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Thomas J.Martin PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentAnesthesiology
Address
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentPhysiology & Pharmacology


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    K21DA000247     (MARTIN, THOMAS J)Sep 30, 1994 - Aug 31, 1999
    NIH
    FUNCTIONAL SIGNIFICANCE OF MU OPIOID RECEPTOR TURNOVER
    Role: Principal Investigator

    R01NS038231     (MARTIN, THOMAS J)Jul 15, 1999 - Jun 30, 2004
    NIH
    OPIOID SELF ADMINISTRATION IN CHRONIC PAIN
    Role: Principal Investigator

    R01DA022599     (MARTIN, THOMAS JEFFREY)Sep 26, 2006 - Nov 30, 2011
    NIH
    Role of the Amygdala in Opioid Self-administration in Rats with Chronic Pain.
    Role: Principal Investigator

    R21NS074357     (MARTIN, THOMAS JEFFREY)Jun 1, 2012 - May 31, 2014
    NIH
    Behavioral effects of deep brain stimulation in rats with chronic pain
    Role: Principal Investigator

    R21NS085533     (MARTIN, THOMAS JEFFREY)Sep 30, 2014 - Aug 31, 2017
    NIH
    The Monogamous Prairie Vole: A Model for the Study of Social Behavior and Pain
    Role: Principal Investigator

    R01DA048490     (MARTIN, THOMAS JEFFREY)Apr 15, 2019 - Feb 29, 2024
    NIH
    Biased Kappa Opioid Agonists as Non-addictive Analgesics
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ririe DG, Eisenach JC, Martin TJ. A Painful Beginning: Early Life Surgery Produces Long-Term Behavioral Disruption in the Rat. Front Behav Neurosci. 2021; 15:630889. PMID: 34025368.
      Citations:    
    2. Damuka N, Orr M, Czoty PW, Weiner JL, Martin TJ, Nader MA, Bansode AH, Liyana Pathirannahel BS, Mintz A, Macauley SL, Craft S, Solingapuram Sai KK. Effect of ethanol and cocaine on [11C]MPC-6827 uptake in SH-SY5Y cells. Mol Biol Rep. 2021 Apr; 48(4):3871-3876. PMID: 33880672.
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    3. Nazarian A, Negus SS, Martin TJ. Factors mediating pain-related risk for opioid use disorder. Neuropharmacology. 2021 03 15; 186:108476. PMID: 33524407.
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    4. Damuka N, Czoty PW, Davis AT, Nader MA, Nader SH, Craft S, Macauley SL, Galbo LK, Epperly PM, Whitlow CT, Davenport AT, Martin TJ, Daunais JB, Mintz A, Sai KKS. PET Imaging of [11C]MPC-6827, a Microtubule-Based Radiotracer in Non-Human Primate Brains. Molecules. 2020 May 13; 25(10). PMID: 32414052.
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    5. Boada MD, Ririe DG, Martin CW, Martin SJ, Kim SA, Eisenach JC, Martin TJ. Nociceptive input after peripheral nerve injury results in cognitive impairment and alterations in primary afferent physiology in rats. Pain. 2020 05; 161(5):960-969. PMID: 32040075.
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    6. Boada MD, Martin TJ, Parker R, Houle TT, Eisenach JC, Ririe DG. Recovery from nerve injury induced behavioral hypersensitivity in rats parallels resolution of abnormal primary sensory afferent signaling. Pain. 2020 05; 161(5):949-959. PMID: 32040074.
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    7. John WS, Martin TJ, Nader MA. Cannabinoid Modulation of Food-Cocaine Choice in Male Rhesus Monkeys. J Pharmacol Exp Ther. 2020 04; 373(1):44-50. PMID: 31941717.
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    8. Hayashida KI, Eisenach JC, Kawatani M, Martin TJ. Peripheral nerve injury in rats induces alternations in choice behavior associated with food reinforcement. J Physiol Sci. 2019 Sep; 69(5):769-777. PMID: 31267368.
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    9. Ririe DG, Boada MD, MacGregor MK, Martin SJ, Strassburg TJ, Kim SA, Eisenach JC, Martin TJ. Incisional Nociceptive Input Impairs Attention-related Behavior and Is Associated with Reduced Neuronal Activity in the Prefrontal Cortex in Rats. Anesthesiology. 2018 10; 129(4):778-790. PMID: 29952818.
