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Donald B. Penzien PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentPsychiatry & Behavioral Medicine
Address
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentEpidemiology & Prevention (Public Health Sciences)

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentNeurology


    Collapse Biography 
    Collapse education and training
    Ohio University, Athens OhioPhD1986Clinical Psychology/Behavioral Medicine
    Brown University Medical School Clinical Psychology Internship Consortium, Providence, RIIntern1986Clinical Psychologyt/Behavioral Medicine
    Ohio University, Athens, OHMS1982Experimental Psychophysiology with Behavioral Medicine Emphasis
    Hope College, Holland, MIAB1979Psychology/Biology
    Collapse awards and honors
    2002Fellow, Society of Behavioral Medicine
    1993Fellow, American Headache Society

    Collapse Overview 
    Collapse overview
    Donald B. Penzien, PhD, FAHS, FSBM, is Professor of Psychiatry and Behavioral Medicine, Neurology, and Epidemiology and Prevention—Social Sciences and Health Policy. He is Director of Research for the Department of Psychiatry as well as Deputy Director for the Center of Integrative Medicine at the Wake Forest School of Medicine. He is widely recognized for his contributions in behavioral medicine—particularly headache and chronic pain research methodologies—and enhancing the accessibility and cost-effectiveness of nonpharmacologic therapies. He is a Fellow of American Headache Society and the Society of Behavioral Medicine with over 150 research articles, book chapters, and books/monographs to his credit. His research has been supported by grants from the NIH, the Department of Defense, the US Department of Veterans Affairs, and other funding agencies. He is Senior Editorial Advisor for Headache, Associate Editor for Frontiers in Pain, editorial board member for Global Advances in Health and Medicine, has served on editorial boards of other scientific journals, and has actively served numerous scientific and professional organizations. Key appointments include: Chair, Nonpharmacological Treatment Group: Headache Treatment Guidelines Project (Agency for Healthcare Research and Quality); Board of Directors, Chair of Behavioral Clinical Trials Guidelines Section, and Chair of Methodology, Design, and Statistical Issues Special Interest Section (American Headache Society), US Headache Treatment Guidelines Consortium (American Academy of Neurology); Common Data Elements Working Group for Headache Clinical Trials (National Institute of Neurological Diseases and Stroke).

    Collapse Research 
    Collapse research activities and funding
         (PENZIEN & McGEARY)Mar 1, 2013 - Mar 1, 2018
    Congressionally Directed Medical Research Program (CDMRP), Department of Defense/Veterans Administration Consortium.
    Randomized Clinical Trial of Cognitive Behavior Therapy for Posttraumatic Headache
    Role: Co-Principal Investigator
    UG1CA189824     (LESSER, GLENN J)Aug 1, 2014 - Jul 31, 2025
    NIH
    Wake Forest NCORP Research Base
    Role: Co-Principal Investigator
         (BYRD & IRBY)Jan 1, 2019 - Jan 1, 2021
    National Institute on Aging (NIA)
    Optimizing Recruitment of African Americans in Alzheimer’s Disease Research (NIA Administrative Supplement)
    Role: Co-Investigator
         (PENZIEN, DONALD B)Sep 1, 2019 - Sep 1, 2024
    NIH HEAL Initiative/National Cancer Institute (NCI)
    Implementing and Evaluating mHealth Pain Coping Skills Training Interventions to Improve Self-Management of Chronic Pain in Cancer Survivors in “Real World” Clinical Practice Settings.
    Role: Co-Principal Investigator
    1U24NS114416-01     (LIMKAKENG & KEEFE)Sep 1, 2019 - Sep 1, 2024
    National Institute of Neurological Disorders and Stroke (NINDS)
    U24: Duke Pain Early-phase Research Clinical Center (PERCC).
    Role: Site Principal Investigator
         (PENZIEN, DONALD B)Sep 1, 2020 - Aug 31, 2024
    NIH HEAL Initiative/National Cancer Institute (NCI).
    Administrative supplement to: “Implementing and evaluating mHealth pain coping skills training interventions to improve self-management of chronic pain in cancer survivors in “real world” clinical practice settings: 3UG1CA189824-06
    Role Description: PROJECT NARRATIVE This administrative supplement is part of the parent grant “Implementing and evaluating mHealth pain coping skills training interventions to improve self-management of chronic pain in cancer survivors in real world clinical practice settings”, also known as IMPACTS. This supplement will provide additional funding to pay site accrual fees and purchase participant incentives resulting from an increase in sample size (from 438 to 456 participants) and to account for an increase in site accrual fees for NCORP community sites in the time since the IMPACTS study was funded.
    Role: Principal Investigator
         (PENZIEN, DONALD B)Sep 15, 2020 - Sep 14, 2022
    1. NIH HEAL Initiative/National Cancer Institute (NCI).
    PROMOTING TRAINING IN CLINICAL PAIN RESEARCH AS AN INITIATIVE OF THE INTERNET-DELIVERED MANAGEMENT OF PAIN AMONG CANCER SURVIVORS (IMPACTS) TRIAL
    Role Description: PROJECT NARRATIVE This is a training application in response to the NIH HEAL Initiative’s call to support the career development of early career scientists seeking to establish themselves as pain researchers. The investigative team and PI of one such HEAL Initiative parent grant (Internet-delivered Management of Pain Among Cancer Treatment Survivors—IMPACTS; supported by 3UG1CA189824-06S1) have identified an individual they believe is an exceptional candidate for the career development opportunities that would be afforded by this supplemental funding (Dr. Megan Bennett Irby) and are strongly endorsing her candidacy. This application presents a thorough and thoughtfully crafted research training plan that would be undertaken by Dr. Irby in collaboration with members of the IMPACTS investigative team and other pain experts during the two years of the award.
    Role: Principal Investigator
         (IRBY & VITOLINS)Oct 1, 2020 - Oct 1, 2022
    Salisbury Foundation for Research & Education.
