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Last Name

Rong Chen, Ph.D.

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentPhysiology and Pharmacology
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    Collapse Research 
    Collapse research activities and funding
    R03DA025954     (CHEN, RONG)Jun 1, 2009 - May 31, 2011
    NIH/NIDA
    PKC-beta Regulation of the Dopmaine Transporter Trafficking
    Role: Principal Investigator

    R03DA030890     (CHEN, RONG)Sep 15, 2010 - Aug 31, 2013
    NIH/NIDA
    Transporter Mechanism of Amphetamine Sensitization
    Role: Principal Investigator

    R01DA042862     (CHEN, RONG)Sep 1, 2017 - Jul 31, 2022
    NIH/NIDA
    RGS2 regulation of D2 receptor signaling
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Luessen DJ, Sun H, McGinnis MM, Hagstrom M, Marrs G, McCool BA, Chen R. Acute ethanol exposure reduces serotonin receptor 1A internalization by increasing ubiquitination and degradation of ß-arrestin2. J Biol Chem. 2019 Sep 20; 294(38):14068-14080. PMID: 31366729.
      View in: PubMed
    2. Severino AL, Chen R, Hayashida K, Aschenbrenner CA, Sun H, Peters CM, Gutierrez S, Pan B, Eisenach JC. Plasticity and Function of Spinal Oxytocin and Vasopressin Signaling during Recovery from Surgery with Nerve Injury. Anesthesiology. 2018 09; 129(3):544-556. PMID: 29912007.
      View in: PubMed
    3. Chen R, McIntosh S, Hemby SE, Sun H, Sexton T, Martin TJ, Childers SR. High and low doses of cocaine intake are differentially regulated by dopamine D2 receptors in the ventral tegmental area and the nucleus accumbens. Neurosci Lett. 2018 04 03; 671:133-139. PMID: 29454035.
      View in: PubMed
    4. Siciliano CA, Saha K, Calipari ES, Fordahl SC, Chen R, Khoshbouei H, Jones SR. Amphetamine Reverses Escalated Cocaine Intake via Restoration of Dopamine Transporter Conformation. J Neurosci. 2018 01 10; 38(2):484-497. PMID: 29175958.
      View in: PubMed
    5. Luessen DJ, Sun H, McGinnis MM, McCool BA, Chen R. Chronic intermittent ethanol exposure selectively alters the expression of Ga subunit isoforms and RGS subtypes in rat prefrontal cortex. Brain Res. 2017 Oct 01; 1672:106-112. PMID: 28736108.
      View in: PubMed
    6. Blume LC, Leone-Kabler S, Luessen DJ, Marrs GS, Lyons E, Bass CE, Chen R, Selley DE, Howlett AC. Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner. J Neurochem. 2016 11; 139(3):396-407. PMID: 27513693.
      View in: PubMed
    7. Luessen DJ, Hinshaw TP, Sun H, Howlett AC, Marrs G, McCool BA, Chen R. RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells. Neuropharmacology. 2016 11; 110(Pt A):297-307. PMID: 27528587.
      View in: PubMed
    8. Rose JH, Karkhanis AN, Chen R, Gioia D, Lopez MF, Becker HC, McCool BA, Jones SR. Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens. Int J Neuropsychopharmacol. 2016 05; 19(5). PMID: 26625893.
      View in: PubMed
    9. Luessen DJ, Chen R. Journal of Biomolecular Research & Therapeutics. Psychostimulants, brain membrane lipids and dopamine transmission. 2016; (5):143.
    10. Sun H, Calipari ES, Beveridge TJ, Jones SR, Chen R. The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration. Neuroscience. 2015 Oct 29; 307:253-61. PMID: 26321241.
      View in: PubMed
    11. Li X, Li S, Zheng W, Pan J, Huang K, Chen R, Pan T, Liao G, Chen Z, Zhou D, Shen W, Zhou W, Liu Y. Environmental enrichment and abstinence attenuate ketamine-induced cardiac and renal toxicity. Sci Rep. 2015 Jun 26; 5:11611. PMID: 26112338.
