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Gagan Deep PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Gerontology & Geriatric Medicine
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentUrology

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentWake Forest Institute for Regenerative Medicine


    Collapse Research 
    Collapse research activities and funding
    R21CA199628     (DEEP, GAGAN)Jul 15, 2015 - Jun 30, 2018
    NIH
    Exosomes Promote Disease Aggressiveness in African American Prostate Cancer
    Role: Principal Investigator
    R01AG061805     (MOLINA, ANTHONY J)Sep 30, 2018 - Apr 30, 2023
    NIH
    Exosome Mediated Alterations in Cellular Metabolism in the Pathogenesis and Progression of Alzheimer's Disease
    Role: Co-Principal Investigator
    R01DA049267     (DEEP, GAGAN)Jul 1, 2019 - Apr 30, 2024
    NIH
    Neuronal exosomes in cocaine abuse and treatment response in socially housed monkeys
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Jha V, Deep G, Pandita N, Ahuja K, Ifthekar S, Kandwal P. Factors affecting urinary outcome after delayed decompression in complete cauda equina syndrome: "A regression model study". Eur J Trauma Emerg Surg. 2021 Jan 16. PMID: 33454810.
      Citations:    
    2. Kumar A, Kim S, Su Y, Sharma M, Kumar P, Singh S, Lee J, Furdui CM, Singh R, Hsu FC, Kim J, Whitlow CT, Nader MA, Deep G. Brain cell-derived exosomes in plasma serve as neurodegeneration biomarkers in male cynomolgus monkeys self-administrating oxycodone. EBioMedicine. 2021 Jan; 63:103192. PMID: 33418508.
      Citations:    
    3. Roque JA, Barrett PC, Cole HD, Lifshits LM, Bradner E, Shi G, von Dohlen D, Kim S, Russo N, Deep G, Cameron CG, Alberto ME, McFarland SA. Os(II) Oligothienyl Complexes as a Hypoxia-Active Photosensitizer Class for Photodynamic Therapy. Inorg Chem. 2020 Nov 16; 59(22):16341-16360. PMID: 33126792.
      Citations:    
    4. Nagpal R, Mishra SK, Deep G, Yadav H. Role of TRP Channels in Shaping the Gut Microbiome. Pathogens. 2020 Sep 16; 9(9). PMID: 32947778.
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    5. Lifshits LM, Roque Iii JA, Konda P, Monro S, Cole HD, von Dohlen D, Kim S, Deep G, Thummel RP, Cameron CG, Gujar S, McFarland SA. Near-infrared absorbing Ru(ii) complexes act as immunoprotective photodynamic therapy (PDT) agents against aggressive melanoma. Chem Sci. 2020 Nov 21; 11(43):11740-11762. PMID: 33976756.
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    6. Ifthekar S, Ahuja K, Mittal S, Sarkar B, Deep G, Thomas W, Kandwal P. Management of Neglected Upper Cervical Spine Injuries. Indian J Orthop. 2021 Jun; 55(3):673-679. PMID: 33995872.
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    7. Roque JA, Barrett PC, Cole HD, Lifshits LM, Shi G, Monro S, von Dohlen D, Kim S, Russo N, Deep G, Cameron CG, Alberto ME, McFarland SA. Breaking the barrier: an osmium photosensitizer with unprecedented hypoxic phototoxicity for real world photodynamic therapy. Chem Sci. 2020 Sep 28; 11(36):9784-9806. PMID: 33738085.
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    8. Kumar A, Deep G. Exosomes in hypoxia-induced remodeling of the tumor microenvironment. Cancer Lett. 2020 09 28; 488:1-8. PMID: 32473240.
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    9. Kumar A, Deep G. Hypoxia in tumor microenvironment regulates exosome biogenesis: Molecular mechanisms and translational opportunities. Cancer Lett. 2020 06 01; 479:23-30. PMID: 32201202.
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    10. Deep G, Jain A, Kumar A, Agarwal C, Kim S, Leevy WM, Agarwal R. Exosomes secreted by prostate cancer cells under hypoxia promote matrix metalloproteinases activity at pre-metastatic niches. Mol Carcinog. 2020 03; 59(3):323-332. PMID: 31943365.