    Feasibility and preliminary effectiveness of ‘Healthy Living Partnerships for Veterans with Migraine’ (HELP VM): An Intensive, group-based lifestyle intervention
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wells RE, O'Connell N, Pierce CR, Estave P, Penzien DB, Loder E, Zeidan F, Houle TT. Effectiveness of Mindfulness Meditation vs Headache Education for Adults With Migraine: A Randomized Clinical Trial. JAMA Intern Med. 2021 Mar 01; 181(3):317-328. PMID: 33315046.
      Citations:    
    2. Langenbahn D, Matsuzawa Y, Lee YSC, Fraser F, Penzien DB, Simon NM, Lipton RB, Minen MT. Underuse of Behavioral Treatments for Headache: a Narrative Review Examining Societal and Cultural Factors. J Gen Intern Med. 2021 Feb 01. PMID: 33527189.
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    3. McGeary DD, Penzien DB, Resick PA, McGeary CA, Jaramillo CA, Eapen BC, Young-McCaughan S, Nabity PS, Moring JC, Houle TT, Keane TM, Peterson AL. Study design for a randomized clinical trial of cognitive-behavioral therapy for posttraumatic headache. Contemp Clin Trials Commun. 2021 Mar; 21:100699. PMID: 33490706.
      Citations:    
    4. McGeary, D, Penzien, D.B., Resick, P., McGeary, C, Jaramillo, C, Eapen, B., Young-McCaughan, S., Nabity, P., Moring, J., Houle, T., & Peterson, A. . Study design for a randomized clinical trial of cognitive-behavioral therapy for posttraumatic headache. Contemporary Clinical Trials Communications. 2021.
    5. Langenbahn, D., Matsuzawa, Y., Lee, Y.S.C., Fraser, F., Penzien, D.B., Simon, N.M., Lipton, R.B., & Minen, M.T. . Underuse of behavioral treatments for headache: A narrative review examining societal and cultural factors. Journal of General Internal Medicine. 2021.
    6. McGeary DD, Resick PA, Penzien DB, Eapen BC, Jaramillo C, McGeary CA, Nabity PS, Peterson AL, Young-McCaughan S, Keane TM, Reed D, Moring J, Sico JJ, Pangarkar SS, Houle TT. Reason to doubt the ICHD-3 7-day inclusion criterion for mild TBI-related posttraumatic headache: A nested cohort study. Cephalalgia. 2020 10; 40(11):1155-1167. PMID: 32867535.
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    7. Gould HM, Atkinson JH, Chircop-Rollick T, D'Andrea J, Garfin S, Patel SM, Funk SD, Capparelli EV, Penzien DB, Wallace M, Weickgenanta AL, Slater M, Rutledge T. A randomized placebo-controlled trial of desipramine, cognitive behavioral therapy, and active placebo therapy for low back pain. Pain. 2020 06; 161(6):1341-1349. PMID: 32068667.
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    8. Rains J.C., & Penzien D.B. . In M.D. Gellman (Ed) Encyclopedia of Behavioral Medicine. Migraine headache. 2020.
    9. Gannon J, Atkinson JH, Chircop-Rollick T, D'Andrea J, Garfin S, Patel S, Penzien DB, Wallace M, Weickgenant AL, Slater M, Holloway R, Rutledge T. Telehealth Therapy Effects of Nurses and Mental Health Professionals From 2 Randomized Controlled Trials for Chronic Back Pain. Clin J Pain. 2019 04; 35(4):295-303. PMID: 30664550.
      Citations:    
    10. Schroter S, Roberts J, Loder E, Penzien DB, Mahadeo S, Houle TT. Biomedical authors' awareness of publication ethics: an international survey. BMJ Open. 2018 11 25; 8(11):e021282. PMID: 30478105.
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    11. Befus DR, Irby MB, Coeytaux RR, Penzien DB. A Critical Exploration of Migraine as a Health Disparity: the Imperative of an Equity-Oriented, Intersectional Approach. Curr Pain Headache Rep. 2018 Oct 05; 22(12):79. PMID: 30291549.
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    12. Rutledge T, Atkinson JH, Holloway R, Chircop-Rollick T, D'Andrea J, Garfin SR, Patel S, Penzien DB, Wallace M, Weickgenant AL, Slater M. Randomized Controlled Trial of Nurse-Delivered Cognitive-Behavioral Therapy Versus Supportive Psychotherapy Telehealth Interventions for Chronic Back Pain. J Pain. 2018 09; 19(9):1033-1039. PMID: 29673974.
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    13. Rutledge T, Atkinson JH, Chircop-Rollick T, D'Andrea J, Garfin S, Patel S, Penzien DB, Wallace M, Weickgenant AL, Slater M. Randomized Controlled Trial of Telephone-delivered Cognitive Behavioral Therapy Versus Supportive Care for Chronic Back Pain. Clin J Pain. 2018 04; 34(4):322-327. PMID: 28877139.
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    14. Smitherman, T.A., Kuka, A.J., Buse, D.C., & Penzien, D.B. . In DC Turk & RJ Gatchel (Eds), Psychological Approaches to Pain Management: A Practitioner’s Handbook. Recurrent headache disorders. 2018; 377-397.
    15. Farris SG, Thomas JG, Abrantes AM, Lipton RB, Pavlovic J, Smitherman TA, Irby MB, Penzien DB, Roth J, O'Leary KC, Bond DS. Pain worsening with physical activity during migraine attacks in women with overweight/obesity: A prospective evaluation of frequency, consistency, and correlates. Cephalalgia. 2018 10; 38(11):1707-1715. PMID: 29237284.
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    16. Crawford P, Penzien DB, Coeytaux R. Reduction in Pain Medication Prescriptions and Self-Reported Outcomes Associated with Acupuncture in a Military Patient Population. Med Acupunct. 2017 Aug 01; 29(4):229-231. PMID: 28874924.