      View in: PubMed
    12. Ferris MJ, Calipari ES, Rose JH, Siciliano CA, Sun H, Chen R, Jones SR. A Single Amphetamine Infusion Reverses Deficits in Dopamine Nerve-Terminal Function Caused by a History of Cocaine Self-Administration. Neuropsychopharmacology. 2015 Jul; 40(8):1826-36. PMID: 25689882.
      View in: PubMed
    13. Luderman KD, Chen R, Ferris MJ, Jones SR, Gnegy ME. Protein kinase C beta regulates the D2-like dopamine autoreceptor. Neuropharmacology. 2015 Feb; 89:335-41. PMID: 25446677.
      View in: PubMed
    14. Ferris MJ, España RA, Locke JL, Konstantopoulos JK, Rose JH, Chen R, Jones SR. Dopamine transporters govern diurnal variation in extracellular dopamine tone. Proc Natl Acad Sci U S A. 2014 Jul 01; 111(26):E2751-9. PMID: 24979798.
      View in: PubMed
    15. Calipari ES, Sun H, Eldeeb K, Luessen DJ, Feng X, Howlett AC, Jones SR, Chen R. Amphetamine self-administration attenuates dopamine D2 autoreceptor function. Neuropsychopharmacology. 2014 Jul; 39(8):1833-42. PMID: 24513972.
      View in: PubMed
    16. Chen R, Hemby SE. Journal of Addiction and Prevention. Dysregulation of RGS proteins by psychostimulants. 2014; (2):1-7.
    17. Chen R, Daining CP, Sun H, Fraser R, Stokes SL, Leitges M, Gnegy ME. Protein kinase Cß is a modulator of the dopamine D2 autoreceptor-activated trafficking of the dopamine transporter. J Neurochem. 2013 Jun; 125(5):663-72. PMID: 23458603.
      View in: PubMed
    18. Kaur K, Parra S, Chen R, Charbeneau RA, Wade SM, Jay PY, Neubig RR. Gai2 signaling: friend or foe in cardiac injury and heart failure? Naunyn Schmiedebergs Arch Pharmacol. 2012 May; 385(5):443-53. PMID: 22411356.
      View in: PubMed
    19. Perry ML, Leinninger GM, Chen R, Luderman KD, Yang H, Gnegy ME, Myers MG, Kennedy RT. Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats. J Neurochem. 2010 Aug; 114(3):666-74. PMID: 20412389.
      View in: PubMed
    20. Chen R, Furman CA, Gnegy ME. Dopamine transporter trafficking: rapid response on demand. Future Neurol. 2010 Jan 01; 5(1):123. PMID: 20174452.
      View in: PubMed
    21. Zarcone TJ, Chen R, Fowler SC. Effects of differing response-force requirements on food-maintained responding in C57Bl/6J mice. J Exp Anal Behav. 2009 Sep; 92(2):257-74. PMID: 20354603.
      View in: PubMed
    22. Furman CA, Chen R, Guptaroy B, Zhang M, Holz RW, Gnegy M. Dopamine and amphetamine rapidly increase dopamine transporter trafficking to the surface: live-cell imaging using total internal reflection fluorescence microscopy. J Neurosci. 2009 Mar 11; 29(10):3328-36. PMID: 19279270.
      View in: PubMed
    23. Chen R, Furman CA, Zhang M, Kim MN, Gereau RW, Leitges M, Gnegy ME. Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. J Pharmacol Exp Ther. 2009 Mar; 328(3):912-20. PMID: 19098163.
      View in: PubMed
    24. Zarcone TJ, Chen R, Fowler SC. Effects of differing response-force requirements on food-maintained responding in CD-1 mice. J Exp Anal Behav. 2007 Nov; 88(3):381-93. PMID: 18047228.
      View in: PubMed
    25. Chen R, Zhang M, Park S, Gnegy ME. C57BL/6J mice show greater amphetamine-induced locomotor activation and dopamine efflux in the striatum than 129S2/SvHsd mice. Pharmacol Biochem Behav. 2007 May; 87(1):158-63. PMID: 17524461.