      Citations:    
    11. Peak TC, Panigrahi GK, Praharaj PP, Su Y, Shi L, Chyr J, Rivera-Chávez J, Flores-Bocanegra L, Singh R, Vander Griend DJ, Oberlies NH, Kerr BA, Hemal A, Bitting RL, Deep G. Syntaxin 6-mediated exosome secretion regulates enzalutamide resistance in prostate cancer. Mol Carcinog. 2020 01; 59(1):62-72. PMID: 31674708.
      Citations:    
    12. Kaur A, Gupta KK, Deep G, Thakur S. Wilson disease - Challenge for safe anesthesia! Saudi J Anaesth. 2019 Oct-Dec; 13(4):384-385. PMID: 31572091.
      Citations:    
    13. Rios-Colon L, Deep G, Kumar D. Emerging role of microRNA 628-5p as a novel biomarker for cancer and other diseases. Tumour Biol. 2019 Oct; 41(10):1010428319881344. PMID: 31608792.
      Citations:    
    14. Joshi M, Stoykova GE, Salzmann-Sullivan M, Dzieciatkowska M, Liebman LN, Deep G, Schlaepfer IR. CPT1A Supports Castration-Resistant Prostate Cancer in Androgen-Deprived Conditions. Cells. 2019 09 20; 8(10). PMID: 31547059.
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    15. Solingapuram Sai KK, Bashetti N, Chen X, Norman S, Hines JW, Meka O, Kumar JVS, Devanathan S, Deep G, Furdui CM, Mintz A. Initial biological evaluations of 18F-KS1, a novel ascorbate derivative to image oxidative stress in cancer. EJNMMI Res. 2019 May 17; 9(1):43. PMID: 31101996.
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    16. Rigby C, Deep G, Jain A, Orlicky DJ, Agarwal C, Agarwal R. Silibinin inhibits ultraviolet B radiation-induced mast cells recruitment and bone morphogenetic protein 2 expression in the skin at early stages in Ptch(+/-) mouse model of basal cell carcinoma. Mol Carcinog. 2019 07; 58(7):1260-1271. PMID: 30912211.
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    17. Peak TC, Su Y, Chapple AG, Chyr J, Deep G. Syntaxin 6: A novel predictive and prognostic biomarker in papillary renal cell carcinoma. Sci Rep. 2019 02 28; 9(1):3146. PMID: 30816681.
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    18. Panigrahi GK, Praharaj PP, Kittaka H, Mridha AR, Black OM, Singh R, Mercer R, van Bokhoven A, Torkko KC, Agarwal C, Agarwal R, Abd Elmageed ZY, Yadav H, Mishra SK, Deep G. Exosome proteomic analyses identify inflammatory phenotype and novel biomarkers in African American prostate cancer patients. Cancer Med. 2019 03; 8(3):1110-1123. PMID: 30623593.
      Citations:    
    19. Niture S, Gyamfi MA, Kedir H, Arthur E, Ressom H, Deep G, Kumar D. Serotonin induced hepatic steatosis is associated with modulation of autophagy and notch signaling pathway. Cell Commun Signal. 2018 11 08; 16(1):78. PMID: 30409162.
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    20. Ali HEA, Lung PY, Sholl AB, Gad SA, Bustamante JJ, Ali HI, Rhim JS, Deep G, Zhang J, Abd Elmageed ZY. Dysregulated gene expression predicts tumor aggressiveness in African-American prostate cancer patients. Sci Rep. 2018 11 05; 8(1):16335. PMID: 30397274.
      Citations:    
    21. Dheeraj A, Agarwal C, Schlaepfer IR, Raben D, Singh R, Agarwal R, Deep G. A novel approach to target hypoxic cancer cells via combining ß-oxidation inhibitor etomoxir with radiation. Hypoxia (Auckl). 2018; 6:23-33. PMID: 30175155.
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    22. Rivera-Chávez J, El-Elimat T, Gallagher JM, Graf TN, Fournier J, Panigrahi GK, Deep G, Bunch RL, Raja HA, Oberlies NH. Delitpyrones: a-Pyrone Derivatives from a Freshwater Delitschia sp. Planta Med. 2019 Jan; 85(1):62-71. PMID: 30016827.
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    23. Dhar D, Deep G, Kumar S, Wempe MF, Raina K, Agarwal C, Agarwal R. Bitter melon juice exerts its efficacy against pancreatic cancer via targeting both bulk and cancer stem cells. Mol Carcinog. 2018 09; 57(9):1166-1180. PMID: 29727019.
