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Jared A.Weis PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentBiomedical Engineering
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    K25CA204599     (WEIS, JARED ANTHONY)Jul 1, 2016 - Jun 30, 2021
    NIH
    Multi-Scale Biomechanical Modeling of Tumor Growth and Response in Breast Cancer
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Miller CE, Jordan JH, Thomas A, Weis JA. Developing a biomechanical model-based elasticity imaging method for assessing hormone receptor positive breast cancer treatment-related myocardial stiffness changes. J Med Imaging (Bellingham). 2021 Sep; 8(5):056002. PMID: 34604442.
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    2. Caldwell B, Meyer AR, Weis JA, Engevik AC, Choi E. Chief cell plasticity is the origin of metaplasia following acute injury in the stomach mucosa. Gut. 2021 Sep 08. PMID: 34497145.
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    3. Dohm AE, Nickles TM, Miller CE, Bowers HJ, Miga MI, Attia A, Chan MD, Weis JA. Clinical Assessment of a Biophysical Model for Distinguishing Tumor Progression from Radiation Necrosis. Med Phys. 2021 May 27. PMID: 34042188.
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    4. Weis VG, Deal AC, Mekkey G, Clouse C, Gaffley M, Whitaker E, Peeler CB, Weis JA, Schwartz MZ, Atala A. Human placental-derived stem cell therapy ameliorates experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2021 04 01; 320(4):G658-G674. PMID: 33566727.
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    5. Meyer AR, Engevik AC, Madorsky T, Belmont E, Stier MT, Norlander AE, Pilkinton MA, McDonnell WJ, Weis JA, Jang B, Mallal SA, Peebles RS, Goldenring JR. Group 2 Innate Lymphoid Cells Coordinate Damage Response in the Stomach. Gastroenterology. 2020 12; 159(6):2077-2091.e8. PMID: 32891625.
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    6. Bowers HJ, Fannin EE, Thomas A, Weis JA. Characterization of multicellular breast tumor spheroids using image data-driven biophysical mathematical modeling. Sci Rep. 2020 07 14; 10(1):11583. PMID: 32665565.
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    7. Narasimhan S, Weis JA, Luo M, Simpson AL, Thompson RC, Miga MI. Accounting for intraoperative brain shift ascribable to cavity collapse during intracranial tumor resection. J Med Imaging (Bellingham). 2020 May; 7(3):031506. PMID: 32613027.
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    8. Collins JA, Heiselman JS, Clements LW, Weis JA, Brown DB, Miga MI. Toward Image Data-Driven Predictive Modeling for Guiding Thermal Ablative Therapy. IEEE Trans Biomed Eng. 2020 06; 67(6):1548-1557. PMID: 31494543.
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    9. McKenna MT, Weis JA, Quaranta V, Yankeelov TE. Leveraging Mathematical Modeling to Quantify Pharmacokinetic and Pharmacodynamic Pathways: Equivalent Dose Metric. Front Physiol. 2019; 10:616. PMID: 31178753.
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    10. Hormuth DA, Sorace AG, Virostko J, Abramson RG, Bhujwalla ZM, Enriquez-Navas P, Gillies R, Hazle JD, Mason RP, Quarles CC, Weis JA, Whisenant JG, Xu J, Yankeelov TE. Translating preclinical MRI methods to clinical oncology. J Magn Reson Imaging. 2019 11; 50(5):1377-1392. PMID: 30925001.
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    11. Narasimhan S, Johnson HB, Nickles TM, Miga MI, Rana N, Attia A, Weis JA. Biophysical model-based parameters to classify tumor recurrence from radiation-induced necrosis for brain metastases. Med Phys. 2019 May; 46(5):2487-2496. PMID: 30816555.
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    12. Narasimhan S, Weis JA, González HFJ, Thompson RC, Miga MI. In vivo modeling of interstitial pressure in a porcine model: approximation of poroelastic properties and effects of enhanced anatomical structure modeling. J Med Imaging (Bellingham). 2018 Oct; 5(4):045002. PMID: 30840744.
