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Laura A. Cox PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Molecular Medicine
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    Other Positions
    TitleAssociate Director
    InstitutionWake Forest School of Medicine
    DepartmentCenter for Precision Medicine (CPM)

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentPathology, Comparative Medicine


    Collapse Biography 
    Collapse education and training
    Old Dominion University, Norfolk, VABS05/1981Biology
    University of California, Davis, CAMS06/1984Genetics
    University of Texas Health Science Center, San Antonio, TXPhD03/1993Cellular & Structural Biology
    University of Texas Institute of Biotechnology, San Antonio, TXPost-doctoral Fellowship12/1995Genetics & Development
    Southwest Foundation for Biomedical Research, San Antonio, TXPost-doctoral Fellowship12/1997Genetics of Cardiovascular Disease

    Collapse Research 
    Collapse research activities and funding
    P51RR013986     (TREVETT, KENNETH PARKHURST)Jun 1, 1999 - Apr 30, 2014
    NIH
    The Southwest National Primate Research Center
    Role: Co-Investigator
    R01HL118556     (COX, LAURA A)Aug 13, 2013 - Jun 30, 2019
    NIH
    Discovery of Gene Variants and Mechanisms Underlying Salt-Sensitive Hypertension
    Role: Principal Investigator
    R24OD017859     (WALL, JEFFREY D)Jul 1, 2014 - Jun 30, 2019
    NIH
    Development of a pedigreed baboon genome resource for biomedical research
    Role: Co-Principal Investigator
    K01HL130697     (KARERE, GENESIO)Aug 1, 2016 - Jul 31, 2021
    NIH
    Identification of molecular mechanisms underlying early atherosclerosis
    Role: Mentor
    R01AG061805     (MOLINA, ANTHONY J)Sep 30, 2018 - Apr 30, 2023
    NIH
    Exosome Mediated Alterations in Cellular Metabolism in the Pathogenesis and Progression of Alzheimer's Disease
    Role: Co-Investigator
    U19AG057758     (NATHANIELSZ, PETER W.)Sep 30, 2018 - May 31, 2023
    NIH
    Womb to Tomb: Developmental Programming and Aging Interactions in Primates
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pereira SP, Tavares LC, Duarte AI, Baldeiras I, Cunha-Oliveira T, Martins JD, Santos MS, Maloyan A, Moreno AJ, Cox LA, Li C, Nathanielsz PW, Nijland MJ, Oliveira PJ. Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction. Clin Sci (Lond). 2021 May 14; 135(9):1103-1126. PMID: 33899910.
      Citations:    
    2. Chan J, Yao W, Howard TD, Hawkins GA, Olivier M, Jorgensen MJ, Cheeseman IH, Cole SA, Cox LA. Efficiency of whole-exome sequencing in old world and new world primates using human capture reagents. J Med Primatol. 2021 Jun; 50(3):176-181. PMID: 33876458.
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    3. Karere GM, Cox LA, Bishop AC, South AM, Shaltout HA, Mercado-Deane MG, Cuda S. Sex Differences in MicroRNA Expression and Cardiometabolic Risk Factors in Hispanic Adolescents with Obesity. J Pediatr. 2021 Apr 06. PMID: 33831442.
      Citations:    
    4. Batra SS, Levy-Sakin M, Robinson J, Guillory J, Durinck S, Vilgalys TP, Kwok PY, Cox LA, Seshagiri S, Song YS, Wall JD. Accurate assembly of the olive baboon (Papio anubis) genome using long-read and Hi-C data. Gigascience. 2020 12 07; 9(12). PMID: 33283855.
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    5. Rosario FJ, Powell TL, Gupta MB, Cox L, Jansson T. mTORC1 Transcriptional Regulation of Ribosome Subunits, Protein Synthesis, and Molecular Transport in Primary Human Trophoblast Cells. Front Cell Dev Biol. 2020; 8:583801. PMID: 33324640.
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    6. Ruggiero AD, Davis A, Sherrill C, Westwood B, Hawkins GA, Palmer ND, Chou JW, Reeves T, Cox LA, Kavanagh K. Skeletal muscle extracellular matrix remodeling with worsening glycemic control in nonhuman primates. Am J Physiol Regul Integr Comp Physiol. 2021 03 01; 320(3):R226-R235. PMID: 33206559.
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    7. Wu FL, Strand AI, Cox LA, Ober C, Wall JD, Moorjani P, Przeworski M. A comparison of humans and baboons suggests germline mutation rates do not track cell divisions. PLoS Biol. 2020 08; 18(8):e3000838. PMID: 32804933.
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    8. Versiani AF, Martins EMN, Andrade LM, Cox L, Pereira GC, Barbosa-Stancioli EF, Nogueira ML, Ladeira LO, da Fonseca FG. Nanosensors based on LSPR are able to serologically differentiate dengue from Zika infections. Sci Rep. 2020 07 09; 10(1):11302. PMID: 32647259.
      Citations:    
    9. Karere GM, Mahaney MC, Newman DE, Riojas AM, Christensen C, Birnbaum S, VandeBerg JL, Cox L. Diet-induced leukocyte telomere shortening in a baboon model for early stage atherosclerosis. Sci Rep. 2019 12 12; 9(1):19001. PMID: 31831784.