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    24. Patterson SA, Deep G, Brinkley TE. Detection of the receptor for advanced glycation endproducts in neuronally-derived exosomes in plasma. Biochem Biophys Res Commun. 2018 06 12; 500(4):892-896. PMID: 29702093.
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    25. Panigrahi GK, Praharaj PP, Peak TC, Long J, Singh R, Rhim JS, Abd Elmageed ZY, Deep G. Author Correction: Hypoxia-induced exosome secretion promotes survival of African-American and Caucasian prostate cancer cells. Sci Rep. 2018 Apr 24; 8(1):6645. PMID: 29691455.
      Citations:    
    26. Peak TC, Praharaj PP, Panigrahi GK, Doyle M, Su Y, Schlaepfer IR, Singh R, Vander Griend DJ, Alickson J, Hemal A, Atala A, Deep G. Exosomes secreted by placental stem cells selectively inhibit growth of aggressive prostate cancer cells. Biochem Biophys Res Commun. 2018 05 23; 499(4):1004-1010. PMID: 29627574.
      Citations:    
    27. Panigrahi GK, Praharaj PP, Peak TC, Long J, Singh R, Rhim JS, Abd Elmageed ZY, Deep G. Hypoxia-induced exosome secretion promotes survival of African-American and Caucasian prostate cancer cells. Sci Rep. 2018 03 01; 8(1):3853. PMID: 29497081.
      Citations:    
    28. Panigrahi GK, Ramteke A, Birks D, Abouzeid Ali HE, Venkataraman S, Agarwal C, Vibhakar R, Miller LD, Agarwal R, Abd Elmageed ZY, Deep G. Exosomal microRNA profiling to identify hypoxia-related biomarkers in prostate cancer. Oncotarget. 2018 Mar 02; 9(17):13894-13910. PMID: 29568403.
      Citations:    
    29. Praharaj PP, Bhutia SK, Nagrath S, Bitting RL, Deep G. Circulating tumor cell-derived organoids: Current challenges and promises in medical research and precision medicine. Biochim Biophys Acta Rev Cancer. 2018 Apr; 1869(2):117-127. PMID: 29360544.
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    30. Ahmadi S, Mainali R, Nagpal R, Sheikh-Zeinoddin M, Soleimanian-Zad S, Wang S, Deep G, Kumar Mishra S, Yadav H. Dietary Polysaccharides in the Amelioration of Gut Microbiome Dysbiosis and Metabolic Diseases. Obes Control Ther. 2017; 4(3). PMID: 30474051.
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    31. Kumar R, Deep G, Wempe MF, Surek J, Kumar A, Agarwal R, Agarwal C. Procyanidin B2 3,3?-di-O-gallate induces oxidative stress-mediated cell death in prostate cancer cells via inhibiting MAP kinase phosphatase activity and activating ERK1/2 and AMPK. Mol Carcinog. 2018 Jan; 57(1):57-69. PMID: 28876465.
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    32. Panigrahi GK, Deep G. Exosomes-based biomarker discovery for diagnosis and prognosis of prostate cancer. Front Biosci (Landmark Ed). 2017 06 01; 22:1682-1696. PMID: 28410139.
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    33. Dheeraj A, Rigby CM, O'Bryant CL, Agarwal C, Singh RP, Deep G, Agarwal R. Silibinin Treatment Inhibits the Growth of Hedgehog Inhibitor-Resistant Basal Cell Carcinoma Cells via Targeting EGFR-MAPK-Akt and Hedgehog Signaling. Photochem Photobiol. 2017 07; 93(4):999-1007. PMID: 28120452.
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    34. Rigby CM, Roy S, Deep G, Guillermo-Lagae R, Jain AK, Dhar D, Orlicky DJ, Agarwal C, Agarwal R. Role of p53 in silibinin-mediated inhibition of ultraviolet B radiation-induced DNA damage, inflammation and skin carcinogenesis. Carcinogenesis. 2017 01; 38(1):40-50. PMID: 27729375.
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    35. Deep G, Kumar R, Nambiar DK, Jain AK, Ramteke AM, Serkova NJ, Agarwal C, Agarwal R. Silibinin inhibits hypoxia-induced HIF-1a-mediated signaling, angiogenesis and lipogenesis in prostate cancer cells: In vitro evidence and in vivo functional imaging and metabolomics. Mol Carcinog. 2017 03; 56(3):833-848. PMID: 27533043.