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    13. Xiao TG, Weis JA, Gayzik FS, Thomas A, Chiba A, Gurcan MN, Topaloglu U, Samykutty A, McNally LR. Applying dynamic contrast enhanced MSOT imaging to intratumoral pharmacokinetic modeling. Photoacoustics. 2018 Sep; 11:28-35. PMID: 30105204.
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    14. McKenna MT, Weis JA, Brock A, Quaranta V, Yankeelov TE. Precision Medicine with Imprecise Therapy: Computational Modeling for Chemotherapy in Breast Cancer. Transl Oncol. 2018 Jun; 11(3):732-742. PMID: 29674173.
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    15. McKenna MT, Weis JA, Quaranta V, Yankeelov TE. Variable Cell Line Pharmacokinetics Contribute to Non-Linear Treatment Response in Heterogeneous Cell Populations. Ann Biomed Eng. 2018 Jun; 46(6):899-911. PMID: 29484528.
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    16. Griesenauer RH, Weis JA, Arlinghaus LR, Meszoely IM, Miga MI. Toward quantitative quasistatic elastography with a gravity-induced deformation source for image-guided breast surgery. J Med Imaging (Bellingham). 2018 Jan; 5(1):015003. PMID: 29430479.
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    17. Hormuth DA, Eldridge SL, Weis JA, Miga MI, Yankeelov TE. Mechanically Coupled Reaction-Diffusion Model to Predict Glioma Growth: Methodological Details. Methods Mol Biol. 2018; 1711:225-241. PMID: 29344892.
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    18. Heiselman JS, Clements LW, Collins JA, Weis JA, Simpson AL, Geevarghese SK, Kingham TP, Jarnagin WR, Miga MI. Characterization and correction of intraoperative soft tissue deformation in image-guided laparoscopic liver surgery. J Med Imaging (Bellingham). 2018 Apr; 5(2):021203. PMID: 29285519.
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    19. Hormuth DA, Weis JA, Barnes SL, Miga MI, Quaranta V, Yankeelov TE. Biophysical Modeling of In Vivo Glioma Response After Whole-Brain Radiation Therapy in a Murine Model of Brain Cancer. Int J Radiat Oncol Biol Phys. 2018 04 01; 100(5):1270-1279. PMID: 29398129.
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    20. Luo M, Frisken SF, Weis JA, Clements LW, Unadkat P, Thompson RC, Golby AJ, Miga MI. Retrospective study comparing model-based deformation correction to intraoperative magnetic resonance imaging for image-guided neurosurgery. J Med Imaging (Bellingham). 2017 Jul; 4(3):035003. PMID: 28924573.
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    21. McKenna MT, Weis JA, Barnes SL, Tyson DR, Miga MI, Quaranta V, Yankeelov TE. A Predictive Mathematical Modeling Approach for the Study of Doxorubicin Treatment in Triple Negative Breast Cancer. Sci Rep. 2017 07 18; 7(1):5725. PMID: 28720897.
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    22. Clements LW, Collins JA, Weis JA, Simpson AL, Kingham TP, Jarnagin WR, Miga MI. Deformation correction for image guided liver surgery: An intraoperative fidelity assessment. Surgery. 2017 09; 162(3):537-547. PMID: 28705490.
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    23. Griesenauer RH, Weis JA, Arlinghaus LR, Meszoely IM, Miga MI. Breast tissue stiffness estimation for surgical guidance using gravity-induced excitation. Phys Med Biol. 2017 Jun 21; 62(12):4756-4776. PMID: 28520556.
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    24. Hormuth DA, Weis JA, Barnes SL, Miga MI, Rericha EC, Quaranta V, Yankeelov TE. A mechanically coupled reaction-diffusion model that incorporates intra-tumoural heterogeneity to predict in vivo glioma growth. J R Soc Interface. 2017 03; 14(128). PMID: 28330985.
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    25. Collins JA, Weis JA, Heiselman JS, Clements LW, Simpson AL, Jarnagin WR, Miga MI. Improving Registration Robustness for Image-Guided Liver Surgery in a Novel Human-to-Phantom Data Framework. IEEE Trans Med Imaging. 2017 07; 36(7):1502-1510. PMID: 28212080.