      Citations:    
    10. Karere GM, Dick EJ, Galindo S, Martinez JC, Martinez JE, Owston M, VandeBerg JL, Cox LA. Histological variation of early stage atherosclerotic lesions in baboons after prolonged challenge with high-cholesterol, high-fat diet. J Med Primatol. 2020 02; 49(1):3-9. PMID: 31709573.
      Citations:    
    11. Olivier M, Asmis R, Hawkins GA, Howard TD, Cox LA. The Need for Multi-Omics Biomarker Signatures in Precision Medicine. Int J Mol Sci. 2019 Sep 26; 20(19). PMID: 31561483.
      Citations:    
    12. Misra BB, Puppala SR, Comuzzie AG, Mahaney MC, VandeBerg JL, Olivier M, Cox LA. Analysis of serum changes in response to a high fat high cholesterol diet challenge reveals metabolic biomarkers of atherosclerosis. PLoS One. 2019; 14(4):e0214487. PMID: 30951537.
      Citations:    
    13. Robinson JA, Belsare S, Birnbaum S, Newman DE, Chan J, Glenn JP, Ferguson B, Cox LA, Wall JD. Analysis of 100 high-coverage genomes from a pedigreed captive baboon colony. Genome Res. 2019 05; 29(5):848-856. PMID: 30926611.
      Citations:    
    14. Karere GM, Glenn JP, Birnbaum S, Garcia R, VandeBerg JL, Cox LA. Identification of coordinately regulated microRNA-gene networks that differ in baboons discordant for LDL-cholesterol. PLoS One. 2019; 14(3):e0213494. PMID: 30875406.
      Citations:    
    15. Rogers J, Raveendran M, Harris RA, Mailund T, Leppälä K, Athanasiadis G, Schierup MH, Cheng J, Munch K, Walker JA, Konkel MK, Jordan V, Steely CJ, Beckstrom TO, Bergey C, Burrell A, Schrempf D, Noll A, Kothe M, Kopp GH, Liu Y, Murali S, Billis K, Martin FJ, Muffato M, Cox L, Else J, Disotell T, Muzny DM, Phillips-Conroy J, Aken B, Eichler EE, Marques-Bonet T, Kosiol C, Batzer MA, Hahn MW, Tung J, Zinner D, Roos C, Jolly CJ, Gibbs RA, Worley KC. The comparative genomics and complex population history of Papio baboons. Sci Adv. 2019 01; 5(1):eaau6947. PMID: 30854422.
      Citations:    
    16. Rosario FJ, Gupta MB, Myatt L, Powell TL, Glenn JP, Cox L, Jansson T. Mechanistic Target of Rapamycin Complex 1 Promotes the Expression of Genes Encoding Electron Transport Chain Proteins and Stimulates Oxidative Phosphorylation in Primary Human Trophoblast Cells by Regulating Mitochondrial Biogenesis. Sci Rep. 2019 01 22; 9(1):246. PMID: 30670706.
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    17. Li C, Jenkins S, Considine MM, Cox LA, Gerow KG, Huber HF, Nathanielsz PW. Effect of maternal obesity on fetal and postnatal baboon (Papio species) early life phenotype. J Med Primatol. 2019 04; 48(2):90-98. PMID: 30569595.
      Citations:    
    18. Misra BB, Bassey E, Bishop AC, Kusel DT, Cox LA, Olivier M. High-resolution gas chromatography/mass spectrometry metabolomics of non-human primate serum. Rapid Commun Mass Spectrom. 2018 Sep 15; 32(17):1497-1506. PMID: 29874398.
      Citations:    
    19. Lomas-Soria C, Reyes-Castro LA, Rodríguez-González GL, Ibáñez CA, Bautista CJ, Cox LA, Nathanielsz PW, Zambrano E. Maternal obesity has sex-dependent effects on insulin, glucose and lipid metabolism and the liver transcriptome in young adult rat offspring. J Physiol. 2018 10; 596(19):4611-4628. PMID: 29972240.
      Citations:    
    20. Misra BB, Langefeld CD, Olivier M, Cox LA. Integrated Omics: Tools, Advances, and Future Approaches. J Mol Endocrinol. 2018 Jul 13. PMID: 30006342.
      Citations:    
    21. Misra BB, Upadhayay RP, Cox LA, Olivier M. Optimized GC-MS metabolomics for the analysis of kidney tissue metabolites. Metabolomics. 2018 05 25; 14(6):75. PMID: 30830353.
      Citations:    
    22. Bishop AC, Libardoni M, Choudary A, Misra B, Lange K, Bernal J, Nijland M, Li C, Olivier M, Nathanielsz PW, Cox LA. Nonhuman primate breath volatile organic compounds associate with developmental programming and cardio-metabolic status. J Breath Res. 2018 05 14; 12(3):036016. PMID: 29593130.
      Citations:    
    23. Puppala S, Li C, Glenn JP, Saxena R, Gawrieh S, Quinn A, Palarczyk J, Dick EJ, Nathanielsz PW, Cox LA. Primate fetal hepatic responses to maternal obesity: epigenetic signalling pathways and lipid accumulation. J Physiol. 2018 12; 596(23):5823-5837. PMID: 29516496.
