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Edgar Alfonso Romero-Sandoval, M.D., Ph.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentAnesthesiology
Address
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    Collapse Research 
    Collapse research activities and funding
    R01DA025211     (ROMERO-SANDOVAL, EDGAR ALFONSO)Jun 1, 2009 - May 31, 2012
    NIH/NIDA
    Cannabinoids and Neuroimmune Interactions
    Role: Principal Investigator

    G11HD076487     (MESSERSMITH, AMY)May 15, 2013 - Apr 30, 2018
    NIH/NICHD
    Developing an Office of Sponsored Projects for Presbyterian College
    Role: Co-Principal Investigator

    R15GM109333     (ROMERO-SANDOVAL, EDGAR ALFONSO)Sep 1, 2014 - Aug 31, 2017
    NIH/NIGMS
    Cell-directed therapy using nanotechnology for the prevention of chronic postoper
    Role: Principal Investigator

    R01NS114653     (ROMERO-SANDOVAL, E. ALFONSO)Feb 15, 2020 - Jan 31, 2025
    NIH/NINDS
    Endoplasmic Reticulum Stress Responses in Pain
    Role: Principal Investigator

    R21CA248106     (ROMERO-SANDOVAL, E. ALFONSO)Apr 1, 2020 - Mar 31, 2022
    NIH/NCI
    IRE1a-XBP1 Signaling as a Driver of Chemotherapy-Induced Peripheral Neuropathy
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kim TE, Townsend RK, Branch CL, Romero-Sandoval EA, Hsu W. Cannabinoids in the Treatment of Back Pain. Neurosurgery. 2020 Aug 01; 87(2):166-175. PMID: 32097466.
      View in: PubMed
    2. Cash MC, Cunnane K, Fan C, Romero-Sandoval EA. Mapping cannabis potency in medical and recreational programs in the United States. PLoS One. 2020; 15(3):e0230167. PMID: 32214334.
      View in: PubMed
    3. Lycan TW, Hsu FC, Ahn CS, Thomas A, Walker FO, Sangueza OP, Shiozawa Y, Park SH, Peters CM, Romero-Sandoval EA, Melin SA, Sorscher S, Ansley K, Lesser GJ, Cartwright MS, Strowd RE. Neuromuscular ultrasound for taxane peripheral neuropathy in breast cancer. Muscle Nerve. 2020 05; 61(5):587-594. PMID: 32052458.
      View in: PubMed
    4. Ferreira DW, Ulecia-Morón C, Alvarado-Vázquez PA, Cunnane K, Moracho-Vilriales C, Grosick RL, Cunha TM, Romero-Sandoval EA. CD163 overexpression using a macrophage-directed gene therapy approach improves wound healing in ex vivo and in vivo human skin models. Immunobiology. 2020 Jan; 225(1):151862. PMID: 31711674.
      View in: PubMed
    5. Chopra S, Giovanelli P, Alvarado-Vazquez PA, Alonso S, Song M, Sandoval TA, Chae CS, Tan C, Fonseca MM, Gutierrez S, Jimenez L, Subbaramaiah K, Iwawaki T, Kingsley PJ, Marnett LJ, Kossenkov AV, Crespo MS, Dannenberg AJ, Glimcher LH, Romero-Sandoval EA, Cubillos-Ruiz JR. IRE1a-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain. Science. 2019 07 19; 365(6450). PMID: 31320508.
      View in: PubMed
    6. Gutierrez S, Alvarado-Vázquez PA, Eisenach JC, Romero-Sandoval EA, Boada MD. Tachykinins modulate nociceptive responsiveness and sensitization: In vivo electrical characterization of primary sensory neurons in tachykinin knockout (Tac1 KO) mice. Mol Pain. 2019 Jan-Dec; 15:1744806919845750. PMID: 31012376.
