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Edgar A. Romero-Sandoval MD, PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentAnesthesiology
Address
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentInternal Medicine, Molecular Medicine

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentSocial Sciences & Health Policy (Public Health Sciences)

    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentPediatrics


    Collapse Research 
    Collapse research activities and funding
    R01DA025211     (ROMERO-SANDOVAL, EDGAR ALFONSO)Jun 1, 2009 - May 31, 2012
    NIH
    Cannabinoids and Neuroimmune Interactions
    Role: Principal Investigator
    G11HD076487     (MESSERSMITH, AMY)May 15, 2013 - Apr 30, 2019
    NIH
    Developing an Office of Sponsored Projects for Presbyterian College
    Role: Co-Principal Investigator
    R15GM109333     (ROMERO-SANDOVAL, EDGAR ALFONSO)Sep 1, 2014 - Aug 31, 2017
    NIH/NIGMS
    Cell-directed therapy using nanotechnology for the prevention of chronic postoper
    Role: Principal Investigator
    R01NS114653     (ROMERO-SANDOVAL, E. ALFONSO)Feb 15, 2020 - Jan 31, 2025
    NIH
    Endoplasmic Reticulum Stress Responses in Pain
    Role: Principal Investigator
    R21CA248106     (ROMERO-SANDOVAL, E. ALFONSO)Apr 1, 2020 - Mar 31, 2022
    NIH
    IRE1a-XBP1 Signaling as a Driver of Chemotherapy-Induced Peripheral Neuropathy
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Awasthi D, Chopra S, Cho BA, Emmanuelli A, Sandoval TA, Hwang SM, Chae CS, Salvagno C, Tan C, Vasquez-Urbina L, Fernandez Rodriguez JJ, Santagostino SF, Iwawaki T, Romero-Sandoval EA, Crespo MS, Morales DK, Iliev ID, Hohl TM, Cubillos-Ruiz JR. Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis. J Clin Invest. 2023 Jul 11. PMID: 37432737.
      Citations:    
    2. Ding H, Kiguchi N, Dobbins M, Romero-Sandoval EA, Kishioka S, Ko MC. Nociceptin Receptor-Related Agonists as Safe and Non-addictive Analgesics. Drugs. 2023 Jun; 83(9):771-793. PMID: 37209211.
      Citations:    
    3. Amann L, Kruse E, Lazard AJ, Reboussin BA, Wagoner KG, Romero-Sandoval EA. CBD Retailers in NC Promote CBD Online to Treat Pain Violating FDA Rules About Medical Claims and Offer Low-CBD/High-Price Products. J Pain Res. 2022; 15:3847-3858. PMID: 36514481.
      Citations:    
    4. Chae CS, Sandoval TA, Hwang SM, Park ES, Giovanelli P, Awasthi D, Salvagno C, Emmanuelli A, Tan C, Chaudhary V, Casado J, Kossenkov AV, Song M, Barrat FJ, Holcomb K, Romero-Sandoval EA, Zamarin D, Pépin D, D'Andrea AD, Färkkilä A, Cubillos-Ruiz JR. Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer. Cancer Discov. 2022 Aug 05; 12(8):1904-1921. PMID: 35552618.
      Citations:    
    5. Dobbins M, Rakkar M, Cunnane K, Pennypacker SD, Wagoner KG, Reboussin BA, Romero-Sandoval EA. Association of Tetrahydrocannabinol Content and Price in Herbal Cannabis Products Offered by Dispensaries in California: A Purview of Consumers/Patients. Front Public Health. 2022; 10:893009. PMID: 35784239.
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    6. Pennypacker SD, Cunnane K, Cash MC, Romero-Sandoval EA. Potency and Therapeutic THC and CBD Ratios: U.S. Cannabis Markets Overshoot. Front Pharmacol. 2022; 13:921493. PMID: 35734402.
      Citations:    
    7. Kiguchi N, Ding H, Park SH, Mabry KM, Kishioka S, Shiozawa Y, Alfonso Romero-Sandoval E, Peters CM, Ko MC. Functional roles of neuromedin B and gastrin-releasing peptide in regulating itch and pain in the spinal cord of non-human primates. Biochem Pharmacol. 2022 Feb 18; 114972. PMID: 35189108.