      Citations:    
    24. Spradling-Reeves KD, Glenn JP, Lange KJ, Kuhn N, Coalson JJ, Nijland MJ, Li C, Nathanielsz PW, Cox LA. The non-human primate kidney transcriptome in fetal development. J Med Primatol. 2018 06; 47(3):157-171. PMID: 29603257.
      Citations:    
    25. Kuo AH, Li C, Mattern V, Huber HF, Comuzzie A, Cox L, Schwab M, Nathanielsz PW, Clarke GD. Sex-dimorphic acceleration of pericardial, subcutaneous, and plasma lipid increase in offspring of poorly nourished baboons. Int J Obes (Lond). 2018 06; 42(5):1092-1096. PMID: 29463919.
      Citations:    
    26. Cox LA, Olivier M, Spradling-Reeves K, Karere GM, Comuzzie AG, VandeBerg JL. Nonhuman Primates and Translational Research-Cardiovascular Disease. ILAR J. 2017 12 01; 58(2):235-250. PMID: 28985395.
      Citations:    
    27. Proffitt JM, Glenn J, Cesnik AJ, Jadhav A, Shortreed MR, Smith LM, Kavanagh K, Cox LA, Olivier M. Proteomics in non-human primates: utilizing RNA-Seq data to improve protein identification by mass spectrometry in vervet monkeys. BMC Genomics. 2017 Nov 13; 18(1):877. PMID: 29132314.
      Citations:    
    28. Short JD, Tavakoli S, Nguyen HN, Carrera A, Farnen C, Cox LA, Asmis R. Dyslipidemic Diet-Induced Monocyte "Priming" and Dysfunction in Non-Human Primates Is Triggered by Elevated Plasma Cholesterol and Accompanied by Altered Histone Acetylation. Front Immunol. 2017; 8:958. PMID: 28878765.
      Citations:    
    29. Li C, Jenkins S, Mattern V, Comuzzie AG, Cox LA, Huber HF, Nathanielsz PW. Effect of moderate, 30 percent global maternal nutrient reduction on fetal and postnatal baboon phenotype. J Med Primatol. 2017 12; 46(6):293-303. PMID: 28744866.
      Citations:    
    30. Mahaney MC, Karere GM, Rainwater DL, Voruganti VS, Dick EJ, Owston MA, Rice KS, Cox LA, Comuzzie AG, VandeBerg JL. Diet-induced early-stage atherosclerosis in baboons: Lipoproteins, atherogenesis, and arterial compliance. J Med Primatol. 2018 02; 47(1):3-17. PMID: 28620920.
      Citations:    
    31. Holmes RS, Spradling-Reeves KD, Cox LA. Mammalian Glutamyl Aminopeptidase Genes (ENPEP) and Proteins: Comparative Studies of a Major Contributor to Arterial Hypertension. J Data Mining Genomics Proteomics. 2017; 8(2). PMID: 29900035.
      Citations:    
    32. Spradling-Reeves KD, Shade RE, Haywood JR, Cox LA. Primate response to angiotensin infusion and high sodium intake differ by sodium lithium countertransport phenotype. J Am Soc Hypertens. 2017 03; 11(3):178-184. PMID: 28238630.
      Citations:    
    33. Xue C, Raveendran M, Harris RA, Fawcett GL, Liu X, White S, Dahdouli M, Rio Deiros D, Below JE, Salerno W, Cox L, Fan G, Ferguson B, Horvath J, Johnson Z, Kanthaswamy S, Kubisch HM, Liu D, Platt M, Smith DG, Sun B, Vallender EJ, Wang F, Wiseman RW, Chen R, Muzny DM, Gibbs RA, Yu F, Rogers J. The population genomics of rhesus macaques (Macaca mulatta) based on whole-genome sequences. Genome Res. 2016 12; 26(12):1651-1662. PMID: 27934697.
      Citations:    
    34. David BA, Rezende RM, Antunes MM, Santos MM, Freitas Lopes MA, Diniz AB, Sousa Pereira RV, Marchesi SC, Alvarenga DM, Nakagaki BN, Araújo AM, Dos Reis DS, Rocha RM, Marques PE, Lee WY, Deniset J, Liew PX, Rubino S, Cox L, Pinho V, Cunha TM, Fernandes GR, Oliveira AG, Teixeira MM, Kubes P, Menezes GB. Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice. Gastroenterology. 2016 12; 151(6):1176-1191. PMID: 27569723.
      Citations:    
    35. Wall JD, Schlebusch SA, Alberts SC, Cox LA, Snyder-Mackler N, Nevonen KA, Carbone L, Tung J. Genomewide ancestry and divergence patterns from low-coverage sequencing data reveal a complex history of admixture in wild baboons. Mol Ecol. 2016 07; 25(14):3469-83. PMID: 27145036.
      Citations:    
    36. Holmes RS, Spradling-Reeves KD, Cox LA. Evolution of Vertebrate Solute Carrier Family 9B Genes and Proteins (SLC9B): Evidence for a Marsupial Origin for Testis Specific SLC9B1 from an Ancestral Vertebrate SLC9B2 Gene. J Phylogenetics Evol Biol. 2016 Aug; 4(3). PMID: 28868326.
