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Dawen Zhao MD, PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentBiomedical Engineering
Address
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentCancer Biology


    Collapse Research 
    Collapse research activities and funding
    R21CA141348     (ZHAO, DAWEN)Jan 1, 2010 - Dec 31, 2012
    NIH
    Dynamic multimodal imaging of tumor hypoxia and vascular profiles in glioblastoma
    Role: Principal Investigator

    R01CA194578     (ZHAO, DAWEN)Apr 8, 2015 - Jul 31, 2021
    NIH
    Convertible MRI Contrast Ignaling Delivery and Release of Anti-glioma Nano-drug
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu Y, Wang L, Song Q, Ali M, Crowe WN, Kucera GL, Hawkins GA, Soker S, Thomas KW, Miller LD, Lu Y, Bellinger CR, Zhang W, Habib AA, Petty WJ, Zhao D. Intrapleural nano-immunotherapy promotes innate and adaptive immune responses to enhance anti-PD-L1 therapy for malignant pleural effusion. Nat Nanotechnol. 2021 Dec 16. PMID: 34916656.
      Citations:    
    2. Gong K, Guo G, Beckley NA, Yang X, Zhang Y, Gerber DE, Minna JD, Burma S, Zhao D, Akbay EA, Habib AA. Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids. Nat Commun. 2021 12 01; 12(1):7014. PMID: 34853306.
      Citations:    
    3. Gong K, Guo G, Panchani N, Bender ME, Gerber DE, Minna JD, Fattah F, Gao B, Peyton M, Kernstine K, Mukherjee B, Burma S, Chiang CM, Zhang S, Sathe AA, Xing C, Dao KH, Zhao D, Akbay EA, Habib AA. EGFR inhibition triggers an adaptive response by co-opting antiviral signaling pathways in lung cancer. Nat Cancer. 2020 Apr; 1(4):394-409. PMID: 33269343.
      Citations:    
    4. Guo G, Gong K, Puliyappadamba VT, Panchani N, Pan E, Mukherjee B, Damanwalla Z, Bharia S, Hatanpaa KJ, Gerber DE, Mickey BE, Patel TR, Sarkaria JN, Zhao D, Burma S, Habib AA. Efficacy of EGFR plus TNF inhibition in a preclinical model of temozolomide-resistant glioblastoma. Neuro Oncol. 2019 12 17; 21(12):1529-1539. PMID: 31363754.
      Citations:    
    5. Liu Y, Crowe WN, Wang L, Lu Y, Petty WJ, Habib AA, Zhao D. An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases. Nat Commun. 2019 11 08; 10(1):5108. PMID: 31704921.
      Citations:    
    6. Crowe W, Wang L, Zhang Z, Varagic J, Bourland JD, Chan MD, Habib AA, Zhao D. MRI evaluation of the effects of whole brain radiotherapy on breast cancer brain metastasis. Int J Radiat Biol. 2019 03; 95(3):338-346. PMID: 30499763.
      Citations:    
    7. Gong K, Guo G, Gerber DE, Gao B, Peyton M, Huang C, Minna JD, Hatanpaa KJ, Kernstine K, Cai L, Xie Y, Zhu H, Fattah FJ, Zhang S, Takahashi M, Mukherjee B, Burma S, Dowell J, Dao K, Papadimitrakopoulou VA, Olivas V, Bivona TG, Zhao D, Habib AA. TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer. J Clin Invest. 2018 06 01; 128(6):2500-2518. PMID: 29613856.
      Citations:    
    8. Bhatt NB, Pandya DN, Dezarn WA, Marini FC, Zhao D, Gmeiner WH, Triozzi PL, Wadas TJ. Practical Guidelines for Cerenkov Luminescence Imaging with Clinically Relevant Isotopes. Methods Mol Biol. 2018; 1790:197-208. PMID: 29858793.
      Citations:    
    9. Guo G, Gong K, Ali S, Ali N, Shallwani S, Hatanpaa KJ, Pan E, Mickey B, Burma S, Wang DH, Kesari S, Sarkaria JN, Zhao D, Habib AA. A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma. Nat Neurosci. 2017 Aug; 20(8):1074-1084. PMID: 28604685.
