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Last Name

Mark John Ferris, Ph.D.

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentPhysiology and Pharmacology
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    Collapse ORNG Applications 
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    Collapse Biography 
    Collapse education and training
    University of South Carolina, Columbia, SCPh.D.12/2007Psychology - Behavioral Neuroscience
    University of South Carolina, Columbia, SCM.A.05/2005Experimental Psychology
    Collapse awards and honors
    2012 - 2018Pathway to Independence Award, National Institutes of Health
    2014 - 2018Research Excellence Award, Wake Forest School of Medicine
    2016 - 2017Research Academy Scholar, Wake Forest Clinical and Translational Institute
    2014ACNP Travel Award, American College of Neuropsychopharmacology
    2012Catecholamine Society Fellowship /Award, Tenth International Catecholamine Symposium (XICS)
    2011Postdoctoral Scholar Award, Wake Forest School of Medicine
    2011Travel Award, Gordon Research Conference and Seminar on Catecholamines
    2007 - 2010Ruth L. Kirschstein Institutional National Research Service Award , National Institutes of Health
    2009Travel Award, Gordon Research Seminar on Catecholamines
    2007Travel Award, Society for Neuroscience (SFN)
    2006Centennial Dera D. Parkinson Predoctoral Fellowship , University of South Carolina
    2006NIH Travel Award, International Society for Developmental Psychobiology
    2005NIDA Junior Investigator Travel Award, College on Problems of Drug Dependence (CPDD)
    2002 - PresPsychology National Honor Society, Psi Chi
    2001John Jarman Scholarship, University of North Carolina at Greensboro
    2007Best Oral Presentation Award, University of South Carolina

    Collapse Research 
    Collapse research activities and funding
    K99DA031791     (FERRIS, MARK JOHN)Jul 1, 2012 - Jun 30, 2014
    NIH/NIDA
    nAChR Sensitivity and Individual Differences in Drug Abuse Vulnerability
    Role: Principal Investigator

    R00DA031791     (FERRIS, MARK J)Aug 1, 2015 - Jul 31, 2018
    NIH/NIDA
    nAChR sensitivity and individual differences in drug abuse vulnerability
    Role: Principal Investigator