      Citations:    
    37. Atkinson EG, Rogers J, Mahaney MC, Cox LA, Cheverud JM. Cortical Folding of the Primate Brain: An Interdisciplinary Examination of the Genetic Architecture, Modularity, and Evolvability of a Significant Neurological Trait in Pedigreed Baboons (Genus Papio). Genetics. 2015 Jun; 200(2):651-65. PMID: 25873632.
      Citations:    
    38. Cox LA, van Eijk LT, Ramakers BP, Dorresteijn MJ, Gerretsen J, Kox M, Pickkers P. Inflammation-induced increases in plasma endocan levels are associated with endothelial dysfunction in humans in vivo. Shock. 2015 Apr; 43(4):322-6. PMID: 25565643.
      Citations:    
    39. Pereira SP, Oliveira PJ, Tavares LC, Moreno AJ, Cox LA, Nathanielsz PW, Nijland MJ. Effects of moderate global maternal nutrient reduction on fetal baboon renal mitochondrial gene expression at 0.9 gestation. Am J Physiol Renal Physiol. 2015 Jun 01; 308(11):F1217-28. PMID: 25761880.
      Citations:    
    40. Johnson Z, Brent L, Alvarenga JC, Comuzzie AG, Shelledy W, Ramirez S, Cox L, Mahaney MC, Huang YY, Mann JJ, Kaplan JR, Rogers J. Genetic influences on response to novel objects and dimensions of personality in Papio baboons. Behav Genet. 2015 Mar; 45(2):215-27. PMID: 25604451.
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    41. Cox LA, Li C, Glenn JP, Lange K, Spradling KD, Nathanielsz PW, Jansson T. Expression of the placental transcriptome in maternal nutrient reduction in baboons is dependent on fetal sex. J Nutr. 2013 Nov; 143(11):1698-708. PMID: 24047701.
      Citations:    
    42. Maloyan A, Muralimanoharan S, Huffman S, Cox LA, Nathanielsz PW, Myatt L, Nijland MJ. Identification and comparative analyses of myocardial miRNAs involved in the fetal response to maternal obesity. Physiol Genomics. 2013 Oct 01; 45(19):889-900. PMID: 23922128.
      Citations:    
    43. Spradling KD, Glenn JP, Garcia R, Shade RE, Cox LA. The baboon kidney transcriptome: analysis of transcript sequence, splice variants, and abundance. PLoS One. 2013; 8(4):e57563. PMID: 23637735.
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    44. Karere GM, Glenn JP, Birnbaum S, Hafizi S, Rainwater DL, Mahaney MC, VandeBerg JL, Cox LA. Identification of candidate genes encoding an LDL-C QTL in baboons. J Lipid Res. 2013 Jul; 54(7):1776-85. PMID: 23596326.
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    45. Moser AB, Hey J, Dranchak PK, Karaman MW, Zhao J, Cox LA, Ryder OA, Hacia JG. Diverse captive non-human primates with phytanic acid-deficient diets rich in plant products have substantial phytanic acid levels in their red blood cells. Lipids Health Dis. 2013 Feb 04; 12:10. PMID: 23379307.
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    46. Cox LA, Comuzzie AG, Havill LM, Karere GM, Spradling KD, Mahaney MC, Nathanielsz PW, Nicolella DP, Shade RE, Voruganti S, VandeBerg JL. Baboons as a model to study genetics and epigenetics of human disease. ILAR J. 2013; 54(2):106-21. PMID: 24174436.
      Citations:    
    47. Shi Q, Cox LA, Hodara V, Wang XL, VandeBerg JL. Repertoire of endothelial progenitor cells mobilized by femoral artery ligation: a nonhuman primate study. J Cell Mol Med. 2012 Sep; 16(9):2060-73. PMID: 22128816.
      Citations:    
    48. Cho I, Yamanishi S, Cox L, Methé BA, Zavadil J, Li K, Gao Z, Mahana D, Raju K, Teitler I, Li H, Alekseyenko AV, Blaser MJ. Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature. 2012 Aug 30; 488(7413):621-6. PMID: 22914093.
      Citations:    
    49. Karere GM, Glenn JP, VandeBerg JL, Cox LA. Differential microRNA response to a high-cholesterol, high-fat diet in livers of low and high LDL-C baboons. BMC Genomics. 2012 Jul 18; 13:320. PMID: 22809019.
      Citations:    
    50. Cox LA, Glenn JP, Spradling KD, Nijland MJ, Garcia R, Nathanielsz PW, Ford SP. A genome resource to address mechanisms of developmental programming: determination of the fetal sheep heart transcriptome. J Physiol. 2012 Jun 15; 590(12):2873-84. PMID: 22508961.
      Citations:    
    51. Northcott CA, Glenn JP, Shade RE, Kammerer CM, Hinojosa-Laborde C, Fink GD, Haywood JR, Cox LA. A custom rat and baboon hypertension gene array to compare experimental models. Exp Biol Med (Maywood). 2012 Jan; 237(1):99-110. PMID: 22228705.
      Citations:    
    52. Holmes RS, Cox LA. Comparative Structures and Evolution of Vertebrate Carboxyl Ester Lipase (CEL) Genes and Proteins with a Major Role in Reverse Cholesterol Transport. Cholesterol. 2011; 2011:781643. PMID: 22162806.
      Citations:    
    53. Holmes RS, Cox LA. Comparative studies of glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1: evidence for a eutherian mammalian origin for the GPIHBP1 gene from an LY6-like gene. 3 Biotech. 2012 Mar; 2(1):37-52. PMID: 22582156.
