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David Soto Pantoja, Ph.D.

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentSurgery Hypertension
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    Other Positions
    TitleAssistant Professor
    InstitutionWake Forest School of Medicine
    DepartmentRadiation Oncology

    TitleAssistant Professor
    InstitutionWake Forest School of Medicine
    DepartmentCancer Biology


    Collapse Research 
    Collapse research activities and funding
    K22CA181274     (SOTO PANTOJA, DAVID R)Sep 1, 2015 - Aug 31, 2019
    NIH/NCI
    Therapeutic targeting of CD47 regulates tumor cell bioenergetics and mitophagy
    Role: Principal Investigator

    R21CA249349     (SOTO PANTOJA, DAVID R)Apr 1, 2020 - Mar 31, 2022
    NIH/NCI
    Combinatorial Strategies for the Treatment of Brain Metastases
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. David R.Soto-Pantoja, Kenysha Y.J. Clear, Adam S. Wilson, Greg Kucera, Edward Levine, Akiko Chiba, Katherine L. Cook. Entero-mammary microbiota signaling axis regulates dietary influences on breast cancer risk. AACR;Cancer Res. 2020; 80(8 Suppl):31: PR11.
    2. David Soto-Pantoja, Kenysha Clear, Katherine Loree Cook. Targeting the unfolded protein response components differentially sensitizes breast tumors to doxorubicin while modulating chemotherapy-induced cardiotoxicities. Cancer Res. 2020; 80(4 Suppl):P5-14-19.
    3. Elizabeth Stirling, Adam Wilson, Mitra Kooshki, Liliya Yamaleyeva, Guanxu Jin, Wei Zhang, Lance Miller, Pierre Triozzi, David Soto-Pantoja. The Thrombospondin-1/CD47 signaling axis serve as potential markers of immune checkpoint blockade response modulating immune cell bioenergetics in the tumor microenvironment. Journal for ImmunoTherapy of Cancer. 2019; 7(Suppl 1):190:O8.
    4. David R. Soto-Pantoja, Elisabeth A. Tallant, Patricia E. Gallagher . Muscadine Grape Extract Prevents Cardiac Cell Cytotoxicity Due to Oxidative Stress by Enhancing Mitochondrial Function. Hypertension. 2019; 74(Suppl_1):AP2007.
    5. Yismelin R. Feliz-Mosquea, Elizabeth Stirling, Katherine L. Cook, Adam Wilson, Manish Bharadwaj, Anthony J. Molina, Liliya Yamaleyeva, Pierre L. Triozzi, and David R. Soto-Pantoja. Anti-CD47 immunotherapy regulates T cell metabolism and hypoxia in the tumor microenvironment. AACR; Cancer Res. 2018; 78(13 Suppl):Abstract nr 3528.
    6. David R. Soto-Pantoja, Yismeilin R. Feliz-Mosquea, Kenysha YJ Clear, Adam S. Wilson, and Katherine L. Cook. Targeting PKR-like endoplasmic reticulum kinase modulates metabolism to promote T-cell effector function and PD1 immunotherapy responsiveness. AACR; Cancer Res. 2018; 78(13 Suppl):Abstract nr 449.
    7. David Soto-Pantoja, Nildris Cruz-Diaz, Mark C Chappell . Angiotensin-(1-7) Preserves Mitochondrial Function in Doxorubicin-exposed Renal Epithelial Cells. Hypertension. 2017; 70(Suppl_1):AP411.
    8. Yismeilin R. Feliz Mosquea, David R. Soto Pantoja, Adam Wilson, Pierre L. Triozzi, and Katherine L. Cook. UPR signaling promotes T-cell dysfunction to prevent immune-mediated cancer cell killing and immune checkpoint therapy resistance. AACR; Cancer Res. 2017; 77(13 Suppl):Abstract nr 1704.
    9. David R. Soto-Pantoja, John M. Sipes, Brian Westwood, Nicole Morris, Nancy J. Emenaker, and David D. Roberts. Thrombospondin-1 regulates intestinal microbiota and bile acid metabolism in a murine model of colorectal cancer. AACR; Cancer Res. 2017; 77(13 Suppl):Abstract nr LB-213.
