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Susan E. Appt DVM

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentPathology, Comparative Medicine
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentClinical and Translational Science Institute

    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentClinical and Translational Science Institute

    TitleSection Head
    InstitutionWake Forest School of Medicine
    DepartmentPathology, Comparative Medicine


    Collapse Research 
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    T32OD010957     (CLINE, J. MARK)Jul 1, 1982 - Mar 31, 2023
    NIH
    Laboratory Animal & Comparative Medicine Training
    Role: Co-Investigator

    P40RR019963     (KAPLAN, JAY ROSS)Jul 1, 2004 - Mar 31, 2015
    NIH/NCRR
    Vervet Research Colony as a Biomedical Resource
    Role: Co-Investigator

    R24RR022191     (KAPLAN, JAY R)Sep 22, 2005 - Aug 31, 2010
    NIH/NCRR
    MODELING THE MENOPAUSAL TRANSITION AND MENOPAUSE
    Role: Co-Investigator

    R01AG027847     (APPT, SUSAN E)Sep 1, 2006 - Jul 31, 2015
    NIH
    Role of the Follicle-Depleted Ovary in the Pathogenesis of Chronic Diseases
    Role: Principal Investigator

    R01HL087103     (SHIVELY, CAROL A.)Dec 1, 2006 - Mar 31, 2020
    NIH
    Dietary Mitigation of Psychosocial Stress Effects on CVD Risk
    Role: Co-Investigator

    R01AG028641     (REGISTER, THOMAS COSTIN)Apr 1, 2007 - Mar 31, 2012
    NIH
    Atherosclerosis Stage, Estrogen Receptors, and Vascular Responses to Estrogen
    Role: Co-Investigator

    P40RR021380     (WAGNER, JANICE D.)Jul 1, 2007 - Apr 30, 2013
    NIH
    WFUSM Macaca fascicularis SPF Breeding Colony
    Role: Co-Investigator

    R25RR024505     (WAGNER, JANICE D.)Sep 25, 2007 - Apr 30, 2012
    NIH
    Training Clinical Veterinarians in Nonhuman Primate Clinical Medicine
    Role: Co-Investigator

    T35OD010946     (KAVANAGH, KYLIE)Apr 1, 2009 - May 31, 2024
    NIH
    Summer Veterinary Student Research Fellows at Wake Forest University
    Role: Co-Investigator

    R21HD060944     (POLOTSKY, ALEX JOEL)Sep 3, 2010 - Jul 31, 2013
    NIH
    Vervet Monkey: Modeling Effects of Diet-Induced Obesity on Reproduction
    Role: Co-Investigator