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    17. Houle TT, Turner DP, Golding AN, Porter JAH, Martin VT, Penzien DB, Tegeler CH. Forecasting Individual Headache Attacks Using Perceived Stress: Development of a Multivariable Prediction Model for Persons With Episodic Migraine. Headache. 2017 Jul; 57(7):1041-1050. PMID: 28699328.
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    18. Rains, J.C., Poceta, J.S., & Penzien, D.B. . In S.R. Pandi-Perumal, R.R. Ruoti, & M. Kramer (Eds) Sleep and Psychosomatic Medicine. Sleep and headache disorders. 2016; 109-126.
    19. Irby MB, Bond DS, Lipton RB, Nicklas B, Houle TT, Penzien DB. Aerobic Exercise for Reducing Migraine Burden: Mechanisms, Markers, and Models of Change Processes. Headache. 2016 Feb; 56(2):357-69. PMID: 26643584.
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    20. Turner DP, Smitherman TA, Black AK, Penzien DB, Porter JAH, Lofland KR, Houle TT. Are migraine and tension-type headache diagnostic types or points on a severity continuum? An exploration of the latent taxometric structure of headache. Pain. 2015 Jul; 156(7):1200-1207. PMID: 25775357.
      Citations:    
    21. Penzien DB, Irby MB, Smitherman TA, Rains JC, Houle TT. Well-Established and Empirically Supported Behavioral Treatments for Migraine. Curr Pain Headache Rep. 2015 Jul; 19(7):34. PMID: 26065542.
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    22. Smitherman, T.A., Penzien D.B., Rains, J.C., Nicholson, R.A., & Houle, T.T. . Headache: Advances in Psychotherapy—Evidence-Based Practice. 2015.
    23. Penzien DB, Irby MB. Insights on treatment mechanisms of cognitive-behavioral migraine therapy. Headache. 2014 Oct; 54(9):1439-40. PMID: 25324164.
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    24. Penzien DB, Taylor FR. Headache toolbox. Behavioral and other nonpharmacologic treatments for headache. Headache. 2014 May; 54(5):955-6. PMID: 24797490.
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    25. Roberts J.L., Houle T.T., Loder E.W., Penzien D.B., Turner D.P., & Rothrock J.F. . In D. Moher, D.G. Altman, K.F. Schulz, I. Simera, & E. Wager (Eds.), Guidelines for Reporting Health Research: A User’s Manual. Establishing a coherent reporting guidelines policy in health journals. 2014; 309-317.
    26. Eriator, I., Marshall, L.H., & Penzien, D. B. . In A.D. Kaye, & R.V. Shah (Eds.), Case Studies in Pain Management. Ethical issues in the substance abusing pain patient. 2014; 399-407.
    27. Turner DP, Smitherman TA, Penzien DB, Porter JA, Martin VT, Houle TT. Nighttime snacking, stress, and migraine activity. J Clin Neurosci. 2014 Apr; 21(4):638-43. PMID: 24417796.
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    28. Baillie LE, Gabriele JM, Penzien DB. A systematic review of behavioral headache interventions with an aerobic exercise component. Headache. 2014 Jan; 54(1):40-53. PMID: 23992549.
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    29. Houle TT, Turner DP, Penzien DB. Type I error in headache research. Headache. 2013 Jul-Aug; 53(7):1031-3. PMID: 23773114.
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    30. Turner DP, Smitherman TA, Penzien DB, Lipton RB, Houle TT. Rethinking headache chronification. Headache. 2013 Jun; 53(6):901-7. PMID: 23721237.
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    31. Houle TT, Turner DP, Houle TA, Smitherman TA, Martin V, Penzien DB, Lipton RB. Rounding behavior in the reporting of headache frequency complicates headache chronification research. Headache. 2013 Jun; 53(6):908-19. PMID: 23721238.
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    32. Houle TT, Turner DP, Smitherman TA, Penzien DB, Lipton RB. Influence of random measurement error on estimated rates of headache chronification and remission. Headache. 2013 Jun; 53(6):920-9. PMID: 23721239.
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    33. Lipton RB, Penzien DB, Turner DP, Smitherman TA, Houle TT. Methodological issues in studying rates and predictors of migraine progression and remission. Headache. 2013 Jun; 53(6):930-4. PMID: 23721240.
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    34. Turner DP, Smitherman TA, Martin VT, Penzien DB, Houle TT. Causality and headache triggers. Headache. 2013 Apr; 53(4):628-35. PMID: 23534872.
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    35. Rains J.C., & Penzien D.B. . In M.D. Gellman, & J.R. Turner (Eds.) Encyclopedia of Behavioral Medicine. Migraine headache. 2013; 349-364.
    36. Smitherman, T A., Penzien, D.B., & Rains, J.C. Migraine and psychiatric comorbidity: Diagnostic and treatment issues. Psychiatric Times. 2013; 30(2).
    37. Houle TT, Butschek RA, Turner DP, Smitherman TA, Rains JC, Penzien DB. Stress and sleep duration predict headache severity in chronic headache sufferers. Pain. 2012 Dec; 153(12):2432-2440. PMID: 23073072.
      Citations:    
    38. Turner DP, Smitherman TA, Eisenach JC, Penzien DB, Houle TT. Predictors of headache before, during, and after pregnancy: a cohort study. Headache. 2012 Mar; 52(3):348-62. PMID: 22268840.
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    39. Houle TT, Turner DP, Penzien DB. How does the migraine attack stop? It is NOT the trigger: common headache triggers do not predict cessation of pain. Headache. 2012 Jan; 52(1):189-90. PMID: 22221183.
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    40. Buse, D.C., Andrasik, F., Lake, A.E., & Penzien, D.B. . Nonpharmacologic approaches to migraine treatment. The Medical Roundtable–General Medicine Edition. 2012; 1(2):131-144.
