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Last Name

Kylie Kavanagh, V.M.S.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentComparative Medicine
Address
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    Collapse Research 
    Collapse research activities and funding
    T35OD010946     (KAVANAGH, KYLIE)Apr 1, 2009 - May 31, 2024
    NIH
    Summer Veterinary Student Research Fellows at Wake Forest University
    Role: Principal Investigator
    K01AG033641     (KAVANAGH, KYLIE)Sep 30, 2009 - Aug 31, 2014
    NIH/NIA
    Chaperone Proteins in a Primate Model of Age-Related Metabolic Disease
    Role: Principal Investigator
    R21AG049160     (KAVANAGH, KYLIE)Apr 15, 2015 - Mar 31, 2017
    NIH/NIA
    Age-Related Changes in Intestinal Function and Sarcopenia in Monkeys
    Role: Principal Investigator
    R01HL142930     (KAVANAGH, KYLIE)Dec 15, 2018 - Nov 30, 2023
    NIH/NHLBI
    Adipose Mitochondial Quality Control and Cardiovascular Function in Metabolically Healthy and Unhealthy Obese Monkeys
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kendziorski JA, Sherrill C, Davis AT, Kavanagh K. Microbial translocation into amniotic fluid of vervet monkeys is common and unrelated to adverse infant outcomes. J Med Primatol. 2019 12; 48(6):367-369. PMID: 31338846.
      View in: PubMed
    2. Wilson QN, Wells M, Davis AT, Sherrill C, Tsilimigras MCB, Jones RB, Fodor AA, Kavanagh K. Greater Microbial Translocation and Vulnerability to Metabolic Disease in Healthy Aged Female Monkeys. Sci Rep. 2018 07 27; 8(1):11373. PMID: 30054517.
      View in: PubMed
    3. Nagpal R, Mainali R, Ahmadi S, Wang S, Singh R, Kavanagh K, Kitzman DW, Kushugulova A, Marotta F, Yadav H. Gut microbiome and aging: Physiological and mechanistic insights. Nutr Healthy Aging. 2018 Jun 15; 4(4):267-285. PMID: 29951588.
      View in: PubMed
    4. Proffitt JM, Glenn J, Cesnik AJ, Jadhav A, Shortreed MR, Smith LM, Kavanagh K, Cox LA, Olivier M. Proteomics in non-human primates: utilizing RNA-Seq data to improve protein identification by mass spectrometry in vervet monkeys. BMC Genomics. 2017 Nov 13; 18(1):877. PMID: 29132314.
      View in: PubMed
    5. Tytell M, Davis AT, Giles J, Snider LC, Xiao R, Dozier SG, Presley TD, Kavanagh K. Alfalfa-derived HSP70 administered intranasally improves insulin sensitivity in mice. Cell Stress Chaperones. 2018 03; 23(2):189-194. PMID: 28822083.
      View in: PubMed
    6. Kavanagh K, Davis AT, Peters DE, LeGrand AC, Bharadwaj MS, Molina AJ. Regulators of mitochondrial quality control differ in subcutaneous fat of metabolically healthy and unhealthy obese monkeys. Obesity (Silver Spring). 2017 04; 25(4):689-696. PMID: 28236433.
      View in: PubMed
    7. Hyre AN, Kavanagh K, Kock ND, Donati GL, Subashchandrabose S. Copper Is a Host Effector Mobilized to Urine during Urinary Tract Infection To Impair Bacterial Colonization. Infect Immun. 2017 03; 85(3). PMID: 28031261.
      View in: PubMed
    8. Cydylo MA, Davis AT, Kavanagh K. Fatty liver promotes fibrosis in monkeys consuming high fructose. Obesity (Silver Spring). 2017 02; 25(2):290-293. PMID: 28124507.
      View in: PubMed
    9. DeBo RJ, Lees CJ, Dugan GO, Caudell DL, Michalson KT, Hanbury DB, Kavanagh K, Cline JM, Register TC. Late Effects of Total-Body Gamma Irradiation on Cardiac Structure and Function in Male Rhesus Macaques. Radiat Res. 2016 07; 186(1):55-64. PMID: 27333082.
      View in: PubMed
    10. Kavanagh K, Brown RN, Davis AT, Uberseder B, Floyd E, Pfisterer B, Shively CA. Microbial translocation and skeletal muscle in young and old vervet monkeys. Age (Dordr). 2016 Jun; 38(3):58. PMID: 27194407.
      View in: PubMed
    11. Kavanagh K, Davis AT, Jenkins KA, Flynn DM. Effects of heated hydrotherapy on muscle HSP70 and glucose metabolism in old and young vervet monkeys. Cell Stress Chaperones. 2016 07; 21(4):717-25. PMID: 27188431.
      View in: PubMed
    12. Kavanagh K, Dendinger MD, Davis AT, Register TC, DeBo R, Dugan G, Cline JM. Type 2 Diabetes is a Delayed Late Effect of Whole-Body Irradiation in Nonhuman Primates. Radiat Res. 2015 Apr; 183(4):398-406. PMID: 25811716.