      Citations:    
    8. Morgan JW, Pennypacker SD, Romero-Sandoval EA, Fonseca MM. Methods and protocols for translatable rodent models of postsurgical pain. Methods Cell Biol. 2022; 168:249-276. PMID: 35366986.
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    9. Pennypacker SD, Fonseca MM, Morgan JW, Dougherty PM, Cubillos-Ruiz JR, Strowd RE, Romero-Sandoval EA. Methods and protocols for chemotherapy-induced peripheral neuropathy (CIPN) mouse models using paclitaxel. Methods Cell Biol. 2022; 168:277-298. PMID: 35366987.
      Citations:    
    10. Caudle RM, Smith MT, Romero-Sandoval EA. Editorial: Verification of Animal Pain Models by Reverse Translation. Front Pharmacol. 2021; 12:778880. PMID: 34690791.
      Citations:    
    11. Casadei M, Fiore E, Rubione J, Domínguez LM, Coronel MF, Leiguarda C, García M, Mazzolini G, Villar MJ, Montaner A, Constandil L, Romero-Sandoval EA, Brumovsky PR. IMT504 blocks allodynia in rats with spared nerve injury by promoting the migration of mesenchymal stem cells and by favoring an anti-inflammatory milieu at the injured nerve. Pain. 2021 Sep 15. PMID: 34711765.
      Citations:    
    12. Wagoner KG, Lazard AJ, Romero-Sandoval EA, Reboussin BA. Health Claims About Cannabidiol Products: A Retrospective Analysis of U.S. Food and Drug Administration Warning Letters from 2015 to 2019. Cannabis Cannabinoid Res. 2021 Jun 17. PMID: 34142863.
      Citations:    
    13. Munoz-Islas E, Elizondo-Martinez CE, Gutierrez-Lopez M, Acosta-Gonzalez RI, Zaga-Clavellina V, Helguera-Repetto AC, Ramirez-Rosas MB, Romero-Sandoval EA, Jimenez-Andrade JM. Effect of Experimental Gestational Diabetes Mellitus on Mechanical Sensitivity, Capsaicin-Induced Pain Behaviors and Hind Paw Glabrous Skin Innervation of Male and Female Mouse Offspring. J Pain Res. 2021; 14:1573-1585. PMID: 34103982.
      Citations:    
    14. Uhelski ML, Li Y, Fonseca MM, Romero-Snadoval EA, Dougherty PM. Role of innate immunity in chemotherapy-induced peripheral neuropathy. Neurosci Lett. 2021 Jun 11; 755:135941. PMID: 33961945.
      Citations:    
    15. Park SH, Eber MR, Fonseca MM, Patel CM, Cunnane KA, Ding H, Hsu FC, Peters CM, Ko MC, Strowd RE, Wilson JA, Hsu W, Romero-Sandoval EA, Shiozawa Y. Usefulness of the measurement of neurite outgrowth of primary sensory neurons to study cancer-related painful complications. Biochem Pharmacol. 2021 Jun; 188:114520. PMID: 33741328.
      Citations:    
    16. Arora V, Morado-Urbina CE, Gwak YS, Parker RA, Kittel CA, Munoz-Islas E, Miguel Jimenez-Andrade J, Romero-Sandoval EA, Eisenach JC, Peters CM. Systemic administration of a ß2-adrenergic receptor agonist reduces mechanical allodynia and suppresses the immune response to surgery in a rat model of persistent post-incisional hypersensitivity. Mol Pain. 2021 Jan-Dec; 17:1744806921997206. PMID: 33829907.
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    17. Pennypacker SD, Romero-Sandoval EA. CBD and THC: Do They Complement Each Other Like Yin and Yang? Pharmacotherapy. 2020 11; 40(11):1152-1165. PMID: 33080058.
      Citations:    
    18. Kim TE, Townsend RK, Branch CL, Romero-Sandoval EA, Hsu W. Cannabinoids in the Treatment of Back Pain. Neurosurgery. 2020 08 01; 87(2):166-175. PMID: 32097466.
      Citations:    
    19. Cash MC, Cunnane K, Fan C, Romero-Sandoval EA. Mapping cannabis potency in medical and recreational programs in the United States. PLoS One. 2020; 15(3):e0230167. PMID: 32214334.
