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Neveen Said MD, PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentCancer Biology
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentPathology

    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentUrology


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    R01CA193437     (SAID, NEVEEN)Jan 11, 2016 - Dec 31, 2020
    NIH
    Regulation of Urinary Bladder Carcinogenesis and Progression by SPARC
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Afify H, Ghoneum A, Almousa S, Abdulfattah AY, Warren B, Langsten K, Gonzalez D, Casals R, Bharadwaj M, Kridel S, Said N. Metabolomic credentialing of murine carcinogen-induced urothelial cancer. Sci Rep. 2021 11 11; 11(1):22085. PMID: 34764423.
      Citations:    
    2. Tu A, Said N, Muddiman DC. Spatially resolved metabolomic characterization of muscle invasive bladder cancer by mass spectrometry imaging. Metabolomics. 2021 07 21; 17(8):70. PMID: 34287708.
      Citations:    
    3. Tu A, Garrard KP, Said N, Muddiman DC. In situ detection of fatty acid C=C positional isomers by coupling on-tissue mCPBA epoxidation with infrared matrix-assisted laser desorption electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom. 2021 Jul 15; 35(13):e9119. PMID: 33942403.
      Citations:    
    4. Ghoneum A, Almousa S, Warren B, Abdulfattah AY, Shu J, Abouelfadl H, Gonzalez D, Livingston C, Said N. Exploring the clinical value of tumor microenvironment in platinum-resistant ovarian cancer. Semin Cancer Biol. 2021 Jan 18. PMID: 33476723.
      Citations:    
    5. Hu L, He F, Huang M, Zhao Q, Cheng L, Said N, Zhou Z, Liu F, Dai YS. SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic ß cells. Sci Rep. 2020 10 16; 10(1):17581. PMID: 33067534.
      Citations:    
    6. Huttanus HM, Vu T, Guruli G, Tracey A, Carswell W, Said N, Du P, Parkinson BG, Orlando G, Robertson JL, Senger RS. Raman chemometric urinalysis (Rametrix) as a screen for bladder cancer. PLoS One. 2020; 15(8):e0237070. PMID: 32822394.
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    7. Ghoneum A, Gonzalez D, Abdulfattah AY, Said N. Metabolic Plasticity in Ovarian Cancer Stem Cells. Cancers (Basel). 2020 May 17; 12(5). PMID: 32429566.
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    8. Ghoneum A, Abdulfattah AY, Warren BO, Shu J, Said N. Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics. Int J Mol Sci. 2020 Apr 28; 21(9). PMID: 32354000.
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    9. Ghoneum A, Abdulfattah AY, Said N. Targeting the PI3K/AKT/mTOR/NF?B Axis in Ovarian Cancer. J Cell Immunol. 2020; 2(2):68-73. PMID: 32395722.
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    10. Biswas K, Sarkar S, Said N, Brautigan DL, Larner JM. Aurora B Kinase Promotes CHIP-Dependent Degradation of HIF1a in Prostate Cancer Cells. Mol Cancer Ther. 2020 04; 19(4):1008-1017. PMID: 31848297.
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    11. Ghoneum A, Said N. PI3K-AKT-mTOR and NF?B Pathways in Ovarian Cancer: Implications for Targeted Therapeutics. Cancers (Basel). 2019 Jul 05; 11(7). PMID: 31284467.
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    12. Said N. Establishing and characterization of human and murine bladder cancer organoids. Transl Androl Urol. 2019 Jul; 8(Suppl 3):S310-S313. PMID: 31392155.
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    13. John B, Naczki C, Patel C, Ghoneum A, Qasem S, Salih Z, Said N. Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC. Oncogene. 2019 05; 38(22):4366-4383. PMID: 30765860.
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    14. Said N. Screening of three-dimensional spheroids of ovarian cancer: identification of novel therapeutics targeting stemness and chemoresistance. Ann Transl Med. 2018 Nov; 6(Suppl 1):S26. PMID: 30613601.