      View in: PubMed
    7. Alvarado-Vázquez PA, Grosick RL, Moracho-Vilrriales C, Ward E, Threatt T, Romero-Sandoval EA. Cytokine production capabilities of human primary monocyte-derived macrophages from patients with diabetes mellitus type 2 with and without diabetic peripheral neuropathy. J Pain Res. 2019; 12:69-81. PMID: 30588081.
      View in: PubMed
    8. Grosick R, Alvarado-Vazquez PA, Messersmith AR, Romero-Sandoval EA. High glucose induces a priming effect in macrophages and exacerbates the production of pro-inflammatory cytokines after a challenge. J Pain Res. 2018; 11:1769-1778. PMID: 30237731.
      View in: PubMed
    9. Romero-Sandoval EA, Fincham JE, Kolano AL, Sharpe BN, Alvarado-Vázquez PA. Cannabis for Chronic Pain: Challenges and Considerations. Pharmacotherapy. 2018 06; 38(6):651-662. PMID: 29637590.
      View in: PubMed
    10. Romero-Sandoval EA, Kolano AL, Alvarado-Vázquez PA. Cannabis and Cannabinoids for Chronic Pain. Curr Rheumatol Rep. 2017 Oct 05; 19(11):67. PMID: 28983880.
      View in: PubMed
    11. Skopelja-Gardner S, Saha M, Alvarado-Vazquez PA, Liponis BS, Martinez E, Romero-Sandoval EA. Mitogen-activated protein kinase phosphatase-3 (MKP-3) in the surgical wound is necessary for the resolution of postoperative pain in mice. J Pain Res. 2017; 10:763-774. PMID: 28405172.
      View in: PubMed
    12. Bort A, Alvarado-Vazquez PA, Moracho-Vilrriales C, Virga KG, Gumina G, Romero-Sandoval A, Asbill S. Effects of JWH015 in cytokine secretion in primary human keratinocytes and fibroblasts and its suitability for topical/transdermal delivery. Mol Pain. 2017 01; 13:1744806916688220. PMID: 28326930.
      View in: PubMed
    13. Bernal L, Alvarado-Vázquez A, Ferreira DW, Paige CA, Ulecia-Morón C, Hill B, Caesar M, Romero-Sandoval EA. Evaluation of a nanotechnology-based approach to induce gene-expression in human THP-1 macrophages under inflammatory conditions. Immunobiology. 2017 02; 222(2):399-408. PMID: 27615510.
      View in: PubMed
    14. Savage SR, Romero-Sandoval A, Schatman M, Wallace M, Fanciullo G, McCarberg B, Ware M. Cannabis in Pain Treatment: Clinical and Research Considerations. J Pain. 2016 06; 17(6):654-68. PMID: 26961090.
      View in: PubMed
    15. Romero-Sandoval EA, Asbill S, Paige CA, Byrd-Glover K. Peripherally Restricted Cannabinoids for the Treatment of Pain. Pharmacotherapy. 2015 Oct; 35(10):917-25. PMID: 26497478.
      View in: PubMed
    16. Heustess A, Spigener S, Sweitzer S, Romero-Sandoval A, Asbill S. Analgesic Efficacy and Transdermal Penetration of Topical Gabapentin Creams: Finding an Optimal Dose and Pre-treatment Time. Int J Pharm Compd. 2015 Mar-Apr; 19(2):167-73. PMID: 26685497.
      View in: PubMed
    17. Romero-Salndoval EA, Sweitzer SM. . Molecular and Cell Biology of Pain. Theodore Price, Greg Dussor, eds. Nonneuronal central mechanisms of pain. 2015; 131:325-358.
    18. Paige C, Hill B, Canterbury J, Sweitzer S, Romero-Sandoval EA. Construction of an affordable and easy-to-build zebrafish facility. J Vis Exp. 2014 Nov 22; (93):e51989. PMID: 25490519.