      View in: PubMed
    13. Silverstein MG, Ordanes D, Wylie AT, Files DC, Milligan C, Presley TD, Kavanagh K. Inducing Muscle Heat Shock Protein 70 Improves Insulin Sensitivity and Muscular Performance in Aged Mice. J Gerontol A Biol Sci Med Sci. 2015 Jul; 70(7):800-8. PMID: 25123646.
      View in: PubMed
    14. Chung S, Cuffe H, Marshall SM, McDaniel AL, Ha JH, Kavanagh K, Hong C, Tontonoz P, Temel RE, Parks JS. Dietary cholesterol promotes adipocyte hypertrophy and adipose tissue inflammation in visceral, but not in subcutaneous, fat in monkeys. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):1880-7. PMID: 24969772.
      View in: PubMed
    15. Chichester L, Wylie AT, Craft S, Kavanagh K. Muscle heat shock protein 70 predicts insulin resistance with aging. J Gerontol A Biol Sci Med Sci. 2015 Feb; 70(2):155-62. PMID: 24532784.
      View in: PubMed
    16. Hooper PL, Balogh G, Rivas E, Kavanagh K, Vigh L. The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes. Cell Stress Chaperones. 2014 Jul; 19(4):447-64. PMID: 24523032.
      View in: PubMed
    17. Kavanagh K, Wylie AT, Tucker KL, Hamp TJ, Gharaibeh RZ, Fodor AA, Cullen JM. Reply to KN Litwak and S Levin. Am J Clin Nutr. 2014 Jan; 99(1):210. PMID: 24363257.
      View in: PubMed
    18. Kavanagh K, Wylie AT, Tucker KL, Hamp TJ, Gharaibeh RZ, Fodor AA, Cullen JM. Reply to JS White. Am J Clin Nutr. 2013 Nov; 98(5):1370. PMID: 24142242.
      View in: PubMed
    19. Kavanagh K, Wylie AT, Tucker KL, Hamp TJ, Gharaibeh RZ, Fodor AA, Cullen JM. Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates. Am J Clin Nutr. 2013 Aug; 98(2):349-57. PMID: 23783298.
      View in: PubMed
    20. Kavanagh K, Espeland MA, Sutton-Tyrrell K, Barinas-Mitchell E, El Khoudary SR, Wildman RP. Liver fat and SHBG affect insulin resistance in midlife women: the Study of Women's Health Across the Nation (SWAN). Obesity (Silver Spring). 2013 May; 21(5):1031-8. PMID: 23784907.
      View in: PubMed
    21. Voruganti VS, Jorgensen MJ, Kaplan JR, Kavanagh K, Rudel LL, Temel R, Fairbanks LA, Comuzzie AG. Significant genotype by diet (G × D) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in vervet monkeys (Chlorocebus aethiops sabaeus). Am J Primatol. 2013 May; 75(5):491-9. PMID: 23315630.
      View in: PubMed
    22. Kavanagh K, Wylie AT, Chavanne TJ, Jorgensen MJ, Voruganti VS, Comuzzie AG, Kaplan JR, McCall CE, Kritchevsky SB. Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance. J Gerontol A Biol Sci Med Sci. 2012 Oct; 67(10):1014-21. PMID: 22403054.
      View in: PubMed
    23. Kavanagh K, Flynn DM, Nelson C, Zhang L, Wagner JD. Characterization and validation of a streptozotocin-induced diabetes model in the vervet monkey. J Pharmacol Toxicol Methods. 2011 May-Jun; 63(3):296-303. PMID: 21356321.
      View in: PubMed
    24. Kavanagh K, Flynn DM, Jenkins KA, Zhang L, Wagner JD. Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys. Am J Physiol Endocrinol Metab. 2011 May; 300(5):E894-901. PMID: 21325107.
      View in: PubMed
    25. Saisho Y, Manesso E, Butler AE, Galasso R, Kavanagh K, Flynn M, Zhang L, Clark P, Gurlo T, Toffolo GM, Cobelli C, Wagner JD, Butler PC. Ongoing beta-cell turnover in adult nonhuman primates is not adaptively increased in streptozotocin-induced diabetes. Diabetes. 2011 Mar; 60(3):848-56. PMID: 21270238.
      View in: PubMed
    26. Rowe PA, Kavanagh K, Zhang L, Harwood HJ, Wagner JD. Short-term hyperglycemia increases arterial superoxide production and iron dysregulation in atherosclerotic monkeys. Metabolism. 2011 Aug; 60(8):1070-80. PMID: 21251685.
      View in: PubMed
    27. Wagner JD, Zhang L, Kavanagh K, Ward GM, Chin JE, Hadcock JR, Auerbach BJ, Harwood HJ. A selective cannabinoid-1 receptor antagonist, PF-95453, reduces body weight and body fat to a greater extent than pair-fed controls in obese monkeys. J Pharmacol Exp Ther. 2010 Oct; 335(1):103-13. PMID: 20605903.
