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Thomas J. Martin PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentAnesthesiology
Address
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    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentTranslational Neuroscience


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    K21DA000247     (MARTIN, THOMAS J)Sep 30, 1994 - Aug 31, 1999
    NIH
    FUNCTIONAL SIGNIFICANCE OF MU OPIOID RECEPTOR TURNOVER
    Role: Principal Investigator
    R01NS038231     (MARTIN, THOMAS J)Jul 15, 1999 - Jun 30, 2004
    NIH
    OPIOID SELF ADMINISTRATION IN CHRONIC PAIN
    Role: Principal Investigator
    R01DA022599     (MARTIN, THOMAS JEFFREY)Sep 26, 2006 - Nov 30, 2011
    NIH
    Role of the Amygdala in Opioid Self-administration in Rats with Chronic Pain.
    Role: Principal Investigator
    R21NS074357     (MARTIN, THOMAS JEFFREY)Jun 1, 2012 - May 31, 2014
    NIH
    Behavioral effects of deep brain stimulation in rats with chronic pain
    Role: Principal Investigator
    R21NS085533     (MARTIN, THOMAS JEFFREY)Sep 30, 2014 - Aug 31, 2017
    NIH
    The Monogamous Prairie Vole: A Model for the Study of Social Behavior and Pain
    Role: Principal Investigator
    R01DA048490     (MARTIN, THOMAS JEFFREY)Apr 15, 2019 - Feb 29, 2024
    NIH
    Biased Kappa Opioid Agonists as Non-addictive Analgesics
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Park SH, Tsuzuki S, Contino KF, Ollodart J, Eber MR, Yu Y, Steele LR, Inaba H, Kamata Y, Kimura T, Coleman I, Nelson PS, Muñoz-Islas E, Jiménez-Andrade JM, Martin TJ, Mackenzie KD, Stratton JR, Hsu FC, Peters CM, Shiozawa Y. Crosstalk between bone metastatic cancer cells and sensory nerves in bone metastatic progression. Life Sci Alliance. 2024 Dec; 7(12). PMID: 39266299.
      Citations:    
    2. Emerick T, Marshall T, Martin TJ, Ririe D, Schwenk ES. Perioperative considerations for patients exposed to hallucinogens: an infographic. Reg Anesth Pain Med. 2024 Mar 01. PMID: 38431307.
      Citations:    
    3. Emerick T, Marshall T, Martin TJ, Ririe D. Perioperative considerations for patients exposed to hallucinogens. Reg Anesth Pain Med. 2024 Feb 15. PMID: 38359966.
      Citations:    
    4. Jimenez-Andrade JM, Ramírez-Rosas MB, Hee Park S, Parker R, Eber MR, Cain R, Newland M, Hsu FC, Kittel CA, Martin TJ, Muñoz-Islas E, Shiozawa Y, Peters CM. Evaluation of pain related behaviors and disease related outcomes in an immunocompetent mouse model of prostate cancer induced bone pain. J Bone Oncol. 2023 Dec; 43:100510. PMID: 38075938.
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    5. Emerick TD, Martin TJ, Ririe DG. Perioperative Considerations for Patients Exposed to Psychostimulants. Anesth Analg. 2023 Sep 01; 137(3):474-487. PMID: 37590793.
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    6. Tappe-Theodor A, Negus SS, Martin TJ. Editorial: Preclinical Animal Models and Measures of Pain: Improving Predictive Validity for Analgesic Drug Development. Front Pain Res (Lausanne). 2022; 3:867786. PMID: 35399151.
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    7. Damuka N, Martin TJ, Bansode AH, Krizan I, Martin CW, Miller M, Whitlow CT, Nader MA, Solingapuram Sai KK. Initial Evaluations of the Microtubule-Based PET Radiotracer, [11C]MPC-6827 in a Rodent Model of Cocaine Abuse. Front Med (Lausanne). 2022; 9:817274. PMID: 35295607.
      Citations:    
    8. Ririe DG, Eisenach JC, Martin TJ. A Painful Beginning: Early Life Surgery Produces Long-Term Behavioral Disruption in the Rat. Front Behav Neurosci. 2021; 15:630889. PMID: 34025368.
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    9. Damuka N, Orr M, Czoty PW, Weiner JL, Martin TJ, Nader MA, Bansode AH, Liyana Pathirannahel BS, Mintz A, Macauley SL, Craft S, Solingapuram Sai KK. Effect of ethanol and cocaine on [11C]MPC-6827 uptake in SH-SY5Y cells. Mol Biol Rep. 2021 Apr; 48(4):3871-3876. PMID: 33880672.