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    10. Arora V, Martin TJ, Aschenbrenner CA, Hayashida K, Kim SA, Parker RA, Eisenach JC, Peters CM. Psychosocial Stress Delays Recovery of Postoperative Pain Following Incisional Surgery in the Rat. Neuroscience. 2018 07 01; 382:35-47. PMID: 29694918.
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    11. Chen R, McIntosh S, Hemby SE, Sun H, Sexton T, Martin TJ, Childers SR. High and low doses of cocaine intake are differentially regulated by dopamine D2 receptors in the ventral tegmental area and the nucleus accumbens. Neurosci Lett. 2018 04 03; 671:133-139. PMID: 29454035.
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    12. John WS, Martin TJ, Solingapuram Sai KK, Nader SH, Gage HD, Mintz A, Nader MA. Chronic ?9-THC in Rhesus Monkeys: Effects on Cognitive Performance and Dopamine D2/D3 Receptor Availability. J Pharmacol Exp Ther. 2018 02; 364(2):300-310. PMID: 29203575.
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    13. Martin TJ, Strassburg TJ, Grigg AL, Kim SA, Ririe DG, Eisenach JC. Assessment of Behavioral Disruption in Rats with Abdominal Inflammation Using Visual Cue Titration and the Five-choice Serial-reaction Time Task. Anesthesiology. 2017 08; 127(2):372-381. PMID: 28542002.
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    14. Ririe DG, Boada MD, Schmidt BS, Martin SJ, Kim SA, Martin TJ. Audiovisual Distraction Increases Prefrontal Cortical Neuronal Activity and Impairs Attentional Performance in the Rat. J Exp Neurosci. 2017; 11:1179069517703080. PMID: 28469479.
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    15. John WS, Martin TJ, Nader MA. Behavioral Determinants of Cannabinoid Self-Administration in Old World Monkeys. Neuropsychopharmacology. 2017 Jun; 42(7):1522-1530. PMID: 28059083.
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    16. Brust TF, Morgenweck J, Kim SA, Rose JH, Locke JL, Schmid CL, Zhou L, Stahl EL, Cameron MD, Scarry SM, Aubé J, Jones SR, Martin TJ, Bohn LM. Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria. Sci Signal. 2016 11 29; 9(456):ra117. PMID: 27899527.
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    17. Boada MD, Martin TJ, Ririe DG. Nerve injury induced activation of fast-conducting high threshold mechanoreceptors predicts non-reflexive pain related behavior. Neurosci Lett. 2016 Oct 06; 632:44-9. PMID: 27544012.
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    18. Arora V, Morado-Urbina CE, Aschenbrenner CA, Hayashida K, Wang F, Martin TJ, Eisenach JC, Peters CM. Disruption of Spinal Noradrenergic Activation Delays Recovery of Acute Incision-Induced Hypersensitivity and Increases Spinal Glial Activation in the Rat. J Pain. 2016 Feb; 17(2):190-202. PMID: 26545342.
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    19. Martin TJ, Sexton T, Kim SA, Severino AL, Peters CM, Young LJ, Childers SR. Regional differences in mu and kappa opioid receptor G-protein activation in brain in male and female prairie voles. Neuroscience. 2015 Dec 17; 311:422-9. PMID: 26523979.
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    20. Greenstein YY, Martin TJ, Rolnitzky L, Felner K, Kaufman B. Goal-Directed Transthoracic Echocardiography During Advanced Cardiac Life Support: A Pilot Study Using Simulation to Assess Ability. Simul Healthc. 2015 Aug; 10(4):193-9; quiz 199-201. PMID: 25932707.
      Citations:    
    21. Peters CM, Hayashida K, Suto T, Houle TT, Aschenbrenner CA, Martin TJ, Eisenach JC. Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat. Anesthesiology. 2015 Apr; 122(4):895-907. PMID: 25581910.
      Citations:    
    22. Czoty PW, Tran P, Thomas LN, Martin TJ, Grigg A, Blough BE, Beveridge TJ. Effects of the dopamine/norepinephrine releaser phenmetrazine on cocaine self-administration and cocaine-primed reinstatement in rats. Psychopharmacology (Berl). 2015 Jul; 232(13):2405-14. PMID: 25673020.