    41. Schafer AM, Rains JC, Penzien DB, Groban L, Smitherman TA, Houle TT. Direct costs of preventive headache treatments: comparison of behavioral and pharmacologic approaches. Headache. 2011 Jun; 51(6):985-91. PMID: 21631481.
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    42. Smitherman TA, Walters AB, Maizels M, Penzien DB. The use of antidepressants for headache prophylaxis. CNS Neurosci Ther. 2011 Oct; 17(5):462-9. PMID: 21951370.
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    43. Penzien, D.B., Smitherman, T.A., & Rains, J.C. . In E. Schulman, A.E. Lake, M. Levin, & E. Loder (Eds.) Refractory Migraine. Identifying Psychiatric Comorbidity in Refractory Migraine Patients. 2010; 80-97.
    44. Cady, R., Farmer, K., Rains, J.C., & Penzien, D.B. . In E. Schulman, A.E. Lake, M. Levin, & E. Loder (Eds.) Refractory Migraine. Creating a Foundation for Successful Treatment: Improving Adherence and Fostering a Therapeutic Relationship. 2010; 341-362.
    45. Smitherman TA, Penzien DB. Were we wrong about the role of psychiatric comorbidities in primary headache? Pain. 2009 Nov; 146(1-2):11-2. PMID: 19692179.
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    46. Smitherman TA, Rains JC, Penzien DB. Psychiatric comorbidities and migraine chronification. Curr Pain Headache Rep. 2009 Aug; 13(4):326-31. PMID: 19586598.
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    47. Penzien DB. Stress management for migraine: recent research and commentary. Headache. 2009 Oct; 49(9):1395-8. PMID: 19549159.
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    48. Rains, J.C. & Penzien, D.B. . In S.R. Pandi-Perumal, J.M. Monti, & A.A. Monjan (Eds.) Principles and Practice of Geriatric Sleep Medicine. Sleep and pain management in the elderly. 2009; 167-182.
    49. Loder, E., & Penzien, D.B. . Improving the quality of research reporting: Headache steps up to the plate. Headache. 2009; 49:335-340.
    50. Houle, T.T., & Penzien, D.B. . Statistical reviewing for Headache. Headache. 2009; 49:59-61.
    51. Smitherman TA, Penzien DB, Maizels M. Anxiety disorders and migraine intractability and progression. Curr Pain Headache Rep. 2008 Jun; 12(3):224-9. PMID: 18796274.
      Citations:    
    52. Rains JC. Change mechanisms in EMG biofeedback training: cognitive changes underlying improvements in tension headache. Headache. 2008 May; 48(5):735-6; discussion 736-7. PMID: 18471128.
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    53. Rains JC, Poceta JS, Penzien DB. Sleep and headaches. Curr Neurol Neurosci Rep. 2008 Mar; 8(2):167-75. PMID: 18460287.
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    54. Smitherman TA, Maizels M, Penzien DB. Headache chronification: screening and behavioral management of comorbid depressive and anxiety disorders. Headache. 2008 Jan; 48(1):45-50. PMID: 18184285.
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    55. Holroyd, K.A., Penzien, D.B., Rains, J.C., Lipchik, G.L., & Buse, D.C. . In S.D. Silberstein, R.B. Lipton, & D.W. Dodick (Eds.), Wolff’s Headache and Other Head Pain. Behavioral management of headache. 2008; 721-746.
    56. Rains, J.C. & Penzien, D.B. . In J.C. Verster, S.R. Pandi-Perumal, & D.L. Streiner (Eds), Sleep and Quality of Life in Medical Illness. Sleep and quality of life in headache and migraine. 2008; 161-173.
    57. Penzien, D.B., & Holroyd, K.A. Change mechanisms in EMG biofeedback training revisited. Headache. 2008; 48:736-737.
    58. Penzien, D.B., Rains, J.C., & Lipton, R.B. . Introduction to the special series on the chronification of headache: Mechanisms, risk factors, and behavioral strategies aimed at primary and secondary prevention of chronic headache. Headache. 2008; 48:5-6.
    59. Smitherman TA, Penzien DB, Rains JC. Challenges of nonpharmacologic interventions in chronic tension-type headache. Curr Pain Headache Rep. 2007 Dec; 11(6):471-7. PMID: 18173984.
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    60. Smitherman TA, Nicholson RA, Penzien DB. Osteopathic treatment versus "relaxation" for tension-type headache. Headache. 2007 Mar; 47(3):450-1; author reply 451-2. PMID: 17371370.
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    61. Penzien DB, Rains JC. Reassuring patients about normal test results. BMJ. 2007 Feb 17; 334(7589):325. PMID: 17303841.
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    62. Smitherman, T. A., Penzien, D. B., & Rains, J. C. Behavioral strategies improve headache outcomes. Southern Pain Society Newsletter. 2007; June:4-5,7.
    63. Rains, J.C., Biondi, D.M., Penzien, D.B., & Poceta, J.S. . In S.R. Pandi-Perumal, R.R. Ruoti, M. Kramer (Eds) Sleep and Psychosomatic Medicine. Sleep and headache disorders. 2007; 157-175.
    64. Miller, B.I., Smitherman, T.A.& Penzien, D.B. . Improving your life by combating stress. JHS Heartbeat. 2007; winter.
    65. Smitherman, T. A., Penzien, D. B., & Maizels, M. Assessing psychiatric symptoms in pain patients. Southern Pain Society Newsletter. 2007; April:7-9.
    66. Rains JC, Penzien DB, Lipchik GL. Behavioral facilitation of medical treatment for headache--part II: Theoretical models and behavioral strategies for improving adherence. Headache. 2006 Oct; 46(9):1395-403. PMID: 17040336.
