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Douglas G. Ririe MD, PhD, MHA

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentAnesthesiology
Address
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    Other Positions
    TitleChair
    InstitutionWake Forest School of Medicine
    DepartmentAnesthesiology

    TitleSection Head
    InstitutionWake Forest School of Medicine


    Collapse Research 
    Collapse research activities and funding
    K08GM072105     (RIRIE, DOUGLAS G)Sep 1, 2004 - Aug 31, 2009
    NIH
    Neurophysiologic Development Responses to Surgery
    Role: Principal Investigator
    R43NS073285     (HORSAGER, ALAN)Mar 15, 2011 - Feb 28, 2014
    NIH
    Development of an Optical Silencer Based Genetic Therapy for Neuropathic Pain
    Role: Co-Principal Investigator
    R01GM104249     (RIRIE, DOUGLAS G)Jul 1, 2013 - Jun 30, 2019
    NIH
    Injury Induced Afferent Activity in Pain Behavior
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Emerick T, Marshall T, Martin TJ, Ririe D, Schwenk ES. Perioperative considerations for patients exposed to hallucinogens: an infographic. Reg Anesth Pain Med. 2024 Mar 01. PMID: 38431307.
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    2. Kim J, Barcus R, Lipford ME, Yuan H, Ririe DG, Jung Y, Vlasova RM, Styner M, Nader MA, Whitlow CT. Effects of multiple anesthetic exposures on rhesus macaque brain development: a longitudinal structural MRI analysis. Cereb Cortex. 2023 Dec 23. PMID: 38142289.
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    3. Emerick TD, Martin TJ, Ririe DG. Perioperative Considerations for Patients Exposed to Psychostimulants. Anesth Analg. 2023 Sep 01; 137(3):474-487. PMID: 37590793.
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    4. Vishneski SR, Saha AK, Fram MR, Templeton LB, Lee LK, Ririe DG, Goenaga-Diaz EJ, Smith LD, Templeton TW. Risk Factors for Administration of Additional Reversal Following Neuromuscular Blockade with Rocuronium in Children: A Retrospective Case-Control Study. Paediatr Anaesth. 2022 Apr 19. PMID: 35438816.
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    5. Ririe DG, Eisenach JC, Martin TJ. A Painful Beginning: Early Life Surgery Produces Long-Term Behavioral Disruption in the Rat. Front Behav Neurosci. 2021; 15:630889. PMID: 34025368.
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    6. Goenaga-Diaz EJ, Smith LD, Pecorella SH, Smith TE, Russell GB, Johnson KN, Downard MG, Ririe DG, Hammon DE, Hodges AS, Templeton TW. A comparison of the breathing apparatus deadspace associated with a supraglottic airway and endotracheal tube using volumetric capnography in young children. Korean J Anesthesiol. 2021 Jun; 74(3):218-225. PMID: 33198431.
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    7. Boada MD, Ririe DG, Martin CW, Martin SJ, Kim SA, Eisenach JC, Martin TJ. Nociceptive input after peripheral nerve injury results in cognitive impairment and alterations in primary afferent physiology in rats. Pain. 2020 05; 161(5):960-969. PMID: 32040075.
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    8. Boada MD, Martin TJ, Parker R, Houle TT, Eisenach JC, Ririe DG. Recovery from nerve injury induced behavioral hypersensitivity in rats parallels resolution of abnormal primary sensory afferent signaling. Pain. 2020 05; 161(5):949-959. PMID: 32040074.
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    9. Templeton TW, Goenaga-Díaz EJ, Downard MG, McLouth CJ, Smith TE, Templeton LB, Pecorella SH, Hammon DE, O'Brien JJ, McLaughlin DH, Lawrence AE, Tennant PR, Ririe DG. Assessment of Common Criteria for Awake Extubation in Infants and Young Children. Anesthesiology. 2019 10; 131(4):801-808. PMID: 31343462.
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    10. Ririe DG, Boada MD, MacGregor MK, Martin SJ, Strassburg TJ, Kim SA, Eisenach JC, Martin TJ. Incisional Nociceptive Input Impairs Attention-related Behavior and Is Associated with Reduced Neuronal Activity in the Prefrontal Cortex in Rats. Anesthesiology. 2018 10; 129(4):778-790. PMID: 29952818.
