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Timothy M. Hughes PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Gerontology & Geriatric Medicine
Address
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentEpidemiology & Prevention (Public Health Sciences)


    Collapse Research 
    Collapse research activities and funding
    U01HL096814     (WAGENKNECHT, LYNNE E)Jul 7, 2010 - Jun 30, 2021
    NIH
    ARIC Neurocognitive Study (ARIC-NCS) Renewal 4 of 5
    Role: Co-Principal Investigator
    R01AG054069     (HUGHES, TIMOTHY M.)Sep 1, 2016 - May 31, 2021
    NIH
    The Macrovascular and Microvascular Contributions to Alzheimer's Disease: MESA VASCAD
    Role: Principal Investigator
    R01AG058969     (HUGHES, TIMOTHY M.)Aug 15, 2018 - Jun 30, 2023
    NIH
    Subclinical Vascular Contributions to Alzheimer's Disease: The Multi Ethnic Study of Atherosclerosis (MESA) Multisite Studyof AD
    Role: Principal Investigator
    R03AG064569     (SCHAICH, CHRISTOPHER)Jul 15, 2019 - Apr 30, 2021
    NIH
    Heart Rate Variability, Cognitive Performance, and Alzheimer Disease-related Pathology in the Multi-Ethnic Study of Atherosclerosis
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Stone K, Fryer S, Meyer ML, Kucharska-Newton A, Faulkner J, Zieff G, Paterson C, Credeur D, Matsushita K, Hughes TM, Tanaka H, Stoner L. The aortic-femoral arterial stiffness gradient: an atherosclerosis risk in communities (ARIC) study. J Hypertens. 2021 Jul 01; 39(7):1370-1377. PMID: 33560059.
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    2. Hughes TM, Hajjar I. Is Late-onset Alzheimer Disease Spelled "ATV(N)"? Neurology. 2021 May 24. PMID: 34031193.
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    3. Besser L, Chang LC, Evenson KR, Hirsch J, Michael Y, Galvin JE, Rapp SR, Fitzpatrick AL, Heckbert SR, Kaufman JD, Hughes TM. Associations Between Neighborhood Park Access and Longitudinal Change in Cognition in Older Adults: The Multi-Ethnic Study of Atherosclerosis. J Alzheimers Dis. 2021 May 15. PMID: 34024841.
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    4. Ip EH, Pierce J, Chen SH, Lovato J, Hughes TM, Hayden KM, Hugenschmidt CE, Craft S, Kitzman D, Rapp S. Conversion between the Modified Mini-Mental State Examination (3MSE) and the Mini-Mental State Examination (MMSE). Alzheimers Dement (Amst). 2021; 13(1):e12161. PMID: 33816754.
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    5. Bailey MJ, Soliman EZ, McClure LA, Howard G, Howard VJ, Judd SE, Unverzagt FW, Wadley V, Sachs BC, Hughes TM. Relation of Atrial Fibrillation to Cognitive Decline (from the REasons for Geographic and Racial Differences in Stroke [REGARDS] Study). Am J Cardiol. 2021 Jun 01; 148:60-68. PMID: 33684372.
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    6. Sullivan KJ, Ranadive R, Su D, Neyland BR, Hughes TM, Hugenschmidt CE, Lockhart SN, Wong DF, Jack CR, Gottesman RF, Mosley TH, Griswold ME, Windham BG. Imaging-based indices of Neuropathology and gait speed decline in older adults: the atherosclerosis risk in communities study. Brain Imaging Behav. 2021 Jan 13. PMID: 33439369.
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    7. Burke GL, Hughes TM. Arterial Changes Connecting Hypertension to Alzheimer's Disease and Related Dementias. JACC Cardiovasc Imaging. 2021 01; 14(1):186-188. PMID: 33413885.
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    8. Dodge HH, Goldstein FC, Wakim NI, Gefen T, Teylan M, Chan KCG, Kukull WA, Barnes LL, Giordani B, Hughes TM, Kramer JH, Loewenstein DA, Marson DC, Mungas DM, Mattek N, Sachs BC, Salmon DP, Willis-Parker M, Welsh-Bohmer KA, Wild KV, Morris JC, Weintraub S. Differentiating among stages of cognitive impairment in aging: Version 3 of the Uniform Data Set (UDS) neuropsychological test battery and MoCA index scores. Alzheimers Dement (N Y). 2020; 6(1):e12103. PMID: 33283037.
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    9. Zlokovic BV, Gottesman RF, Bernstein KE, Seshadri S, McKee A, Snyder H, Greenberg SM, Yaffe K, Schaffer CB, Yuan C, Hughes TM, Daemen MJ, Williamson JD, González HM, Schneider J, Wellington CL, Katusic ZS, Stoeckel L, Koenig JI, Corriveau RA, Fine L, Galis ZS, Reis J, Wright JD, Chen J. Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop. Alzheimers Dement. 2020 12; 16(12):1714-1733. PMID: 33030307.
