comorbidities and treatment patterns among patients with type 2 diabetes mellitus in a large integrated health system. BMJ Open Diabetes Res Care. 2015; 3(1):e000093. PMID: 26217493.
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    34. Kannan S, Pantalone KM, Matsuda S, Wells BJ, Karafa M, Zimmerman RS. Risk of overall mortality and cardiovascular events in patients with type 2 diabetes on dual drug therapy including metformin: A large database study from the Cleveland Clinic. J Diabetes. 2016 Mar; 8(2):279-85. PMID: 25929426.
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    35. Fox RJ, Salter A, Alster JM, Dawson NV, Kattan MW, Miller D, Ramesh S, Tyry T, Wells BW, Cutter G. Risk tolerance to MS therapies: Survey results from the NARCOMS registry. Mult Scler Relat Disord. 2015 May; 4(3):241-9. PMID: 26008941.
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    36. Wells BJ, Chagin KM, Li L, Hu B, Yu C, Kattan MW. Using the landmark method for creating prediction models in large datasets derived from electronic health records. Health Care Manag Sci. 2015 Mar; 18(1):86-92. PMID: 24752545.
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    37. Wells BJ, Kattan MW, Cooper GS, Jackson L, Koroukian S. Colorectal cancer predicted risk online (CRC-PRO) calculator using data from the multi-ethnic cohort study. J Am Board Fam Med. 2014 Jan-Feb; 27(1):42-55. PMID: 24390885.
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    38. Wells BJ, Chagin KM, Nowacki AS, Kattan MW. Strategies for handling missing data in electronic health record derived data. EGEMS (Wash DC). 2013; 1(3):1035. PMID: 25848578.
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    39. Sun GE, Wells BJ, Yip K, Zimmerman R, Raghavan D, Kattan MW, Kashyap SR. Gender-specific effects of oral hypoglycaemic agents on cancer risk in type 2 diabetes mellitus. Diabetes Obes Metab. 2014 Mar; 16(3):276-83. PMID: 24199848.
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    40. Nowacki AS, Wells BJ, Yu C, Kattan MW. Adding propensity scores to pure prediction models fails to improve predictive performance. PeerJ. 2013; 1:e123. PMID: 23940836.
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    41. Al-Sayed NA, Gao T, Wells BJ, Yu C, Zimmerman RS. Angiotensin-converting enzyme inhibitors reduce albuminuria more than angiotensin receptor blockers in patients with type 2 diabetes. Endocr Pract. 2013 Jul-Aug; 19(4):579-86. PMID: 23425642.
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    42. Wells BJ, Roth R, Nowacki AS, Arrigain S, Yu C, Rosenkrans WA, Kattan MW. Prediction of morbidity and mortality in patients with type 2 diabetes. PeerJ. 2013; 1:e87. PMID: 23781409.
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    43. Kumbhani DJ, Wells BJ, Lincoff AM, Jain A, Arrigain S, Yu C, Goormastic M, Ellis SG, Blackstone E, Kattan MW. Predictive models for short- and long-term adverse outcomes following discharge in a contemporary population with acute coronary syndromes. Am J Cardiovasc Dis. 2013; 3(1):39-52. PMID: 23467552.
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    44. Choi I, Kattan MW, Wells BJ, Yu C. A hybrid approach to survival model building using integration of clinical and molecular information in censored data. IEEE/ACM Trans Comput Biol Bioinform. 2012 Jul-Aug; 9(4):1091-1105. PMID: 22350208.
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    45. Pantalone KM, Kattan MW, Yu C, Wells BJ, Arrigain S, Jain A, Atreja A, Zimmerman RS. Increase in overall mortality risk in patients with type 2 diabetes receiving glipizide, glyburide or glimepiride monotherapy versus metformin: a retrospective analysis. Diabetes Obes Metab. 2012 Sep; 14(9):803-9. PMID: 22486923.
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    46. Choi I, Wells BJ, Yu C, Kattan MW. An empirical approach to model selection through validation for censored survival data. J Biomed Inform. 2011 Aug; 44(4):595-606. PMID: 21335102.
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    47. Pantalone KM, Kattan MW, Yu C, Wells BJ, Arrigain S, Jain A, Atreja A, Zimmerman RS. The risk of overall mortality in patients with type 2 diabetes receiving glipizide, glyburide, or glimepiride monotherapy: a retrospective analysis. Diabetes Care. 2010 Jun; 33(6):1224-9. PMID: 20215447.
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    48. Nguyen CT, Fu AZ, Gilligan TD, Wells BJ, Klein EA, Kattan MW, Stephenson AJ. Defining the optimal treatment for clinical stage I nonseminomatous germ cell testicular cancer using decision analysis. J Clin Oncol. 2010 Jan 01; 28(1):119-25. PMID: 19917846.