    R24OD011895     (BETHEA, CYNTHIA LOUISE)Aug 18, 2012 - Jun 30, 2017
    NIH
    Postmenopausal Monkey Resource
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nudy M, Xie R, O'Sullivan DM, Jiang X, Appt S, Register TC, Kaplan JR, Clarkson TB, Schnatz PF. Association between coronary artery vitamin D receptor expression and select systemic risks factors for coronary artery atherosclerosis. Climacteric. 2021 Oct 25; 1-7. PMID: 34694941.
      Citations:    
    2. Johnson CS, Shively C, Michalson KT, Lea AJ, DeBo RJ, Howard TD, Hawkins GA, Appt SE, Liu Y, McCall CE, Herrington DM, Ip EH, Register TC, Snyder-Mackler N. Contrasting effects of Western vs Mediterranean diets on monocyte inflammatory gene expression and social behavior in a primate model. Elife. 2021 08 02; 10. PMID: 34338633.
      Citations:    
    3. Newman TM, Shively CA, Register TC, Appt SE, Yadav H, Colwell RR, Fanelli B, Dadlani M, Graubics K, Nguyen UT, Ramamoorthy S, Uberseder B, Clear KYJ, Wilson AS, Reeves KD, Chappell MC, Tooze JA, Cook KL. Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model. Microbiome. 2021 05 05; 9(1):100. PMID: 33952353.
      Citations:    
    4. Roy Chowdhury U, Kudgus RA, Holman BH, Rinkoski TA, Hann CR, Bahler CK, McCloud E, Appt SE, Reid JM, Dosa PI, Fautsch MP. Pharmacological Profile and Ocular Hypotensive Effects of Cromakalim Prodrug 1, a Novel ATP-Sensitive Potassium Channel Opener, in Normotensive Dogs and Nonhuman Primates. J Ocul Pharmacol Ther. 2021 Mar 30. PMID: 33784195.
      Citations:    
    5. Frye BM, Craft S, Register TC, Andrews RN, Appt SE, Vitolins MZ, Uberseder B, Silverstein-Metzler MG, Chen H, Whitlow CT, Kim J, Barcus RA, Lockhart SN, Hoscheidt S, Say BM, Corbitt SE, Shively CA. Diet, psychosocial stress, and Alzheimer's disease-related neuroanatomy in female nonhuman primates. Alzheimers Dement. 2021 May; 17(5):733-744. PMID: 33270373.
      Citations:    
    6. Shively CA, Appt SE, Chen H, Day SM, Frye BM, Shaltout HA, Silverstein-Metzler MG, Snyder-Mackler N, Uberseder B, Vitolins MZ, Register TC. Mediterranean diet, stress resilience, and aging in nonhuman primates. Neurobiol Stress. 2020 Nov; 13:100254. PMID: 33344709.
      Citations:    
    7. Meléndez GC, Vasu S, Lesnefsky EJ, Kaplan JR, Appt S, D'Agostino RB, Hundley WG, Jordan JH. Myocardial Extracellular and Cardiomyocyte Volume Expand After Doxorubicin Treatment Similar to Adjuvant Breast Cancer Therapy. JACC Cardiovasc Imaging. 2020 04; 13(4):1084-1085. PMID: 31864989.
      Citations:    
    8. Testerman TL, Semino-Mora C, Cann JA, Qiang B, Peña EA, Liu H, Olsen CH, Chen H, Appt SE, Kaplan JR, Register TC, Merrell DS, Dubois A. Both diet and Helicobacter pylori infection contribute to atherosclerosis in pre- and postmenopausal cynomolgus monkeys. PLoS One. 2019; 14(9):e0222001. PMID: 31490998.
      Citations:    
    9. Gonzalez-Armenta JL, Gao Z, Appt SE, Vitolins MZ, Michalson KT, Register TC, Shively CA, Molina AJA. Skeletal Muscle Mitochondrial Respiration Is Elevated in Female Cynomolgus Macaques Fed a Western Compared with a Mediterranean Diet. J Nutr. 2019 09 01; 149(9):1493-1502. PMID: 31112997.
      Citations:    
    10. Atkins HM, Bharadwaj MS, O'Brien Cox A, Furdui CM, Appt SE, Caudell DL. Endometrium and endometriosis tissue mitochondrial energy metabolism in a nonhuman primate model. Reprod Biol Endocrinol. 2019 Aug 24; 17(1):70. PMID: 31445519.
      Citations:    
    11. Shively CA, Appt SE, Vitolins MZ, Uberseder B, Michalson KT, Silverstein-Metzler MG, Register TC. Response to "Two Bad Diets for Monkeys". Obesity (Silver Spring). 2019 10; 27(10):1554. PMID: 31420940.
      Citations:    
