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Last Name

Neveen Said, M.D., Ph.D.

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentCancer Biology
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    Other Positions
    TitleAssistant Professor
    InstitutionWake Forest School of Medicine
    DepartmentPathology

    TitleAssistant Professor
    InstitutionWake Forest School of Medicine
    DepartmentSurgical Sciences-Urology


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    R01CA193437     (SAID, NEVEEN)Jan 11, 2016 - Dec 31, 2020
    NIH/NCI
    Regulation of Urinary Bladder Carcinogenesis and Progression by SPARC
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ghoneum A, Said N. PI3K-AKT-mTOR and NF?B Pathways in Ovarian Cancer: Implications for Targeted Therapeutics. Cancers (Basel). 2019 Jul 05; 11(7). PMID: 31284467.
      View in: PubMed
    2. Said N. Establishing and characterization of human and murine bladder cancer organoids. Transl Androl Urol. 2019 Jul; 8(Suppl 3):S310-S313. PMID: 31392155.
      View in: PubMed
    3. John B, Naczki C, Patel C, Ghoneum A, Qasem S, Salih Z, Said N. Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC. Oncogene. 2019 May; 38(22):4366-4383. PMID: 30765860.
      View in: PubMed
    4. Said N. Screening of three-dimensional spheroids of ovarian cancer: identification of novel therapeutics targeting stemness and chemoresistance. Ann Transl Med. 2018 Nov; 6(Suppl 1):S26. PMID: 30613601.
      View in: PubMed
    5. Naczki C, John B, Patel C, Lafferty A, Ghoneum A, Afify H, White M, Davis A, Jin G, Kridel S, Said N. SPARC Inhibits Metabolic Plasticity in Ovarian Cancer. Cancers (Basel). 2018 Oct 16; 10(10). PMID: 30332737.
      View in: PubMed
    6. Ghoneum A, Afify H, Salih Z, Kelly M, Said N. Role of tumor microenvironment in the pathobiology of ovarian cancer: Insights and therapeutic opportunities. Cancer Med. 2018 Oct; 7(10):5047-5056. PMID: 30133163.
      View in: PubMed
    7. Samykutty A, Grizzle WE, Fouts BL, McNally MW, Chuong P, Thomas A, Chiba A, Otali D, Woloszynska A, Said N, Frederick PJ, Jasinski J, Liu J, McNally LR. Optoacoustic imaging identifies ovarian cancer using a microenvironment targeted theranostic wormhole mesoporous silica nanoparticle. Biomaterials. 2018 11; 182:114-126. PMID: 30118979.
      View in: PubMed
    8. Ghoneum A, Afify H, Salih Z, Kelly M, Said N. Role of tumor microenvironment in ovarian cancer pathobiology. Oncotarget. 2018 Apr 27; 9(32):22832-22849. PMID: 29854318.
      View in: PubMed
    9. John BA, Said N. Insights from animal models of bladder cancer: recent advances, challenges, and opportunities. Oncotarget. 2017 Aug 22; 8(34):57766-57781. PMID: 28915710.
      View in: PubMed
    10. Said N. Roles of SPARC in urothelial carcinogenesis, progression and metastasis. Oncotarget. 2016 Oct 11; 7(41):67574-67585. PMID: 27564266.
      View in: PubMed
    11. Sharma S, Xing F, Liu Y, Wu K, Said N, Pochampally R, Shiozawa Y, Lin HK, Balaji KC, Watabe K. Secreted Protein Acidic and Rich in Cysteine (SPARC) Mediates Metastatic Dormancy of Prostate Cancer in Bone. J Biol Chem. 2016 09 09; 291(37):19351-63. PMID: 27422817.
      View in: PubMed
    12. ElShamy WM, Sinha A, Said N. Aggressiveness Niche: Can It Be the Foster Ground for Cancer Metastasis Precursors? Stem Cells Int. 2016; 2016:4829106. PMID: 27493669.
      View in: PubMed
    13. Saad M, Kamar M, Said N. Diabetes Technology & Therapeutics . 198 The Relation between glucose variability and painful neuropathy in type 2 diabetes. 2016; 18(Suppl 1):A80.