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    23. Martin TJ, Grigg A, Kim SA, Ririe DG, Eisenach JC. Assessment of attention threshold in rats by titration of visual cue duration during the five choice serial reaction time task. J Neurosci Methods. 2015 Feb 15; 241:37-43. PMID: 25528113.
      Citations:    
    24. Boada DM, Martin TJ, Peters CM, Hayashida K, Harris MH, Houle TT, Boyden ES, Eisenach JC, Ririe DG. Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats. Pain. 2014 Dec; 155(12):2646-2655. PMID: 25267211.
      Citations:    
    25. Ewan EE, Martin TJ. Differential suppression of intracranial self-stimulation, food-maintained operant responding, and open field activity by paw incision and spinal nerve ligation in rats. Anesth Analg. 2014 Apr; 118(4):854-62. PMID: 24651240.
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    26. Ewan EE, Martin TJ. Analgesics as reinforcers with chronic pain: Evidence from operant studies. Neurosci Lett. 2013 Dec 17; 557 Pt A:60-4. PMID: 23973302.
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    27. Morello L, Martin TJ. Hypertension and ventricular tachycardia with perioperative use of Vick's Vapor InhalerR. Anesth Analg. 2013 Feb; 116(2):506-7. PMID: 23340752.
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    28. Ewan EE, Martin TJ. Intracranial self-stimulation of the paraventricular nucleus of the hypothalamus: increased faciliation by morphine compared to cocaine. Anesthesiology. 2012 May; 116(5):1116-23. PMID: 22421421.
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    29. Ewan EE, Martin TJ. Rewarding electrical brain stimulation in rats after peripheral nerve injury: decreased facilitation by commonly abused prescription opioids. Anesthesiology. 2011 Dec; 115(6):1271-80. PMID: 21946150.
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    30. Hains LE, Loram LC, Taylor FR, Strand KA, Wieseler JL, Barrientos RM, Young JJ, Frank MG, Sobesky J, Martin TJ, Eisenach JC, Maier SF, Johnson JD, Fleshner M, Watkins LR. Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors. J Neuroimmunol. 2011 Oct 28; 239(1-2):53-60. PMID: 21907418.
      Citations:    
    31. Ewan EE, Martin TJ. Opioid facilitation of rewarding electrical brain stimulation is suppressed in rats with neuropathic pain. Anesthesiology. 2011 Mar; 114(3):624-32. PMID: 21293250.
      Citations:    
    32. Martin TJ, Buechler NL, Kim SA, Ewan EE, Xiao R, Childers SR. Involvement of the lateral amygdala in the antiallodynic and reinforcing effects of heroin in rats after peripheral nerve injury. Anesthesiology. 2011 Mar; 114(3):633-42. PMID: 21293255.
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    33. Hains LE, Loram LC, Weiseler JL, Frank MG, Bloss EB, Sholar P, Taylor FR, Harrison JA, Martin TJ, Eisenach JC, Maier SF, Watkins LR. Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming. J Pain. 2010 Oct; 11(10):1004-14. PMID: 20434956.
      Citations:    
    34. Martin TJ, Ewan E. Chronic pain alters drug self-administration: implications for addiction and pain mechanisms. Exp Clin Psychopharmacol. 2008 Oct; 16(5):357-66. PMID: 18837632.
      Citations:    
    35. Murthy V, Martin TJ, Kim S, Davies HM, Childers SR. In vivo characterization of a novel phenylisothiocyanate tropane analog at monoamine transporters in rat brain. J Pharmacol Exp Ther. 2008 Aug; 326(2):587-95. PMID: 18492949.
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    36. Martin TJ, Coller M, Co C, Smith JE. Micro-opioid receptor alkylation in the ventral pallidum and ventral tegmental area, but not in the nucleus accumbens, attenuates the effects of heroin on cocaine self-administration in rats. Neuropsychopharmacology. 2008 Apr; 33(5):1171-8. PMID: 17581528.
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    37. Martin TJ, Kahn WR, Xiao R, Childers SR. Differential regional effects of methadone maintenance compared to heroin dependence on mu-opioid receptor desensitization in rat brain. Synapse. 2007 Mar; 61(3):176-84. PMID: 17152089.