         (Ferris, Mark John)Jan 1, 2018 - Jan 1, 2019
    Peter F. McManus Charitable Trust
    A Neurobiological Mechanism for Vulnerability to Drug Addiction
    Role Description: The goal of this award is to understand individual differences in calcium channel modulation of mesolimbic dopamine signals as a mechanism for individual differences in drug abuse vulnerability using in vivo calcium imaging (fiber photometry) combined with fast scan cyclic voltammetry.
    Role: Principle Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Leach AC, Ferris MJ. Stimulation of muscarinic acetylcholine M1 receptors reallocates choice between cocaine and an alternative reinforcer. Neuropsychopharmacology. 2020 Jun 15. PMID: 32541906.
      View in: PubMed
    2. Pitts EG, Stowe TA, Christensen BA, Ferris MJ. Comparing dopamine release, uptake, and D2 autoreceptor function across the ventromedial to dorsolateral striatum in adolescent and adult male and female rats. Neuropharmacology. 2020 May 29; 175:108163. PMID: 32479812.
      View in: PubMed
    3. Chen R, Ferris M, Wang S. Dopamine D2 autoreceptor interactome: Targeting the receptor complex as a strategy for treatment of substance use disorder. Pharmacol Ther. 2020 May 27; 107583. PMID: 32473160.
      View in: PubMed
    4. Fennell AM, Pitts EG, Sexton LL, Ferris MJ. Phasic Dopamine Release Magnitude Tracks Individual Differences in Sensitization of Locomotor Response following a History of Nicotine Exposure. Sci Rep. 2020 01 13; 10(1):173. PMID: 31932634.
      View in: PubMed
    5. Karkhanis AN, Leach AC, Yorgason JT, Uneri A, Barth S, Niere F, Alexander NJ, Weiner JL, McCool BA, Raab-Graham KF, Ferris MJ, Jones SR. Chronic Social Isolation Stress during Peri-Adolescence Alters Presynaptic Dopamine Terminal Dynamics via Augmentation in Accumbal Dopamine Availability. ACS Chem Neurosci. 2019 Apr 17; 10(4):2033-2044. PMID: 30284806.
      View in: PubMed
    6. Siciliano CA, McIntosh JM, Jones SR, Ferris MJ. a6ß2 subunit containing nicotinic acetylcholine receptors exert opposing actions on rapid dopamine signaling in the nucleus accumbens of rats with high-versus low-response to novelty. Neuropharmacology. 2017 Nov; 126:281-291. PMID: 28666811.
      View in: PubMed
    7. Brodnik ZD, Ferris MJ, Jones SR, España RA. Reinforcing Doses of Intravenous Cocaine Produce Only Modest Dopamine Uptake Inhibition. ACS Chem Neurosci. 2017 02 15; 8(2):281-289. PMID: 27936579.
      View in: PubMed
    8. Shaw JK, Ferris MJ, Locke JL, Brodnik ZD, Jones SR, España RA. Hypocretin/orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine. Addict Biol. 2017 Nov; 22(6):1695-1705. PMID: 27480648.
      View in: PubMed
    9. Karkhanis AN, Beveridge TJ, Blough BE, Jones SR, Ferris MJ. The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine. Drug Alcohol Depend. 2016 Sep 01; 166:51-60. PMID: 27394931.
      View in: PubMed
    10. Yorgason JT, Calipari ES, Ferris MJ, Karkhanis AN, Fordahl SC, Weiner JL, Jones SR. Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum. Neuropharmacology. 2016 Feb; 101:471-9. PMID: 26525189.
      View in: PubMed
    11. Siciliano CA, Ferris MJ, Jones SR. Cocaine self-administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine. Eur J Neurosci. 2015 Aug; 42(4):2091-6. PMID: 26037018.
      View in: PubMed
    12. Melchior JR, Ferris MJ, Stuber GD, Riddle DR, Jones SR. Optogenetic versus electrical stimulation of dopamine terminals in the nucleus accumbens reveals local modulation of presynaptic release. J Neurochem. 2015 09; 134(5):833-44. PMID: 26011081.
      View in: PubMed
    13. Ferris MJ, Calipari ES, Rose JH, Siciliano CA, Sun H, Chen R, Jones SR. A Single Amphetamine Infusion Reverses Deficits in Dopamine Nerve-Terminal Function Caused by a History of Cocaine Self-Administration. Neuropsychopharmacology. 2015 Jul; 40(8):1826-36. PMID: 25689882.
      View in: PubMed
    14. Luderman KD, Chen R, Ferris MJ, Jones SR, Gnegy ME. Protein kinase C beta regulates the D2-like dopamine autoreceptor. Neuropharmacology. 2015 Feb; 89:335-41. PMID: 25446677.
      View in: PubMed
    15. Siciliano CA, Calipari ES, Ferris MJ, Jones SR. Adaptations of presynaptic dopamine terminals induced by psychostimulant self-administration. ACS Chem Neurosci. 2015 Jan 21; 6(1):27-36. PMID: 25491345.
      View in: PubMed
    16. Calipari ES, Ferris MJ, Siciliano CA, Jones SR. Differential influence of dopamine transport rate on the potencies of cocaine, amphetamine, and methylphenidate. ACS Chem Neurosci. 2015 Jan 21; 6(1):155-62. PMID: 25474655.
      View in: PubMed
    17. Yorgason JT, Rose JH, McIntosh JM, Ferris MJ, Jones SR. Greater ethanol inhibition of presynaptic dopamine release in C57BL/6J than DBA/2J mice: Role of nicotinic acetylcholine receptors. Neuroscience. 2015 Jan 22; 284:854-864. PMID: 25451295.
      View in: PubMed
    18. Ferris MJ, España RA, Locke JL, Konstantopoulos JK, Rose JH, Chen R, Jones SR. Dopamine transporters govern diurnal variation in extracellular dopamine tone. Proc Natl Acad Sci U S A. 2014 Jul 01; 111(26):E2751-9. PMID: 24979798.