      Citations:    
    54. Holmes RS, Vandeberg JL, Cox LA. Genomics and proteomics of vertebrate cholesterol ester lipase (LIPA) and cholesterol 25-hydroxylase (CH25H). 3 Biotech. 2011 Sep; 1(2):99-109. PMID: 22582164.
      Citations:    
    55. Vinson A, Curran JE, Johnson MP, Dyer TD, Moses EK, Blangero J, Cox LA, Rogers J, Havill LM, Vandeberg JL, Mahaney MC. Genetical genomics of Th1 and Th2 immune response in a baboon model of atherosclerosis risk factors. Atherosclerosis. 2011 Aug; 217(2):387-94. PMID: 21762917.
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    56. Lillvis JH, Erdman R, Schworer CM, Golden A, Derr K, Gatalica Z, Cox LA, Shen J, Vander Heide RS, Lenk GM, Hlavaty L, Li L, Elmore JR, Franklin DP, Gray JL, Garvin RP, Carey DJ, Lancaster WD, Tromp G, Kuivaniemi H. Regional expression of HOXA4 along the aorta and its potential role in human abdominal aortic aneurysms. BMC Physiol. 2011 May 31; 11:9. PMID: 21627813.
      Citations:    
    57. Holmes RS, Vandeberg JL, Cox LA. Comparative studies of vertebrate lipoprotein lipase: a key enzyme of very low density lipoprotein metabolism. Comp Biochem Physiol Part D Genomics Proteomics. 2011 Jun; 6(2):224-34. PMID: 21561822.
      Citations:    
    58. Holmes RS, Vandeberg JL, Cox LA. Vertebrate hepatic lipase genes and proteins: a review supported by bioinformatic studies. Open Access Bioinformatics. 2011 Apr 22; 2011(3):85-95. PMID: 22408368.
      Citations:    
    59. Holmes RS, Vandeberg JL, Cox LA. Vertebrate endothelial lipase: comparative studies of an ancient gene and protein in vertebrate evolution. Genetica. 2011 Mar; 139(3):291-304. PMID: 21267636.
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    60. Antonow-Schlorke I, Schwab M, Cox LA, Li C, Stuchlik K, Witte OW, Nathanielsz PW, McDonald TJ. Vulnerability of the fetal primate brain to moderate reduction in maternal global nutrient availability. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):3011-6. PMID: 21252306.
      Citations:    
    61. Kirby J, Ning K, Ferraiuolo L, Heath PR, Ismail A, Kuo SW, Valori CF, Cox L, Sharrack B, Wharton SB, Ince PG, Shaw PJ, Azzouz M. Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis. Brain. 2011 Feb; 134(Pt 2):506-17. PMID: 21228060.
      Citations:    
    62. Kamat A, Nijland MJ, McDonald TJ, Cox LA, Nathanielsz PW, Li C. Moderate global reduction in maternal nutrition has differential stage of gestation specific effects on {beta}1- and {beta}2-adrenergic receptors in the fetal baboon liver. Reprod Sci. 2011 Apr; 18(4):398-405. PMID: 21079239.
      Citations:    
    63. Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T, Ishibashi S, Lehner R, Miyazaki M, Perkins EJ, Potter PM, Redinbo MR, Robert J, Satoh T, Yamashita T, Yan B, Yokoi T, Zechner R, Maltais LJ. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Mamm Genome. 2010 Oct; 21(9-10):427-41. PMID: 20931200.
      Citations:    
    64. Karere GM, Glenn JP, VandeBerg JL, Cox LA. Identification of baboon microRNAs expressed in liver and lymphocytes. J Biomed Sci. 2010 Jul 01; 17:54. PMID: 20594335.
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    65. Holmes RS, Cox LA, VandeBerg JL. Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo). Comp Biochem Physiol Part D Genomics Proteomics. 2010 Sep; 5(3):217-26. PMID: 20598663.
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    66. Bose T, Voruganti VS, Tejero ME, Proffit JM, Cox LA, VandeBerg JL, Mahaney MC, Rogers J, Freeland-Graves JH, Cole SA, Comuzzie AG. Identification of a QTL for adipocyte volume and of shared genetic effects with aspartate aminotransferase. Biochem Genet. 2010 Jun; 48(5-6):538-47. PMID: 20390338.
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    67. Holmes RS, Cox LA, VandeBerg JL. Mammalian carboxylesterase 3: comparative genomics and proteomics. Genetica. 2010 Jul; 138(7):695-708. PMID: 20422440.
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    68. Nijland MJ, Mitsuya K, Li C, Ford S, McDonald TJ, Nathanielsz PW, Cox LA. Epigenetic modification of fetal baboon hepatic phosphoenolpyruvate carboxykinase following exposure to moderately reduced nutrient availability. J Physiol. 2010 Apr 15; 588(Pt 8):1349-59. PMID: 20176628.
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    69. Bose T, Voruganti VS, Tejero ME, Proffitt JM, Cox LA, VandeBerg JL, Mahaney MC, Rogers J, Freeland-Graves JH, Cole SA, Comuzzie AG. Quantitative loci regulating plasma levels of gamma glutamyl transferase and albumin and their genetic correlations with cardiovascular risk factors. Exp Biol Med (Maywood). 2009 Dec; 234(12):vi, 1519-24. PMID: 19934372.