      Citations:    
    20. Lycan TW, Hsu FC, Ahn CS, Thomas A, Walker FO, Sangueza OP, Shiozawa Y, Park SH, Peters CM, Romero-Sandoval EA, Melin SA, Sorscher S, Ansley K, Lesser GJ, Cartwright MS, Strowd RE. Neuromuscular ultrasound for taxane peripheral neuropathy in breast cancer. Muscle Nerve. 2020 05; 61(5):587-594. PMID: 32052458.
      Citations:    
    21. Ferreira DW, Ulecia-Morón C, Alvarado-Vázquez PA, Cunnane K, Moracho-Vilriales C, Grosick RL, Cunha TM, Romero-Sandoval EA. CD163 overexpression using a macrophage-directed gene therapy approach improves wound healing in ex vivo and in vivo human skin models. Immunobiology. 2020 01; 225(1):151862. PMID: 31711674.
      Citations:    
    22. Chopra S, Giovanelli P, Alvarado-Vazquez PA, Alonso S, Song M, Sandoval TA, Chae CS, Tan C, Fonseca MM, Gutierrez S, Jimenez L, Subbaramaiah K, Iwawaki T, Kingsley PJ, Marnett LJ, Kossenkov AV, Crespo MS, Dannenberg AJ, Glimcher LH, Romero-Sandoval EA, Cubillos-Ruiz JR. IRE1a-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain. Science. 2019 07 19; 365(6450). PMID: 31320508.
      Citations:    
    23. Gutierrez S, Alvarado-Vázquez PA, Eisenach JC, Romero-Sandoval EA, Boada MD. Tachykinins modulate nociceptive responsiveness and sensitization: In vivo electrical characterization of primary sensory neurons in tachykinin knockout (Tac1 KO) mice. Mol Pain. 2019 Jan-Dec; 15:1744806919845750. PMID: 31012376.
      Citations:    
    24. Alvarado-Vázquez PA, Grosick RL, Moracho-Vilrriales C, Ward E, Threatt T, Romero-Sandoval EA. Cytokine production capabilities of human primary monocyte-derived macrophages from patients with diabetes mellitus type 2 with and without diabetic peripheral neuropathy. J Pain Res. 2019; 12:69-81. PMID: 30588081.
      Citations:    
    25. Grosick R, Alvarado-Vazquez PA, Messersmith AR, Romero-Sandoval EA. High glucose induces a priming effect in macrophages and exacerbates the production of pro-inflammatory cytokines after a challenge. J Pain Res. 2018; 11:1769-1778. PMID: 30237731.
      Citations:    
    26. Romero-Sandoval EA, Fincham JE, Kolano AL, Sharpe BN, Alvarado-Vázquez PA. Cannabis for Chronic Pain: Challenges and Considerations. Pharmacotherapy. 2018 06; 38(6):651-662. PMID: 29637590.
      Citations:    
    27. Romero-Sandoval EA, Kolano AL, Alvarado-Vázquez PA. Cannabis and Cannabinoids for Chronic Pain. Curr Rheumatol Rep. 2017 Oct 05; 19(11):67. PMID: 28983880.
      Citations:    
    28. Skopelja-Gardner S, Saha M, Alvarado-Vazquez PA, Liponis BS, Martinez E, Romero-Sandoval EA. Mitogen-activated protein kinase phosphatase-3 (MKP-3) in the surgical wound is necessary for the resolution of postoperative pain in mice. J Pain Res. 2017; 10:763-774. PMID: 28405172.
      Citations:    
    29. Bort A, Alvarado-Vazquez PA, Moracho-Vilrriales C, Virga KG, Gumina G, Romero-Sandoval A, Asbill S. Effects of JWH015 in cytokine secretion in primary human keratinocytes and fibroblasts and its suitability for topical/transdermal delivery. Mol Pain. 2017 01; 13:1744806916688220. PMID: 28326930.
      Citations:    
    30. Bernal L, Alvarado-Vázquez A, Ferreira DW, Paige CA, Ulecia-Morón C, Hill B, Caesar M, Romero-Sandoval EA. Evaluation of a nanotechnology-based approach to induce gene-expression in human THP-1 macrophages under inflammatory conditions. Immunobiology. 2017 02; 222(2):399-408. PMID: 27615510.
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    31. Savage SR, Romero-Sandoval A, Schatman M, Wallace M, Fanciullo G, McCarberg B, Ware M. Cannabis in Pain Treatment: Clinical and Research Considerations. J Pain. 2016 06; 17(6):654-68. PMID: 26961090.