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    11. Templeton TW, Goenaga-Díaz EJ, Templeton LB, Ririe DG. An inconvenient truth: Supraglottic devices can lead to potentially significant increases in the apparatus dead space in the anesthetized infant. Paediatr Anaesth. 2018 07; 28(7):672-673. PMID: 30133912.
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    12. Templeton TW, Goenaga-Díaz EJ, Templeton LB, Ririe DG. An in vitro analysis of the dead space in 5 supraglottic airway devices intended for use in small children and infants. Paediatr Anaesth. 2018 06; 28(6):570-572. PMID: 29878544.
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    13. Templeton TW, Templeton LB, Lawrence AE, Sieren LM, Downard MG, Ririe DG. An initial experience with an Extraluminal EZ-Blocker® : A new alternative for 1-lung ventilation in pediatric patients. Paediatr Anaesth. 2018 04; 28(4):347-351. PMID: 29430803.
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    14. Sudo RT, do Amaral RV, Monteiro CEDS, Pitta IDR, Lima MDC, Montes GC, Ririe DG, Hayashida K, Zapata-Sudo G. Antinociception induced by a novel a2A adrenergic receptor agonist in rodents acute and chronic pain models. Eur J Pharmacol. 2017 Nov 15; 815:210-218. PMID: 28935564.
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    15. Martin TJ, Strassburg TJ, Grigg AL, Kim SA, Ririe DG, Eisenach JC. Assessment of Behavioral Disruption in Rats with Abdominal Inflammation Using Visual Cue Titration and the Five-choice Serial-reaction Time Task. Anesthesiology. 2017 08; 127(2):372-381. PMID: 28542002.
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    16. Ririe DG, Boada MD, Schmidt BS, Martin SJ, Kim SA, Martin TJ. Audiovisual Distraction Increases Prefrontal Cortical Neuronal Activity and Impairs Attentional Performance in the Rat. J Exp Neurosci. 2017; 11:1179069517703080. PMID: 28469479.
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    17. Boada MD, Ririe DG, Eisenach JC. Post-discharge hyperpolarization is an endogenous modulatory factor limiting input from fast-conducting nociceptors (AHTMRs). Mol Pain. 2017 Jan-Dec; 13:1744806917726255. PMID: 28825337.
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    18. Templeton TW, Hoke LK, Templeton LB, Ririe DG, Rose DM, Bryan YF. A comparison of 3 ventilation strategies in children younger than 1 year using a Proseal laryngeal mask airway: a randomized controlled trial. J Clin Anesth. 2016 Dec; 35:502-508. PMID: 27871584.
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    19. Boada MD, Martin TJ, Ririe DG. Nerve injury induced activation of fast-conducting high threshold mechanoreceptors predicts non-reflexive pain related behavior. Neurosci Lett. 2016 Oct 06; 632:44-9. PMID: 27544012.
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    20. Boada MD, Eisenach JC, Ririe DG. Mechanical sensibility of nociceptive and non-nociceptive fast-conducting afferents is modulated by skin temperature. J Neurophysiol. 2016 Jan 01; 115(1):546-53. PMID: 26581873.
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    21. Ririe DG. How long does incisional pain last: early life vulnerability could make it last a lifetime. Anesthesiology. 2015 Jun; 122(6):1189-91. PMID: 25859905.
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    22. Crantford JC, Wood BC, Claiborne JR, Ririe DG, Couture DE, Thompson JT, David LR. Evaluating the safety and efficacy of tranexamic acid administration in pediatric cranial vault reconstruction. J Craniofac Surg. 2015 Jan; 26(1):104-7. PMID: 25534062.
      Citations:    
    23. Martin TJ, Grigg A, Kim SA, Ririe DG, Eisenach JC. Assessment of attention threshold in rats by titration of visual cue duration during the five choice serial reaction time task. J Neurosci Methods. 2015 Feb 15; 241:37-43. PMID: 25528113.
      Citations:    
    24. Boada MD, Gutierrez S, Aschenbrenner CA, Houle TT, Hayashida K, Ririe DG, Eisenach JC. Nerve injury induces a new profile of tactile and mechanical nociceptor input from undamaged peripheral afferents. J Neurophysiol. 2015 Jan 01; 113(1):100-9. PMID: 25274350.
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    25. Boada DM, Martin TJ, Peters CM, Hayashida K, Harris MH, Houle TT, Boyden ES, Eisenach JC, Ririe DG. Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats. Pain. 2014 Dec; 155(12):2646-2655. PMID: 25267211.