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    70. Cox LA, Nathanielsz PW. The importance of altered gene promoter methylation and transcription factor binding in developmental programming of central appetitive drive. J Physiol. 2009 Oct 15; 587(Pt 20):4763-4. PMID: 19828521.
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    71. Holmes RS, Cox LA, Vandeberg JL. A new class of mammalian carboxylesterase CES6. Comp Biochem Physiol Part D Genomics Proteomics. 2009 Sep; 4(3):209-17. PMID: 20161041.
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    72. Unterberger A, Szyf M, Nathanielsz PW, Cox LA. Organ and gestational age effects of maternal nutrient restriction on global methylation in fetal baboons. J Med Primatol. 2009 Aug; 38(4):219-27. PMID: 19602098.
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    73. Farley D, Tejero ME, Comuzzie AG, Higgins PB, Cox L, Werner SL, Jenkins SL, Li C, Choi J, Dick EJ, Hubbard GB, Frost P, Dudley DJ, Ballesteros B, Wu G, Nathanielsz PW, Schlabritz-Loutsevitch NE. Feto-placental adaptations to maternal obesity in the baboon. Placenta. 2009 Sep; 30(9):752-60. PMID: 19632719.
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    74. Shi Q, Cox LA, Glenn J, Tejero ME, Hondara V, Vandeberg JL, Wang XL. Molecular pathways mediating differential responses to lipopolysaccharide between human and baboon arterial endothelial cells. Clin Exp Pharmacol Physiol. 2010 Feb; 37(2):178-84. PMID: 19650795.
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    75. Cox LA, Glenn J, Ascher S, Birnbaum S, VandeBerg JL. Integration of genetic and genomic methods for identification of genes and gene variants encoding QTLs in the nonhuman primate. Methods. 2009 Sep; 49(1):63-9. PMID: 19596448.
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    76. Li C, Schlabritz-Loutsevitch NE, Hubbard GB, Han V, Nygard K, Cox LA, McDonald TJ, Nathanielsz PW. Effects of maternal global nutrient restriction on fetal baboon hepatic insulin-like growth factor system genes and gene products. Endocrinology. 2009 Oct; 150(10):4634-42. PMID: 19574404.
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    77. Doubleday AF, Kaestle FA, Cox LA, Birnbaum S, Mahaney MC, Havill LM. LRP5 sequence and polymorphisms in the baboon. J Med Primatol. 2009 Apr; 38(2):97-106. PMID: 19367734.
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    78. Rainwater DL, Cox LA, Rogers J, VandeBerg JL, Mahaney MC. Localization of multiple pleiotropic genes for lipoprotein metabolism in baboons. J Lipid Res. 2009 Jul; 50(7):1420-8. PMID: 19270339.
      Citations:    
    79. Holmes RS, Cox LA, Vandeberg JL. Bovine Carboxylesterases: Evidence for Two CES1 and Five Families of CES Genes on Chromosome 18. Comp Biochem Physiol Part D Genomics Proteomics. 2009 Mar 01; 4(1):11-20. PMID: 20161341.
      Citations:    
    80. Holmes RS, Glenn JP, VandeBerg JL, Cox LA. Baboon carboxylesterases 1 and 2: sequences, structures and phylogenetic relationships with human and other primate carboxylesterases. J Med Primatol. 2009 Feb; 38(1):27-38. PMID: 19187434.
      Citations:    
    81. Zheng X, Kammerer CM, Cox LA, Morrison A, Turner ST, Ferrell RE. Association of SLC34A2 variation and sodium-lithium countertransport activity in humans and baboons. Am J Hypertens. 2009 Mar; 22(3):288-93. PMID: 19119262.
      Citations:    
    82. Holmes RS, Cox LA, Vandeberg JL. Horse carboxylesterases: evidence for six CES1 and four families of CES genes on chromosome 3. Comp Biochem Physiol Part D Genomics Proteomics. 2009 Mar; 4(1):54-65. PMID: 20403742.
      Citations:    
    83. Holmes RS, Cox LA, Vandeberg JL. Mammalian carboxylesterase 5: comparative biochemistry and genomics. Comp Biochem Physiol Part D Genomics Proteomics. 2008 Sep; 3(3):195-204. PMID: 19727319.
      Citations:    
    84. Sherwood RJ, Duren DL, Havill LM, Rogers J, Cox LA, Towne B, Mahaney MC. A genomewide linkage scan for quantitative trait loci influencing the craniofacial complex in baboons (Papio hamadryas spp.). Genetics. 2008 Sep; 180(1):619-28. PMID: 18757921.
      Citations:    
    85. Vinson A, Mahaney MC, Diego VP, Cox LA, Rogers J, VandeBerg JL, Rainwater DL. Genotype-by-diet effects on co-variation in Lp-PLA2 activity and LDL-cholesterol concentration in baboons fed an atherogenic diet. J Lipid Res. 2008 Jun; 49(6):1295-302. PMID: 18334716.
      Citations:    
    86. Holmes RS, Chan J, Cox LA, Murphy WJ, VandeBerg JL. Opossum carboxylesterases: sequences, phylogeny and evidence for CES gene duplication events predating the marsupial-eutherian common ancestor. BMC Evol Biol. 2008 Feb 20; 8:54. PMID: 18289373.
