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Michael C.Seeds PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentWake Forest Institute for Regenerative Medicine
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    Other Positions
    TitleAssistant Professor
    InstitutionWake Forest School of Medicine
    DepartmentInternal Medicine, Molecular Medicine

    TitleAssistant Professor
    InstitutionWake Forest School of Medicine
    DepartmentInternal Medicine, Pulmonary, Critical Care, Allergy and Immunologic Diseases


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reynolds LM, Howard TD, Ruczinski I, Kanchan K, Seeds MC, Mathias RA, Chilton FH. Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression. PLoS One. 2018; 13(3):e0194610. PMID: 29590160.
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    2. Chilton FH, Dutta R, Reynolds LM, Sergeant S, Mathias RA, Seeds MC. Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases. Nutrients. 2017 Oct 25; 9(11). PMID: 29068398.
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    3. Rahbar E, Ainsworth HC, Howard TD, Hawkins GA, Ruczinski I, Mathias R, Seeds MC, Sergeant S, Hixson JE, Herrington DM, Langefeld CD, Chilton FH. Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster. PLoS One. 2017; 12(9):e0180903. PMID: 28957329.
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    4. Bass DA, Parce JW, Dechatelet LR, Szejda P, Seeds MC, Thomas M. Pillars Article: Flow Cytometric Studies of Oxidative Product Formation by Neutrophils: A Graded Response to Membrane Stimulation. J. Immunol. 1983. 130: 1910-1917. J Immunol. 2016 08 01; 197(3):683-90. PMID: 27431983.
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    5. Cui T, Hester AG, Seeds MC, Rahbar E, Howard TD, Sergeant S, Chilton FH. Impact of Genetic and Epigenetic Variations Within the FADS Cluster on the Composition and Metabolism of Polyunsaturated Fatty Acids in Prostate Cancer. Prostate. 2016 09; 76(13):1182-91. PMID: 27197070.
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    6. Miller LR, Jorgensen MJ, Kaplan JR, Seeds MC, Rahbar E, Morgan TM, Welborn A, Chilton SM, Gillis J, Hester A, Rukstalis M, Sergeant S, Chilton FH. Alterations in levels and ratios of n-3 and n-6 polyunsaturated fatty acids in the temporal cortex and liver of vervet monkeys from birth to early adulthood. Physiol Behav. 2016 Mar 15; 156:71-8. PMID: 26705667.
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    7. Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O. Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Sci Transl Med. 2015 Mar 11; 7(278):278ra32. PMID: 25761888.
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    8. Chilton FH, Murphy RC, Wilson BA, Sergeant S, Ainsworth H, Seeds MC, Mathias RA. Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. Nutrients. 2014 May 21; 6(5):1993-2022. PMID: 24853887.
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    9. Howard TD, Mathias RA, Seeds MC, Herrington DM, Hixson JE, Shimmin LC, Hawkins GA, Sellers M, Ainsworth HC, Sergeant S, Miller LR, Chilton FH. DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver. PLoS One. 2014; 9(5):e97510. PMID: 24842322.
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    10. Seeds MC, Grier BL, Suckling BN, Safta AM, Long DL, Waite BM, Morris PE, Hite RD. Secretory phospholipase A2-mediated depletion of phosphatidylglycerol in early acute respiratory distress syndrome. Am J Med Sci. 2012 Jun; 343(6):446-51. PMID: 22173044.
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    11. Hite RD, Grier BL, Waite BM, Veldhuizen RA, Possmayer F, Yao LJ, Seeds MC. Surfactant protein B inhibits secretory phospholipase A2 hydrolysis of surfactant phospholipids. . 2012 Jan 15; 302(2):L257-65. PMID: 22037357.
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    12. Weaver KL, Ivester P, Seeds M, Case LD, Arm JP, Chilton FH. Effect of dietary fatty acids on inflammatory gene expression in healthy humans. J Biol Chem. 2009 Jun 05; 284(23):15400-7. PMID: 19359242.
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    13. Seeds MC, Peachman KK, Bowton DL, Sivertson KL, Chilton FH. Regulation of arachidonate remodeling enzymes impacts eosinophil survival during allergic asthma. Am J Respir Cell Mol Biol. 2009 Sep; 41(3):358-66. PMID: 19151322.
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    14. Chilton FH, Rudel LL, Parks JS, Arm JP, Seeds MC. Mechanisms by which botanical lipids affect inflammatory disorders. Am J Clin Nutr. 2008 Feb; 87(2):498S-503S. PMID: 18258646.
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    15. Lorenz E, Muhlebach MS, Tessier PA, Alexis NE, Duncan Hite R, Seeds MC, Peden DB, Meredith W. Different expression ratio of S100A8/A9 and S100A12 in acute and chronic lung diseases. Respir Med. 2008 Apr; 102(4):567-73. PMID: 18164192.
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    16. Sivertson KL, Seeds MC, Long DL, Peachman KK, Bass DA. The differential effect of dexamethasone on granulocyte apoptosis involves stabilization of Mcl-1L in neutrophils but not in eosinophils. Cell Immunol. 2007 Mar; 246(1):34-45. PMID: 17573055.
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    17. El Mezayen R, El Gazzar M, Seeds MC, McCall CE, Dreskin SC, Nicolls MR. Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. Immunol Lett. 2007 Jul 31; 111(1):36-44. PMID: 17568691.
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    18. Hite RD, Seeds MC, Jacinto RB, Grier BL, Waite BM, Bass DA. Lysophospholipid and fatty acid inhibition of pulmonary surfactant: non-enzymatic models of phospholipase A2 surfactant hydrolysis. Biochim Biophys Acta. 2005 Dec 30; 1720(1-2):14-21. PMID: 16376294.