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    36. Deep G, Schlaepfer IR. Aberrant Lipid Metabolism Promotes Prostate Cancer: Role in Cell Survival under Hypoxia and Extracellular Vesicles Biogenesis. Int J Mol Sci. 2016 Jul 02; 17(7). PMID: 27384557.
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    37. Ting H, Deep G, Kumar S, Jain AK, Agarwal C, Agarwal R. Beneficial effects of the naturally occurring flavonoid silibinin on the prostate cancer microenvironment: role of monocyte chemotactic protein-1 and immune cell recruitment. Carcinogenesis. 2016 06; 37(6):589-599. PMID: 27207648.
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    38. Kaur A, Raja HA, Swenson DC, Agarwal R, Deep G, Falkinham JO, Oberlies NH. Talarolutins A-D: Meroterpenoids from an endophytic fungal isolate of Talaromyces minioluteus. Phytochemistry. 2016 Jun; 126:4-10. PMID: 27048854.
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    39. Deep G, Kumar R, Jain AK, Dhar D, Panigrahi GK, Hussain A, Agarwal C, El-Elimat T, Sica VP, Oberlies NH, Agarwal R. Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity. Sci Rep. 2016 Mar 16; 6:23135. PMID: 26979487.
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    40. Rani V, Deep G, Singh RK, Palle K, Yadav UC. Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies. Life Sci. 2016 Mar 01; 148:183-93. PMID: 26851532.
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    41. Yadav UC, Rani V, Deep G, Singh RK, Palle K. Oxidative Stress in Metabolic Disorders: Pathogenesis, Prevention, and Therapeutics. Oxid Med Cell Longev. 2016; 2016:9137629. PMID: 26949450.
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    42. Khadse SV, Bajaj G, Vibhakar P, Nainani P, Ahuja R, Deep G. Evaluation of Specificity and Sensitivity of Oral Fluid for Diagnosis of Hepatitis B. J Clin Diagn Res. 2016 Jan; 10(1):BC12-4. PMID: 26894057.
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    43. Guillermo-Lagae R, Deep G, Ting H, Agarwal C, Agarwal R. Silibinin enhances the repair of ultraviolet B-induced DNA damage by activating p53-dependent nucleotide excision repair mechanism in human dermal fibroblasts. Oncotarget. 2015 Nov 24; 6(37):39594-606. PMID: 26447614.
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    44. Nambiar DK, Rajamani P, Deep G, Jain AK, Agarwal R, Singh RP. Silibinin Preferentially Radiosensitizes Prostate Cancer by Inhibiting DNA Repair Signaling. . 2015 Dec; 14(12):2722-34. PMID: 26516160.
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    45. Kaur A, Raja HA, Deep G, Agarwal R, Oberlies NH. Pannorin B, a new naphthopyrone from an endophytic fungal isolate of Penicillium sp. Magn Reson Chem. 2016 Feb; 54(2):164-7. PMID: 26365944.
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    46. Schlaepfer IR, Nambiar DK, Ramteke A, Kumar R, Dhar D, Agarwal C, Bergman B, Graner M, Maroni P, Singh RP, Agarwal R, Deep G. Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation. Oncotarget. 2015 Sep 08; 6(26):22836-56. PMID: 26087400.
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    47. Schlaepfer IR, Glodé LM, Hitz CA, Pac CT, Boyle KE, Maroni P, Deep G, Agarwal R, Lucia SM, Cramer SD, Serkova NJ, Eckel RH. Inhibition of Lipid Oxidation Increases Glucose Metabolism and Enhances 2-Deoxy-2-[(18)F]Fluoro-D-Glucose Uptake in Prostate Cancer Mouse Xenografts. Mol Imaging Biol. 2015 Aug; 17(4):529-38. PMID: 25561013.
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    48. Tilley C, Deep G, Agarwal R. Chemopreventive opportunities to control basal cell carcinoma: Current perspectives. Mol Carcinog. 2015 Sep; 54(9):688-97. PMID: 26053157.
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    49. Kumar R, Deep G, Agarwal R. An Overview of Ultraviolet B Radiation-Induced Skin Cancer Chemoprevention by Silibinin. Curr Pharmacol Rep. 2015 Jun 01; 1(3):206-215. PMID: 26097804.