      Citations:    
    26. Peters CM, Ririe D, Houle TT, Aschenbrenner CA, Eisenach JC. Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats. Anesthesiology. 2014 Apr; 120(4):976-86. PMID: 24296762.
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    27. Boada MD, Gutierrez S, Giffear K, Eisenach JC, Ririe DG. Skin incision-induced receptive field responses of mechanosensitive peripheral neurons are developmentally regulated in the rat. J Neurophysiol. 2012 Aug; 108(4):1122-9. PMID: 22673323.
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    28. Boada MD, Gutierrez S, Houle T, Eisenach JC, Ririe DG. Developmental differences in peripheral glabrous skin mechanosensory nerve receptive field and intracellular electrophysiologic properties: phenotypic characterization in infant and juvenile rats. Int J Dev Neurosci. 2011 Dec; 29(8):847-54. PMID: 21856407.
      Citations:    
    29. Ririe DG, Smith TE, Wood BC, Glazier SS, Couture DE, Argenta LC, David LR. Time-dependent perioperative anesthetic management and outcomes of the first 100 consecutive cases of spring-assisted surgery for sagittal craniosynostosis. Paediatr Anaesth. 2011 Oct; 21(10):1015-9. PMID: 21585615.
      Citations:    
    30. Kiuchi MG, Zapata-Sudo G, Trachez MM, Ririe D, Sudo RT. The influence of age on bupivacaine cardiotoxicity. Anesth Analg. 2011 Mar; 112(3):574-80. PMID: 21304156.
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    31. Boada MD, Houle TT, Eisenach JC, Ririe DG. Differing neurophysiologic mechanosensory input from glabrous and hairy skin in juvenile rats. J Neurophysiol. 2010 Dec; 104(6):3568-75. PMID: 20926608.
      Citations:    
    32. Smith TE, Ririe DG. Late diagnosis of H-Type tracheoesophageal fistula. Paediatr Anaesth. 2010 Oct; 20(10):969-70. PMID: 20849511.
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    33. Ririe DG, Smith TE, David LR, Argenta LC. Better for some, maybe not for all: a response to preemptive transfusion and infusion strategy in children during craniofacial reconstruction. Paediatr Anaesth. 2010 Jun; 20(6):574-5. PMID: 20609119.
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    34. O'Brien JJ, Ririe DG. Anesthetic experience in a patient with Cantú syndrome. Paediatr Anaesth. 2008 Dec; 18(12):1255-7. PMID: 19076592.
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    35. Ririe DG, Bremner LR, Fitzgerald M. Comparison of the immediate effects of surgical incision on dorsal horn neuronal receptive field size and responses during postnatal development. Anesthesiology. 2008 Oct; 109(4):698-706. PMID: 18813050.
      Citations:    
    36. Ririe DG, Liu B, Clayton B, Tong C, Eisenach JC. Electrophysiologic characteristics of large neurons in dorsal root ganglia during development and after hind paw incision in the rat. Anesthesiology. 2008 Jul; 109(1):111-7. PMID: 18580180.
      Citations:    
    37. Tong C, Conklin DR, Liu B, Ririe DG, Eisenach JC. Assessment of behavior during labor in rats and effect of intrathecal morphine. Anesthesiology. 2008 Jun; 108(6):1081-6. PMID: 18497609.
      Citations:    
    38. Gardner JC, Turner CS, Ririe DG. Vagal hypertonia and anesthesia in Angelman syndrome. Paediatr Anaesth. 2008 Apr; 18(4):348-9. PMID: 18315655.
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    39. Ririe DG, Prout HD, Barclay D, Tong C, Lin M, Eisenach JC. Developmental differences in spinal cyclooxygenase 1 expression after surgical incision. Anesthesiology. 2006 Mar; 104(3):426-31. PMID: 16508388.
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    40. Ririe DG, Eisenach JC. Age-dependent responses to nerve injury-induced mechanical allodynia. Anesthesiology. 2006 Feb; 104(2):344-50. PMID: 16436855.
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    41. Ririe DG, Lantz PE, Glazier SS, Argenta LC. Transfusion-related acute lung injury in an infant during craniofacial surgery. Anesth Analg. 2005 Oct; 101(4):1003-6, table of contents. PMID: 16192509.