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    67. Rains JC, Lipchik GL, Penzien DB. Behavioral facilitation of medical treatment for headache--part I: Review of headache treatment compliance. Headache. 2006 Oct; 46(9):1387-94. PMID: 17040335.
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    68. O'Bryant SE, Marcus DA, Rains JC, Penzien DB. The neuropsychology of recurrent headache. Headache. 2006 Oct; 46(9):1364-76. PMID: 17040333.
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    69. Maizels M, Smitherman TA, Penzien DB. A review of screening tools for psychiatric comorbidity in headache patients. Headache. 2006 Oct; 46 Suppl 3:S98-109. PMID: 17034404.
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    70. Lipchik GL, Smitherman TA, Penzien DB, Holroyd KA. Basic principles and techniques of cognitive-behavioral therapies for comorbid psychiatric symptoms among headache patients. Headache. 2006 Oct; 46 Suppl 3:S119-32. PMID: 17034390.
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    71. Rains JC, Penzien DB, Lipchik GL. Behavioral facilitation of medical treatment of headache: implications of noncompliance and strategies for improving adherence. Headache. 2006 Oct; 46 Suppl 3:S142-3. PMID: 17034392.
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    72. Lake AE, Lipchik GL, Penzien DB, Rains JC, Saper JR, Lipton RB. Psychiatric comorbidity with chronic headache: evidence-based clinical implications--introduction to the supplement. Headache. 2006 Oct; 46 Suppl 3:S73-5. PMID: 17034401.
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    73. Houle TT, Dhingra LK, Remble TA, Rokicki LA, Penzien DB. Not tonight, I have a headache? Headache. 2006 Jun; 46(6):983-90. PMID: 16732844.
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    74. Penzien, D.B., Rains, J.C., Lake, A.E, Lipchik, G.L., Lipton, R.B., & Saper, J.R. . Complex comorbidities of recurrent headache disorders: Introduction to the special series. Headache. 2006; 46(9):1364-1376.
    75. Nicholson, R.A., Penzien, D.B. Lipchik, G.L., & Houle, T.T. . A role for blocked randomization. Headache. 2006; 46:343-345.
    76. Penzien, D.B., Rains, J.C., & McGrath, P.J. In J. Olesen, P. Goadsby, N. Ramadan, P. Tfelt-Hansen, & K.M.A Welch, The Headaches. Psychological and behavioral treatments of migraine. 2006; 441-448.
    77. Penzien, D.B., Peatfield, R.C. & Lipchik, G.L. . In J. Olesen, P. Goadsby, N. Ramadan, P. Tfelt-Hansen, & K.M.A Welch, The Headaches. Headache in patients with co-morbid psychiatric disease. 2006; 1117-1124.
    78. Kibler JL, Rhudy JL, Penzien DB, Rains JC, Meeks GR, Bennett W, Dollar KM. Hormones, menstrual distress, and migraine across the phases of the menstrual cycle. Headache. 2005 Oct; 45(9):1181-9. PMID: 16178948.
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    79. Martin VT, Penzien DB, Houle TT, Andrew ME, Lofland KR. The predictive value of abbreviated migraine diagnostic criteria. Headache. 2005 Oct; 45(9):1102-12. PMID: 16178941.
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    80. Penzien DB, Andrasik F, Freidenberg BM, Houle TT, Lake AE, Lipchik GL, Holroyd KA, Lipton RB, McCrory DC, Nash JM, Nicholson RA, Powers SW, Rains JC, Wittrock DA. Guidelines for trials of behavioral treatments for recurrent headache, first edition: American Headache Society Behavioral Clinical Trials Workgroup. Headache. 2005 May; 45 Suppl 2:S110-32. PMID: 15921503.
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    81. Houle TT, Penzien DB, Houle CK. Statistical power and sample size estimation for headache research: an overview and power calculation tools. Headache. 2005 May; 45(5):414-8. PMID: 15953257.
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    82. Houle TT, Penzien DB, Rains JC. Time-series features of headache: individual distributions, patterns, and predictability of pain. Headache. 2005 May; 45(5):445-58. PMID: 15953261.
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    83. Penzien DB, Rains JC, Lipchik GL, Nicholson RA, Lake AE, Hursey KG. Future directions in behavioral headache research: applications for an evolving health care environment. Headache. 2005 May; 45(5):526-34. PMID: 15953270.
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    84. Lake AE, Rains JC, Penzien DB, Lipchik GL. Headache and psychiatric comorbidity: historical context, clinical implications, and research relevance. Headache. 2005 May; 45(5):493-506. PMID: 15953266.
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    85. Rains JC, Penzien DB. Behavioral research and the double-blind placebo-controlled methodology: challenges in applying the biomedical standard to behavioral headache research. Headache. 2005 May; 45(5):479-86. PMID: 15953264.
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    86. Hursey KG, Rains JC, Penzien DB, Nash JM, Nicholson RA. Behavioral headache research: methodologic considerations and research design alternatives. Headache. 2005 May; 45(5):466-78. PMID: 15953263.
      Citations:    
    87. Lipchik GL, Nicholson RA, Penzien DB. Allocation of patients to conditions in headache clinical trials: randomization, stratification, and treatment matching. Headache. 2005 May; 45(5):419-28. PMID: 15953258.
      Citations:    
    88. Penzien DB. Headache research methodology: introduction to the special series. Headache. 2005 May; 45(5):408-10. PMID: 15953255.
      Citations:    
    89. O'Bryant SE, Marcus DA, Rains JC, Penzien DB. Neuropsychology of migraine: present status and future directions. Expert Rev Neurother. 2005 May; 5(3):363-70. PMID: 15938669.
      Citations:    
    90. Rains JC, Penzien DB, McCrory DC, Gray RN. Behavioral headache treatment: history, review of the empirical literature, and methodological critique. Headache. 2005 May; 45 Suppl 2:S92-109. PMID: 15921506.