      Citations:    
    10. Nazarian A, Negus SS, Martin TJ. Factors mediating pain-related risk for opioid use disorder. Neuropharmacology. 2021 03 15; 186:108476. PMID: 33524407.
      Citations:    
    11. Damuka N, Czoty PW, Davis AT, Nader MA, Nader SH, Craft S, Macauley SL, Galbo LK, Epperly PM, Whitlow CT, Davenport AT, Martin TJ, Daunais JB, Mintz A, Sai KKS. PET Imaging of [11C]MPC-6827, a Microtubule-Based Radiotracer in Non-Human Primate Brains. Molecules. 2020 May 13; 25(10). PMID: 32414052.
      Citations:    
    12. Boada MD, Ririe DG, Martin CW, Martin SJ, Kim SA, Eisenach JC, Martin TJ. Nociceptive input after peripheral nerve injury results in cognitive impairment and alterations in primary afferent physiology in rats. Pain. 2020 05; 161(5):960-969. PMID: 32040075.
      Citations:    
    13. Boada MD, Martin TJ, Parker R, Houle TT, Eisenach JC, Ririe DG. Recovery from nerve injury induced behavioral hypersensitivity in rats parallels resolution of abnormal primary sensory afferent signaling. Pain. 2020 05; 161(5):949-959. PMID: 32040074.
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    14. John WS, Martin TJ, Nader MA. Cannabinoid Modulation of Food-Cocaine Choice in Male Rhesus Monkeys. J Pharmacol Exp Ther. 2020 04; 373(1):44-50. PMID: 31941717.
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    15. Hayashida KI, Eisenach JC, Kawatani M, Martin TJ. Peripheral nerve injury in rats induces alternations in choice behavior associated with food reinforcement. J Physiol Sci. 2019 Sep; 69(5):769-777. PMID: 31267368.
      Citations:    
    16. Ririe DG, Boada MD, MacGregor MK, Martin SJ, Strassburg TJ, Kim SA, Eisenach JC, Martin TJ. Incisional Nociceptive Input Impairs Attention-related Behavior and Is Associated with Reduced Neuronal Activity in the Prefrontal Cortex in Rats. Anesthesiology. 2018 10; 129(4):778-790. PMID: 29952818.
      Citations:    
    17. Arora V, Martin TJ, Aschenbrenner CA, Hayashida K, Kim SA, Parker RA, Eisenach JC, Peters CM. Psychosocial Stress Delays Recovery of Postoperative Pain Following Incisional Surgery in the Rat. Neuroscience. 2018 07 01; 382:35-47. PMID: 29694918.
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    18. Chen R, McIntosh S, Hemby SE, Sun H, Sexton T, Martin TJ, Childers SR. High and low doses of cocaine intake are differentially regulated by dopamine D2 receptors in the ventral tegmental area and the nucleus accumbens. Neurosci Lett. 2018 04 03; 671:133-139. PMID: 29454035.
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    19. John WS, Martin TJ, Solingapuram Sai KK, Nader SH, Gage HD, Mintz A, Nader MA. Chronic ?9-THC in Rhesus Monkeys: Effects on Cognitive Performance and Dopamine D2/D3 Receptor Availability. J Pharmacol Exp Ther. 2018 02; 364(2):300-310. PMID: 29203575.
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    20. Martin TJ, Strassburg TJ, Grigg AL, Kim SA, Ririe DG, Eisenach JC. Assessment of Behavioral Disruption in Rats with Abdominal Inflammation Using Visual Cue Titration and the Five-choice Serial-reaction Time Task. Anesthesiology. 2017 08; 127(2):372-381. PMID: 28542002.
      Citations:    
    21. Ririe DG, Boada MD, Schmidt BS, Martin SJ, Kim SA, Martin TJ. Audiovisual Distraction Increases Prefrontal Cortical Neuronal Activity and Impairs Attentional Performance in the Rat. J Exp Neurosci. 2017; 11:1179069517703080. PMID: 28469479.
      Citations:    
    22. John WS, Martin TJ, Nader MA. Behavioral Determinants of Cannabinoid Self-Administration in Old World Monkeys. Neuropsychopharmacology. 2017 Jun; 42(7):1522-1530. PMID: 28059083.