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    10. Stoner L, Meyer ML, Kucharska-Newton A, Stone K, Zieff G, Dave G, Fryer S, Credeur D, Faulkner J, Matsushita K, Hughes TM, Tanaka H. Associations between carotid-femoral and heart-femoral pulse wave velocity in older adults: the Atherosclerosis Risk In Communities study. J Hypertens. 2020 09; 38(9):1786-1793. PMID: 32371771.
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    11. Sachs BC, Steenland K, Zhao L, Hughes TM, Weintraub S, Dodge HH, Barnes LL, Craft S, Parker ML, Goldstein FC. Expanded Demographic Norms for Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set. Alzheimer Dis Assoc Disord. 2020 Jul-Sep; 34(3):191-197. PMID: 32483017.
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    12. Bennett EE, Gianattasio KZ, Hughes TM, Mosley TH, Wong DF, Gottesman RF, Power MC. The association between midlife lipid levels and late-life brain amyloid deposition. Neurobiol Aging. 2020 08; 92:73-74. PMID: 32402985.
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    13. Schaich CL, Malaver D, Chen H, Shaltout HA, Zeki Al Hazzouri A, Herrington DM, Hughes TM. Association of Heart Rate Variability With Cognitive Performance: The Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2020 04 07; 9(7):e013827. PMID: 32200711.
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    14. Gottesman RF, Mosley TH, Knopman DS, Hao Q, Wong D, Wagenknecht LE, Hughes TM, Qiao Y, Dearborn J, Wasserman BA. Association of Intracranial Atherosclerotic Disease With Brain ß-Amyloid Deposition: Secondary Analysis of the ARIC Study. JAMA Neurol. 2020 03 01; 77(3):350-357. PMID: 31860001.
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    15. Alber J, Alladi S, Bae HJ, Barton DA, Beckett LA, Bell JM, Berman SE, Biessels GJ, Black SE, Bos I, Bowman GL, Brai E, Brickman AM, Callahan BL, Corriveau RA, Fossati S, Gottesman RF, Gustafson DR, Hachinski V, Hayden KM, Helman AM, Hughes TM, Isaacs JD, Jefferson AL, Johnson SC, Kapasi A, Kern S, Kwon JC, Kukolja J, Lee A, Lockhart SN, Murray A, Osborn KE, Power MC, Price BR, Rhodius-Meester HFM, Rondeau JA, Rosen AC, Rosene DL, Schneider JA, Scholtzova H, Shaaban CE, Silva NCBS, Snyder HM, Swardfager W, Troen AM, van Veluw SJ, Vemuri P, Wallin A, Wellington C, Wilcock DM, Xie SX, Hainsworth AH. White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities. Alzheimers Dement (N Y). 2019; 5:107-117. PMID: 31011621.
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    16. Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV. Vascular dysfunction-The disregarded partner of Alzheimer's disease. Alzheimers Dement. 2019 01; 15(1):158-167. PMID: 30642436.
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    17. Mahapatra G, Smith SC, Hughes TM, Wagner B, Maldjian JA, Freedman BI, Molina AJA. Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes. Clin Sci (Lond). 2018 12 12; 132(23):2509-2518. PMID: 30401689.
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    18. Koch M, DeKosky ST, Fitzpatrick AL, Furtado JD, Lopez OL, Kuller LH, Mackey RH, Hughes TM, Mukamal KJ, Jensen MK. Apolipoproteins and Alzheimer's pathophysiology. Alzheimers Dement (Amst). 2018; 10:545-553. PMID: 30370330.
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    19. Rawlings AM, Juraschek SP, Heiss G, Hughes T, Meyer ML, Selvin E, Sharrett AR, Windham BG, Gottesman RF. Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline. Neurology. 2018 08 21; 91(8):e759-e768. PMID: 30045960.
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    20. Hughes TM, Sink KM, Williamson JD, Hugenschmidt CE, Wagner BC, Whitlow CT, Xu J, Smith SC, Launer LJ, Barzilay JI, Ismail-Beigi F, Bryan RN, Hsu FC, Bowden DW, Maldjian JA, Divers J, Freedman BI. Relationships between cerebral structure and cognitive function in African Americans with type 2 diabetes. J Diabetes Complications. 2018 Oct; 32(10):916-921. PMID: 30042057.
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    21. Hughes TM, Wagenknecht LE, Craft S, Mintz A, Heiss G, Palta P, Wong D, Zhou Y, Knopman D, Mosley TH, Gottesman RF. Arterial stiffness and dementia pathology: Atherosclerosis Risk in Communities (ARIC)-PET Study. Neurology. 2018 04 03; 90(14):e1248-e1256. PMID: 29549223.
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    22. Moazzami K, Ostovaneh MR, Ambale Venkatesh B, Habibi M, Yoneyama K, Wu C, Liu K, Pimenta I, Fitzpatrick A, Shea S, McClelland RL, Heckbert S, Gottesman RF, Bluemke DA, Hughes TM, Lima JAC. Left Ventricular Hypertrophy and Remodeling and Risk of Cognitive Impairment and Dementia: MESA (Multi-Ethnic Study of Atherosclerosis). Hypertension. 2018 03; 71(3):429-436. PMID: 29378853.