      View in: PubMed
    19. Asbill S, Sweitzer SM, Spigener S, Romero-Sandoval A. Compounded pain formulations: what is the evidence? Int J Pharm Compd. 2014 Jul-Aug; 18(4):278-86. PMID: 25508635.
      View in: PubMed
    20. Ndong C, Landry RP, Saha M, Romero-Sandoval EA. Mitogen-activated protein kinase (MAPK) phosphatase-3 (MKP-3) displays a p-JNK-MAPK substrate preference in astrocytes in vitro. Neurosci Lett. 2014 Jul 11; 575:13-8. PMID: 24861519.
      View in: PubMed
    21. Saha M, Skopelja S, Martinez E, Alvarez DL, Liponis BS, Romero-Sandoval EA. Spinal mitogen-activated protein kinase phosphatase-3 (MKP-3) is necessary for the normal resolution of mechanical allodynia in a mouse model of acute postoperative pain. J Neurosci. 2013 Oct 23; 33(43):17182-7. PMID: 24155322.
      View in: PubMed
    22. Romero-Sandoval EA. Peripheral benzodiazepine receptors: are they potential biomarkers for glial activation in pain states? Eur J Pain. 2013 May; 17(5):635-7. PMID: 23526770.
      View in: PubMed
    23. Landry RP, Martinez E, DeLeo JA, Romero-Sandoval EA. Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain. J Pain. 2012 Sep; 13(9):836-48. PMID: 22901764.
      View in: PubMed
    24. Ndong C, Landry RP, DeLeo JA, Romero-Sandoval EA. Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain. Mol Pain. 2012 Apr 27; 8:34. PMID: 22540262.
      View in: PubMed
    25. Jacobs VL, Landry RP, Liu Y, Romero-Sandoval EA, De Leo JA. Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia. Neuro Oncol. 2012 Feb; 14(2):119-31. PMID: 22086978.
      View in: PubMed
    26. Landry RP, Jacobs VL, Romero-Sandoval EA, DeLeo JA. Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages. Exp Neurol. 2012 Apr; 234(2):340-50. PMID: 22119425.
      View in: PubMed
    27. Romero-Sandoval EA. Depression and pain: does ketamine improve the quality of life of patients in chronic pain by targeting their mood? Anesthesiology. 2011 Oct; 115(4):687-8. PMID: 21841467.
      View in: PubMed
    28. Horvath RJ, Romero-Sandoval EA, De Leo JA. Inhibition of microglial P2X4 receptors attenuates morphine tolerance, Iba1, GFAP and mu opioid receptor protein expression while enhancing perivascular microglial ED2. Pain. 2010 Sep; 150(3):401-13. PMID: 20573450.
      View in: PubMed
    29. Alkaitis MS, Solorzano C, Landry RP, Piomelli D, DeLeo JA, Romero-Sandoval EA. Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain. PLoS One. 2010 May 28; 5(5):e10891. PMID: 20531936.
      View in: PubMed
    30. Horvath RJ, Landry RP, Romero-Sandoval EA, DeLeo JA. Morphine tolerance attenuates the resolution of postoperative pain and enhances spinal microglial p38 and extracellular receptor kinase phosphorylation. Neuroscience. 2010 Aug 25; 169(2):843-54. PMID: 20493931.
      View in: PubMed
    31. Romero-Sandoval EA, Horvath R, Landry RP, DeLeo JA. Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation. Mol Pain. 2009 May 28; 5:25. PMID: 19476641.
      View in: PubMed
    32. Romero-Sandoval EA, Horvath RJ, DeLeo JA. Neuroimmune interactions and pain: focus on glial-modulating targets. Curr Opin Investig Drugs. 2008 Jul; 9(7):726-34. PMID: 18600578.
      View in: PubMed
    33. Romero-Sandoval A, Chai N, Nutile-McMenemy N, Deleo JA. A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain. Brain Res. 2008 Jul 11; 1219:116-26. PMID: 18538310.