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    23. Brust TF, Morgenweck J, Kim SA, Rose JH, Locke JL, Schmid CL, Zhou L, Stahl EL, Cameron MD, Scarry SM, Aubé J, Jones SR, Martin TJ, Bohn LM. Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria. Sci Signal. 2016 11 29; 9(456):ra117. PMID: 27899527.
      Citations:    
    24. Boada MD, Martin TJ, Ririe DG. Nerve injury induced activation of fast-conducting high threshold mechanoreceptors predicts non-reflexive pain related behavior. Neurosci Lett. 2016 Oct 06; 632:44-9. PMID: 27544012.
      Citations:    
    25. Arora V, Morado-Urbina CE, Aschenbrenner CA, Hayashida K, Wang F, Martin TJ, Eisenach JC, Peters CM. Disruption of Spinal Noradrenergic Activation Delays Recovery of Acute Incision-Induced Hypersensitivity and Increases Spinal Glial Activation in the Rat. J Pain. 2016 Feb; 17(2):190-202. PMID: 26545342.
      Citations:    
    26. Martin TJ, Sexton T, Kim SA, Severino AL, Peters CM, Young LJ, Childers SR. Regional differences in mu and kappa opioid receptor G-protein activation in brain in male and female prairie voles. Neuroscience. 2015 Dec 17; 311:422-9. PMID: 26523979.
      Citations:    
    27. Peters CM, Hayashida K, Suto T, Houle TT, Aschenbrenner CA, Martin TJ, Eisenach JC. Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat. Anesthesiology. 2015 Apr; 122(4):895-907. PMID: 25581910.
      Citations:    
    28. Czoty PW, Tran P, Thomas LN, Martin TJ, Grigg A, Blough BE, Beveridge TJ. Effects of the dopamine/norepinephrine releaser phenmetrazine on cocaine self-administration and cocaine-primed reinstatement in rats. Psychopharmacology (Berl). 2015 Jul; 232(13):2405-14. PMID: 25673020.
      Citations:    
    29. Martin TJ, Grigg A, Kim SA, Ririe DG, Eisenach JC. Assessment of attention threshold in rats by titration of visual cue duration during the five choice serial reaction time task. J Neurosci Methods. 2015 Feb 15; 241:37-43. PMID: 25528113.
      Citations:    
    30. Boada DM, Martin TJ, Peters CM, Hayashida K, Harris MH, Houle TT, Boyden ES, Eisenach JC, Ririe DG. Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats. Pain. 2014 Dec; 155(12):2646-2655. PMID: 25267211.
      Citations:    
    31. Ewan EE, Martin TJ. Differential suppression of intracranial self-stimulation, food-maintained operant responding, and open field activity by paw incision and spinal nerve ligation in rats. Anesth Analg. 2014 Apr; 118(4):854-62. PMID: 24651240.
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    32. Ewan EE, Martin TJ. Intracranial self-stimulation of the paraventricular nucleus of the hypothalamus: increased faciliation by morphine compared to cocaine. Anesthesiology. 2012 May; 116(5):1116-23. PMID: 22421421.
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    33. Ewan EE, Martin TJ. Rewarding electrical brain stimulation in rats after peripheral nerve injury: decreased facilitation by commonly abused prescription opioids. Anesthesiology. 2011 Dec; 115(6):1271-80. PMID: 21946150.
      Citations:    
    34. Ewan EE, Martin TJ. Opioid facilitation of rewarding electrical brain stimulation is suppressed in rats with neuropathic pain. Anesthesiology. 2011 Mar; 114(3):624-32. PMID: 21293250.
      Citations:    
    35. Martin TJ, Buechler NL, Kim SA, Ewan EE, Xiao R, Childers SR. Involvement of the lateral amygdala in the antiallodynic and reinforcing effects of heroin in rats after peripheral nerve injury. Anesthesiology. 2011 Mar; 114(3):633-42. PMID: 21293255.
      Citations:    
    36. Martin TJ, Ewan E. Chronic pain alters drug self-administration: implications for addiction and pain mechanisms. Exp Clin Psychopharmacol. 2008 Oct; 16(5):357-66. PMID: 18837632.
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    37. Kong KC, Gandhi U, Martin TJ, Anz CB, Yan H, Misior AM, Pascual RM, Deshpande DA, Penn RB. Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization. Biochemistry. 2008 Sep 02; 47(35):9279-88. PMID: 18690720.