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    50. Somasagara RR, Deep G, Shrotriya S, Patel M, Agarwal C, Agarwal R. Bitter melon juice targets molecular mechanisms underlying gemcitabine resistance in pancreatic cancer cells. Int J Oncol. 2015 Apr; 46(4):1849-57. PMID: 25672620.
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    51. Raja HA, Kaur A, El-Elimat T, Figueroa M, Kumar R, Deep G, Agarwal R, Faeth SH, Cech NB, Oberlies NH. Phylogenetic and chemical diversity of fungal endophytes isolated from Silybum marianum (L) Gaertn. (milk thistle). Mycology. 2015 Jan 02; 6(1):8-27. PMID: 26000195.
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    52. Kumar R, Deep G, Wempe MF, Agarwal R, Agarwal C. Procyanidin B2 3,3?-di-O-gallate inhibits endothelial cells growth and motility by targeting VEGFR2 and integrin signaling pathways. Curr Cancer Drug Targets. 2015; 15(1):14-26. PMID: 25552257.
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    53. Deep G, Panigrahi GK. Hypoxia-Induced Signaling Promotes Prostate Cancer Progression: Exosomes Role as Messenger of Hypoxic Response in Tumor Microenvironment. Crit Rev Oncog. 2015; 20(5-6):419-34. PMID: 27279239.
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    54. Shrotriya S, Deep G, Lopert P, Patel M, Agarwal R, Agarwal C. Grape seed extract targets mitochondrial electron transport chain complex III and induces oxidative and metabolic stress leading to cytoprotective autophagy and apoptotic death in human head and neck cancer cells. Mol Carcinog. 2015 Dec; 54(12):1734-47. PMID: 25557495.
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    55. Tilley C, Deep G, Agarwal C, Wempe MF, Biedermann D, Valentová K, Kren V, Agarwal R. Silibinin and its 2,3-dehydro-derivative inhibit basal cell carcinoma growth via suppression of mitogenic signaling and transcription factors activation. Mol Carcinog. 2016 Jan; 55(1):3-14. PMID: 25492239.
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    56. Nambiar DK, Deep G, Singh RP, Agarwal C, Agarwal R. Silibinin inhibits aberrant lipid metabolism, proliferation and emergence of androgen-independence in prostate cancer cells via primarily targeting the sterol response element binding protein 1. Oncotarget. 2014 Oct 30; 5(20):10017-33. PMID: 25294820.
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    57. Deep G, Kumar R, Jain AK, Agarwal C, Agarwal R. Silibinin inhibits fibronectin induced motility, invasiveness and survival in human prostate carcinoma PC3 cells via targeting integrin signaling. Mutat Res. 2014 Oct; 768:35-46. PMID: 25285031.
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    58. Kavitha CV, Jain AK, Agarwal C, Pierce A, Keating A, Huber KM, Serkova NJ, Wempe MF, Agarwal R, Deep G. Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo. Mol Carcinog. 2015 Nov; 54(11):1417-29. PMID: 25252179.
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    59. Bailwad SA, Singh N, Jani DR, Patil P, Singh M, Deep G, Singh S. Alterations in serum lipid profile patterns in oral cancer: correlation with histological grading and tobacco abuse. Oral Health Dent Manag. 2014 Sep; 13(3):573-9. PMID: 25284514.
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    60. Bauerle KT, Schweppe RE, Lund G, Kotnis G, Deep G, Agarwal R, Pozdeyev N, Wood WM, Haugen BR. Nuclear factor ?B-dependent regulation of angiogenesis, and metastasis in an in vivo model of thyroid cancer is associated with secreted interleukin-8. J Clin Endocrinol Metab. 2014 Aug; 99(8):E1436-44. PMID: 24758177.
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    61. Ting HJ, Deep G, Jain AK, Cimic A, Sirintrapun J, Romero LM, Cramer SD, Agarwal C, Agarwal R. Silibinin prevents prostate cancer cell-mediated differentiation of naïve fibroblasts into cancer-associated fibroblast phenotype by targeting TGF ß2. Mol Carcinog. 2015 Sep; 54(9):730-41. PMID: 24615813.
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    62. Deep G, Jain AK, Ramteke A, Ting H, Vijendra KC, Gangar SC, Agarwal C, Agarwal R. SNAI1 is critical for the aggressiveness of prostate cancer cells with low E-cadherin. Mol Cancer. 2014 Feb 24; 13:37. PMID: 24565133.
