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Mark J. Ferris PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentTranslational Neuroscience
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    Collapse Biography 
    Collapse education and training
    University of South Carolina, Columbia, SCPh.D.12/2007Psychology - Behavioral Neuroscience
    University of South Carolina, Columbia, SCM.A.05/2005Experimental Psychology
    Collapse awards and honors
    2022Early Career Investigator in Basic/Translational Sciences Award, Wake Forest University School of Medicine
    2014 - 2019Research Excellence Award, Wake Forest School of Medicine
    2012 - 2018Pathway to Independence Award, National Institutes of Health
    2016 - 2017Research Academy Scholar, Wake Forest Clinical and Translational Institute
    2014ACNP Travel Award, American College of Neuropsychopharmacology
    2012Catecholamine Society Fellowship /Award, Tenth International Catecholamine Symposium (XICS)
    2011Postdoctoral Scholar Award, Wake Forest School of Medicine
    2011Travel Award, Gordon Research Conference and Seminar on Catecholamines
    2009Travel Award, Gordon Research Seminar on Catecholamines
    2007 - 2010Ruth L. Kirschstein Institutional National Research Service Award , National Institutes of Health
    2007Travel Award, Society for Neuroscience (SFN)
    2007Best Oral Presentation Award, University of South Carolina
    2006Centennial Dera D. Parkinson Predoctoral Fellowship , University of South Carolina
    2006NIH Travel Award, International Society for Developmental Psychobiology
    2005NIDA Junior Investigator Travel Award, College on Problems of Drug Dependence (CPDD)
    2002 - PresPsychology National Honor Society, Psi Chi
    2001John Jarman Scholarship, University of North Carolina at Greensboro

    Collapse Research 
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    K99DA031791     (FERRIS, MARK J)Jul 1, 2012 - Jun 30, 2015
    NIH
    nAChR Sensitivity and Individual Differences in Drug Abuse Vulnerability
    Role: Principal Investigator
    R00DA031791     (FERRIS, MARK J)Aug 1, 2015 - Jan 31, 2019
    NIH
    nAChR sensitivity and individual differences in drug abuse vulnerability
    Role: Principal Investigator
    Peter F. McManus Charitable Trust     (FERRIS, MARK J)Jan 1, 2018 - Jan 1, 2019

    A Neurobiological Mechanism for Vulnerability to Drug Addiction
    Role Description: The goal of this award is to understand individual differences in calcium channel modulation of mesolimbic dopamine signals as a mechanism for individual differences in drug abuse vulnerability using in vivo calcium imaging (fiber photometry) combined with fast scan cyclic voltammetry.
    Role: Principle Investigator
    R01DA052460     (FERRIS, MARK J)Aug 31, 2021 - Jun 1, 2026
    NIDA
    Circadian Rhythms and Cocaine Use Disorder
    Role Description: This research investigates circadian rhythms in motivation, learning, vulnerability to cocaine use disorder and corresponding dopamine/acetylcholine interactions in the striatum
    Role: Principle Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Davis SE, Ferris MJ, Ananthan S, Augelli-Szafran CE, Zhu J. Novel Allosteric Modulator Southern Research Institute-32743 Reverses HIV-1 Transactivator of Transcription-Induced Increase in Dopamine Release in the Caudate Putamen of Inducible Transactivator of Transcription Transgenic Mice. J Pharmacol Exp Ther. 2023 Feb; 384(2):306-314. PMID: 36456195.
      Citations:    
    2. Stowe TA, Pitts EG, Leach AC, Iacino MC, Niere F, Graul B, Raab-Graham KF, Yorgason JT, Ferris MJ. Diurnal rhythms in cholinergic modulation of rapid dopamine signals and associative learning in the striatum. Cell Rep. 2022 Apr 05; 39(1):110633. PMID: 35385720.
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    3. Leach AC, Pitts EG, Siciliano CA, Ferris MJ. a7 nicotinic acetylcholine receptor modulation of accumbal dopamine release covaries with novelty seeking. Eur J Neurosci. 2022 Mar; 55(5):1162-1173. PMID: 35141983.
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    4. Burgos-Aguilar C, Ferris MJ, Sexton LL, Sun H, Xiao R, Chen R, Childers SR, Howlett AC. Metabotropic glutamate 2,3 receptor stimulation desensitizes agonist activation of G-protein signaling and alters transcription regulators in mesocorticolimbic brain regions. Synapse. 2021 Apr; 75(4):e22190. PMID: 33025628.
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    5. Leach AC, Ferris MJ. Stimulation of muscarinic acetylcholine M1 receptors reallocates choice between cocaine and an alternative reinforcer. Neuropsychopharmacology. 2020 11; 45(12):1965-1966. PMID: 32541906.
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    6. Pitts EG, Stowe TA, Christensen BA, Ferris MJ. Comparing dopamine release, uptake, and D2 autoreceptor function across the ventromedial to dorsolateral striatum in adolescent and adult male and female rats. Neuropharmacology. 2020 09 15; 175:108163. PMID: 32479812.