    10. Ashley A. Smith, Adam S. Wilson, and David R. Soto-Pantoja. Targeting CD47 expression on macrophages regulates immunometabolism enhancing tumoricidal activity against cancer cells. AACR; Cancer Res. 2017; 77(13 Suppl):Abstract nr 5661.
    11. KL Cook, A Wilson, B Westwood, and DR Soto-Pantoja. Targeting of the unfolded protein response signaling arms differentially regulates macrophage proliferation, plasticity, and breast cancer cell clearance. AACR; Cancer Res. 2017; 77(4 Suppl):Abstract nr P2-04-06.
    12. Cook KL, Soto-Pantoja DR, Clarke PA, Cruz MI, Zwart A, Wärri A, Hilakivi-Clarke L, Roberts DD, Clarke R. Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer. Cancer Res. 2016 10 01; 76(19):5657-5670. PMID: 27698188.
      View in: PubMed
    13. David D. Roberts, Ashley Smith, John M. Sipes, Adam Wilson, Lesley Mathews-Griner, Rajarshi Guha, Craig J. Thomas, Marc Ferrer, and David R. Soto-Pantoja. High-throughput matrix screening reveals synergistic chemotherapeutic combinations with blockade of CD47 to enhance cytotoxicity in breast cancer. AACR; Cancer Res. 2016; 76(14 Suppl):Abstract nr 1352.
    14. Soto-Pantoja DR, Sipes JM, Martin-Manso G, Westwood B, Morris NL, Ghosh A, Emenaker NJ, Roberts DD. Dietary fat overcomes the protective activity of thrombospondin-1 signaling in the Apc(Min/+) model of colon cancer. Oncogenesis. 2016 May 30; 5(5):e230. PMID: 27239962.
      View in: PubMed
    15. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
      View in: PubMed
    16. Miller TW, Soto-Pantoja DR, Schwartz AL, Sipes JM, DeGraff WG, Ridnour LA, Wink DA, Roberts DD. CD47 Receptor Globally Regulates Metabolic Pathways That Control Resistance to Ionizing Radiation. J Biol Chem. 2015 Oct 09; 290(41):24858-74. PMID: 26311851.
      View in: PubMed
    17. David R. Soto-Pantoja, John M. Sipes, Nicole Morris, Nancy J. Emmenaker, and David D. Roberts. Thrombospondin-1 regulates energy metabolism to increase carcinogenesis in an in vivo model of colorectal cancer. AACR; Cancer Res. 2015; 75(15 Suppl):Abstract nr 1202.
    18. Ridnour LA, Cheng RY, Weiss JM, Kaur S, Soto-Pantoja DR, Basudhar D, Heinecke JL, Stewart CA, DeGraff W, Sowers AL, Thetford A, Kesarwala AH, Roberts DD, Young HA, Mitchell JB, Trinchieri G, Wiltrout RH, Wink DA. NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay. Cancer Res. 2015 Jul 15; 75(14):2788-99. PMID: 25990221.
      View in: PubMed
    19. Nancy Emenaker, David Soto Pantoja, Michael Snipes, Niccole Morris, David Roberts . Thrombospondin-1 Regulates Hepatic Lipid and Energy Metabolism to Increase Carcinogenesis in an In Vivo Model of Colorectal Cancer. FASEB J. 2015; 29(1):394.1.
    20. Priya MK, Sahu G, Soto-Pantoja DR, Goldy N, Sundaresan AM, Jadhav V, Barathkumar TR, Saran U, Jaffar Ali BM, Roberts DD, Bera AK, Chatterjee S. Tipping off endothelial tubes: nitric oxide drives tip cells. Angiogenesis. 2015 Apr; 18(2):175-89. PMID: 25510468.