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    63. Ting H, Deep G, Agarwal C, Agarwal R. The strategies to control prostate cancer by chemoprevention approaches. Mutat Res. 2014 Feb; 760:1-15. PMID: 24389535.
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    64. Ramteke A, Ting H, Agarwal C, Mateen S, Somasagara R, Hussain A, Graner M, Frederick B, Agarwal R, Deep G. Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules. Mol Carcinog. 2015 Jul; 54(7):554-65. PMID: 24347249.
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    65. Shrotriya S, Tyagi A, Deep G, Orlicky DJ, Wisell J, Wang XJ, Sclafani RA, Agarwal R, Agarwal C. Grape seed extract and resveratrol prevent 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological responses. Mol Carcinog. 2015 Apr; 54(4):291-300. PMID: 24243690.
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    66. Deep G, Agarwal R. Targeting tumor microenvironment with silibinin: promise and potential for a translational cancer chemopreventive strategy. Curr Cancer Drug Targets. 2013 Jun; 13(5):486-99. PMID: 23617249.
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    67. Ting H, Deep G, Agarwal R. Molecular mechanisms of silibinin-mediated cancer chemoprevention with major emphasis on prostate cancer. AAPS J. 2013 Jul; 15(3):707-16. PMID: 23588585.
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    68. Agarwal C, Wadhwa R, Deep G, Biedermann D, Gažák R, Kren V, Agarwal R. Anti-cancer efficacy of silybin derivatives -- a structure-activity relationship. PLoS One. 2013; 8(3):e60074. PMID: 23555889.
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    69. Kaur M, Deep G, Jain AK, Raina K, Agarwal C, Wempe MF, Agarwal R. Bitter melon juice activates cellular energy sensor AMP-activated protein kinase causing apoptotic death of human pancreatic carcinoma cells. Carcinogenesis. 2013 Jul; 34(7):1585-92. PMID: 23475945.
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    70. Narayanapillai S, Agarwal C, Deep G, Agarwal R. Silibinin inhibits ultraviolet B radiation-induced DNA-damage and apoptosis by enhancing interleukin-12 expression in JB6 cells and SKH-1 hairless mouse skin. Mol Carcinog. 2014 Jun; 53(6):471-9. PMID: 23359305.
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    71. Kavitha CV, Deep G, Gangar SC, Jain AK, Agarwal C, Agarwal R. Silibinin inhibits prostate cancer cells- and RANKL-induced osteoclastogenesis by targeting NFATc1, NF-?B, and AP-1 activation in RAW264.7 cells. Mol Carcinog. 2014 Mar; 53(3):169-80. PMID: 23115104.
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    72. Deep G, Gangar SC, Rajamanickam S, Raina K, Gu M, Agarwal C, Oberlies NH, Agarwal R. Angiopreventive efficacy of pure flavonolignans from milk thistle extract against prostate cancer: targeting VEGF-VEGFR signaling. PLoS One. 2012; 7(4):e34630. PMID: 22514647.
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    73. Sikka A, Kaur M, Agarwal C, Deep G, Agarwal R. Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation. Cell Cycle. 2012 Apr 01; 11(7):1374-82. PMID: 22421144.
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    74. Shrotriya S, Deep G, Gu M, Kaur M, Jain AK, Inturi S, Agarwal R, Agarwal C. Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells. Carcinogenesis. 2012 Apr; 33(4):848-58. PMID: 22266465.
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    75. Roy S, Deep G, Agarwal C, Agarwal R. Silibinin prevents ultraviolet B radiation-induced epidermal damages in JB6 cells and mouse skin in a p53-GADD45a-dependent manner. Carcinogenesis. 2012 Mar; 33(3):629-36. PMID: 22166495.
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    76. Ravichandran K, Tyagi A, Deep G, Agarwal C, Agarwal R. Interleukin-1beta-induced iNOS expression in human lung carcinoma A549 cells: involvement of STAT and MAPK pathways. Indian J Exp Biol. 2011 Nov; 49(11):840-7. PMID: 22126015.
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    77. Kavitha CV, Agarwal C, Agarwal R, Deep G. Asiatic acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture models. PLoS One. 2011; 6(8):e22745. PMID: 21826202.