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    26. Weis VG, Petersen CP, Weis JA, Meyer AR, Choi E, Mills JC, Goldenring JR. Maturity and age influence chief cell ability to transdifferentiate into metaplasia. Am J Physiol Gastrointest Liver Physiol. 2017 01 01; 312(1):G67-G76. PMID: 27881402.
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    27. Weis JA, Miga MI, Yankeelov TE. Three-dimensional Image-based Mechanical Modeling for Predicting the Response of Breast Cancer to Neoadjuvant Therapy. Comput Methods Appl Mech Eng. 2017 Feb 01; 314:494-512. PMID: 28042181.
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    28. Yankeelov TE, An G, Saut O, Luebeck EG, Popel AS, Ribba B, Vicini P, Zhou X, Weis JA, Ye K, Genin GM. Multi-scale Modeling in Clinical Oncology: Opportunities and Barriers to Success. Ann Biomed Eng. 2016 09; 44(9):2626-41. PMID: 27384942.
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    29. Clements LW, Collins JA, Weis JA, Simpson AL, Adams LB, Jarnagin WR, Miga MI. Evaluation of model-based deformation correction in image-guided liver surgery via tracked intraoperative ultrasound. J Med Imaging (Bellingham). 2016 Jan; 3(1):015003. PMID: 27081664.
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    30. Abramson RG, Arlinghaus LR, Dula AN, Quarles CC, Stokes AM, Weis JA, Whisenant JG, Chekmenev EY, Zhukov I, Williams JM, Yankeelov TE. MR Imaging Biomarkers in Oncology Clinical Trials. Magn Reson Imaging Clin N Am. 2016 Feb; 24(1):11-29. PMID: 26613873.
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    31. Weis JA, Miga MI, Arlinghaus LR, Li X, Abramson V, Chakravarthy AB, Pendyala P, Yankeelov TE. Predicting the Response of Breast Cancer to Neoadjuvant Therapy Using a Mechanically Coupled Reaction-Diffusion Model. Cancer Res. 2015 Nov 15; 75(22):4697-707. PMID: 26333809.
      Citations:    
    32. Weis JA, Flint KM, Sanchez V, Yankeelov TE, Miga MI. Assessing the accuracy and reproducibility of modality independent elastography in a murine model of breast cancer. J Med Imaging (Bellingham). 2015 Jul; 2(3):036001. PMID: 26158120.
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    33. Conley RH, Meszoely IM, Weis JA, Pheiffer TS, Arlinghaus LR, Yankeelov TE, Miga MI. Realization of a biomechanical model-assisted image guidance system for breast cancer surgery using supine MRI. Int J Comput Assist Radiol Surg. 2015 Dec; 10(12):1985-96. PMID: 26092657.
      Citations:    
    34. Hormuth DA, Weis JA, Barnes SL, Miga MI, Rericha EC, Quaranta V, Yankeelov TE. Predicting in vivo glioma growth with the reaction diffusion equation constrained by quantitative magnetic resonance imaging data. Phys Biol. 2015 Jun 04; 12(4):046006. PMID: 26040472.
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    35. Felix DD, Gore JC, Yankeelov TE, Peterson TE, Barnes S, Whisenant J, Weis J, Shoukouhi S, Virostko J, Nickels M, McIntyre JO, Sanders M, Abramson V, Tantawy MN. Detection of breast cancer microcalcification using (99m)Tc-MDP SPECT or Osteosense 750EX FMT imaging. Nucl Med Biol. 2015 Mar; 42(3):269-73. PMID: 25533764.
      Citations:    
    36. Sun K, Pheiffer TS, Simpson AL, Weis JA, Thompson RC, Miga MI. Near Real-Time Computer Assisted Surgery for Brain Shift Correction Using Biomechanical Models. IEEE J Transl Eng Health Med. 2014 Apr 30; 2. PMID: 25914864.