      Citations:    
    38. Murthy V, Martin TJ, Kim S, Davies HM, Childers SR. In vivo characterization of a novel phenylisothiocyanate tropane analog at monoamine transporters in rat brain. J Pharmacol Exp Ther. 2008 Aug; 326(2):587-95. PMID: 18492949.
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    39. Martin TJ, Coller M, Co C, Smith JE. Micro-opioid receptor alkylation in the ventral pallidum and ventral tegmental area, but not in the nucleus accumbens, attenuates the effects of heroin on cocaine self-administration in rats. Neuropsychopharmacology. 2008 Apr; 33(5):1171-8. PMID: 17581528.
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    40. Martin TJ, Kahn WR, Xiao R, Childers SR. Differential regional effects of methadone maintenance compared to heroin dependence on mu-opioid receptor desensitization in rat brain. Synapse. 2007 Mar; 61(3):176-84. PMID: 17152089.
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    41. Martin TJ, Kim SA, Buechler NL, Porreca F, Eisenach JC. Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Anesthesiology. 2007 Feb; 106(2):312-22. PMID: 17264726.
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    42. Martin TJ, Eisenach JC, Misler J, Childers SR. Chronic activation of spinal adenosine A1 receptors results in hypersensitivity. Neuroreport. 2006 Oct 23; 17(15):1619-22. PMID: 17001280.
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    43. Martin TJ, McIntosh S, Smith JE. Alkylation of opioid receptors by 5'-naltrindole-isothiocyanate injected into the nucleus accumbens of rats: receptor selectivity and anatomical diffusion. Synapse. 2006 Oct; 60(5):384-91. PMID: 16847946.
      Citations:    
    44. Martin TJ, Buechler NL, Eisenach JC. Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats. Anesth Analg. 2006 Sep; 103(3):690-5. PMID: 16931682.
      Citations:    
    45. Martin TJ, Kim SA, Eisenach JC. Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation. Pain. 2006 Dec 05; 125(3):257-263. PMID: 16806709.
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    46. Martin TJ, Kahn W, Cannon DG, Smith JE. Self-administration of heroin, cocaine and their combination under a discrete trial schedule of reinforcement in rats. Drug Alcohol Depend. 2006 May 20; 82(3):282-6. PMID: 16413144.
      Citations:    
    47. Smith JE, Co C, Coller MD, Hemby SE, Martin TJ. Self-administered heroin and cocaine combinations in the rat: additive reinforcing effects-supra-additive effects on nucleus accumbens extracellular dopamine. Neuropsychopharmacology. 2006 Jan; 31(1):139-50. PMID: 15956989.
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    48. Martin TJ, Kahn WR, Eisenach JC. Abdominal surgery decreases food-reinforced operant responding in rats: relevance of incisional pain. Anesthesiology. 2005 Sep; 103(3):629-37. PMID: 16129990.
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    49. Maher CE, Martin TJ, Childers SR. Mechanisms of mu opioid receptor/G-protein desensitization in brain by chronic heroin administration. Life Sci. 2005 Jul 22; 77(10):1140-54. PMID: 15890372.
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    50. Martin TJ, Zhang Y, Buechler N, Conklin DR, Eisenach JC. Intrathecal morphine and ketorolac analgesia after surgery: comparison of spontaneous and elicited responses in rats. Pain. 2005 Feb; 113(3):376-385. PMID: 15661447.
      Citations:    
    51. Martin TJ, Buechler NL, Kahn W, Crews JC, Eisenach JC. Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain. Anesthesiology. 2004 Jul; 101(1):191-203. PMID: 15220791.
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    52. Smith JE, Co C, Yin X, Sizemore GM, Liguori A, Johnson WE, Martin TJ. Involvement of cholinergic neuronal systems in intravenous cocaine self-administration. Neurosci Biobehav Rev. 2004 Jan; 27(8):841-50. PMID: 15019433.
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    53. Sizemore GM, Co C, Koves TR, Martin TJ, Smith JE. Time-dependent recovery from the effects of 6-hydroxydopamine lesions of the rat nucleus accumbens on cocaine self-administration and the levels of dopamine in microdialysates. Psychopharmacology (Berl). 2004 Feb; 171(4):413-20. PMID: 14504679.
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    54. Ward SJ, Martin TJ, Roberts DC. Beta-funaltrexamine affects cocaine self-administration in rats responding on a progressive ratio schedule of reinforcement. Pharmacol Biochem Behav. 2003 May; 75(2):301-7. PMID: 12873620.