      View in: PubMed
    21. Soto-Pantoja DR, Shih HB, Maxhimer JB, Cook KL, Ghosh A, Isenberg JS, Roberts DD. Thrombospondin-1 and CD47 signaling regulate healing of thermal injury in mice. Matrix Biol. 2014 Jul; 37:25-34. PMID: 24840925.
      View in: PubMed
    22. David R. Soto-Pantoja, John M. Sipes, Arunima Ghosh, Maria J. Merino, and David D. Roberts. Therapeutic targeting of CD47 regulates cell bioenergetics and autophagy to reduce breast tumor growth and protect against anthracycline-mediated cardiac toxicity. AACR; Cancer Res. 2014; 74(19 Suppl):Abstract nr 2434.
    23. Katherine L. Cook, Anni Warri, Rong Hu, Lu Jin, Alan Zwart, David R. Soto Pantoja, Jie Liu, Toren Finkel, and Robert Clarke. Autophagy and unfolded protein response (UPR) signaling regulates progression of apoptosis in mammary gland involution. AACR; Cancer Res. 2013; 73(8 Suppl):Abstract nr 1667.
    24. Patricia E. Gallagher, Alison L. Arter, David R. Soto-Pantoja, and E. Ann Tallant. Angiotensin-(1-7) attenuates triple-negative breast cancer growth and progression through regulation of protein phosphatases. AACR; Cancer Res 2013. 2013; 73(3 Suppl):Abstract nr C66.
    25. David R. Soto Pantoja, Terabe Masaki, Lisa A. Ridnour, William DeGraff, Jay A. Berzofsky, and David D. Roberts. Lack of CD47 in the tumor microenvironment enhances anti-tumor adaptive immune responses when combined with ionizing radiation. AACR; Cancer Res. 2012; 72(8 Suppl):Abstract nr 3451.
    26. Nancy J. Emenaker, David R. Soto Pantoja, David D. Roberts . Lack of thrombospondin-1 increases tumorigenesis and decreases survival of in a new mouse model of colorectal cancer. FASEB J. 2012; 26(1).
    27. KL Cook, D Soto Pantoja, P Gallagher, and E Tallant. Angiotensin-(1-7) inhibition of human breast tumors with distinct hormone receptor expression results in a differential regulation of Akt. Cancer Res. 2009; 69(2 Suppl):Abstract nr 3127.
    28. DR Soto-Pantoja, W Petty, PE Gallagher, and E Tallant. Angiotensin-(1-7) inhibits triple negative tumor growth through the inhibition of angiogenesis and a reduction in placental growth factor PlGF. Cancer Res. 2009; 69(2 Suppl):Abstract nr 901.
    29. Patricia E. Gallagher, David R. Soto-Pantoja, E. Ann Tallant. Angiotensin-(1–7) Reduces Endothelial Cell Growth and Migration and Increases VEGI to Inhibit Angiogenesis. Hypertension. 2008; 52(4):e72;P080.
    30. David Soto-Pantoja, Jyotsana Menon, Patricia Gallagher, and E. Ann Tallant. Angiotensin-(1-7) inhibits the growth of human triple negative breast tumors in an orthotopic model. Proceedings of the 99th Annual Meeting of the American Association for Cancer Research; AACR. 2008; 68(9 Suppl):Abstract 2416.
    31. Jyotsana Menon, Mark Miller, David Soto-Pantoja, Michael Callahan, E. Ann Tallant, and Patricia Gallagher. Angiotensin-(1-7) reduces lung tumor incidence in a novel bitransgenic Ki-rasG12C mouse model of lung tumorigenesis through a reduction in cyclooxygenase-2. AACR. 2008; 68(9 Suppl):Abstract 4654 .
    32. David R. Soto-Pantoja, Patricia E. Gallagher, and E. Ann Tallant. Inhibition of angiogenesis by angiotensin-(1-7). Proc Amer Assoc Cancer Res. 2006; 47:Abstr 950.
    33. David R. Soto Pantoja, E. Ann Tallant, and Patricia E. Gallagher. Inhibition of human breast cancer cell growth by angiotensin-(1–7). Proc Amer Assoc Cancer Res. 2004; 45:Abstr 3824.
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