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    15. Naczki C, John B, Patel C, Lafferty A, Ghoneum A, Afify H, White M, Davis A, Jin G, Kridel S, Said N. SPARC Inhibits Metabolic Plasticity in Ovarian Cancer. Cancers (Basel). 2018 Oct 16; 10(10). PMID: 30332737.
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    16. Ghoneum A, Afify H, Salih Z, Kelly M, Said N. Role of tumor microenvironment in the pathobiology of ovarian cancer: Insights and therapeutic opportunities. Cancer Med. 2018 10; 7(10):5047-5056. PMID: 30133163.
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    17. Samykutty A, Grizzle WE, Fouts BL, McNally MW, Chuong P, Thomas A, Chiba A, Otali D, Woloszynska A, Said N, Frederick PJ, Jasinski J, Liu J, McNally LR. Optoacoustic imaging identifies ovarian cancer using a microenvironment targeted theranostic wormhole mesoporous silica nanoparticle. Biomaterials. 2018 11; 182:114-126. PMID: 30118979.
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    18. Ghoneum A, Afify H, Salih Z, Kelly M, Said N. Role of tumor microenvironment in ovarian cancer pathobiology. Oncotarget. 2018 Apr 27; 9(32):22832-22849. PMID: 29854318.
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    19. John BA, Said N. Insights from animal models of bladder cancer: recent advances, challenges, and opportunities. Oncotarget. 2017 Aug 22; 8(34):57766-57781. PMID: 28915710.
      Citations:    
    20. Said N. Roles of SPARC in urothelial carcinogenesis, progression and metastasis. Oncotarget. 2016 Oct 11; 7(41):67574-67585. PMID: 27564266.
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    21. Sharma S, Xing F, Liu Y, Wu K, Said N, Pochampally R, Shiozawa Y, Lin HK, Balaji KC, Watabe K. Secreted Protein Acidic and Rich in Cysteine (SPARC) Mediates Metastatic Dormancy of Prostate Cancer in Bone. J Biol Chem. 2016 09 09; 291(37):19351-63. PMID: 27422817.
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    22. ElShamy WM, Sinha A, Said N. Aggressiveness Niche: Can It Be the Foster Ground for Cancer Metastasis Precursors? Stem Cells Int. 2016; 2016:4829106. PMID: 27493669.
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    23. Abbasi A, Khalaj M, Akiyama K, Mukai Y, Matsumoto H, Acosta TJ, Said N, Yoshida M, Kunieda T. Lack of Rev7 function results in development of tubulostromal adenomas in mouse ovary. Mol Cell Endocrinol. 2015 Sep 05; 412:19-25. PMID: 26004212.
      Citations:    
    24. Sobeih D, Hussein KA, Said N, Motamed K, Al-Shabrawey M. Deletion of SPARC Enhances Retinal Vaso-Obliteration in Mouse Model of Oxygen-Induced Retinopathy. HSOA J Ophthalmol Clin Res. 2014 Dec; 1(1). PMID: 26636134.
      Citations:    
    25. Said N, Frierson HF, Sanchez-Carbayo M, Brekken RA, Theodorescu D. Loss of SPARC in bladder cancer enhances carcinogenesis and progression. J Clin Invest. 2013 Feb; 123(2):751-66. PMID: 23321672.
      Citations:    
    26. Said N, Theodorescu D. RhoGDI2 suppresses bladder cancer metastasis via reduction of inflammation in the tumor microenvironment. Oncoimmunology. 2012 Oct 01; 1(7):1175-1177. PMID: 23170270.
      Citations:    
    27. Said N, Theodorescu D. Permissive role of endothelin receptors in tumor metastasis. Life Sci. 2012 Oct 15; 91(13-14):522-7. PMID: 22846215.