      View in: PubMed
    28. Kavanagh K, Sajadian S, Jenkins KA, Wilson MD, Carr JJ, Wagner JD, Rudel LL. Neonatal and fetal exposure to trans-fatty acids retards early growth and adiposity while adversely affecting glucose in mice. Nutr Res. 2010 Jun; 30(6):418-26. PMID: 20650350.
      View in: PubMed
    29. Cann JA, Kavanagh K, Jorgensen MJ, Mohanan S, Howard TD, Gray SB, Hawkins GA, Fairbanks LA, Wagner JD. Clinicopathologic characterization of naturally occurring diabetes mellitus in vervet monkeys. Vet Pathol. 2010 Jul; 47(4):713-8. PMID: 20460450.
      View in: PubMed
    30. Kavanagh K, Brown KK, Berquist ML, Zhang L, Wagner JD. Fluid compartmental shifts with efficacious pioglitazone therapy in overweight monkeys: implications for peroxisome proliferator-activated receptor-gamma agonist use in prediabetes. Metabolism. 2010 Jun; 59(6):914-20. PMID: 20197197.
      View in: PubMed
    31. Wagner JD, Shadoan MK, Zhang L, Ward GM, Royer LJ, Kavanagh K, Francone OL, Auerbach BJ, Harwood HJ. A selective peroxisome proliferator-activated receptor alpha agonist, CP-900691, improves plasma lipids, lipoproteins, and glycemic control in diabetic monkeys. J Pharmacol Exp Ther. 2010 Jun; 333(3):844-53. PMID: 20190014.
      View in: PubMed
    32. Saisho Y, Butler AE, Manesso E, Galasso R, Zhang L, Gurlo T, Toffolo GM, Cobelli C, Kavanagh K, Wagner JD, Butler PC. Relationship between fractional pancreatic beta cell area and fasting plasma glucose concentration in monkeys. Diabetologia. 2010 Jan; 53(1):111-4. PMID: 19847395.
      View in: PubMed
    33. Kavanagh K, Davis MA, Zhang L, Wilson MD, Register TC, Adams MR, Rudel LL, Wagner JD. Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in monkeys. Arterioscler Thromb Vasc Biol. 2009 Oct; 29(10):1471-7. PMID: 19759374.
      View in: PubMed
    34. Clark PB, Kavanagh K, Gage HD, Garg P, Garg S, Calles-Escandon J, Wagner JD, Morton K. Enhanced cholinergic response in pancreata of nonhuman primates with impaired glucose tolerance shown on [18F]fluorobenzyltrozamicol positron emission tomography. Diabetes Technol Ther. 2009 Jul; 11(7):451-5. PMID: 19580359.
      View in: PubMed
    35. Wagner JD, Zhang L, Shadoan MK, Kavanagh K, Chen H, Tresnasari K, Kaplan JR, Adams MR. Effects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeys. Metabolism. 2008 Jul; 57(7 Suppl 1):S24-31. PMID: 18555850.
      View in: PubMed
    36. Kavanagh K, Jones KL, Zhang L, Flynn DM, Shadoan MK, Wagner JD. High isoflavone soy diet increases insulin secretion without decreasing insulin sensitivity in premenopausal nonhuman primates. Nutr Res. 2008 Jun; 28(6):368-76. PMID: 19083434.
      View in: PubMed
    37. Kavanagh K, Fairbanks LA, Bailey JN, Jorgensen MJ, Wilson M, Zhang L, Rudel LL, Wagner JD. Characterization and heritability of obesity and associated risk factors in vervet monkeys. Obesity (Silver Spring). 2007 Jul; 15(7):1666-74. PMID: 17636084.
      View in: PubMed
    38. Kavanagh K, Jones KL, Sawyer J, Kelley K, Carr JJ, Wagner JD, Rudel LL. Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeys. Obesity (Silver Spring). 2007 Jul; 15(7):1675-84. PMID: 17636085.
      View in: PubMed
    39. Shadoan MK, Kavanagh K, Zhang L, Anthony MS, Wagner JD. Addition of medroxyprogesterone acetate to conjugated equine estrogens results in insulin resistance in adipose tissue. Metabolism. 2007 Jun; 56(6):830-7. PMID: 17512317.
      View in: PubMed
    40. Wagner JE, Kavanagh K, Ward GM, Auerbach BJ, Harwood HJ, Kaplan JR. Old world nonhuman primate models of type 2 diabetes mellitus. ILAR J. 2006; 47(3):259-71. PMID: 16804200.
      View in: PubMed
    41. Kavanagh K, Koudy Williams J, Wagner JD. Naturally occurring menopause in cynomolgus monkeys: changes in hormone, lipid, and carbohydrate measures with hormonal status. J Med Primatol. 2005 Aug; 34(4):171-7. PMID: 16053494.
      View in: PubMed
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