      View in: PubMed
    19. Daigle TL, Ferris MJ, Gainetdinov RR, Sotnikova TD, Urs NM, Jones SR, Caron MG. Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission. Neuropsychopharmacology. 2014 Sep; 39(10):2450-62. PMID: 24776686.
      View in: PubMed
    20. Ferris MJ, Milenkovic M, Liu S, Mielnik CA, Beerepoot P, John CE, España RA, Sotnikova TD, Gainetdinov RR, Borgland SL, Jones SR, Ramsey AJ. Sustained N-methyl-d-aspartate receptor hypofunction remodels the dopamine system and impairs phasic signaling. Eur J Neurosci. 2014 Jul; 40(1):2255-63. PMID: 24754704.
      View in: PubMed
    21. Siciliano CA, Calipari ES, Ferris MJ, Jones SR. Biphasic mechanisms of amphetamine action at the dopamine terminal. J Neurosci. 2014 Apr 16; 34(16):5575-82. PMID: 24741047.
      View in: PubMed
    22. Calipari ES, Ferris MJ, Siciliano CA, Zimmer BA, Jones SR. Intermittent cocaine self-administration produces sensitization of stimulant effects at the dopamine transporter. J Pharmacol Exp Ther. 2014 May; 349(2):192-8. PMID: 24566123.
      View in: PubMed
    23. Calipari ES, Ferris MJ, Jones SR. Extended access of cocaine self-administration results in tolerance to the dopamine-elevating and locomotor-stimulating effects of cocaine. J Neurochem. 2014 Jan; 128(2):224-32. PMID: 24102293.
      View in: PubMed
    24. Yorgason JT, Ferris MJ, Steffensen SC, Jones SR. Frequency-dependent effects of ethanol on dopamine release in the nucleus accumbens. Alcohol Clin Exp Res. 2014 Feb; 38(2):438-47. PMID: 24117706.
      View in: PubMed
    25. Ferris MJ, Calipari ES, Melchior JR, Roberts DC, España RA, Jones SR. Paradoxical tolerance to cocaine after initial supersensitivity in drug-use-prone animals. Eur J Neurosci. 2013 Aug; 38(4):2628-36. PMID: 23725404.
      View in: PubMed
    26. Calipari ES, Ferris MJ, Zimmer BA, Roberts DC, Jones SR. Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine transporter. Neuropsychopharmacology. 2013 Nov; 38(12):2385-92. PMID: 23719505.
      View in: PubMed
    27. Calipari ES, Ferris MJ. Amphetamine mechanisms and actions at the dopamine terminal revisited. J Neurosci. 2013 May 22; 33(21):8923-5. PMID: 23699503.
      View in: PubMed
    28. Ferris MJ, Calipari ES, Yorgason JT, Jones SR. Examining the complex regulation and drug-induced plasticity of dopamine release and uptake using voltammetry in brain slices. ACS Chem Neurosci. 2013 May 15; 4(5):693-703. PMID: 23581570.
      View in: PubMed
    29. Calipari ES, Ferris MJ, Salahpour A, Caron MG, Jones SR. Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression. Nat Commun. 2013; 4:2720. PMID: 24193139.
      View in: PubMed
    30. Calipari ES, Ferris MJ, Melchior JR, Bermejo K, Salahpour A, Roberts DC, Jones SR. Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations. Addict Biol. 2014 Mar; 19(2):145-55. PMID: 22458761.
      View in: PubMed
    31. Oleson EB, Ferris MJ, España RA, Harp J, Jones SR. Effects of the histamine H1 receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward. Eur J Pharmacol. 2012 May 15; 683(1-3):161-5. PMID: 22445882.
      View in: PubMed
    32. Ferris MJ, Calipari ES, Mateo Y, Melchior JR, Roberts DC, Jones SR. Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate. Neuropsychopharmacology. 2012 Jun; 37(7):1708-16. PMID: 22395730.
      View in: PubMed
    33. Ferris MJ, Mateo Y, Roberts DC, Jones SR. Cocaine-insensitive dopamine transporters with intact substrate transport produced by self-administration. Biol Psychiatry. 2011 Feb 01; 69(3):201-7. PMID: 20801429.
      View in: PubMed
    34. Ferris MJ, Frederick-Duus D, Fadel J, Mactutus CF, Booze RM. Hyperdopaminergic tone in HIV-1 protein treated rats and cocaine sensitization. J Neurochem. 2010 Nov; 115(4):885-96. PMID: 20796175.
      View in: PubMed
    35. Ferris MJ, Frederick-Duus D, Fadel J, Mactutus CF, Booze RM. In vivo microdialysis in awake, freely moving rats demonstrates HIV-1 Tat-induced alterations in dopamine transmission. Synapse. 2009 Mar; 63(3):181-5. PMID: 19086089.
      View in: PubMed
    36. Ferris MJ, Frederick-Duus D, Fadel J, Mactutus CF, Booze RM. The human immunodeficiency virus-1-associated protein, Tat1-86, impairs dopamine transporters and interacts with cocaine to reduce nerve terminal function: a no-net-flux microdialysis study. Neuroscience. 2009 Apr 10; 159(4):1292-9. PMID: 19344635.
      View in: PubMed
    37. Ferris MJ, Mactutus CF, Booze RM. Neurotoxic profiles of HIV, psychostimulant drugs of abuse, and their concerted effect on the brain: current status of dopamine system vulnerability in NeuroAIDS. Neurosci Biobehav Rev. 2008 Jul; 32(5):883-909. PMID: 18430470.
      View in: PubMed
    38. Ferris MJ, Mactutus CF, Silvers JM, Hasselrot U, Beaudin SA, Strupp BJ, Booze RM. Sex mediates dopamine and adrenergic receptor expression in adult rats exposed prenatally to cocaine. Int J Dev Neurosci. 2007 Nov; 25(7):445-54. PMID: 17933484.
      View in: PubMed
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