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    32. Romero-Sandoval EA, Asbill S, Paige CA, Byrd-Glover K. Peripherally Restricted Cannabinoids for the Treatment of Pain. Pharmacotherapy. 2015 Oct; 35(10):917-25. PMID: 26497478.
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    33. Heustess A, Spigener S, Sweitzer S, Romero-Sandoval A, Asbill S. Analgesic Efficacy and Transdermal Penetration of Topical Gabapentin Creams: Finding an Optimal Dose and Pre-treatment Time. Int J Pharm Compd. 2015 Mar-Apr; 19(2):167-73. PMID: 26685497.
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    34. Romero-Salndoval EA, Sweitzer SM. . Molecular and Cell Biology of Pain. Theodore Price, Greg Dussor, eds. Nonneuronal central mechanisms of pain. 2015; 131:325-358.
    35. Paige C, Hill B, Canterbury J, Sweitzer S, Romero-Sandoval EA. Construction of an affordable and easy-to-build zebrafish facility. J Vis Exp. 2014 Nov 22; (93):e51989. PMID: 25490519.
      Citations:    
    36. Asbill S, Sweitzer SM, Spigener S, Romero-Sandoval A. Compounded pain formulations: what is the evidence? Int J Pharm Compd. 2014 Jul-Aug; 18(4):278-86. PMID: 25508635.
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    37. Ndong C, Landry RP, Saha M, Romero-Sandoval EA. Mitogen-activated protein kinase (MAPK) phosphatase-3 (MKP-3) displays a p-JNK-MAPK substrate preference in astrocytes in vitro. Neurosci Lett. 2014 Jul 11; 575:13-8. PMID: 24861519.
      Citations:    
    38. Saha M, Skopelja S, Martinez E, Alvarez DL, Liponis BS, Romero-Sandoval EA. Spinal mitogen-activated protein kinase phosphatase-3 (MKP-3) is necessary for the normal resolution of mechanical allodynia in a mouse model of acute postoperative pain. J Neurosci. 2013 Oct 23; 33(43):17182-7. PMID: 24155322.
      Citations:    
    39. Romero-Sandoval EA. Peripheral benzodiazepine receptors: are they potential biomarkers for glial activation in pain states? Eur J Pain. 2013 May; 17(5):635-7. PMID: 23526770.
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    40. Landry RP, Martinez E, DeLeo JA, Romero-Sandoval EA. Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain. J Pain. 2012 Sep; 13(9):836-48. PMID: 22901764.
      Citations:    
    41. Ndong C, Landry RP, DeLeo JA, Romero-Sandoval EA. Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain. Mol Pain. 2012 Apr 27; 8:34. PMID: 22540262.
      Citations:    
    42. Jacobs VL, Landry RP, Liu Y, Romero-Sandoval EA, De Leo JA. Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia. Neuro Oncol. 2012 Feb; 14(2):119-31. PMID: 22086978.
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    43. Landry RP, Jacobs VL, Romero-Sandoval EA, DeLeo JA. Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages. Exp Neurol. 2012 Apr; 234(2):340-50. PMID: 22119425.
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    44. Romero-Sandoval EA. Depression and pain: does ketamine improve the quality of life of patients in chronic pain by targeting their mood? Anesthesiology. 2011 Oct; 115(4):687-8. PMID: 21841467.
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    45. Horvath RJ, Romero-Sandoval AE, De Leo JA. Inhibition of microglial P2X4 receptors attenuates morphine tolerance, Iba1, GFAP and mu opioid receptor protein expression while enhancing perivascular microglial ED2. Pain. 2010 Sep; 150(3):401-413. PMID: 20573450.
      Citations:    
    46. Alkaitis MS, Solorzano C, Landry RP, Piomelli D, DeLeo JA, Romero-Sandoval EA. Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain. PLoS One. 2010 May 28; 5(5):e10891. PMID: 20531936.
      Citations:    
    47. Horvath RJ, Landry RP, Romero-Sandoval EA, DeLeo JA. Morphine tolerance attenuates the resolution of postoperative pain and enhances spinal microglial p38 and extracellular receptor kinase phosphorylation. Neuroscience. 2010 Aug 25; 169(2):843-54. PMID: 20493931.