    12. Shively CA, Appt SE, Vitolins MZ, Uberseder B, Michalson KT, Silverstein-Metzler MG, Register TC. Erratum: Mediterranean versus Western Diet Effects on Caloric Intake, Obesity, Metabolism, and Hepatosteatosis in Nonhuman Primates. Obesity (Silver Spring). 2019 Jul; 27(7):1211. PMID: 31231955.
      Citations:    
    13. Shively CA, Appt SE, Vitolins MZ, Uberseder B, Michalson KT, Silverstein-Metzler MG, Register TC. Mediterranean versus Western Diet Effects on Caloric Intake, Obesity, Metabolism, and Hepatosteatosis in Nonhuman Primates. Obesity (Silver Spring). 2019 05; 27(5):777-784. PMID: 31012294.
      Citations:    
    14. Michalson KT, Groban L, Howard TD, Shively CA, Sophonsritsuk A, Appt SE, Cline JM, Clarkson TB, Carr JJ, Kitzman DW, Register TC. Estradiol Treatment Initiated Early After Ovariectomy Regulates Myocardial Gene Expression and Inhibits Diastolic Dysfunction in Female Cynomolgus Monkeys: Potential Roles for Calcium Homeostasis and Extracellular Matrix Remodeling. J Am Heart Assoc. 2018 11 06; 7(21):e009769. PMID: 30571375.
      Citations:    
    15. Shively CA, Register TC, Appt SE, Clarkson TB, Uberseder B, Clear KYJ, Wilson AS, Chiba A, Tooze JA, Cook KL. Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations. Cell Rep. 2018 10 02; 25(1):47-56.e3. PMID: 30282037.
      Citations:    
    16. Anantharamaiah GM, Garber DW, Goldberg D, Morrel E, Datta G, Palgunachari MN, Register TC, Appt SE, White CR. Novel fatty acyl apoE mimetic peptides have increased potency to reduce plasma cholesterol in mice and macaques. J Lipid Res. 2018 11; 59(11):2075-2083. PMID: 30201630.
      Citations:    
    17. Atkins HM, Appt SE, Taylor RN, Torres-Mendoza Y, Lenk EE, Rosenthal NS, Caudell DL. Systemic Iron Deficiency in a Nonhuman Primate Model of Endometriosis. Comp Med. 2018 08 01; 68(4):298-307. PMID: 29871715.
      Citations:    
    18. Nagpal R, Shively CA, Appt SA, Register TC, Michalson KT, Vitolins MZ, Yadav H. Gut Microbiome Composition in Non-human Primates Consuming a Western or Mediterranean Diet. Front Nutr. 2018; 5:28. PMID: 29922651.
      Citations:    
    19. Justice JN, Silverstein-Metzler MG, Uberseder B, Appt SE, Clarkson TB, Register TC, Kritchevsky SB, Shively CA. Relationships of depressive behavior and sertraline treatment with walking speed and activity in older female nonhuman primates. Geroscience. 2017 12; 39(5-6):585-600. PMID: 29080976.
      Citations:    
    20. Silverstein-Metzler MG, Justice JN, Appt SE, Groban L, Kitzman DW, Carr JJ, Register TC, Shively CA. Long-term sertraline treatment and depression effects on carotid artery atherosclerosis in premenopausal female primates. Menopause. 2017 Oct; 24(10):1175-1184. PMID: 28609387.
      Citations:    
    21. Abbott DH, Rayome BH, Dumesic DA, Lewis KC, Edwards AK, Wallen K, Wilson ME, Appt SE, Levine JE. Clustering of PCOS-like traits in naturally hyperandrogenic female rhesus monkeys. Hum Reprod. 2017 04 01; 32(4):923-936. PMID: 28333238.
      Citations:    
    22. Dhungana S, Carlson JE, Pathmasiri W, McRitchie S, Davis M, Sumner S, Appt SE. Impact of a western diet on the ovarian and serum metabolome. Maturitas. 2016 Oct; 92:134-142. PMID: 27621251.
      Citations:    
    23. Atkins HM, Lombardini ED, Caudell DL, Appt SE, Dubois A, Cline JM. Decidualization of Endometriosis in Macaques. Vet Pathol. 2016 11; 53(6):1252-1258. PMID: 27281017.
      Citations:    
    24. Kuokkanen S, Polotsky AJ, Chosich J, Bradford AP, Jasinska A, Phang T, Santoro N, Appt SE. Corpus luteum as a novel target of weight changes that contribute to impaired female reproductive physiology and function. Syst Biol Reprod Med. 2016 Aug; 62(4):227-42. PMID: 27187064.
      Citations:    
    25. Silverstein-Metzler MG, Shively CA, Clarkson TB, Appt SE, Carr JJ, Kritchevsky SB, Jones SR, Register TC. Sertraline inhibits increases in body fat and carbohydrate dysregulation in adult female cynomolgus monkeys. Psychoneuroendocrinology. 2016 06; 68:29-38. PMID: 26939086.
