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Kip D. Zimmerman PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Molecular Medicine
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    Collapse Biography 
    Collapse education and training
    Wake Forest University, Winston-Salem, NC01/2022Biostatistics
    Wake Forest University, Winston-Salem, NCPhD01/2021Molecular Genetics and Genomics
    Rollins College, Winter Park, FLBAS05/2014Marine Biology

    Collapse Overview 
    Collapse overview
    I am a biostatistician with an interest in applying and developing statistical methods to identify genomic drivers of disease. I am currently working on assembling computational pipelines for the analysis of proteomic and metabolomic data generated in Dr. Michael Olivier’s laboratory. In addition, I am maturing statistical methods for integrating metabolomic data together proteomic and transcriptomic data in an effort to understand complex biological processes at more than one individual level of omics data. I have a special interest in understanding some of the biological mechanisms related to gene splicing and the role gene splicing plays in healthy development and aging.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pullikuth AK, Routh ED, Zimmerman KD, Chifman J, Chou JW, Soike MH, Jin G, Su J, Song Q, Black MA, Print C, Bedognetti D, Howard-McNatt M, O'Neill SS, Thomas A, Langefeld CD, Sigalov AB, Lu Y, Miller LD. Bulk and Single-Cell Profiling of Breast Tumors Identifies TREM-1 as a Dominant Immune Suppressive Marker Associated With Poor Outcomes. Front Oncol. 2021; 11:734959. PMID: 34956864.
      Citations:    
    2. Ghodke-Puranik Y, Jin Z, Zimmerman KD, Ainsworth HC, Fan W, Jensen MA, Dorschner JM, Vsetecka DM, Amin S, Makol A, Ernste F, Osborn T, Moder K, Chowdhary V, Langefeld CD, Niewold TB. Single-cell expression quantitative trait loci (eQTL) analysis of SLE-risk loci in lupus patient monocytes. Arthritis Res Ther. 2021 11 30; 23(1):290. PMID: 34847931.
      Citations:    
    3. Marion MC, Ramos PS, Bachali P, Labonte AC, Zimmerman KD, Ainsworth HC, Heuer SE, Robl RD, Catalina MD, Kelly JA, Howard TD, Lipsky PE, Grammer AC, Langefeld CD. Nucleic Acid-Sensing and Interferon-Inducible Pathways Show Differential Methylation in MZ Twins Discordant for Lupus and Overexpression in Independent Lupus Samples: Implications for Pathogenic Mechanism and Drug Targeting. Genes (Basel). 2021 11 26; 12(12). PMID: 34946847.
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    4. Malaab M, Renaud L, Takamura N, Zimmerman KD, da Silveira WA, Ramos PS, Haddad S, Peters-Golden M, Penke LR, Wolf B, Hardiman G, Langefeld CD, Medsger TA, Feghali-Bostwick CA. Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis. Ann Rheum Dis. 2022 02; 81(2):268-277. PMID: 34750102.
      Citations:    
    5. Zimmerman KD, Schurr TG, Chen WM, Nayak U, Mychaleckyj JC. Genetic landscape of Gullah African Americans. Am J Phys Anthropol. 2021 May 19. PMID: 34008864.
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    6. Zimmerman KD, Langefeld CD. Hierarchicell: an R-package for estimating power for tests of differential expression with single-cell data. BMC Genomics. 2021 May 01; 22(1):319. PMID: 33932993.
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    7. Walsh KB, Zimmerman KD, Zhang X, Demel SL, Luo Y, Langefeld CD, Wohleb E, Schulert G, Woo D, Adeoye O. miR-181a Mediates Inflammatory Gene Expression After Intracerebral Hemorrhage: An Integrated Analysis of miRNA-seq and mRNA-seq in a Swine ICH Model. J Mol Neurosci. 2021 Mar 23. PMID: 33755911.
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    8. Zimmerman KD, Espeland MA, Langefeld CD. A practical solution to pseudoreplication bias in single-cell studies. Nat Commun. 2021 02 02; 12(1):738. PMID: 33531494.
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    9. Jensen ET, Langefeld CD, Zimmerman KD, Howard TD, Dellon ES. Epigenetic methylation in Eosinophilic Esophagitis: Molecular ageing and novel biomarkers for treatment response. Clin Exp Allergy. 2020 12; 50(12):1372-1380. PMID: 32986922.
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    10. Owen KA, Price A, Ainsworth H, Aidukaitis BN, Bachali P, Catalina MD, Dittman JM, Howard TD, Kingsmore KM, Labonte AC, Marion MC, Robl RD, Zimmerman KD, Langefeld CD, Grammer AC, Lipsky PE. Analysis of Trans-Ancestral SLE Risk Loci Identifies Unique Biologic Networks and Drug Targets in African and European Ancestries. Am J Hum Genet. 2020 11 05; 107(5):864-881. PMID: 33031749.
      Citations:    
    11. Walker SJ, Langefeld CD, Zimmerman K, Schwartz MZ, Krigsman A. A molecular biomarker for prediction of clinical outcome in children with ASD, constipation, and intestinal inflammation. Sci Rep. 2019 04 12; 9(1):5987. PMID: 30979947.
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    12. Ramos PS, Zimmerman KD, Haddad S, Langefeld CD, Medsger TA, Feghali-Bostwick CA. Integrative analysis of DNA methylation in discordant twins unveils distinct architectures of systemic sclerosis subsets. Clin Epigenetics. 2019 04 04; 11(1):58. PMID: 30947741.
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    13. Sunwook K, Nussbaum MA, Quandt SA, Laurienti PJ, Arcury TA. Effects of Lifetime Occupational Pesticide Exposure on Postural Control Among Farmworkers and Non-Farmworkers. J Occup Environ Med. 2016 Feb; 58(2):133-9. PMID: 29671961.
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