      Citations:    
    48. Romero-Sandoval EA, Horvath R, Landry RP, DeLeo JA. Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation. Mol Pain. 2009 May 28; 5:25. PMID: 19476641.
      Citations:    
    49. Romero-Sandoval EA, Horvath RJ, DeLeo JA. Neuroimmune interactions and pain: focus on glial-modulating targets. Curr Opin Investig Drugs. 2008 Jul; 9(7):726-34. PMID: 18600578.
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    50. Romero-Sandoval A, Chai N, Nutile-McMenemy N, Deleo JA. A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain. Brain Res. 2008 Jul 11; 1219:116-26. PMID: 18538310.
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    51. Romero-Sandoval A, Nutile-McMenemy N, DeLeo JA. Spinal microglial and perivascular cell cannabinoid receptor type 2 activation reduces behavioral hypersensitivity without tolerance after peripheral nerve injury. Anesthesiology. 2008 Apr; 108(4):722-34. PMID: 18362605.
      Citations:    
    52. Summer GJ, Romero-Sandoval EA, Bogen O, Dina OA, Khasar SG, Levine JD. Proinflammatory cytokines mediating burn-injury pain. Pain. 2008 Mar; 135(1-2):98-107. PMID: 17590515.
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    53. Romero-Sandoval A, Eisenach JC. Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision. Anesthesiology. 2007 Apr; 106(4):787-94. PMID: 17413917.
      Citations:    
    54. Romero-Sandoval A, Bynum T, Eisenach JC. Analgesia induced by perineural clonidine is enhanced in persistent neuritis. Neuroreport. 2007 Jan 08; 18(1):67-71. PMID: 17259863.
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    55. Romero-Sandoval EA, Curros-Criado MM, Gaitan G, Molina C, Herrero JF. Nitroparacetamol (NCX-701) and pain: first in a series of novel analgesics. CNS Drug Rev. 2007; 13(3):279-95. PMID: 17894645.
      Citations:    
    56. Romero-Sandoval A, Eisenach JC. Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis. Brain Behav Immun. 2007 Jul; 21(5):569-80. PMID: 17079113.
      Citations:    
    57. Alfonso Romero-Sandoval E, Molina C, Herrero JF. Enhancement of the analgesic activity of paracetamol and nitroparacetamol by the oral administration of all-trans retinoic acid. Neuropharmacology. 2006 Sep; 51(4):858-65. PMID: 16870215.
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    58. Romero-Sandoval EA, Molina C, Alique M, Moreno-Manzano V, Lucio FJ, Herrero JF. Vitamin A active metabolite, all-trans retinoic acid, induces spinal cord sensitization. I. Effects after oral administration. Br J Pharmacol. 2006 Sep; 149(1):56-64. PMID: 16847436.
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    59. Romero-Sandoval A, Eisenach JC. Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury. Anesthesiology. 2006 Feb; 104(2):351-5. PMID: 16436856.
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    60. Romero-Sandoval EA, McCall C, Eisenach JC. Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain. J Neurosci. 2005 Sep 28; 25(39):8988-94. PMID: 16192389.
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    61. Romero-Sandoval EA, Alique M, Moreno-Manzano V, Molina C, Lucio FJ, Herrero JF. The oral administration of retinoic acid enhances nociceptive withdrawal reflexes in rats with soft-tissue inflammation. Inflamm Res. 2004 Jul; 53(7):297-303. PMID: 15241564.
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    62. Alfonso Romero-Sandoval E, Del Soldato P, Herrero JF. The effects of sham and full spinalization on the antinociceptive effects of NCX-701 (nitroparacetamol) in monoarthritic rats. Neuropharmacology. 2003 Sep; 45(3):412-9. PMID: 12871658.
      Citations:    
    63. Herrero JF, Romero-Sandoval EA, Gaitan G, Mazario J. Antinociception and the new COX inhibitors: research approaches and clinical perspectives. CNS Drug Rev. 2003; 9(3):227-52. PMID: 14530796.
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    64. Romero-Sandoval EA, Mazario J, Howat D, Herrero JF. NCX-701 (nitroparacetamol) is an effective antinociceptive agent in rat withdrawal reflexes and wind-up. Br J Pharmacol. 2002 Mar; 135(6):1556-62. PMID: 11906970.
      Citations:    
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