      Citations:    
    26. Register TC, Appt SE, Clarkson TB. Atherosclerosis and Vascular Biologic Responses to Estrogens: Histologic, Immunohistochemical, Biochemical, and Molecular Methods. Methods Mol Biol. 2016; 1366:517-532. PMID: 26585161.
      Citations:    
    27. Register TC, Appt SE, Clarkson TB. Erratum to: Atherosclerosis and Vascular Biologic Responses to Estrogens: Histologic, Immunohistochemical, Biochemical, and Molecular Methods. Methods Mol Biol. 2016; 1366:E5. PMID: 29549626.
      Citations:    
    28. Appt SE. Myometrial artery calcification: significance for perimenopausal and postmenopausal women. Menopause. 2015 Dec; 22(12):1271-2. PMID: 26575112.
      Citations:    
    29. Bradford AP, Jones K, Kechris K, Chosich J, Montague M, Warren WC, May MC, Al-Safi Z, Kuokkanen S, Appt SE, Polotsky AJ. Joint MiRNA/mRNA expression profiling reveals changes consistent with development of dysfunctional corpus luteum after weight gain. PLoS One. 2015; 10(8):e0135163. PMID: 26258540.
      Citations:    
    30. Schnatz PF, Nudy M, Jiang X, Demko JE, Appt SE. Vitamin D deficiency and cardiovascular disease in postmenopausal women: contributions from human and nonhuman primate studies. Menopause. 2015 May; 22(5):554-63. PMID: 25563796.
      Citations:    
    31. Shively CA, Register TC, Appt SE, Clarkson TB. Effects of long-term sertraline treatment and depression on coronary artery atherosclerosis in premenopausal female primates. Psychosom Med. 2015 Apr; 77(3):267-78. PMID: 25829239.
      Citations:    
    32. Meléndez GC, Register TC, Appt SE, Clarkson TB, Franke AA, Kaplan JR. Beneficial effects of soy supplementation on postmenopausal atherosclerosis are dependent on pretreatment stage of plaque progression. Menopause. 2015 Mar; 22(3):289-96. PMID: 25072952.
      Citations:    
    33. Silverstein MG, Kaplan JR, Appt SE, Register TC, Shively CA. Effect of soy isoflavones on thyroid hormones in intact and ovariectomized cynomolgus monkeys (Macaca fascicularis). Menopause. 2014 Oct; 21(10):1136-42. PMID: 24618766.
      Citations:    
    34. Eyster KM, Appt S, Chalpe A, Mark-Kappeler CJ, Register TC, Clarkson TB. Effects of estradiol on transcriptional profiles in atherosclerotic iliac arteries in ovariectomized cynomolgus macaques. Menopause. 2014 Feb; 21(2):143-52. PMID: 23760433.
      Citations:    
    35. Atkins HM, Willson CJ, Silverstein M, Jorgensen M, Floyd E, Kaplan JR, Appt SE. Characterization of ovarian aging and reproductive senescence in vervet monkeys (Chlorocebus aethiops sabaeus). Comp Med. 2014 Feb; 64(1):55-62. PMID: 24512962.
      Citations:    
    36. Clarkson TB, Ethun KF, Pajewski NM, Golden D, Floyd E, Appt SE. Effects of bazedoxifene, conjugated equine estrogens, and a tissue-selective estrogen complex containing both bazedoxifene and conjugated equine estrogens on cerebral artery atherosclerosis in postmenopausal monkeys. Menopause. 2014 Jan; 21(1):8-14. PMID: 23676638.
      Citations:    
    37. Eyster K, Appt S, Chalpe A, Register T, Clarkson T. Effects of equol on gene expression in female cynomolgus monkey iliac arteries. Nutr Metab Cardiovasc Dis. 2014 Apr; 24(4):423-7. PMID: 24525253.
      Citations:    
    38. Stephens SM, Pau FK, Yalcinkaya TM, May MC, Berga SL, Post MD, Appt SE, Polotsky AJ. Assessing the pulsatility of luteinizing hormone in female vervet monkeys (Chlorocebus aethiops sabaeus). Comp Med. 2013 Oct; 63(5):432-8. PMID: 24210020.
      Citations:    
    39. Ethun KF, Wood CE, Cline JM, Register TC, Appt SE, Clarkson TB. Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model. Menopause. 2013 Jul; 20(7):777-84. PMID: 23793168.
      Citations:    