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    55. Martin TJ, Kim SA, Lyupina Y, Smith JE. Differential involvement of mu-opioid receptors in the rostral versus caudal nucleus accumbens in the reinforcing effects of heroin in rats: evidence from focal injections of beta-funaltrexamine. Psychopharmacology (Berl). 2002 May; 161(2):152-9. PMID: 11981595.
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    56. Martin TJ, Eisenach JC. Pharmacology of opioid and nonopioid analgesics in chronic pain states. J Pharmacol Exp Ther. 2001 Dec; 299(3):811-7. PMID: 11714863.
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    57. Sizemore GM, Martin TJ. Toward a mathematical description of dose-effect functions for self-administered drugs in laboratory animal models. Psychopharmacology (Berl). 2000 Dec; 153(1):57-66. PMID: 11255929.
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    58. Martin TJ, Kim SA, Cannon DG, Sizemore GM, Bian D, Porreca F, Smith JE. Antagonism of delta(2)-opioid receptors by naltrindole-5'-isothiocyanate attenuates heroin self-administration but not antinociception in rats. J Pharmacol Exp Ther. 2000 Sep; 294(3):975-82. PMID: 10945849.
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    59. Meek EN, Butterworth J, Kon ND, Zvara DA, Ash GE, Martin TJ. Pituitary apoplexy following mitral valve repair. Anesthesiology. 1998 Dec; 89(6):1580-2. PMID: 9856739.
      Citations:    
    60. Martin TJ, DeMontis MG, Kim SA, Sizemore GM, Dworkin SI, Smith JE. Effects of beta-funaltrexamine on dose-effect curves for heroin self-administration in rats: comparison with alteration of [3H]DAMGO binding to rat brain sections. Drug Alcohol Depend. 1998 Oct 1; 52(2):135-47. PMID: 9800143.
      Citations:    
    61. Martin TJ, Hairston CT, Lutz PO, Harris LS, Porreca F. Anti-allodynic actions of intravenous opioids in the nerve injured rat: potential utility of heroin and dihydroetorphine against neuropathic pain. Eur J Pharmacol. 1998 Sep 11; 357(1):25-32. PMID: 9788770.
      Citations:    
    62. Martin TJ, Smith JE, Dworkin SI. Training dose and session time as contextual determinants of heroin self-administration in rats. Pharmacol Biochem Behav. 1998 Jun; 60(2):415-21. PMID: 9632224.
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    63. Martin TJ, Bell DA, Wilson JA. Papilledema in a man with an "occult" dural arteriovenous malformation. J Neuroophthalmol. 1998 Mar; 18(1):49-52. PMID: 9532542.
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    64. Martin TJ, Sim LJ, Selley DE, deMontis MG, Childers SR. Effects of intracerebroventricular administration of beta-funaltrexamine on DAMGO-stimulated [35S]GTP-gamma-S binding in rat brain sections. Synapse. 1997 Nov; 27(3):177-82. PMID: 9329153.
      Citations:    
    65. Martin TJ, Miller M, Dworkin SI, Smith JE, Porrino LJ. Alteration of local cerebral glucose utilization following intravenous administration of heroin in Fischer 344 rats. Brain Res. 1997 May 2; 755(2):313-8. PMID: 9175898.
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    66. Martin TJ, Kim SA, Harris LS, Smith JE. Potent reinforcing effects of dihydroetorphine in rats. Eur J Pharmacol. 1997 Apr 18; 324(2-3):141-5. PMID: 9145764.
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    67. Hemby SE, Martin TJ, Co C, Dworkin SI, Smith JE. The effects of intravenous heroin administration on extracellular nucleus accumbens dopamine concentrations as determined by in vivo microdialysis. J Pharmacol Exp Ther. 1995 May; 273(2):591-8. PMID: 7752060.
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    68. Martin TJ, Troost BT, Ginsberg LE, Tegeler CH, Weaver RG. Left dural to right cavernous sinus fistula. A case report. J Neuroophthalmol. 1995 Mar; 15(1):31-5. PMID: 7780569.
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    69. Dworkin SI, Gleeson S, Meloni D, Koves TR, Martin TJ. Effects of ibogaine on responding maintained by food, cocaine and heroin reinforcement in rats. Psychopharmacology (Berl). 1995 Feb; 117(3):257-61. PMID: 7770600.
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