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Jeffrey S. Willey PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Rheumatology
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentOrthopedic Surgery

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentPathology, Comparative Medicine

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentWake Forest Institute for Regenerative Medicine


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    R21AR072806     (WILLEY, JEFFREY S)Apr 1, 2018 - Mar 31, 2021
    NIH
    Targeting IRE-1? to protect against radiation therapy-induced bone loss
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kwok AT, Mohamed NS, Plate JF, Yammani RR, Rosas S, Bateman TA, Livingston E, Moore JE, Kerr BA, Lee J, Furdui CM, Tan L, Bouxsein ML, Ferguson VL, Stodieck LS, Zawieja DC, Delp MD, Mao XW, Willey JS. Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents. Sci Rep. 2021 May 18; 11(1):10469. PMID: 34006989.
      Citations:    
    2. Rusin M, Ghobrial N, Takacs E, Willey JS, Dean D. Changes in ionizing radiation dose rate affect cell cycle progression in adipose derived stem cells. PLoS One. 2021; 16(4):e0250160. PMID: 33905436.
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    3. Kerr BA, Harris KS, Shi L, Willey JS, Soto-Pantoja DR, Byzova TV. Platelet TSP-1 controls prostate cancer-induced osteoclast differentiation and bone marrow-derived cell mobilization through TGFß-1. Am J Clin Exp Urol. 2021; 9(1):18-31. PMID: 33816691.
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    4. Kerr BA, Shi L, Jinnah AH, Harris KS, Willey JS, Lennon DP, Caplan AI, Byzova TV. Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis. Exp Cell Res. 2021 02 15; 399(2):112456. PMID: 33417921.
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    5. Jinnah AH, Whitlock P, Willey JS, Danelson K, Kerr BA, Hassan OA, Emory CL, Smith TL, Bracey DN. Improved osseointegration using porcine xenograft compared to demineralized bone matrix for the treatment of critical defects in a small animal model. Xenotransplantation. 2021 Mar; 28(2):e12662. PMID: 33242920.
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    6. da Silveira WA, Fazelinia H, Rosenthal SB, Laiakis EC, Kim MS, Meydan C, Kidane Y, Rathi KS, Smith SM, Stear B, Ying Y, Zhang Y, Foox J, Zanello S, Crucian B, Wang D, Nugent A, Costa HA, Zwart SR, Schrepfer S, Elworth RAL, Sapoval N, Treangen T, MacKay M, Gokhale NS, Horner SM, Singh LN, Wallace DC, Willey JS, Schisler JC, Meller R, McDonald JT, Fisch KM, Hardiman G, Taylor D, Mason CE, Costes SV, Beheshti A. Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact. Cell. 2020 11 25; 183(5):1185-1201.e20. PMID: 33242417.
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    7. Mao XW, Nishiyama NC, Byrum SD, Stanbouly S, Jones T, Holley J, Sridharan V, Boerma M, Tackett AJ, Willey JS, Pecaut MJ, Delp MD. Spaceflight induces oxidative damage to blood-brain barrier integrity in a mouse model. FASEB J. 2020 11; 34(11):15516-15530. PMID: 32981077.
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    8. Farris MK, Helis CA, Hughes RT, LeCompte MC, Borg AM, Nieto K, Munley MT, Willey JS. Bench to Bedside: Animal Models of Radiation Induced Musculoskeletal Toxicity. Cancers (Basel). 2020 Feb 12; 12(2). PMID: 32059447.
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    9. Pen OV, Antinozzi PA, Kock ND, Robinson MB, Willey JS, Bourland JD. Automated, quantitative assessment of epidermal necrosis expression resulting from skin exposure to beta radiation. Biomed Phys Eng Express. 2019 11 25; 6(1):015007. PMID: 33438595.
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    10. Kwok A, Rosas S, Bateman TA, Livingston E, Smith TL, Moore J, Zawieja DC, Hampton T, Mao XW, Delp MD, Willey JS. Altered rodent gait characteristics after ~35 days in orbit aboard the International Space Station. Life Sci Space Res (Amst). 2020 Feb; 24:9-17. PMID: 31987483.