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    7. Chen R, Ferris MJ, Wang S. Dopamine D2 autoreceptor interactome: Targeting the receptor complex as a strategy for treatment of substance use disorder. Pharmacol Ther. 2020 09; 213:107583. PMID: 32473160.
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    8. Fennell AM, Pitts EG, Sexton LL, Ferris MJ. Phasic Dopamine Release Magnitude Tracks Individual Differences in Sensitization of Locomotor Response following a History of Nicotine Exposure. Sci Rep. 2020 01 13; 10(1):173. PMID: 31932634.
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    9. Karkhanis AN, Leach AC, Yorgason JT, Uneri A, Barth S, Niere F, Alexander NJ, Weiner JL, McCool BA, Raab-Graham KF, Ferris MJ, Jones SR. Chronic Social Isolation Stress during Peri-Adolescence Alters Presynaptic Dopamine Terminal Dynamics via Augmentation in Accumbal Dopamine Availability. ACS Chem Neurosci. 2019 04 17; 10(4):2033-2044. PMID: 30284806.
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    10. Siciliano CA, McIntosh JM, Jones SR, Ferris MJ. a6ß2 subunit containing nicotinic acetylcholine receptors exert opposing actions on rapid dopamine signaling in the nucleus accumbens of rats with high-versus low-response to novelty. Neuropharmacology. 2017 Nov; 126:281-291. PMID: 28666811.
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    11. Brodnik ZD, Ferris MJ, Jones SR, España RA. Reinforcing Doses of Intravenous Cocaine Produce Only Modest Dopamine Uptake Inhibition. ACS Chem Neurosci. 2017 02 15; 8(2):281-289. PMID: 27936579.
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    12. Shaw JK, Ferris MJ, Locke JL, Brodnik ZD, Jones SR, España RA. Hypocretin/orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine. Addict Biol. 2017 Nov; 22(6):1695-1705. PMID: 27480648.
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    13. Karkhanis AN, Beveridge TJ, Blough BE, Jones SR, Ferris MJ. The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine. Drug Alcohol Depend. 2016 Sep 01; 166:51-60. PMID: 27394931.
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    14. Yorgason JT, Calipari ES, Ferris MJ, Karkhanis AN, Fordahl SC, Weiner JL, Jones SR. Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum. Neuropharmacology. 2016 Feb; 101:471-9. PMID: 26525189.
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    15. Siciliano CA, Ferris MJ, Jones SR. Cocaine self-administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine. Eur J Neurosci. 2015 Aug; 42(4):2091-6. PMID: 26037018.
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    16. Melchior JR, Ferris MJ, Stuber GD, Riddle DR, Jones SR. Optogenetic versus electrical stimulation of dopamine terminals in the nucleus accumbens reveals local modulation of presynaptic release. J Neurochem. 2015 09; 134(5):833-44. PMID: 26011081.
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    17. Ferris MJ, Calipari ES, Rose JH, Siciliano CA, Sun H, Chen R, Jones SR. A Single Amphetamine Infusion Reverses Deficits in Dopamine Nerve-Terminal Function Caused by a History of Cocaine Self-Administration. Neuropsychopharmacology. 2015 Jul; 40(8):1826-36. PMID: 25689882.
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    18. Luderman KD, Chen R, Ferris MJ, Jones SR, Gnegy ME. Protein kinase C beta regulates the D2-like dopamine autoreceptor. Neuropharmacology. 2015 Feb; 89:335-41. PMID: 25446677.
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    19. Siciliano CA, Calipari ES, Ferris MJ, Jones SR. Adaptations of presynaptic dopamine terminals induced by psychostimulant self-administration. ACS Chem Neurosci. 2015 Jan 21; 6(1):27-36. PMID: 25491345.
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    20. Calipari ES, Ferris MJ, Siciliano CA, Jones SR. Differential influence of dopamine transport rate on the potencies of cocaine, amphetamine, and methylphenidate. ACS Chem Neurosci. 2015 Jan 21; 6(1):155-62. PMID: 25474655.
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    21. Yorgason JT, Rose JH, McIntosh JM, Ferris MJ, Jones SR. Greater ethanol inhibition of presynaptic dopamine release in C57BL/6J than DBA/2J mice: Role of nicotinic acetylcholine receptors. Neuroscience. 2015 Jan 22; 284:854-864. PMID: 25451295.
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    22. Ferris MJ, España RA, Locke JL, Konstantopoulos JK, Rose JH, Chen R, Jones SR. Dopamine transporters govern diurnal variation in extracellular dopamine tone. Proc Natl Acad Sci U S A. 2014 Jul 01; 111(26):E2751-9. PMID: 24979798.
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    23. Daigle TL, Ferris MJ, Gainetdinov RR, Sotnikova TD, Urs NM, Jones SR, Caron MG. Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission. Neuropsychopharmacology. 2014 Sep; 39(10):2450-62. PMID: 24776686.