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    23. Walker KA, Windham BG, Brown CH, Knopman DS, Jack CR, Mosley TH, Selvin E, Wong DF, Hughes TM, Zhou Y, Gross AL, Gottesman RF. The Association of Mid- and Late-Life Systemic Inflammation with Brain Amyloid Deposition: The ARIC-PET Study. J Alzheimers Dis. 2018; 66(3):1041-1052. PMID: 30400093.
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    24. Hughes TM, Lockhart SN, Smagula SF. Blood Pressure's Role in Alzheimer Disease Pathology. Am J Geriatr Psychiatry. 2018 01; 26(1):23-24. PMID: 29050913.
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    25. Hughes TM, Craft S, Baker LD, Espeland MA, Rapp SR, Sink KM, Bertoni AG, Burke GL, Gottesman RF, Michos ED, Luchsinger JA, Fitzpatrick AL, Hayden KM. Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis. Alzheimers Dement (Amst). 2017; 8:18-25. PMID: 28435852.
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    26. Hughes TM, Worrall BB. Acute interatrial block is a distinct risk factor for ischemic stroke. Neurology. 2016 07 26; 87(4):344-5. PMID: 27343065.
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    27. Hughes TM, Craft S. The role of insulin in the vascular contributions to age-related dementia. Biochim Biophys Acta. 2016 05; 1862(5):983-91. PMID: 26657615.
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    28. Hughes TM, Sink KM. Hypertension and Its Role in Cognitive Function: Current Evidence and Challenges for the Future. Am J Hypertens. 2016 Feb; 29(2):149-57. PMID: 26563965.
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    29. Hughes TM, Craft S, Lopez OL. Review of 'the potential role of arterial stiffness in the pathogenesis of Alzheimer's disease'. Neurodegener Dis Manag. 2015; 5(2):121-35. PMID: 25894876.
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    30. Hughes T, Harrer JU. Treating arterial disease to prevent brain injury: Break out the bubbly or back to the bench? Neurology. 2015 Feb 03; 84(5):440-1. PMID: 25552574.
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    31. Espeland MA, Beavers KM, Gibbs BB, Johnson KC, Hughes TM, Baker LD, Jakicic J, Korytkowski M, Miller M, Bray GA. Ankle-brachial index and inter-artery blood pressure differences as predictors of cognitive function in overweight and obese older adults with diabetes: results from the Action for Health in Diabetes movement and memory study. Int J Geriatr Psychiatry. 2015 Oct; 30(10):999-1007. PMID: 25546032.
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    32. Hughes TM, Kuller LH, Barinas-Mitchell EJ, McDade EM, Klunk WE, Cohen AD, Mathis CA, Dekosky ST, Price JC, Lopez OL. Arterial stiffness and ß-amyloid progression in nondemented elderly adults. JAMA Neurol. 2014 May; 71(5):562-8. PMID: 24687165.
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    33. Hughes TM, Kuller LH, Barinas-Mitchell EJ, Mackey RH, McDade EM, Klunk WE, Aizenstein HJ, Cohen AD, Snitz BE, Mathis CA, Dekosky ST, Lopez OL. Pulse wave velocity is associated with ß-amyloid deposition in the brains of very elderly adults. Neurology. 2013 Nov 05; 81(19):1711-8. PMID: 24132374.
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    34. Hughes TM, Lopez OL, Evans RW, Kamboh MI, Williamson JD, Klunk WE, Mathis CA, Price JC, Cohen AD, Snitz BE, Dekosky ST, Kuller LH. Markers of cholesterol transport are associated with amyloid deposition in the brain. Neurobiol Aging. 2014 Apr; 35(4):802-7. PMID: 24199960.
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    35. Hughes TM, Ryan CM, Aizenstein HJ, Nunley K, Gianaros PJ, Miller R, Costacou T, Strotmeyer ES, Orchard TJ, Rosano C. Frontal gray matter atrophy in middle aged adults with type 1 diabetes is independent of cardiovascular risk factors and diabetes complications. J Diabetes Complications. 2013 Nov-Dec; 27(6):558-64. PMID: 23994432.
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    36. Hughes TM, Rosano C, Evans RW, Kuller LH. Brain cholesterol metabolism, oxysterols, and dementia. J Alzheimers Dis. 2013; 33(4):891-911. PMID: 23076077.
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    37. Hughes TM, Althouse AD, Niemczyk NA, Hawkins MS, Kuipers AL, Sutton-Tyrrell K. Effects of weight loss and insulin reduction on arterial stiffness in the SAVE trial. Cardiovasc Diabetol. 2012 Sep 22; 11:114. PMID: 22998737.
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    38. Hughes TM, Kuller LH, Lopez OL, Becker JT, Evans RW, Sutton-Tyrrell K, Rosano C. Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's disease. J Alzheimers Dis. 2012; 30(1):53-61. PMID: 22377780.
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    39. Launer LJ, Hughes TM, White LR. Microinfarcts, brain atrophy, and cognitive function: the Honolulu Asia Aging Study Autopsy Study. Ann Neurol. 2011 Nov; 70(5):774-80. PMID: 22162060.
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