    40. Sophonsritsuk A, Appt SE, Clarkson TB, Shively CA, Espeland MA, Register TC. Differential effects of estradiol on carotid artery inflammation when administered early versus late after surgical menopause. Menopause. 2013 May; 20(5):540-7. PMID: 23615645.
      Citations:    
    41. Clarkson TB, Ethun KF, Chen H, Golden D, Floyd E, Appt SE. Effects of bazedoxifene alone and with conjugated equine estrogens on coronary and peripheral artery atherosclerosis in postmenopausal monkeys. Menopause. 2013 Mar; 20(3):274-81. PMID: 23435024.
      Citations:    
    42. Clarkson TB, Meléndez GC, Appt SE. Timing hypothesis for postmenopausal hormone therapy: its origin, current status, and future. Menopause. 2013 Mar; 20(3):342-53. PMID: 23435033.
      Citations:    
    43. Kundu MC, May MC, Chosich J, Bradford AP, Lasley B, Gee N, Santoro N, Appt SE, Polotsky AJ. Assessment of luteal function in the vervet monkey as a means to develop a model for obesity-related reproductive phenotype. Syst Biol Reprod Med. 2013 Apr; 59(2):74-81. PMID: 23278149.
      Citations:    
    44. Appt SE, Chen H, Clarkson TB, Kaplan JR. Premenopausal antimüllerian hormone concentration is associated with subsequent atherosclerosis. Menopause. 2012 Dec; 19(12):1353-9. PMID: 22929037.
      Citations:    
    45. Ethun KF, Wood CE, Register TC, Cline JM, Appt SE, Clarkson TB. Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys. Menopause. 2012 Nov; 19(11):1242-52. PMID: 23103754.
      Citations:    
    46. Schnatz PF, Vila-Wright S, Jiang X, Register TC, Kaplan JR, Clarkson TB, Appt SE. The association between plasma 25-hydroxyvitamin D3 concentrations, C-reactive protein levels, and coronary artery atherosclerosis in postmenopausal monkeys. Menopause. 2012 Oct; 19(10):1074-80. PMID: 22713861.
      Citations:    
    47. Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE. Coronary artery vitamin D receptor expression and plasma concentrations of 25-hydroxyvitamin D: their association with atherosclerosis. Menopause. 2012 Sep; 19(9):967-73. PMID: 22617336.
      Citations:    
    48. Schnatz PF, Marakovits KA, O'Sullivan DM, Ethun K, Clarkson TB, Appt SE. Response to an adequate dietary intake of vitamin D3 modulates the effect of estrogen therapy on bone density. J Womens Health (Larchmt). 2012 Aug; 21(8):858-64. PMID: 22691032.
      Citations:    
    49. Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE. The quantification of vitamin D receptors in coronary arteries and their association with atherosclerosis. Maturitas. 2012 Oct; 73(2):143-7. PMID: 22542390.
      Citations:    
    50. Ulu A, Appt S, Morisseau C, Hwang SH, Jones PD, Rose TE, Dong H, Lango J, Yang J, Tsai HJ, Miyabe C, Fortenbach C, Adams MR, Hammock BD. Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys. Br J Pharmacol. 2012 Mar; 165(5):1401-12. PMID: 21880036.
      Citations:    
    51. Eyster KM, Appt SE, Mark-Kappeler CJ, Chalpe A, Register TC, Clarkson TB. Gene expression signatures differ with extent of atherosclerosis in monkey iliac artery. Menopause. 2011 Oct; 18(10):1087-95. PMID: 21646924.
      Citations:    
    52. Ethun KF, Cline JM, Appt SE. Endocrine profile of an ovariectomized cynomolgus monkey (Macaca fascicularis) with a supernumerary ovary. Comp Med. 2011 Oct; 61(5):462-6. PMID: 22330356.
      Citations:    
    53. Schnatz PF, Nudy M, O'Sullivan DM, Ethun K, Appt SE, Clarkson TB. Identification of a mechanism for increased cardiovascular risk among individuals with low vitamin D concentrations. Menopause. 2011 Sep; 18(9):994-1000. PMID: 21593696.
      Citations:    
    54. Ethun KF, Wood CE, Parker CR, Kaplan JR, Chen H, Appt SE. Effect of ovarian aging on androgen biosynthesis in a cynomolgus macaque model. Climacteric. 2012 Feb; 15(1):82-92. PMID: 21864136.
      Citations:    