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    11. Bracey DN, Jinnah AH, Willey JS, Seyler TM, Hutchinson ID, Whitlock PW, Smith TL, Danelson KA, Emory CL, Kerr BA. Investigating the Osteoinductive Potential of a Decellularized Xenograft Bone Substitute. Cells Tissues Organs. 2019; 207(2):97-113. PMID: 31655811.
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    12. Overbey EG, da Silveira WA, Stanbouly S, Nishiyama NC, Roque-Torres GD, Pecaut MJ, Zawieja DC, Wang C, Willey JS, Delp MD, Hardiman G, Mao XW. Spaceflight influences gene expression, photoreceptor integrity, and oxidative stress-related damage in the murine retina. Sci Rep. 2019 09 16; 9(1):13304. PMID: 31527661.
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    13. Rosas S, Tipton S, Luo TD, Kerr BA, Plate JF, Willey JS, Emory CL. A History of Past Prostate Cancer Still Carries Risk After Total Knee Arthroplasty. J Knee Surg. 2021 Feb; 34(3):293-297. PMID: 31461758.
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    14. Rosas S, Hughes RT, Farris M, Lee H, McTyre ER, Plate JF, Shi L, Emory CL, Blackstock AW, Kerr BA, Willey JS. Cartilage oligomeric matrix protein in patients with osteoarthritis is independently associated with metastatic disease in prostate cancer. Oncotarget. 2019 Jul 30; 10(46):4776-4785. PMID: 31413818.
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    15. Taylor V, Hicks J, Ferguson C, Willey J, Danelson K. Effects of tissue culture on the biomechanical properties of porcine meniscus explants. Clin Biomech (Bristol, Avon). 2019 10; 69:120-126. PMID: 31330461.
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    16. Rosas S, Tipton S, Luo TD, Plate JF, Willey JS, Emory CL. Complications and Costs Are Not Increased After Total Hip Arthroplasty in Patients With a History of Prostate Cancer. J Arthroplasty. 2019 Dec; 34(12):2968-2971. PMID: 31326242.
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    17. Mao XW, Nishiyama NC, Byrum SD, Stanbouly S, Jones T, Drew A, Sridharan V, Boerma M, Tackett AJ, Zawieja D, Willey JS, Delp M, Pecaut MJ. Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations. Sci Rep. 2019 06 03; 9(1):8215. PMID: 31160660.
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    18. Kwok AT, Moore JE, Rosas S, Kerr BA, Andrews RN, Nguyen CM, Lee J, Furdui CM, Collins BE, Munley MT, Willey JS. Knee and Hip Joint Cartilage Damage from Combined Spaceflight Hazards of Low-Dose Radiation Less than 1 Gy and Prolonged Hindlimb Unloading. Radiat Res. 2019 06; 191(6):497-506. PMID: 30925135.
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    19. Luo TD, Vines JB, Zabarsky ZK, Mowry KC, Marquez-Lara A, Jinnah AH, Ma X, Berwick BW, Willey JS, Smith TL, Li Z, O'Gara TJ. Evaluation of Percutaneous Intradiscal Amniotic Suspension Allograft in a Rabbit Model of Intervertebral Disc Degeneration. Spine (Phila Pa 1976). 2019 03 15; 44(6):E329-E337. PMID: 30138254.
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    20. Bracey DN, Seyler TM, Jinnah AH, Lively MO, Willey JS, Smith TL, Van Dyke ME, Whitlock PW. A Decellularized Porcine Xenograft-Derived Bone Scaffold for Clinical Use as a Bone Graft Substitute: A Critical Evaluation of Processing and Structure. J Funct Biomater. 2018 Jul 12; 9(3). PMID: 30002336.
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    21. Farris M, McTyre ER, Okoukoni C, Dugan G, Johnson BJ, Blackstock AW, Munley MT, Bourland JD, Cline JM, Willey JS. Cortical Thinning and Structural Bone Changes in Non-Human Primates after Single-Fraction Whole-Chest Irradiation. Radiat Res. 2018 07; 190(1):63-71. PMID: 29738279.
