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Steven M. Block

TitleProfessor Emeritus of Pediatrics, Winston-Salem - Neonatology
InstitutionWake Forest School of Medicine
DepartmentPediatrics, Winston-Salem - Neonatology
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    R01GM051453     (BLOCK, STEVEN M)Aug 1, 1994 - Mar 31, 2013
    NIH/NIGMS
    Microtubule Motors Studied on a Molecular Scale
    Role: Principal Investigator
    R01GM057035     (BLOCK, STEVEN M)Sep 30, 1997 - Nov 30, 2009
    NIH/NIGMS
    Nucleic Acid Enzymes Studied at the Molecular Level
    Role: Principal Investigator
    R37GM057035     (BLOCK, STEVEN M)Sep 30, 1997 - Nov 30, 2019
    NIH/NIGMS
    Nucleic Acid Enzymes and Nucleic Acids Studied at the Molecular Level
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chakraborty A, Meng CA, Block SM. Observing Single RNA Polymerase Molecules Down to Base-Pair Resolution. Methods Mol Biol. 2017; 1486:391-409. PMID: 27844437.
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    2. Duesterberg VK, Fischer-Hwang IT, Perez CF, Hogan DW, Block SM. Observation of long-range tertiary interactions during ligand binding by the TPP riboswitch aptamer. Elife. 2015 Dec 28; 4. PMID: 26709838.
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    3. Fazal FM, Koslover DJ, Luisi BF, Block SM. Direct observation of processive exoribonuclease motion using optical tweezers. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):15101-6. PMID: 26598710.
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    4. Fazal FM, Meng CA, Murakami K, Kornberg RD, Block SM. Real-time observation of the initiation of RNA polymerase II transcription. Nature. 2015 Sep 10; 525(7568):274-7. PMID: 26331540.
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    5. García-García C, Frieda KL, Feoktistova K, Fraser CS, Block SM. RNA BIOCHEMISTRY. Factor-dependent processivity in human eIF4A DEAD-box helicase. Science. 2015 Jun 26; 348(6242):1486-8. PMID: 26113725.
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    6. Andreasson JO, Milic B, Chen GY, Guydosh NR, Hancock WO, Block SM. Examining kinesin processivity within a general gating framework. Elife. 2015 Apr 22; 4. PMID: 25902401.
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    7. Andreasson JO, Shastry S, Hancock WO, Block SM. The Mechanochemical Cycle of Mammalian Kinesin-2 KIF3A/B under Load. Curr Biol. 2015 May 04; 25(9):1166-75. PMID: 25866395.
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    8. Block SM, Sonnino RE, Bellini L. Defining "faculty" in academic medicine: responding to the challenges of a changing environment. Acad Med. 2015 Mar; 90(3):279-82. PMID: 25406611.
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    9. Blakely BL, Dumelin CE, Trappmann B, McGregor LM, Choi CK, Anthony PC, Duesterberg VK, Baker BM, Block SM, Liu DR, Chen CS. A DNA-based molecular probe for optically reporting cellular traction forces. Nat Methods. 2014 Dec; 11(12):1229-32. PMID: 25306545.
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    10. Milic B, Andreasson JO, Hancock WO, Block SM. Kinesin processivity is gated by phosphate release. Proc Natl Acad Sci U S A. 2014 Sep 30; 111(39):14136-40. PMID: 25197045.
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    11. Larson MH, Mooney RA, Peters JM, Windgassen T, Nayak D, Gross CA, Block SM, Greenleaf WJ, Landick R, Weissman JS. A pause sequence enriched at translation start sites drives transcription dynamics in vivo. Science. 2014 May 30; 344(6187):1042-7. PMID: 24789973.
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    12. Schweikhard V, Meng C, Murakami K, Kaplan CD, Kornberg RD, Block SM. Transcription factors TFIIF and TFIIS promote transcript elongation by RNA polymerase II by synergistic and independent mechanisms. Proc Natl Acad Sci U S A. 2014 May 06; 111(18):6642-7. PMID: 24733897.
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    13. Savinov A, Perez CF, Block SM. Single-molecule studies of riboswitch folding. Biochim Biophys Acta. 2014 Oct; 1839(10):1030-1045. PMID: 24727093.
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    14. Woodside MT, Block SM. Reconstructing folding energy landscapes by single-molecule force spectroscopy. Annu Rev Biophys. 2014; 43:19-39. PMID: 24895850.