      Citations:    
    91. Penzien DB. Guidelines for trials of behavioral treatments for recurrent headache: purpose, process, and product. Headache. 2005 May; 45 Suppl 2:S87-9. PMID: 15921504.
      Citations:    
    92. Penzien, D.B. & Rains, J.C. . How behavioral headache treatments can help you fine-tune outcomes. Practical Neurology. 2005; 4:40-46, 49.
    93. Penzien, D.B. The neural matrix of pain processing, placebo analgesia, and cognitive factors. Headache Currents. 2005; 2(6):139-142.
    94. Penzien DB, Rains JC, Lipchik GL, Creer TL. Behavioral interventions for tension-type headache: overview of current therapies and recommendation for a self-management model for chronic headache. Curr Pain Headache Rep. 2004 Dec; 8(6):489-99. PMID: 15509464.
      Citations:    
    95. Nicholson, R.A., Penzien, D.B., McCrory, D.C., Gray, R.N., Nash, J.M., & Dickersin, K. . Behavioral therapies for migraine. The Cochrane Database of Systematic Reviews. 2004.
    96. Psychiatric co-morbidities in patients with headache. Seminars in Pain Medicine. 2004; 2:93-105.
    97. Evans RW, Penzien DB. Your headache is a cow. Headache. 2003 Feb; 43(2):168-9. PMID: 12558773.
      Citations:    
    98. Rains JC, Penzien DB. Sleep and chronic pain: challenges to the alpha-EEG sleep pattern as a pain specific sleep anomaly. J Psychosom Res. 2003 Jan; 54(1):77-83. PMID: 12505558.
      Citations:    
    99. Penzien, D.B., & Gabb, M.G. . Non-pharmacologic Prevention and Treatment of Recurrent Headache. Advanced Studies in Medicine. 2003; 3:S168-S174.
    100. Rains JC, Penzien DB. Chronic headache and sleep disturbance. Curr Pain Headache Rep. 2002 Dec; 6(6):498-504. PMID: 12413410.
      Citations:    
    101. Rains JC, Penzien DB. Behavioral treatment strategies for migraine and tension-type headache: a review of the evidence and future directions. Expert Rev Neurother. 2002 Sep; 2(5):749-60. PMID: 19810992.
      Citations:    
    102. Penzien DB, Rains JC, Andrasik F. Behavioral management of recurrent headache: three decades of experience and empiricism. Appl Psychophysiol Biofeedback. 2002 Jun; 27(2):163-81. PMID: 12206049.
      Citations:    
    103. Nash JM, Holroyd KA, Rokicki LA, Kvaal S, Penzien DB. The influence of placebo awareness on stimulant drug response in a double-blind trial. Psychopharmacology (Berl). 2002 May; 161(3):213-21. PMID: 12021824.
      Citations:    
    104. Rains JC, Penzien DB, Martin VT. Migraine and women's health. J Am Med Womens Assoc (1972). 2002; 57(2):73-8. PMID: 11991424.
      Citations:    
    105. Rains JC, Penzien DB, Lipchik GL, Ramadan NM. Diagnosis of migraine: empirical analysis of a large clinical sample of atypical migraine (IHS 1.7) patients and proposed revision of the IHS criteria. Cephalalgia. 2001 Jun; 21(5):584-95. PMID: 11472385.
      Citations:    
    106. McCrory, D.C., Penzien, D.B., Hasselblad, V., & Gray, R.N. Evidence Report: Behavioral and Physical Treatments for Tension-type and Cervicogenic Headache. 2001.
    107. Holroyd, K.A., Penzien, D.B., & Lipchik, G.L. . In S.D. Silberstein, R.B. Lipton, & D.J. Dalessio (Eds.), Wolff’s Headache and Other Head Pain. Behavioral management of headache. 2001; 562-598.
    108. McCrory, D.C., Penzien, D.B., Hasselblad, V., & Gray, R.N. . Verhaltenstherapie und physikalische Behandlungen bei spannungs- und zervikogenen Kopfschmerzen (Behavior therapy and physical treatments for tension and cervicogenic headache). Manuelle Medizin und Osteopathische Medizin,. 2001; 39:177-181.
    109. Penzien, D.B. Physical and complementary treatments for headache: Overview. Headache: American Council for Headache Education Newsletter. 2001; 11:1-4.
    110. Campbell, J.K., Penzien, D.B., Wall, E.M. . Evidence-based guidelines for migraine headaches: Behavioral and physical treatments. 2000. View Publication.
    111. Penzien, D.B. & Roberson-Nay, R. . Behavioral therapies for migraine. Migraine Association of Ireland Newsletter,. 2000; 20(1):3-4.
    112. McGrady AV, Andrasik F, Davies T, Striefel S, Wickramasekera I, Baskin SM, Penzien DB, Tietjen G. Psychophysiologic Therapy for Chronic Headache in Primary Care. Prim Care Companion J Clin Psychiatry. 1999 Aug; 1(4):96-102. PMID: 15014681.
      Citations:    
    113. Bruehl S, Lofland KR, Semenchuk EM, Rokicki LA, Penzien DB. Use of cluster analysis to validate IHS diagnostic criteria for migraine and tension-type headache. Headache. 1999 Mar; 39(3):181-9. PMID: 15613212.
      Citations:    
    114. Goslin, R.E., Gray, R.N., McCrory, D.C., Penzien, D.B., Rains, J.C., & Hasselblad, V. . Behavioral and Physical Treatments for Migraine Headache. Technical Review 2.2. 1999.
    115. Lipchik GL, Rains JC, Penzien DB, Holroyd KA, Sheftell FD. Recurrent headache: a neglected women's health problem. Womens Health Issues. 1998 Jan-Feb; 8(1):60-4. PMID: 9504040.