      Citations:    
    87. Tejero ME, Voruganti VS, Rodríguez-Sánchez IP, Proffitt JM, Blangero J, Cox LA, Mahaney MC, Rogers J, VandeBerg JL, Cole SA, Comuzzie AG. Genetics of variation in adiponectin in pedigreed baboons: evidence for pleiotropic effects on adipocyte volume and serum adiponectin. Heredity (Edinb). 2008 Apr; 100(4):382-9. PMID: 18285814.
      Citations:    
    88. Voruganti VS, Tejero ME, Proffitt JM, Cole SA, Cox LA, Mahaney MC, Rogers JA, Freeland-Graves JH, Comuzzie AG. Characterization of ghrelin in pedigreed baboons: evidence for heritability and pleiotropy. Obesity (Silver Spring). 2008 Apr; 16(4):804-10. PMID: 18239597.
      Citations:    
    89. Vinson A, Mahaney MC, Cox LA, Rogers J, VandeBerg JL, Rainwater DL. A pleiotropic QTL on 2p influences serum Lp-PLA2 activity and LDL cholesterol concentration in a baboon model for the genetics of atherosclerosis risk factors. Atherosclerosis. 2008 Feb; 196(2):667-73. PMID: 17767937.
      Citations:    
    90. Cox LA, Birnbaum S, Mahaney MC, Rainwater DL, Williams JT, VandeBerg JL. Identification of promoter variants in baboon endothelial lipase that regulate high-density lipoprotein cholesterol levels. Circulation. 2007 Sep 04; 116(10):1185-95. PMID: 17709635.
      Citations:    
    91. Bertin A, Mahaney MC, Cox LA, Rogers J, VandeBerg JL, Brugnara C, Platt OS. Quantitative trait loci for peripheral blood cell counts: a study in baboons. Mamm Genome. 2007 May; 18(5):361-72. PMID: 17557178.
      Citations:    
    92. Schmitz T, Cox LA, Li C, Levine BA, Ford SP, McDonald TJ, Nathanielsz PW. Prostaglandin E2 receptor expression in fetal baboon lung at 0.7 gestation after betamethasone exposure. Pediatr Res. 2007 Apr; 61(4):421-6. PMID: 17515865.
      Citations:    
    93. Cox LA, Nathanielsz PW. Importance of genetic differences in developmental programming: gene by environment interactions in models of maternal dietary restriction. J Physiol. 2007 Jun 01; 581(Pt 2):421-2. PMID: 17379628.
      Citations:    
    94. Nijland MJ, Schlabritz-Loutsevitch NE, Hubbard GB, Nathanielsz PW, Cox LA. Non-human primate fetal kidney transcriptome analysis indicates mammalian target of rapamycin (mTOR) is a central nutrient-responsive pathway. J Physiol. 2007 Mar 15; 579(Pt 3):643-56. PMID: 17185341.
      Citations:    
    95. Havill LM, Rogers J, Cox LA, Mahaney MC. QTL with pleiotropic effects on serum levels of bone-specific alkaline phosphatase and osteocalcin maps to the baboon ortholog of human chromosome 6p23-21.3. J Bone Miner Res. 2006 Dec; 21(12):1888-96. PMID: 17002583.
      Citations:    
    96. Cox LA, Mahaney MC, Vandeberg JL, Rogers J. A second-generation genetic linkage map of the baboon (Papio hamadryas) genome. Genomics. 2006 Sep; 88(3):274-81. PMID: 16697552.
      Citations:    
    97. Cox LA, Nijland MJ, Gilbert JS, Schlabritz-Loutsevitch NE, Hubbard GB, McDonald TJ, Shade RE, Nathanielsz PW. Effect of 30 per cent maternal nutrient restriction from 0.16 to 0.5 gestation on fetal baboon kidney gene expression. J Physiol. 2006 Apr 01; 572(Pt 1):67-85. PMID: 16513668.
      Citations:    
    98. Gilbert JS, Cox LA, Mitchell G, Nijland MJ. Nutrient-restricted fetus and the cardio-renal connection in hypertensive offspring. Expert Rev Cardiovasc Ther. 2006 Mar; 4(2):227-37. PMID: 16509818.
      Citations:    
    99. Cox LA, Schlabritz-Loutsevitch N, Hubbard GB, Nijland MJ, McDonald TJ, Nathanielsz PW. Gene expression profile differences in left and right liver lobes from mid-gestation fetal baboons: a cautionary tale. J Physiol. 2006 Apr 01; 572(Pt 1):59-66. PMID: 16484296.
      Citations:    
    100. Havill LM, Cox LA, Rogers J, Mahaney MC. Cross-species replication of a serum osteocalcin quantitative trait locus on human chromosome 16q in pedigreed baboons. Calcif Tissue Int. 2005 Oct; 77(4):205-11. PMID: 16193232.
      Citations:    
    101. Rainwater DL, Mahaney MC, Wang XL, Rogers J, Cox LA, Vandeberg JL. Determinants of variation in serum paraoxonase enzyme activity in baboons. J Lipid Res. 2005 Jul; 46(7):1450-6. PMID: 15834129.