      View in: PubMed
    26. Chen R, Wei H, Hill ER, Chen L, Jiang L, Han DD, Gu HH. Direct evidence that two cysteines in the dopamine transporter form a disulfide bond. Mol Cell Biochem. 2007 Apr; 298(1-2):41-8. PMID: 17131045.
      View in: PubMed
    27. Chen R, Tilley MR, Wei H, Zhou F, Zhou FM, Ching S, Quan N, Stephens RL, Hill ER, Nottoli T, Han DD, Gu HH. Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9333-8. PMID: 16754872.
      View in: PubMed
    28. Han DD, Chen R, Hill ER, Tilley MR, Gu HH. Cause and solutions to the polymerase chain reaction smear problem in genotyping. Anal Biochem. 2006 Jun 15; 353(2):296-8. PMID: 16626617.
      View in: PubMed
    29. Chen R, Wu X, Wei H, Han DD, Gu HH. Molecular cloning and functional characterization of the dopamine transporter from Eloria noyesi, a caterpillar pest of cocaine-rich coca plants. Gene. 2006 Jan 17; 366(1):152-60. PMID: 16310975.
      View in: PubMed
    30. Chen R, Han DD, Gu HH. A triple mutation in the second transmembrane domain of mouse dopamine transporter markedly decreases sensitivity to cocaine and methylphenidate. J Neurochem. 2005 Jul; 94(2):352-9. PMID: 15998286.
      View in: PubMed
    31. Zarcone TJ, Chen R, Fowler SC. Differential acquisition of food-reinforced disk pressing by CD-1, BALB/cJ and C57BL/6J mice. Behav Brain Res. 2004 Jun 04; 152(1):1-9. PMID: 15135964.
      View in: PubMed
    32. Chen R, Osterhaus G, McKerchar T, Fowler SC. The role of exogenous testosterone in cocaine-induced behavioral sensitization and plasmalemmal or vesicular dopamine uptake in castrated rats. Neurosci Lett. 2003 Nov 20; 351(3):161-4. PMID: 14623131.
      View in: PubMed
    33. Chen R, Wei J, Fowler SC, Wu JY. Demonstration of functional coupling between dopamine synthesis and its packaging into synaptic vesicles. J Biomed Sci. 2003 Nov-Dec; 10(6 Pt 2):774-81. PMID: 14631117.
      View in: PubMed
    34. Fowler SC, Birkestrand B, Chen R, Vorontsova E, Zarcone T. Behavioral sensitization to amphetamine in rats: changes in the rhythm of head movements during focused stereotypies. Psychopharmacology (Berl). 2003 Nov; 170(2):167-77. PMID: 12827349.
      View in: PubMed
    35. Fowler SC, Zarcone TJ, Vorontsova E, Chen R. Motor and associative deficits in D2 dopamine receptor knockout mice. Int J Dev Neurosci. 2002 Jun-Aug; 20(3-5):309-21. PMID: 12175868.
      View in: PubMed
    36. Fowler SC, Zarcone TJ, Chen R, Taylor MD, Wright DE. Low grip strength, impaired tongue force and hyperactivity induced by overexpression of neurotrophin-3 in mouse skeletal muscle. Int J Dev Neurosci. 2002 Jun-Aug; 20(3-5):303-8. PMID: 12175867.
      View in: PubMed
    37. Moss SJ, Wang G, Chen R, Pal R, Fowler SC. 3-acetylpyridine reduces tongue protrusion force but does not abolish lick rhythm in the rat. Brain Res. 2001 Nov 30; 920(1-2):1-9. PMID: 11716805.
      View in: PubMed
    38. Fowler SC, Birkestrand BR, Chen R, Moss SJ, Vorontsova E, Wang G, Zarcone TJ. A force-plate actometer for quantitating rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor. J Neurosci Methods. 2001 May 30; 107(1-2):107-24. PMID: 11389948.
      View in: PubMed
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