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    78. Deep G, Gangar SC, Agarwal C, Agarwal R. Role of E-cadherin in antimigratory and antiinvasive efficacy of silibinin in prostate cancer cells. Cancer Prev Res (Phila). 2011 Aug; 4(8):1222-32. PMID: 21546539.
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    79. Deep G, Gangar SC, Oberlies NH, Kroll DJ, Agarwal R. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-?B, and androgen receptor signaling. Mol Carcinog. 2010 Oct; 49(10):902-12. PMID: 20721970.
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    80. Deep G, Agarwal R. Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer. Cancer Metastasis Rev. 2010 Sep; 29(3):447-63. PMID: 20714788.
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    81. Velmurugan B, Gangar SC, Kaur M, Tyagi A, Deep G, Agarwal R. Silibinin exerts sustained growth suppressive effect against human colon carcinoma SW480 xenograft by targeting multiple signaling molecules. Pharm Res. 2010 Oct; 27(10):2085-97. PMID: 20628792.
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    82. Kaur M, Velmurugan B, Tyagi A, Deep G, Katiyar S, Agarwal C, Agarwal R. Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft. . 2009 Aug; 8(8):2366-74. PMID: 19638451.
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    83. Singh RP, Raina K, Deep G, Chan D, Agarwal R. Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of extracellular signal-regulated kinase 1/2 and inhibition of signal transducers and activators of transcription signaling. Clin Cancer Res. 2009 Jan 15; 15(2):613-21. PMID: 19147767.
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    84. Deep G, Raina K, Singh RP, Oberlies NH, Kroll DJ, Agarwal R. Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: comparison with silymarin and silibinin. Int J Cancer. 2008 Dec 15; 123(12):2750-8. PMID: 18798272.
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    85. Agarwal R, Deep G. Kava, a tonic for relieving the irrational development of natural preventive agents. Cancer Prev Res (Phila). 2008 Nov; 1(6):409-12. PMID: 19138987.
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    86. Raina K, Rajamanickam S, Singh RP, Deep G, Chittezhath M, Agarwal R. Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model. Cancer Res. 2008 Aug 15; 68(16):6822-30. PMID: 18701508.
      Citations:    
    87. Chittezhath M, Deep G, Singh RP, Agarwal C, Agarwal R. Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells. . 2008 Jul; 7(7):1817-26. PMID: 18644994.
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    88. Deep G, Oberlies NH, Kroll DJ, Agarwal R. Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells. Int J Cancer. 2008 Jul 01; 123(1):41-50. PMID: 18435416.
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    89. Deep G, Agarwal R. New combination therapies with cell-cycle agents. Curr Opin Investig Drugs. 2008 Jun; 9(6):591-604. PMID: 18516759.
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    90. Raina K, Rajamanickam S, Deep G, Singh M, Agarwal R, Agarwal C. Chemopreventive effects of oral gallic acid feeding on tumor growth and progression in TRAMP mice. . 2008 May; 7(5):1258-67. PMID: 18445658.
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    91. Raina K, Blouin MJ, Singh RP, Majeed N, Deep G, Varghese L, Glodé LM, Greenberg NM, Hwang D, Cohen P, Pollak MN, Agarwal R. Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Res. 2007 Nov 15; 67(22):11083-91. PMID: 18006855.
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    92. Singh RP, Deep G, Blouin MJ, Pollak MN, Agarwal R. Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft. Carcinogenesis. 2007 Dec; 28(12):2567-74. PMID: 17916909.
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    93. Deep G, Agarwal R. Chemopreventive efficacy of silymarin in skin and prostate cancer. Integr Cancer Ther. 2007 Jun; 6(2):130-45. PMID: 17548792.
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    94. Deep G, Oberlies NH, Kroll DJ, Agarwal R. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul; 28(7):1533-42. PMID: 17389612.
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    95. Singh RP, Deep G, Chittezhath M, Kaur M, Dwyer-Nield LD, Malkinson AM, Agarwal R. Effect of silibinin on the growth and progression of primary lung tumors in mice. J Natl Cancer Inst. 2006 Jun 21; 98(12):846-55. PMID: 16788158.
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    96. Deep G, Dasgupta T, Rao AR, Kale RK. Cancer preventive potential of Momordica charantia L. against benzo(a)pyrene induced fore-stomach tumourigenesis in murine model system. Indian J Exp Biol. 2004 Mar; 42(3):319-22. PMID: 15233304.
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