      Citations:    
    116. Penzien, D.B. Personality and headache. Headache: American Council for Headache Education Newsletter. 1998; 9:8.
    117. Penzien, D.B. Taking control of headaches. Headache. 1998; 39:325.
    118. Holroyd, K.A., Lipchik, G.L., & Penzien, D.B. . . In K.S. Dobson & K.D. Craig (Eds.), Best practice: Developing and promoting empirically supported interventions. Psychological management of recurrent headache disorders: Empirical basis for clinical practice. 1998; 187-235.
    119. Boutelle, K.N., & Penzien, D.B. . Minimizing weight gain with headache therapy. Headache: American Council for Headache Education Newsletter. 1997; 8:3.
    120. Holroyd, K.A., & Penzien, D.B. Self-management of chronic headache. Medicina. 1997; 30:476-493.
    121. Mosley TH, Payne TJ, Plaud JJ, Johnson CA, Wittrock DA, Seville JL, Penzien DB, Rodriguez G. Psychometric properties of the Weekly Stress Inventory (WSI): extension to a patient sample with coronary heart disease. J Behav Med. 1996 Jun; 19(3):273-87. PMID: 8740469.
      Citations:    
    122. Lipchik, G.L., & Penzien, D.B. Treatment of headache: Resources for patients and clinicians. The Mississippi Psychologist. 1996; 21:15-18.
    123. Turk, D.C., Penzien, D.B., & Rains, J.C. . In A.J. Goreczny (Ed.), Handbook of health and rehabilitation psychology. Temporomandibular disorders. 1996; 55-77.
    124. Payne TJ, Johnson CA, Penzien DB, Porzelius J, Eldridge G, Parisi S, Beckham J, Pbert L, Prather R, Rodriguez G. Chest pain self-management training for patients with coronary artery disease. J Psychosom Res. 1994 Jul; 38(5):409-18. PMID: 7965930.
      Citations:    
    125. Holm JE, Penzien DB, Holroyd KA, Brown TA. Headache and depression: confounding effects of transdiagnostic symptoms. Headache. 1994 Jul-Aug; 34(7):418-23. PMID: 7928326.
      Citations:    
    126. Jamison RN, Rudy TE, Penzien DB, Mosley TH. Cognitive-behavioral classifications of chronic pain: replication and extension of empirically derived patient profiles. Pain. 1994 Jun; 57(3):277-292. PMID: 7936707.
      Citations:    
    127. Holroyd KA, Penzien DB. Psychosocial interventions in the management of recurrent headache disorders. 1: Overview and effectiveness. Behav Med. 1994; 20(2):53-63. PMID: 7803937.
      Citations:    
    128. Penzien, D.B. Headache and personality: Results of a community sample of young adults. Pain Digest. 1994; 4:74.
    129. Penzien, D.B. . The role of helplessness in the response to disease modifying drugs in rheumatoid arthritis. Pain Digest. 1994; 4:75-76.
    130. Penzien, D.B. Family and headache. Headache: American Council for Headache Education Newsletter. 1994; 5(3):1-3.
    131. Penzien, D.B., & Holroyd, K.A. . Psychosocial interventions in the management of recurrent headache disorders--II: Description of treatment techniques. Behavioral Medicine. 1994; 20:64-73.
    132. Penzien, D.B., Johnson, C.A., Seville, J., Rubman, S., Boggess, J.T., & Rains, J.C. . Interrelationships among daily and global self-report measures of headache. Headache Quarterly. 1994; 5:8-14.
    133. Penzien, D.B., & Rains, J.C. . Psychiatric Aspects of Headache. Archives of Neurology. 1994; 51:445-446.
    134. Penzien, D.B., Rains, J.C., & Jamison, R.N. . Interdisciplinary approach to management of chronic benign pain. Pain Digest. 1994; 4:212-218.
    135. Holroyd, K.A., & Penzien, D.B. . Self-management of recurrent headache. Geneva, Switzerland: World Health Organization. {Invited by the WHO for their series, "Behavioral Science Learning Modules for the Health Professions."}. 1993.
    136. Penzien, D.B., Rains, J.C., & Holroyd, K.A. . In C.D. Tollison & R.S. Kunkel (Eds.), Headache: Diagnosis and Treatment. Psychological assessment of the recurrent headache sufferer. 1993; 39-49.
    137. Andrew ME, Penzien DB, Rains JC, Knowlton GE, McAnulty RD. Development of a computer application for headache diagnosis: the Headache Diagnostic System. Int J Biomed Comput. 1992 Jul; 31(1):17-24. PMID: 1644498.
      Citations:    
    138. Beckham JC, Krug LM, Penzien DB, Johnson CA, Mosley TH, Meeks GR, Pbert LA, Prather RC. The relationship of ovarian steroids, headache activity and menstrual distress: a pilot study with female migraineurs. Headache. 1992 Jun; 32(6):292-7. PMID: 1399550.
      Citations:    
    139. Penzien, D.B., Rains, J.C., & Holroyd, K.A. . A review of alternative behavioral treatments for headache. The Mississippi Psychologist. 1992; 17(1):8-9.
    140. Rains, J.C., Penzien, D.B., & Jamison, R.N. . In L. VandeCreek, S. Knapp, & T.L. Jackson (Eds.), Innovations in Clinical Practice: A Source Book. A structured approach to the management of chronic pain. 1992; 11:521-539.
    141. Holroyd KA, Penzien DB, Cordingley GE. Propranolol in the management of recurrent migraine: a meta-analytic review. Headache. 1991 May; 31(5):333-40. PMID: 1830566.
      Citations:    
    142. Payne TJ, Stetson B, Stevens VM, Johnson CA, Penzien DB, Van Dorsten B. The impact of cigarette smoking on headache activity in headache patients. Headache. 1991 May; 31(5):329-32. PMID: 1860793.