    55. Hamilton RT, Rettberg JR, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. Hippocampal responsiveness to 17ß-estradiol and equol after long-term ovariectomy: implication for a therapeutic window of opportunity. Brain Res. 2011 Mar 16; 1379:11-22. PMID: 21241683.
      Citations:    
    56. Rettberg JR, Hamilton RT, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys. Brain Res. 2011 Mar 16; 1379:23-33. PMID: 21238431.
      Citations:    
    57. Kaplan JR, Chen H, Appt SE, Lees CJ, Franke AA, Berga SL, Wilson ME, Manuck SB, Clarkson TB. Impairment of ovarian function and associated health-related abnormalities are attributable to low social status in premenopausal monkeys and not mitigated by a high-isoflavone soy diet. Hum Reprod. 2010 Dec; 25(12):3083-94. PMID: 20956266.
      Citations:    
    58. Appt SE, Clarkson TB, Hoyer PB, Kock ND, Goode AK, May MC, Persyn JT, Vail NK, Ethun KF, Chen H, Sen N, Kaplan JR. Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis). Comp Med. 2010 Oct; 60(5):380-8. PMID: 21262124.
      Citations:    
    59. Appt SE, Chen H, Goode AK, Hoyer PB, Clarkson TB, Adams MR, Wilson ME, Franke AA, Kaplan JR. The effect of diet and cardiovascular risk on ovarian aging in cynomolgus monkeys (Macaca fascicularis). Menopause. 2010 Jul; 17(4):741-8. PMID: 20458254.
      Citations:    
    60. Jones JC, Appt SE, Werre SR, Tan JC, Kaplan JR. Validation of multi-detector computed tomography as a non-invasive method for measuring ovarian volume in macaques (Macaca fascicularis). Am J Primatol. 2010 Jun; 72(6):530-8. PMID: 20131358.
      Citations:    
    61. Appt SE, Ethun KF. Reproductive aging and risk for chronic disease: Insights from studies of nonhuman primates. Maturitas. 2010 Sep; 67(1):7-14. PMID: 20430541.
      Citations:    
    62. Appt SE, Clarkson TB, Chen H, Adams MR, Christian PJ, Hoyer PB, Wilson ME, Kaplan JR. Serum antimüllerian hormone predicts ovarian reserve in a monkey model. Menopause. 2009 May-Jun; 16(3):597-601. PMID: 19188851.
      Citations:    
    63. Muhammad FS, Goode AK, Kock ND, Arifin EA, Cline JM, Adams MR, Hoyer PB, Christian PJ, Isom S, Kaplan JR, Appt SE. Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes. Comp Med. 2009 Feb; 59(1):46-59. PMID: 19295054.
      Citations:    
    64. Törmälä R, Appt S, Clarkson TB, Mueck AO, Seeger H, Mikkola TS, Ylikorkala O. Impact of soy supplementation on sex steroids and vascular inflammation markers in postmenopausal women using tibolone: role of equol production capability. Climacteric. 2008 Oct; 11(5):409-15. PMID: 18781486.
      Citations:    
    65. Walker SE, Register TC, Appt SE, Adams MR, Clarkson TB, Chen H, Isom S, Franke AA, Kaplan JR. Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burden. Menopause. 2008 Sep-Oct; 15(5):950-7. PMID: 18427358.
      Citations:    
    66. Appt SE, Törmälä R, Franke AA, Mikkola TS, Tikkanen MJ, Ylikorkala O, Clarkson TB. Soy-tibolone combination - effect on lipids in postmenopausal monkeys and women. Maturitas. 2008 Jul-Aug; 60(3-4):216-22. PMID: 18687539.
      Citations:    
    67. Wood CE, Hester JM, Appt SE, Geisinger KR, Cline JM. Estrogen effects on epithelial proliferation and benign proliferative lesions in the postmenopausal primate mammary gland. Lab Invest. 2008 Sep; 88(9):938-48. PMID: 18607345.
      Citations:    
    68. Appt SE. Peer review and reflection continues forever. Fertil Steril. 2008 Apr; 89(4):1034-5. PMID: 18325504.
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    69. Törmälä RM, Appt S, Clarkson TB, Tikkanen MJ, Ylikorkala O, Mikkola TS. Individual differences in equol production capability modulate blood pressure in tibolone-treated postmenopausal women: lack of effect of soy supplementation. Climacteric. 2007 Dec; 10(6):471-9. PMID: 18049940.