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    22. Luo TD, Marquez-Lara A, Zabarsky ZK, Vines JB, Mowry KC, Jinnah AH, Ma X, Berwick BW, Willey JS, Li Z, Smith TL, O'Gara TJ. A percutaneous, minimally invasive annulus fibrosus needle puncture model of intervertebral disc degeneration in rabbits. J Orthop Surg (Hong Kong). 2018 May-Aug; 26(3):2309499018792715. PMID: 30114959.
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    23. Luo TD, Marois AJ, Smith TL, Willey JS, Emory CL. Ascorbic Acid and Its Clinical Role in Orthopaedic Surgery. J Surg Orthop Adv. 2018 Winter; 27(4):261-268. PMID: 30777823.
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    24. Rosas S, Marquez-Lara A, Jinnah AH, Roche MW, Willey JS, Gwam C, Emory CL. Hemiarthroplasty for Fractures of Metastatic Bone Disease Have Different Outcomes Compared to Fractures Without Metastasis: A Matched-Pair Analysis. Surg Technol Int. 2017 Dec 22; 31:339-345. PMID: 29316590.
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    25. Okoukoni C, Randolph DM, McTyre ER, Kwok A, Weaver AA, Blackstock AW, Munley MT, Willey JS. Early dose-dependent cortical thinning of the femoral neck in anal cancer patients treated with pelvic radiation therapy. Bone. 2017 01; 94:84-89. PMID: 27780791.
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    26. Willey JS, Kwok AT, Moore JE, Payne V, Lindburg CA, Balk SA, Olson J, Black PJ, Walb MC, Yammani RR, Munley MT. Spaceflight-Relevant Challenges of Radiation and/or Reduced Weight Bearing Cause Arthritic Responses in Knee Articular Cartilage. Radiat Res. 2016 Oct; 186(4):333-344. PMID: 27602483.
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    27. Okoukoni C, Lynch SK, McTyre ER, Randolph DM, Weaver AA, Blackstock AW, Lally BE, Munley MT, Willey JS. A cortical thickness and radiation dose mapping approach identifies early thinning of ribs after stereotactic body radiation therapy. Radiother Oncol. 2016 06; 119(3):449-53. PMID: 27072937.
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    28. Sunwook K, Nussbaum MA, Quandt SA, Laurienti PJ, Arcury TA. Effects of Lifetime Occupational Pesticide Exposure on Postural Control Among Farmworkers and Non-Farmworkers. J Occup Environ Med. 2016 Feb; 58(2):133-9. PMID: 33902391.
      Citations:    
    29. Willey JS, Bracey DN, Gallagher PE, Tallant EA, Wiggins WF, Callahan MF, Smith TL, Emory CL. Angiotensin-(1-7) Attenuates Skeletal Muscle Fibrosis and Stiffening in a Mouse Model of Extremity Sarcoma Radiation Therapy. J Bone Joint Surg Am. 2016 Jan 06; 98(1):48-55. PMID: 26738903.
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    30. Brown M, Held K, Mason K, McBride B, Willey J, Williams J. Whither ICRR? Radiat Res. 2015 Dec; 184(6):563-4. PMID: 26600171.
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    31. Walb MC, Black PJ, Payne VS, Munley MT, Willey JS. A reproducible radiation delivery method for unanesthetized rodents during periods of hind limb unloading. Life Sci Space Res (Amst). 2015 Jul; 6:10-4. PMID: 26097807.
      Citations:    
    32. Goyden J, Tawara K, Hedeen D, Willey JS, Oxford JT, Jorcyk CL. The Effect of OSM on MC3T3-E1 Osteoblastic Cells in Simulated Microgravity with Radiation. PLoS One. 2015; 10(6):e0127230. PMID: 26030441.
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    33. Hutchinson ID, Olson J, Lindburg CA, Payne V, Collins B, Smith TL, Munley MT, Wheeler KT, Willey JS. Total-body irradiation produces late degenerative joint damage in rats. Int J Radiat Biol. 2014 Sep; 90(9):821-30. PMID: 24885745.