      Citations:    
    42. Grace BE, Cnota JF, Hines MH, Payne RM, Ririe DG. Images in cardiovascular medicine. Traumatic coronary artery fistula in a child. Circulation. 2005 May 03; 111(17):e272-3. PMID: 15867187.
      Citations:    
    43. Du D, Eisenach JC, Ririe DG, Tong C. The antinociceptive effects of spinal cyclooxygenase inhibitors on uterine cervical distension. Brain Res. 2004 Oct 22; 1024(1-2):130-6. PMID: 15451374.
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    44. Ririe DG, Prout HM, Eisenach JC. Effect of cyclooxygenase-1 inhibition in postoperative pain is developmentally regulated. Anesthesiology. 2004 Oct; 101(4):1031-5. PMID: 15448542.
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    45. Smith TE, d'Hulst D, Ririe DG. A well-fertilized bulb should blossom. Anesth Analg. 2004 Aug; 99(2):622. PMID: 15271754.
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    46. Ririe DG, Barclay D, Prout H, Tong C, Tobin JR, Eisenach JC. Preoperative sciatic nerve block decreases mechanical allodynia more in young rats: is preemptive analgesia developmentally modulated? Anesth Analg. 2004 Jul; 99(1):140-5. PMID: 15281520.
      Citations:    
    47. Hines MH, Raines KH, Payne RM, Covitz W, Cnota JF, Smith TE, O'Brien JJ, Ririe DG. Video-assisted ductal ligation in premature infants. Ann Thorac Surg. 2003 Nov; 76(5):1417-20; discussion 1420. PMID: 14602260.
      Citations:    
    48. Ririe DG, David LR, Glazier SS, Smith TE, Argenta LC. Surgical advancement influences perioperative care: a comparison of two surgical techniques for sagittal craniosynostosis repair. Anesth Analg. 2003 Sep; 97(3):699-703. PMID: 12933388.
      Citations:    
    49. Ririe DG, Vernon TL, Tobin JR, Eisenach JC. Age-dependent responses to thermal hyperalgesia and mechanical allodynia in a rat model of acute postoperative pain. Anesthesiology. 2003 Aug; 99(2):443-8. PMID: 12883418.
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    50. Ririe DG, James RL, O'Brien JJ, Lin YA, Bennett J, Barclay D, Hines MH, Butterworth JF. The pharmacokinetics of epsilon-aminocaproic acid in children undergoing surgical repair of congenital heart defects. Anesth Analg. 2002 Jan; 94(1):44-9, table of contents. PMID: 11772798.
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    51. Ririe DG, Lundell JC, Neville MJ. Direct effects of propofol on myocardial and vascular tissue from mature and immature rats. J Cardiothorac Vasc Anesth. 2001 Dec; 15(6):745-9. PMID: 11748525.
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    52. Ririe DG, Roberts PR, Shouse MN, Zaloga GP. Vasodilatory actions of the dietary peptide carnosine. Nutrition. 2000 Mar; 16(3):168-72. PMID: 10705070.
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    53. Ririe DG, Walker FO, James RL, Butterworth J. Effect of alkalinization of lidocaine on median nerve block. Br J Anaesth. 2000 Feb; 84(2):163-8. PMID: 10743447.
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    54. Butterworth J, Ririe DG, Thompson RB, Walker FO, Jackson D, James RL. Differential onset of median nerve block: randomized, double-blind comparison of mepivacaine and bupivacaine in healthy volunteers. Br J Anaesth. 1998 Oct; 81(4):515-21. PMID: 9924223.
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    55. Ririe DG, Butterworth JF, Hines M, Hammon JW, Zaloga GP. Effects of cardiopulmonary bypass and deep hypothermic circulatory arrest on the thyroid axis during and after repair of congenital heart defects: preservation by deep hypothermia? Anesth Analg. 1998 Sep; 87(3):543-8. PMID: 9728824.
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    56. Ririe DG, Ririe KL, Sethna NF, Fox L. Unexpected interaction of methylphenidate (Ritalin) with anaesthetic agents. Paediatr Anaesth. 1997; 7(1):69-72. PMID: 9041578.
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    57. Ririe DG, Butterworth JF, Royster RL, MacGregor DA, Zaloga GP. Triiodothyronine increases contractility independent of beta-adrenergic receptors or stimulation of cyclic-3',5'-adenosine monophosphate. Anesthesiology. 1995 Apr; 82(4):1004-12. PMID: 7717535.
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