      Citations:    
    37. Weis JA, Miga MI, Arlinghaus LR, Li X, Chakravarthy AB, Abramson V, Farley J, Yankeelov TE. A mechanically coupled reaction-diffusion model for predicting the response of breast tumors to neoadjuvant chemotherapy. Phys Med Biol. 2013 Sep 07; 58(17):5851-66. PMID: 23920113.
      Citations:    
    38. Yankeelov TE, Atuegwu N, Hormuth D, Weis JA, Barnes SL, Miga MI, Rericha EC, Quaranta V. Clinically relevant modeling of tumor growth and treatment response. Sci Transl Med. 2013 May 29; 5(187):187ps9. PMID: 23720579.
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    39. Abramson RG, Arlinghaus LR, Weis JA, Li X, Dula AN, Chekmenev EY, Smith SA, Miga MI, Abramson VG, Yankeelov TE. Current and emerging quantitative magnetic resonance imaging methods for assessing and predicting the response of breast cancer to neoadjuvant therapy. Breast Cancer (Dove Med Press). 2012 Oct; 2012(4):139-154. PMID: 23154619.
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    40. Simpson AL, Dumpuri P, Ondrake JE, Weis JA, Jarnagin WR, Miga MI. Preliminary study of a novel method for conveying corrected image volumes in surgical navigation. Int J Med Robot. 2013 Mar; 9(1):109-18. PMID: 22991306.
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    41. Weis VG, Sousa JF, LaFleur BJ, Nam KT, Weis JA, Finke PE, Ameen NA, Fox JG, Goldenring JR. Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression. Gut. 2013 Sep; 62(9):1270-9. PMID: 22773549.
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    42. Weis JA, Granero-Moltó F, Myers TJ, Longobardi L, Spagnoli A, Miga MI. Comparison of microCT and an inverse finite element approach for biomechanical analysis: results in a mesenchymal stem cell therapeutic system for fracture healing. J Biomech. 2012 Aug 09; 45(12):2164-70. PMID: 22766379.
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    43. Myers TJ, Yan Y, Granero-Molto F, Weis JA, Longobardi L, Li T, Li Y, Contaldo C, Ozkan H, Ozkhan H, Spagnoli A. Systemically delivered insulin-like growth factor-I enhances mesenchymal stem cell-dependent fracture healing. Growth Factors. 2012 Aug; 30(4):230-41. PMID: 22559791.
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    44. Granero-Moltó F, Myers TJ, Weis JA, Longobardi L, Li T, Yan Y, Case N, Rubin J, Spagnoli A. Mesenchymal stem cells expressing insulin-like growth factor-I (MSCIGF) promote fracture healing and restore new bone formation in Irs1 knockout mice: analyses of MSCIGF autocrine and paracrine regenerative effects. Stem Cells. 2011 Oct; 29(10):1537-48. PMID: 21786367.
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    45. Weis JA, Miga MI, Granero-Moltó F, Spagnoli A. A finite element inverse analysis to assess functional improvement during the fracture healing process. J Biomech. 2010 Feb 10; 43(3):557-62. PMID: 19875119.
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    46. Granero-Moltó F, Weis JA, Miga MI, Landis B, Myers TJ, O'Rear L, Longobardi L, Jansen ED, Mortlock DP, Spagnoli A. Regenerative effects of transplanted mesenchymal stem cells in fracture healing. Stem Cells. 2009 Aug; 27(8):1887-98. PMID: 19544445.
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    47. Granero-Molto F, Weis JA, Longobardi L, Spagnoli A. Role of mesenchymal stem cells in regenerative medicine: application to bone and cartilage repair. Expert Opin Biol Ther. 2008 Mar; 8(3):255-68. PMID: 18294098.
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    48. Spagnoli A, O'Rear L, Chandler RL, Granero-Molto F, Mortlock DP, Gorska AE, Weis JA, Longobardi L, Chytil A, Shimer K, Moses HL. TGF-beta signaling is essential for joint morphogenesis. J Cell Biol. 2007 Jun 18; 177(6):1105-17. PMID: 17576802.
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