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    34. Lindburg CA, Willey JS, Dean D. Effects of low dose X-ray irradiation on porcine articular cartilage explants. J Orthop Res. 2013 Nov; 31(11):1780-5. PMID: 23913833.
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    35. Long DL, Willey JS, Loeser RF. Rac1 is required for matrix metalloproteinase 13 production by chondrocytes in response to fibronectin fragments. Arthritis Rheum. 2013 Jun; 65(6):1561-8. PMID: 23460186.
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    36. Willey JS, Long DL, Vanderman KS, Loeser RF. Ionizing radiation causes active degradation and reduces matrix synthesis in articular cartilage. Int J Radiat Biol. 2013 Apr; 89(4):268-77. PMID: 23134087.
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    37. Lloyd SA, Bandstra ER, Willey JS, Riffle SE, Tirado-Lee L, Nelson GA, Pecaut MJ, Bateman TA. Effect of proton irradiation followed by hindlimb unloading on bone in mature mice: a model of long-duration spaceflight. Bone. 2012 Oct; 51(4):756-64. PMID: 22789684.
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    38. Willey JS, Lloyd SA, Nelson GA, Bateman TA. Ionizing Radiation and Bone Loss: Space Exploration and Clinical Therapy Applications. Clin Rev Bone Miner Metab. 2011 Mar; 9(1):54-62. PMID: 22826690.
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    39. Willey JS, Lloyd SA, Nelson GA, Bateman TA. Space Radiation and Bone Loss. Gravit Space Biol Bull. 2011; 25(1):14-21. PMID: 22826632.
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    40. Willey JS, Livingston EW, Robbins ME, Bourland JD, Tirado-Lee L, Smith-Sielicki H, Bateman TA. Risedronate prevents early radiation-induced osteoporosis in mice at multiple skeletal locations. Bone. 2010 Jan; 46(1):101-11. PMID: 19747571.
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    41. Bandstra ER, Thompson RW, Nelson GA, Willey JS, Judex S, Cairns MA, Benton ER, Vazquez ME, Carson JA, Bateman TA. Musculoskeletal changes in mice from 20-50 cGy of simulated galactic cosmic rays. Radiat Res. 2009 Jul; 172(1):21-9. PMID: 19580504.
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    42. Willey JS, Lloyd SA, Robbins ME, Bourland JD, Smith-Sielicki H, Bowman LC, Norrdin RW, Bateman TA. Early increase in osteoclast number in mice after whole-body irradiation with 2 Gy X rays. Radiat Res. 2008 Sep; 170(3):388-92. PMID: 18763868.
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    43. Bandstra ER, Pecaut MJ, Anderson ER, Willey JS, De Carlo F, Stock SR, Gridley DS, Nelson GA, Levine HG, Bateman TA. Long-term dose response of trabecular bone in mice to proton radiation. Radiat Res. 2008 Jun; 169(6):607-14. PMID: 18494551.
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    44. Lloyd SA, Bandstra ER, Travis ND, Nelson GA, Bourland JD, Pecaut MJ, Gridley DS, Willey JS, Bateman TA. Spaceflight-relevant types of ionizing radiation and cortical bone: Potential LET effect? Adv Space Res. 2008; 42(12):1889-1897. PMID: 19122806.
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    45. Reilly SM, Willey JS, Biknevicius AR, Blob RW. Hindlimb function in the alligator: integrating movements, motor patterns, ground reaction forces and bone strain of terrestrial locomotion. J Exp Biol. 2005 Mar; 208(Pt 6):993-1009. PMID: 15767301.
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    46. Miesse AM, Willey JS, Bateman TA. Potential role of proinflammatory cytokines in nerve damage related bone loss. Biomed Sci Instrum. 2004; 40:266-71. PMID: 15133969.
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    47. Willey JS, Biknevicius AR, Reilly SM, Earls KD. The tale of the tail: limb function and locomotor mechanics in Alligator mississippiensis. J Exp Biol. 2004 Jan; 207(Pt 3):553-63. PMID: 14691103.
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