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    38. Martin TJ, Kim SA, Buechler NL, Porreca F, Eisenach JC. Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Anesthesiology. 2007 Feb; 106(2):312-22. PMID: 17264726.
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    39. Martin TJ, Eisenach JC, Misler J, Childers SR. Chronic activation of spinal adenosine A1 receptors results in hypersensitivity. Neuroreport. 2006 Oct 23; 17(15):1619-22. PMID: 17001280.
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    40. Martin TJ, McIntosh S, Smith JE. Alkylation of opioid receptors by 5'-naltrindole-isothiocyanate injected into the nucleus accumbens of rats: receptor selectivity and anatomical diffusion. Synapse. 2006 Oct; 60(5):384-91. PMID: 16847946.
      Citations:    
    41. Martin TJ, Buechler NL, Eisenach JC. Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats. Anesth Analg. 2006 Sep; 103(3):690-5. PMID: 16931682.
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    42. Martin TJ, Kim SA, Eisenach JC. Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation. Pain. 2006 Dec 05; 125(3):257-263. PMID: 16806709.
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    43. Martin TJ, Kahn W, Cannon DG, Smith JE. Self-administration of heroin, cocaine and their combination under a discrete trial schedule of reinforcement in rats. Drug Alcohol Depend. 2006 May 20; 82(3):282-6. PMID: 16413144.
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    44. Smith JE, Co C, Coller MD, Hemby SE, Martin TJ. Self-administered heroin and cocaine combinations in the rat: additive reinforcing effects-supra-additive effects on nucleus accumbens extracellular dopamine. Neuropsychopharmacology. 2006 Jan; 31(1):139-50. PMID: 15956989.
      Citations:    
    45. Martin TJ, Kahn WR, Eisenach JC. Abdominal surgery decreases food-reinforced operant responding in rats: relevance of incisional pain. Anesthesiology. 2005 Sep; 103(3):629-37. PMID: 16129990.
      Citations:    
    46. Maher CE, Martin TJ, Childers SR. Mechanisms of mu opioid receptor/G-protein desensitization in brain by chronic heroin administration. Life Sci. 2005 Jul 22; 77(10):1140-54. PMID: 15890372.
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    47. Karsdal MA, Henriksen K, Sørensen MG, Gram J, Schaller S, Dziegiel MH, Heegaard AM, Christophersen P, Martin TJ, Christiansen C, Bollerslev J. Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption. Am J Pathol. 2005 Feb; 166(2):467-76. PMID: 15681830.
      Citations:    
    48. Martin TJ, Zhang Y, Buechler N, Conklin DR, Eisenach JC. Intrathecal morphine and ketorolac analgesia after surgery: comparison of spontaneous and elicited responses in rats. Pain. 2005 Feb; 113(3):376-385. PMID: 15661447.
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    49. Martin TJ, Buechler NL, Kahn W, Crews JC, Eisenach JC. Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain. Anesthesiology. 2004 Jul; 101(1):191-203. PMID: 15220791.
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    50. Smith JE, Co C, Yin X, Sizemore GM, Liguori A, Johnson WE, Martin TJ. Involvement of cholinergic neuronal systems in intravenous cocaine self-administration. Neurosci Biobehav Rev. 2004 Jan; 27(8):841-50. PMID: 15019433.
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    51. Sizemore GM, Co C, Koves TR, Martin TJ, Smith JE. Time-dependent recovery from the effects of 6-hydroxydopamine lesions of the rat nucleus accumbens on cocaine self-administration and the levels of dopamine in microdialysates. Psychopharmacology (Berl). 2004 Feb; 171(4):413-20. PMID: 14504679.
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    52. Ward SJ, Martin TJ, Roberts DC. Beta-funaltrexamine affects cocaine self-administration in rats responding on a progressive ratio schedule of reinforcement. Pharmacol Biochem Behav. 2003 May; 75(2):301-7. PMID: 12873620.
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    53. Martin TJ, Kim SA, Lyupina Y, Smith JE. Differential involvement of mu-opioid receptors in the rostral versus caudal nucleus accumbens in the reinforcing effects of heroin in rats: evidence from focal injections of beta-funaltrexamine. Psychopharmacology (Berl). 2002 May; 161(2):152-9. PMID: 11981595.
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