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    19. Pascual RM, Carr EM, Seeds MC, Guo M, Panettieri RA, Peters SP, Penn RB. Regulatory features of interleukin-1beta-mediated prostaglandin E2 synthesis in airway smooth muscle. . 2006 Mar; 290(3):L501-8. PMID: 16299051.
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    20. Hite RD, Seeds MC, Safta AM, Jacinto RB, Gyves JI, Bass DA, Waite BM. Lysophospholipid generation and phosphatidylglycerol depletion in phospholipase A(2)-mediated surfactant dysfunction. . 2005 Apr; 288(4):L618-24. PMID: 15516491.
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    21. Hite RD, Seeds MC, Bowton DL, Grier BL, Safta AM, Balkrishnan R, Waite BM, Bass DA. Surfactant phospholipid changes after antigen challenge: a role for phosphatidylglycerol in dysfunction. . 2005 Apr; 288(4):L610-7. PMID: 15347567.
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    22. Henke MO, Renner A, Huber RM, Seeds MC, Rubin BK. MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions. Am J Respir Cell Mol Biol. 2004 Jul; 31(1):86-91. PMID: 14988081.
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    23. Seeds MC, Bowton DL, Hite RD, Gyves JI, Bass DA. Human eosinophil group IID secretory phospholipase A2 causes surfactant dysfunction. Chest. 2003 Mar; 123(3 Suppl):376S-7S. PMID: 12628992.
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    24. Bowton DL, Seeds MC, Bass DA. Eosinophil cationic protein concentration in saliva does not correlate with eosinophil cationic protein concentration in sputum. Chest. 2003 Mar; 123(3 Suppl):372S. PMID: 12628986.
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    25. Seeds MC, Jones KA, Duncan Hite R, Willingham MC, Borgerink HM, Woodruff RD, Bowton DL, Bass DA. Cell-specific expression of group X and group V secretory phospholipases A(2) in human lung airway epithelial cells. Am J Respir Cell Mol Biol. 2000 Jul; 23(1):37-44. PMID: 10873151.
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    26. Seeds MC, Bass DA. Regulation and metabolism of arachidonic acid. Clin Rev Allergy Immunol. 1999 Spring-Summer; 17(1-2):5-26. PMID: 10436856.
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    27. Seeds MC, Nixon AB, Wykle RL, Bass DA. Differential activation of human neutrophil cytosolic phospholipase A2 and secretory phospholipase A2 during priming by 1,2-diacyl- and 1-O-alkyl-2-acylglycerols. Biochim Biophys Acta. 1998 Nov 02; 1394(2-3):224-34. PMID: 9795228.
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    28. Hite RD, Seeds MC, Jacinto RB, Balasubramanian R, Waite M, Bass D. Hydrolysis of surfactant-associated phosphatidylcholine by mammalian secretory phospholipases A2. Am J Physiol. 1998 10; 275(4):L740-7. PMID: 9755106.
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    29. Seeds MC, Jones DF, Chilton FH, Bass DA. Secretory and cytosolic phospholipases A2 are activated during TNF priming of human neutrophils. Biochim Biophys Acta. 1998 Jan 23; 1389(3):273-84. PMID: 9512652.
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    30. Nixon AB, Seeds MC, Bass DA, Smitherman PK, O'Flaherty JT, Daniel LW, Wykle RL. Comparison of alkylacylglycerol vs. diacylglycerol as activators of mitogen-activated protein kinase and cytosolic phospholipase A2 in human neutrophil priming. Biochim Biophys Acta. 1997 Aug 16; 1347(2-3):219-30. PMID: 9295167.
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    31. Bowton DL, Seeds MC, Fasano MB, Goldsmith B, Bass DA. Phospholipase A2 and arachidonate increase in bronchoalveolar lavage fluid after inhaled antigen challenge in asthmatics. Am J Respir Crit Care Med. 1997 Feb; 155(2):421-5. PMID: 9032172.
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    32. Triggiani M, Oriente A, Seeds MC, Bass DA, Marone G, Chilton FH. Migration of human inflammatory cells into the lung results in the remodeling of arachidonic acid into a triglyceride pool. J Exp Med. 1995 Nov 01; 182(5):1181-90. PMID: 7595189.
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    33. Ely EW, Seeds MC, Chilton FH, Bass DA. Neutrophil release of arachidonic acid, oxidants, and proteinases: causally related or independent. Biochim Biophys Acta. 1995 Sep 14; 1258(2):135-44. PMID: 7548176.
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    34. Bass DA, Seeds MC, Jones DF, Chilton FH, Bauldry SA. Priming of phospholipases A2 of human neutrophils by tumor necrosis factor. Chest. 1994 Mar; 105(3 Suppl):99S-100S. PMID: 8131631.
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    35. Bass DA, Olbrantz P, Szejda P, Seeds MC, McCall CE. Subpopulations of neutrophils with increased oxidative product formation in blood of patients with infection. J Immunol. 1986 Feb 01; 136(3):860-6. PMID: 3001188.
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    36. Seeds MC, Parce JW, Szejda P, Bass DA. Independent stimulation of membrane potential changes and the oxidative metabolic burst in polymorphonuclear leukocytes. Blood. 1985 Jan; 65(1):233-40. PMID: 3965049.
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    37. Bass DA, Parce JW, Dechatelet LR, Szejda P, Seeds MC, Thomas M. Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J Immunol. 1983 Apr; 130(4):1910-7. PMID: 6833755.
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