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    49. de Campos-Lobato LF, Campos-Lobato LF, Wells B, Wick E, Pronty K, Kiran R, Remzi F, Vogel JD. Predicting organ space surgical site infection with a nomogram. J Gastrointest Surg. 2009 Nov; 13(11):1986-92. PMID: 19760301.
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    50. Fu AZ, Qiu Y, Radican L, Wells BJ. Health care and productivity costs associated with diabetic patients with macrovascular comorbid conditions. Diabetes Care. 2009 Dec; 32(12):2187-92. PMID: 19729528.
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    51. Barsoum WK, Murray TG, Klika AK, Green K, Miniaci SL, Wells BJ, Kattan MW. Predicting patient discharge disposition after total joint arthroplasty in the United States. J Arthroplasty. 2010 Sep; 25(6):885-92. PMID: 19729270.
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    52. Pantalone KM, Kattan MW, Yu C, Wells BJ, Arrigain S, Jain A, Atreja A, Zimmerman RS. The risk of developing coronary artery disease or congestive heart failure, and overall mortality, in type 2 diabetic patients receiving rosiglitazone, pioglitazone, metformin, or sulfonylureas: a retrospective analysis. Acta Diabetol. 2009 Jun; 46(2):145-54. PMID: 19194648.
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    53. Wells BJ, Jain A, Arrigain S, Yu C, Rosenkrans WA, Kattan MW. Predicting 6-year mortality risk in patients with type 2 diabetes. Diabetes Care. 2008 Dec; 31(12):2301-6. PMID: 18809629.
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    54. Taylor ML, Wells BJ, Smolak MJ. Statins and cancer: a meta-analysis of case-control studies. Eur J Cancer Prev. 2008 Jun; 17(3):259-68. PMID: 18414198.
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    55. Everett CJ, Wells BJ, Frithsen IL, Koopman RJ. Smoking, fibrinogen and cancer mortality. J Natl Med Assoc. 2007 Apr; 99(4):328-33. PMID: 17444421.
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    56. Wells BJ, Mainous AG, Everett CJ, Gill JM. Iron, cholesterol, and the risk of cancer in an 18-year cohort. Asian Pac J Cancer Prev. 2005 Oct-Dec; 6(4):505-9. PMID: 16436001.
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    57. Taylor ML, Mainous AG, Wells BJ. Prostate cancer and sexually transmitted diseases: a meta-analysis. Fam Med. 2005 Jul-Aug; 37(7):506-12. PMID: 15988645.
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    58. Mainous AG, Wells BJ, Koopman RJ, Everett CJ, Gill JM. Iron, lipids, and risk of cancer in the Framingham Offspring cohort. Am J Epidemiol. 2005 Jun 15; 161(12):1115-22. PMID: 15937020.
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    59. Wells BJ, Hueston WJ. Are thyroid peroxidase antibodies associated with cardiovascular disease risk in patients with subclinical hypothyroidism? Clin Endocrinol (Oxf). 2005 May; 62(5):580-4. PMID: 15853828.
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    60. Wells BJ, Mainous AG, Everett CJ. Association between dietary arginine and C-reactive protein. Nutrition. 2005 Feb; 21(2):125-30. PMID: 15723738.
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    61. Mainous AG, Eschenbach SL, Wells BJ, Everett CJ, Gill JM. Cholesterol, transferrin saturation, and the development of dementia and Alzheimer's disease: results from an 18-year population-based cohort. Fam Med. 2005 Jan; 37(1):36-42. PMID: 15619154.
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    62. Wells BJ, Mainous AG, Dickerson LM. Antibiotics for the secondary prevention of ischemic heart disease: a meta-analysis of randomized controlled trials. Arch Intern Med. 2004 Oct 25; 164(19):2156-61. PMID: 15505130.
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    63. Wells BJ, Mainous AG, King DE, Gill JM, Carek PJ, Geesey ME. The combined effect of transferrin saturation and low density lipoprotein on mortality. Fam Med. 2004 May; 36(5):324-9. PMID: 15129378.
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    64. Mainous AG, Wells BJ, Everett CJ, Gill JM, King DE. Association of ferritin and lipids with C-reactive protein. Am J Cardiol. 2004 Mar 01; 93(5):559-62. PMID: 14996579.
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    65. Wells BJ, Lobel KD, Dickerson LM. Using the electronic medical record to enhance the use of combination drugs. Am J Med Qual. 2003 Jul-Aug; 18(4):147-9. PMID: 12934950.
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    66. King DE, Wells BJ. End-of-life issues and spiritual histories. South Med J. 2003 Apr; 96(4):391-3. PMID: 12916559.
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    67. Wells BJ. Use of feeding tubes in elderly patients with dementia. Am Fam Physician. 2002 Nov 15; 66(10):1836, 1838. PMID: 12469957.
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