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    15. Frieda KL, Block SM. Direct observation of cotranscriptional folding in an adenine riboswitch. Science. 2012 Oct 19; 338(6105):397-400. PMID: 23087247.
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    16. Zhou J, Schweikhard V, Block SM. Single-molecule studies of RNAPII elongation. Biochim Biophys Acta. 2013 Jan; 1829(1):29-38. PMID: 22982192.
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    17. Koslover DJ, Fazal FM, Mooney RA, Landick R, Block SM. Binding and translocation of termination factor rho studied at the single-molecule level. J Mol Biol. 2012 Nov 09; 423(5):664-76. PMID: 22885804.
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    18. Palangat M, Larson MH, Hu X, Gnatt A, Block SM, Landick R. Efficient reconstitution of transcription elongation complexes for single-molecule studies of eukaryotic RNA polymerase II. Transcription. 2012 May-Jun; 3(3):146-53. PMID: 22771949.
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    19. Larson MH, Zhou J, Kaplan CD, Palangat M, Kornberg RD, Landick R, Block SM. Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6555-60. PMID: 22493230.
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    20. Anthony PC, Sim AY, Chu VB, Doniach S, Block SM, Herschlag D. Electrostatics of nucleic acid folding under conformational constraint. J Am Chem Soc. 2012 Mar 14; 134(10):4607-14. PMID: 22369617.
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    21. Anthony PC, Perez CF, García-García C, Block SM. Folding energy landscape of the thiamine pyrophosphate riboswitch aptamer. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1485-9. PMID: 22219369.
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    22. Zhou J, Ha KS, La Porta A, Landick R, Block SM. Applied force provides insight into transcriptional pausing and its modulation by transcription factor NusA. Mol Cell. 2011 Nov 18; 44(4):635-46. PMID: 22099310.
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    23. Fazal FM, Block SM. Optical tweezers study life under tension. Nat Photonics. 2011 May 31; 5:318-321. PMID: 22145010.
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    24. Webb P, Block S. Support for agriculture during economic transformation: impacts on poverty and undernutrition. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12309-14. PMID: 21173245.
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    25. Coe K, Butler M, Reavis N, Klinepeter ME, Purkey C, Oliver T, Starbuck A, Griffin J, Wilmoth C, Block S. Special Premie Oxygen Targeting (SPOT): a program to decrease the incidence of blindness in infants with retinopathy of prematurity. J Nurs Care Qual. 2006 Jul-Sep; 21(3):230-5. PMID: 16816603.
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    26. Anstrom JA, Thore CR, Moody DM, Challa VR, Block SM, Brown WR. Germinal matrix cells associate with veins and a glial scaffold in the human fetal brain. Brain Res Dev Brain Res. 2005 Nov 07; 160(1):96-100. PMID: 16168493.
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    27. Anstrom JA, Thore CR, Moody DM, Challa VR, Block SM, Brown WR. Morphometric assessment of collagen accumulation in germinal matrix vessels of premature human neonates. Neuropathol Appl Neurobiol. 2005 Apr; 31(2):181-90. PMID: 15771711.
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    28. Kemper K, Martin K, Block SM, Shoaf R, Woods C. Attitudes and expectations about music therapy for premature infants among staff in a neonatal intensive care unit. Altern Ther Health Med. 2004 Mar-Apr; 10(2):50-4. PMID: 15055094.
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    29. Anstrom JA, Brown WR, Moody DM, Thore CR, Challa VR, Block SM. Subependymal veins in premature neonates: implications for hemorrhage. Pediatr Neurol. 2004 Jan; 30(1):46-53. PMID: 14738951.
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    30. Lang MJ, Block SM. Resource Letter: LBOT-1: Laser-based optical tweezers. Am J Phys. 2003 Mar; 71(3):201-215. PMID: 16971965.
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    31. Anstrom JA, Brown WR, Moody DM, Thore CR, Challa VR, Block SM. Anatomical analysis of the developing cerebral vasculature in premature neonates: absence of precapillary arteriole-to-venous shunts. Pediatr Res. 2002 Oct; 52(4):554-60. PMID: 12357050.
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    32. Anstrom JA, Brown WR, Moody DM, Thore CR, Challa VR, Block SM. Temporal expression pattern of cerebrovascular endothelial cell alkaline phosphatase during human gestation. J Neuropathol Exp Neurol. 2002 Jan; 61(1):76-84. PMID: 11829346.
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