      Citations:    
    143. Mosley, T.H., Penzien, D.B., Johnson, C.A., Brantley, P.J., Wittrock, D.A., Andrew, M.E., & Payne, T.J. . Time-series analysis of stress and headache. Cephalalgia. 1991; 11:306-307.
    144. All in your head. American Council for Headache Education Newsletter. 1991; 2(4):1.
    145. Penzien, D.B., Andrew, M.E., Knowlton, G.E., McAnulty, R.D., Rains, J.C., Johnson, C.A., Hursey, K.G., & Jacks, S.D. . Computer-aided system for headache diagnosis with the IHS headache diagnostic criteria: Development and validation. Cephalalgia. 1991; 11:325-326.
    146. Wittrock, D.A., Penzien, D.B., Mosley, T.H., & Johnson, C.A. . The Recurrent Illness Impairment Profile: Preliminary results using the headache version. Headache Quarterly. 1991; 2:138-139.
    147. Martin NJ, Holroyd KA, Penzien DB. The headache-specific locus of control scale: adaptation to recurrent headaches. Headache. 1990 Nov; 30(11):729-34. PMID: 2074167.
      Citations:    
    148. Holroyd KA, Penzien DB. Pharmacological versus non-pharmacological prophylaxis of recurrent migraine headache: a meta-analytic review of clinical trials. Pain. 1990 Jul; 42(1):1-13. PMID: 2146583.
      Citations:    
    149. Rains, J.C., & Penzien, D.B. Women's health research. The Mississippi Psychologist. 1990; 15(4):8,18.
    150. Penzien, D.B., & Hursey, K.G. . Primary prevention of ischemic heart disease. Medical Times. 1990; 118:23-28.
    151. Holroyd KA, Holm JF, Penzien DB, Cordingley GE, Hursey KG, Martin NJ, Theofanous A. Long-term maintenance of improvements achieved with (abortive) pharmacological and nonpharmacological treatments for migraine: preliminary findings. Biofeedback Self Regul. 1989 Dec; 14(4):301-8. PMID: 2698751.
      Citations:    
    152. Holroyd KA, Penzien DB. Meta-analysis minus the analysis: a prescription for confusion. Pain. 1989 Dec; 39(3):359-361. PMID: 2616186.
      Citations:    
    153. Lefebvre, R.C., Penzien, D.B., & Hursey, K.G. . In P.A. Keller, & S.R. Heyman (Eds.), Innovations in Clinical Practice: A Source Book. Behavioral interventions for coronary heart disease. 1988; 7:23-37.
    154. Holroyd, K.A., Holm, J.E., & Penzien, D.B. . In P.A. Keller, & S.R. Heyman (Eds.), Innovations in Clinical Practice: A Source Book. Clinical issues in the behavioral treatment of recurrent headache. 1988; 7:433-457.
    155. Holroyd, K.A., Holm, J.E., Hursey, K.G., Penzien, D.B., Cordingley, G.E., Theofanous, A.G., Richardson, S.C., & Tobin, D.L. Home-based behavioral treatment vs. abortive pharmacological treatment. Journal of Consulting and Clinical Psychology. 1988; (56):218-223.
    156. Penzien, D.B. The behavioral treatment of migraine headache: A meta-analytic review of the literature. 1987.
    157. Holroyd KA, Penzien DB. Client variables and the behavioral treatment of recurrent tension headache: a meta-analytic review. J Behav Med. 1986 Dec; 9(6):515-36. PMID: 3550097.
      Citations:    
    158. Holm JE, Holroyd KA, Hursey KG, Penzien DB. The role of stress in recurrent tension headache. Headache. 1986 Apr; 26(4):160-7. PMID: 3710769.
      Citations:    
    159. Holroyd, K.A., Penzien, D.B., & Holm, J.E. . In H.C.H. Koch (Ed.), Community Clinical Psychology. Behavioural medicine. 1986; 295-315.
    160. Penzien DB, Hursey KG, Kotses H. The effects of anticipatory stress on heart rate and T-wave amplitude revisited: a reply to Furedy and Heslegrave. Biol Psychol. 1985 Nov; 21(3):229-31. PMID: 4084627.
      Citations:    
    161. Hursey KG, Holroyd KA, Penzien DB, Holm JE. The influence of pain state on physiological reactivity of tension headache sufferers. Headache. 1985 Mar; 25(2):79-84. PMID: 3988503.
      Citations:    
    162. Penzien DB, Holroyd KA, Holm JE, Hursey KG. Psychometric characteristics of the Bakal Headache Assessment Questionnaire. Headache. 1985 Jan; 25(1):55-8. PMID: 3972570.
      Citations:    
    163. Holroyd KA, Penzien DB, Hursey KG, Tobin DL, Rogers L, Holm JE, Marcille PJ, Hall JR, Chila AG. Change mechanisms in EMG biofeedback training: cognitive changes underlying improvements in tension headache. J Consult Clin Psychol. 1984 Dec; 52(6):1039-53. PMID: 6520274.
      Citations:    
    164. Holroyd, K.A., & Penzien, D.B. . In K.A. Holroyd, B.A. Schlote, & H. Zenz (Eds.), Perspectives in research on headache. EMG biofeedback and tension headache: Therapeutic mechanisms. 1983; 147-162.
    165. Penzien DB, Hursey KG, Kotses H, Beazel HA. The effects of anticipatory stress on heart rate and T-wave amplitude. Biol Psychol. 1982 Nov-Dec; 15(3-4):241-8. PMID: 7159649.
      Citations:    
    166. Penzien DB, Motiff JP, Scott DR. The effects of lead toxication on learning in rats. Arch Environ Health. 1982 Mar-Apr; 37(2):85-7. PMID: 7073328.
      Citations:    
    167. Holroyd, K.A., & Penzien, D.B. . Cognitive change underlying the effectiveness of biofeedback training. Cognitive Behavior Therapy. 1982; 15:6-10.
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