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    24. Ferris MJ, Milenkovic M, Liu S, Mielnik CA, Beerepoot P, John CE, España RA, Sotnikova TD, Gainetdinov RR, Borgland SL, Jones SR, Ramsey AJ. Sustained N-methyl-d-aspartate receptor hypofunction remodels the dopamine system and impairs phasic signaling. Eur J Neurosci. 2014 Jul; 40(1):2255-63. PMID: 24754704.
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    25. Siciliano CA, Calipari ES, Ferris MJ, Jones SR. Biphasic mechanisms of amphetamine action at the dopamine terminal. J Neurosci. 2014 Apr 16; 34(16):5575-82. PMID: 24741047.
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    26. Calipari ES, Ferris MJ, Siciliano CA, Zimmer BA, Jones SR. Intermittent cocaine self-administration produces sensitization of stimulant effects at the dopamine transporter. J Pharmacol Exp Ther. 2014 May; 349(2):192-8. PMID: 24566123.
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    27. Calipari ES, Ferris MJ, Jones SR. Extended access of cocaine self-administration results in tolerance to the dopamine-elevating and locomotor-stimulating effects of cocaine. J Neurochem. 2014 Jan; 128(2):224-32. PMID: 24102293.
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    28. Yorgason JT, Ferris MJ, Steffensen SC, Jones SR. Frequency-dependent effects of ethanol on dopamine release in the nucleus accumbens. Alcohol Clin Exp Res. 2014 Feb; 38(2):438-47. PMID: 24117706.
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    29. Ferris MJ, Calipari ES, Melchior JR, Roberts DC, España RA, Jones SR. Paradoxical tolerance to cocaine after initial supersensitivity in drug-use-prone animals. Eur J Neurosci. 2013 Aug; 38(4):2628-36. PMID: 23725404.
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    30. Calipari ES, Ferris MJ, Zimmer BA, Roberts DC, Jones SR. Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine transporter. Neuropsychopharmacology. 2013 Nov; 38(12):2385-92. PMID: 23719505.
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    31. Calipari ES, Ferris MJ. Amphetamine mechanisms and actions at the dopamine terminal revisited. J Neurosci. 2013 May 22; 33(21):8923-5. PMID: 23699503.
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    32. Ferris MJ, Calipari ES, Yorgason JT, Jones SR. Examining the complex regulation and drug-induced plasticity of dopamine release and uptake using voltammetry in brain slices. ACS Chem Neurosci. 2013 May 15; 4(5):693-703. PMID: 23581570.
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    33. Calipari ES, Ferris MJ, Salahpour A, Caron MG, Jones SR. Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression. Nat Commun. 2013; 4:2720. PMID: 24193139.
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    34. Calipari ES, Ferris MJ, Melchior JR, Bermejo K, Salahpour A, Roberts DC, Jones SR. Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations. Addict Biol. 2014 Mar; 19(2):145-55. PMID: 22458761.
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    35. Oleson EB, Ferris MJ, España RA, Harp J, Jones SR. Effects of the histamine H1 receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward. Eur J Pharmacol. 2012 May 15; 683(1-3):161-5. PMID: 22445882.
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    36. Ferris MJ, Calipari ES, Mateo Y, Melchior JR, Roberts DC, Jones SR. Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate. Neuropsychopharmacology. 2012 Jun; 37(7):1708-16. PMID: 22395730.
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    37. Ferris MJ, Mateo Y, Roberts DC, Jones SR. Cocaine-insensitive dopamine transporters with intact substrate transport produced by self-administration. Biol Psychiatry. 2011 Feb 01; 69(3):201-7. PMID: 20801429.
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    38. Ferris MJ, Frederick-Duus D, Fadel J, Mactutus CF, Booze RM. Hyperdopaminergic tone in HIV-1 protein treated rats and cocaine sensitization. J Neurochem. 2010 Nov; 115(4):885-96. PMID: 20796175.
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    39. Ferris MJ, Frederick-Duus D, Fadel J, Mactutus CF, Booze RM. In vivo microdialysis in awake, freely moving rats demonstrates HIV-1 Tat-induced alterations in dopamine transmission. Synapse. 2009 Mar; 63(3):181-5. PMID: 19086089.
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    40. Ferris MJ, Frederick-Duus D, Fadel J, Mactutus CF, Booze RM. The human immunodeficiency virus-1-associated protein, Tat1-86, impairs dopamine transporters and interacts with cocaine to reduce nerve terminal function: a no-net-flux microdialysis study. Neuroscience. 2009 Apr 10; 159(4):1292-9. PMID: 19344635.
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    41. Ferris MJ, Mactutus CF, Booze RM. Neurotoxic profiles of HIV, psychostimulant drugs of abuse, and their concerted effect on the brain: current status of dopamine system vulnerability in NeuroAIDS. Neurosci Biobehav Rev. 2008 Jul; 32(5):883-909. PMID: 18430470.
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    42. Ferris MJ, Mactutus CF, Silvers JM, Hasselrot U, Beaudin SA, Strupp BJ, Booze RM. Sex mediates dopamine and adrenergic receptor expression in adult rats exposed prenatally to cocaine. Int J Dev Neurosci. 2007 Nov; 25(7):445-54. PMID: 17933484.
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