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    28. Al-Hassan NN, Behzadian A, Caldwell R, Ivanova VS, Syed V, Motamed K, Said NA. Differential roles of uPAR in peritoneal ovarian carcinomatosis. Neoplasia. 2012 Apr; 14(4):259-70. PMID: 22577342.
      Citations:    
    29. Said N, Sanchez-Carbayo M, Smith SC, Theodorescu D. RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration. J Clin Invest. 2012 Apr; 122(4):1503-18. PMID: 22406535.
      Citations:    
    30. Said N, Smith S, Sanchez-Carbayo M, Theodorescu D. Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer. J Clin Invest. 2011 Jan; 121(1):132-47. PMID: 21183790.
      Citations:    
    31. Said N, Theodorescu D. Pathways of metastasis suppression in bladder cancer. Cancer Metastasis Rev. 2009 Dec; 28(3-4):327-33. PMID: 20013033.
      Citations:    
    32. Socha MJ, Said N, Dai Y, Kwong J, Ramalingam P, Trieu V, Desai N, Mok SC, Motamed K. Aberrant promoter methylation of SPARC in ovarian cancer. Neoplasia. 2009 Feb; 11(2):126-35. PMID: 19177197.
      Citations:    
    33. Said NA, Elmarakby AA, Imig JD, Fulton DJ, Motamed K. SPARC ameliorates ovarian cancer-associated inflammation. Neoplasia. 2008 Oct; 10(10):1092-104. PMID: 18813349.
      Citations:    
    34. Said N, Socha MJ, Olearczyk JJ, Elmarakby AA, Imig JD, Motamed K. Normalization of the ovarian cancer microenvironment by SPARC. Mol Cancer Res. 2007 Oct; 5(10):1015-30. PMID: 17951402.
      Citations:    
    35. Socha MJ, Manhiani M, Said N, Imig JD, Motamed K. Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension. Am J Pathol. 2007 Oct; 171(4):1104-12. PMID: 17717147.
      Citations:    
    36. Said N, Najwer I, Motamed K. Secreted protein acidic and rich in cysteine (SPARC) inhibits integrin-mediated adhesion and growth factor-dependent survival signaling in ovarian cancer. Am J Pathol. 2007 Mar; 170(3):1054-63. PMID: 17322388.
      Citations:    
    37. Said NA, Najwer I, Socha MJ, Fulton DJ, Mok SC, Motamed K. SPARC inhibits LPA-mediated mesothelial-ovarian cancer cell crosstalk. Neoplasia. 2007 Jan; 9(1):23-35. PMID: 17325741.
      Citations:    
    38. Said N, Motamed K. Absence of host-secreted protein acidic and rich in cysteine (SPARC) augments peritoneal ovarian carcinomatosis. Am J Pathol. 2005 Dec; 167(6):1739-52. PMID: 16314484.
      Citations:    
    39. Said NA, Shoeir AT, Panjwani N, Garate M, Cao Z. Local and systemic humoral immune response during acute and chronic Acanthamoeba keratitis in rabbits. Curr Eye Res. 2004 Dec; 29(6):429-39. PMID: 15764087.
      Citations:    
    40. Cao Z, Said N, Wu HK, Kuwabara I, Liu FT, Panjwani N. Galectin-7 as a potential mediator of corneal epithelial cell migration. Arch Ophthalmol. 2003 Jan; 121(1):82-6. PMID: 12523890.
      Citations:    
    41. Cao Z, Said N, Amin S, Wu HK, Bruce A, Garate M, Hsu DK, Kuwabara I, Liu FT, Panjwani N. Galectins-3 and -7, but not galectin-1, play a role in re-epithelialization of wounds. J Biol Chem. 2002 Nov 01; 277(44):42299-305. PMID: 12194966.
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    42. Kouros M, Said N. Cancer Research. Polymeric albumin-free paclitaxel intraperitoneal therapy demonstrates superior efficacy over nab-paclitaxel intravenous therapy in a mouse model of metastatic ovarian cancer. 75(Suppl 15):5532.
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