      View in: PubMed
    34. Romero-Sandoval A, Nutile-McMenemy N, DeLeo JA. Spinal microglial and perivascular cell cannabinoid receptor type 2 activation reduces behavioral hypersensitivity without tolerance after peripheral nerve injury. Anesthesiology. 2008 Apr; 108(4):722-34. PMID: 18362605.
      View in: PubMed
    35. Summer GJ, Romero-Sandoval EA, Bogen O, Dina OA, Khasar SG, Levine JD. Proinflammatory cytokines mediating burn-injury pain. Pain. 2008 Mar; 135(1-2):98-107. PMID: 17590515.
      View in: PubMed
    36. Romero-Sandoval A, Eisenach JC. Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision. Anesthesiology. 2007 Apr; 106(4):787-94. PMID: 17413917.
      View in: PubMed
    37. Romero-Sandoval A, Bynum T, Eisenach JC. Analgesia induced by perineural clonidine is enhanced in persistent neuritis. Neuroreport. 2007 Jan 08; 18(1):67-71. PMID: 17259863.
      View in: PubMed
    38. Romero-Sandoval EA, Curros-Criado MM, Gaitan G, Molina C, Herrero JF. Nitroparacetamol (NCX-701) and pain: first in a series of novel analgesics. CNS Drug Rev. 2007; 13(3):279-95. PMID: 17894645.
      View in: PubMed
    39. Romero-Sandoval A, Eisenach JC. Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis. Brain Behav Immun. 2007 Jul; 21(5):569-80. PMID: 17079113.
      View in: PubMed
    40. Alfonso Romero-Sandoval E, Molina C, Herrero JF. Enhancement of the analgesic activity of paracetamol and nitroparacetamol by the oral administration of all-trans retinoic acid. Neuropharmacology. 2006 Sep; 51(4):858-65. PMID: 16870215.
      View in: PubMed
    41. Romero-Sandoval EA, Molina C, Alique M, Moreno-Manzano V, Lucio FJ, Herrero JF. Vitamin A active metabolite, all-trans retinoic acid, induces spinal cord sensitization. I. Effects after oral administration. Br J Pharmacol. 2006 Sep; 149(1):56-64. PMID: 16847436.
      View in: PubMed
    42. Romero-Sandoval A, Eisenach JC. Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury. Anesthesiology. 2006 Feb; 104(2):351-5. PMID: 16436856.
      View in: PubMed
    43. Romero-Sandoval EA, McCall C, Eisenach JC. Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain. J Neurosci. 2005 Sep 28; 25(39):8988-94. PMID: 16192389.
      View in: PubMed
    44. Romero-Sandoval EA, Alique M, Moreno-Manzano V, Molina C, Lucio FJ, Herrero JF. The oral administration of retinoic acid enhances nociceptive withdrawal reflexes in rats with soft-tissue inflammation. Inflamm Res. 2004 Jul; 53(7):297-303. PMID: 15241564.
      View in: PubMed
    45. Alfonso Romero-Sandoval E, Del Soldato P, Herrero JF. The effects of sham and full spinalization on the antinociceptive effects of NCX-701 (nitroparacetamol) in monoarthritic rats. Neuropharmacology. 2003 Sep; 45(3):412-9. PMID: 12871658.
      View in: PubMed
    46. Herrero JF, Romero-Sandoval EA, Gaitan G, Mazario J. Antinociception and the new COX inhibitors: research approaches and clinical perspectives. CNS Drug Rev. 2003; 9(3):227-52. PMID: 14530796.
      View in: PubMed
    47. Romero-Sandoval EA, Mazario J, Howat D, Herrero JF. NCX-701 (nitroparacetamol) is an effective antinociceptive agent in rat withdrawal reflexes and wind-up. Br J Pharmacol. 2002 Mar; 135(6):1556-62. PMID: 11906970.
      View in: PubMed
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