      Citations:    
    102. Tejero ME, Cole SA, Cai G, Peebles KW, Freeland-Graves JH, Cox LA, Mahaney MC, Rogers J, VandeBerg JL, Blangero J, Comuzzie AG. Genome-wide scan of resistin mRNA expression in omental adipose tissue of baboons. Int J Obes (Lond). 2005 Apr; 29(4):406-12. PMID: 15326464.
      Citations:    
    103. Havill LM, Mahaney MC, Cox LA, Morin PA, Joslyn G, Rogers J. A quantitative trait locus for normal variation in forearm bone mineral density in pedigreed baboons maps to the ortholog of human chromosome 11q. J Clin Endocrinol Metab. 2005 Jun; 90(6):3638-45. PMID: 15755864.
      Citations:    
    104. Tejero ME, Proffitt JM, Cole SA, Freeland-Graves JH, Cai G, Peebles KW, Cox LA, Mahaney MC, Rogers J, Vandeberg JL, Blangero J, Comuzzie AG. Quantitative genetic analysis of glucose transporter 4 mRNA levels in baboon adipose. Obes Res. 2004 Oct; 12(10):1652-7. PMID: 15536229.
      Citations:    
    105. Rainwater DL, Kammerer CM, Mahaney MC, Rogers J, Cox LA, Schneider JL, VandeBerg JL. Localization of genes that control LDL size fractions in baboons. Atherosclerosis. 2003 May; 168(1):15-22. PMID: 12732382.
      Citations:    
    106. Kammerer CM, Rainwater DL, Schneider JL, Cox LA, Mahaney MC, Rogers J, VandeBerg JF. Two loci affect angiotensin I-converting enzyme activity in baboons. Hypertension. 2003 Mar; 41(3 Pt 2):854-9. PMID: 12624008.
      Citations:    
    107. Cox LA, Birnbaum S, VandeBerg JL. Identification of candidate genes regulating HDL cholesterol using a chromosomal region expression array. Genome Res. 2002 Nov; 12(11):1693-702. PMID: 12421756.
      Citations:    
    108. Kammerer CM, Rainwater DL, Cox LA, Schneider JL, Mahaney MC, Rogers J, VandeBerg JL. Locus controlling LDL cholesterol response to dietary cholesterol is on baboon homologue of human chromosome 6. Arterioscler Thromb Vasc Biol. 2002 Oct 01; 22(10):1720-5. PMID: 12377755.
      Citations:    
    109. Rainwater DL, Kammerer CM, Cox LA, Rogers J, Carey KD, Dyke B, Mahaney MC, McGill HC, VandeBerg JL. A major gene influences variation in large HDL particles and their response to diet in baboons. Atherosclerosis. 2002 Aug; 163(2):241-8. PMID: 12052470.
      Citations:    
    110. Cox LA. The FIC1 gene: structure and polymorphisms in baboon. J Med Primatol. 2002 Feb; 31(1):17-28. PMID: 12076045.
      Citations:    
    111. Kammerer CM, Cox LA, Mahaney MC, Rogers J, Shade RE. Sodium-lithium countertransport activity is linked to chromosome 5 in baboons. Hypertension. 2001 Feb; 37(2 Pt 2):398-402. PMID: 11230307.
      Citations:    
    112. Yuan SS, Cox LA, Dasika GK, Lee EY. Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos. Dev Biol. 1999 Mar 01; 207(1):62-75. PMID: 10049565.
      Citations:    
    113. Cox LA, Jett C, Hixson JE. Molecular basis of an apolipoprotein[a] null allele: a splice site mutation is associated with deletion of a single exon. J Lipid Res. 1998 Jul; 39(7):1319-26. PMID: 9684734.
      Citations:    
    114. Lee EY, Hu N, Yuan SS, Cox LA, Bradley A, Lee WH, Herrup K. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev. 1994 Sep 01; 8(17):2008-21. PMID: 7958874.
      Citations:    
    115. Cox LA, Chen G, Lee EY. Tumor suppressor genes and their roles in breast cancer. Breast Cancer Res Treat. 1994; 32(1):19-38. PMID: 7819583.
      Citations:    
    116. Hixson JE, Borenstein S, Cox LA. PvuII RFLP for the lecithin-cholesterol acyltransferase gene (LCAT) in baboons. Nucleic Acids Res. 1990 Jan 25; 18(2):384. PMID: 1970162.
      Citations:    
    117. Hixson JE, Kammerer CM, Cox LA, Mott GE. Identification of LDL receptor gene marker associated with altered levels of LDL cholesterol and apolipoprotein B in baboons. Arteriosclerosis. 1989 Nov-Dec; 9(6):829-35. PMID: 2574032.
      Citations:    
    118. Hixson JE, Borenstein S, Cox LA, Rainwater DL, VandeBerg JL. The baboon gene for apolipoprotein A-I: characterization of a cDNA clone and identification of DNA polymorphisms for genetic studies of cholesterol metabolism. Gene. 1988 Dec 30; 74(2):483-90. PMID: 2907746.
      Citations:    
    119. Hixson JE, Cox LA, Borenstein S. The baboon apolipoprotein E gene: structure, expression, and linkage with the gene for apolipoprotein C-1. Genomics. 1988 May; 2(4):315-23. PMID: 3220472.
      Citations:    
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