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    70. Törmälä R, Appt S, Clarkson TB, Groop PH, Rönnback M, Ylikorkala O, Mikkola TS. Equol production capability is associated with favorable vascular function in postmenopausal women using tibolone; no effect with soy supplementation. Atherosclerosis. 2008 May; 198(1):174-8. PMID: 17961576.
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    71. Jones JC, Appt SE, Bourland JD, Hoyer PB, Clarkson TB, Kaplan JR. Multidetector computed tomographic morphology of ovaries in cynomolgus macaques (Macaca fascicularis). J Am Assoc Lab Anim Sci. 2007 Sep; 46(5):54-63. PMID: 17877330.
      Citations:    
    72. Appt SE, Kaplan JR, Clarkson TB, Cline JM, Christian PJ, Hoyer PB. Destruction of primordial ovarian follicles in adult cynomolgus macaques after exposure to 4-vinylcyclohexene diepoxide: a nonhuman primate model of the menopausal transition. Fertil Steril. 2006 Oct; 86(4 Suppl):1210-6. PMID: 16952357.
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    73. Stroud FC, Appt SE, Wilson ME, Franke AA, Adams MR, Kaplan JR. Concentrations of isoflavones in macaques consuming standard laboratory monkey diet. J Am Assoc Lab Anim Sci. 2006 Jul; 45(4):20-3. PMID: 16884174.
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    74. Wood CE, Appt SE, Clarkson TB, Franke AA, Lees CJ, Doerge DR, Cline JM. Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys. Biol Reprod. 2006 Sep; 75(3):477-86. PMID: 16723506.
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    75. Appt SE, Clarkson TB, Lees CJ, Anthony MS. Low dose estrogens inhibit coronary artery atherosclerosis in postmenopausal monkeys. Maturitas. 2006 Sep 20; 55(2):187-94. PMID: 16574351.
      Citations:    
    76. Wood CE, Clarkson TB, Appt SE, Franke AA, Boue SM, Burow ME, McCoy T, Cline JM. Effects of soybean glyceollins and estradiol in postmenopausal female monkeys. Nutr Cancer. 2006; 56(1):74-81. PMID: 17176220.
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    77. Badeau M, Tikkanen MJ, Appt SE, Adlercreutz H, Clarkson TB, Hoikkala A, Wähälä K, Mikkola TS. Determination of plasma genistein fatty acid esters following administration of genistein or genistein 4'7-O-dioleate in monkeys. Biochim Biophys Acta. 2005 Dec 30; 1738(1-3):115-20. PMID: 16326136.
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    78. Clarkson TB, Appt SE. Controversies about HRT--lessons from monkey models. Maturitas. 2005 May 16; 51(1):64-74. PMID: 15883111.
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    79. Clarkson TB, Appt SE, Wood CE, Cline JM. Lessons to be learned from animal studies on hormones and the breast. Maturitas. 2004 Sep 24; 49(1):79-89. PMID: 15351099.
      Citations:    
    80. Pazol K, Kaplan JR, Abbott D, Appt SE, Wilson ME. Practical measurement of total and bioavailable estradiol in female macaques. Clin Chim Acta. 2004 Feb; 340(1-2):117-26. PMID: 14734203.
      Citations:    
    81. Appt SE. Usefulness of the monkey model to investigate the role soy in postmenopausal women's health. ILAR J. 2004; 45(2):200-11. PMID: 15111739.
      Citations:    
    82. Clarkson TB, Appt SE. MPA and postmenopausal coronary artery atherosclerosis revisited. Steroids. 2003 Nov; 68(10-13):941-51. PMID: 14667987.
      Citations:    
    83. Blair RM, Appt SE, Franke AA, Clarkson TB. Treatment with antibiotics reduces plasma equol concentration in cynomolgus monkeys (Macaca fascicularis). J Nutr. 2003 Jul; 133(7):2262-7. PMID: 12840190.
      Citations:    
    84. Blair RM, Appt SE, Bennetau-Pelissero C, Clarkson TB, Anthony MS, Lamothe V, Potter SM. Dietary soy and soy isoflavones have gender-specific effects on plasma lipids and isoflavones in golden Syrian f(1)b hybrid hamsters. J Nutr. 2002 Dec; 132(12):3585-91. PMID: 12468592.
      Citations:    
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