    14. Abbasi A, Khalaj M, Akiyama K, Mukai Y, Matsumoto H, Acosta TJ, Said N, Yoshida M, Kunieda T. Lack of Rev7 function results in development of tubulostromal adenomas in mouse ovary. Mol Cell Endocrinol. 2015 Sep 05; 412:19-25. PMID: 26004212.
      View in: PubMed
    15. Said N, Frierson HF, Sanchez-Carbayo M, Brekken RA, Theodorescu D. Loss of SPARC in bladder cancer enhances carcinogenesis and progression. J Clin Invest. 2013 Feb; 123(2):751-66. PMID: 23321672.
      View in: PubMed
    16. Said N, Theodorescu D. RhoGDI2 suppresses bladder cancer metastasis via reduction of inflammation in the tumor microenvironment. Oncoimmunology. 2012 Oct 01; 1(7):1175-1177. PMID: 23170270.
      View in: PubMed
    17. Al-Hassan NN, Behzadian A, Caldwell R, Ivanova VS, Syed V, Motamed K, Said NA. Differential roles of uPAR in peritoneal ovarian carcinomatosis. Neoplasia. 2012 Apr; 14(4):259-70. PMID: 22577342.
      View in: PubMed
    18. Said N, Sanchez-Carbayo M, Smith SC, Theodorescu D. RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration. J Clin Invest. 2012 Apr; 122(4):1503-18. PMID: 22406535.
      View in: PubMed
    19. Said N, Smith S, Sanchez-Carbayo M, Theodorescu D. Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer. J Clin Invest. 2011 Jan; 121(1):132-47. PMID: 21183790.
      View in: PubMed
    20. Socha MJ, Said N, Dai Y, Kwong J, Ramalingam P, Trieu V, Desai N, Mok SC, Motamed K. Aberrant promoter methylation of SPARC in ovarian cancer. Neoplasia. 2009 Feb; 11(2):126-35. PMID: 19177197.
      View in: PubMed
    21. Said NA, Elmarakby AA, Imig JD, Fulton DJ, Motamed K. SPARC ameliorates ovarian cancer-associated inflammation. Neoplasia. 2008 Oct; 10(10):1092-104. PMID: 18813349.
      View in: PubMed
    22. Said N, Socha MJ, Olearczyk JJ, Elmarakby AA, Imig JD, Motamed K. Normalization of the ovarian cancer microenvironment by SPARC. Mol Cancer Res. 2007 Oct; 5(10):1015-30. PMID: 17951402.
      View in: PubMed
    23. Socha MJ, Manhiani M, Said N, Imig JD, Motamed K. Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension. Am J Pathol. 2007 Oct; 171(4):1104-12. PMID: 17717147.
      View in: PubMed
    24. Said N, Najwer I, Motamed K. Secreted protein acidic and rich in cysteine (SPARC) inhibits integrin-mediated adhesion and growth factor-dependent survival signaling in ovarian cancer. Am J Pathol. 2007 Mar; 170(3):1054-63. PMID: 17322388.
      View in: PubMed
    25. Said NA, Najwer I, Socha MJ, Fulton DJ, Mok SC, Motamed K. SPARC inhibits LPA-mediated mesothelial-ovarian cancer cell crosstalk. Neoplasia. 2007 Jan; 9(1):23-35. PMID: 17325741.
      View in: PubMed
    26. Said N, Motamed K. Absence of host-secreted protein acidic and rich in cysteine (SPARC) augments peritoneal ovarian carcinomatosis. Am J Pathol. 2005 Dec; 167(6):1739-52. PMID: 16314484.
      View in: PubMed
    27. Cao Z, Said N, Amin S, Wu HK, Bruce A, Garate M, Hsu DK, Kuwabara I, Liu FT, Panjwani N. Galectins-3 and -7, but not galectin-1, play a role in re-epithelialization of wounds. J Biol Chem. 2002 Nov 01; 277(44):42299-305. PMID: 12194966.
      View in: PubMed
    28. Kouros M, Said N. Cancer Research. Polymeric albumin-free paclitaxel intraperitoneal therapy demonstrates superior efficacy over nab-paclitaxel intravenous therapy in a mouse model of metastatic ovarian cancer. 75(Suppl 15):5532.
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