      Citations:    
    10. Zhao D. Bacteriogenic magnetic nanoparticles as magnetic resonance imaging contrast agents. Transl Cancer Res. 2017 May; 6(Suppl 3):S512-S514. PMID: 31531290.
      Citations:    
    11. Wang L, Habib AA, Mintz A, Li KC, Zhao D. Phosphatidylserine-Targeted Nanotheranostics for Brain Tumor Imaging and Therapeutic Potential. Mol Imaging. 2017 01 01; 16:1536012117708722. PMID: 28654387.
      Citations:    
    12. Zhang L, Habib AA, Zhao D. Phosphatidylserine-targeted liposome for enhanced glioma-selective imaging. Oncotarget. 2016 Jun 21; 7(25):38693-38706. PMID: 27231848.
      Citations:    
    13. Glowa C, Karger CP, Brons S, Zhao D, Mason RP, Huber PE, Debus J, Peschke P. Carbon ion radiotherapy decreases the impact of tumor heterogeneity on radiation response in experimental prostate tumors. Cancer Lett. 2016 08 10; 378(2):97-103. PMID: 27224892.
      Citations:    
    14. Guo G, Gong K, Wohlfeld B, Hatanpaa KJ, Zhao D, Habib AA. Ligand-Independent EGFR Signaling. Cancer Res. 2015 Sep 01; 75(17):3436-41. PMID: 26282175.
      Citations:    
    15. Wu Y, Hao G, Ramezani S, Saha D, Zhao D, Sun X, Sherry AD. [(68) Ga]-HP-DO3A-nitroimidazole: a promising agent for PET detection of tumor hypoxia. Contrast Media Mol Imaging. 2015 Nov-Dec; 10(6):465-72. PMID: 26122548.
      Citations:    
    16. Zhao D, Pacheco-Torres J, Hallac RR, White D, Peschke P, Cerdán S, Mason RP. Dynamic oxygen challenge evaluated by NMR T1 and T2*--insights into tumor oxygenation. NMR Biomed. 2015 Aug; 28(8):937-947. PMID: 26058575.
      Citations:    
    17. Zhang L, Zhang Z, Mason RP, Sarkaria JN, Zhao D. Convertible MRI contrast: Sensing the delivery and release of anti-glioma nano-drugs. Sci Rep. 2015 May 12; 5:9874. PMID: 25962872.
      Citations:    
    18. Zhang Z, Yuan Q, Zhou H, Zhao D, Li L, Gerberich JL, Mason RP. Assessment of tumor response to oxygen challenge using quantitative diffusion MRI in an animal model. J Magn Reson Imaging. 2015 Nov; 42(5):1450-7. PMID: 25866057.
      Citations:    
    19. Zhang L, Zhao D. Applications of nanoparticles for brain cancer imaging and therapy. J Biomed Nanotechnol. 2014 Sep; 10(9):1713-31. PMID: 25992438.
      Citations:    
    20. Zhou H, Stafford JH, Hallac RR, Zhang L, Huang G, Mason RP, Gao J, Thorpe PE, Zhao D. Phosphatidylserine-targeted molecular imaging of tumor vasculature by magnetic resonance imaging. J Biomed Nanotechnol. 2014 May; 10(5):846-55. PMID: 24734537.
      Citations:    
    21. Zhang L, Zhou H, Belzile O, Thorpe P, Zhao D. Phosphatidylserine-targeted bimodal liposomal nanoparticles for in vivo imaging of breast cancer in mice. J Control Release. 2014 Jun 10; 183:114-23. PMID: 24698945.
      Citations:    
    22. Zhou H, Zhao D. Ultrasound imaging-guided intracardiac injection to develop a mouse model of breast cancer brain metastases followed by longitudinal MRI. J Vis Exp. 2014 Mar 06; (85). PMID: 24637963.
      Citations:    
    23. Zhang L, Zhao D. Liposomal encapsulation enhances in vivo near infrared imaging of exposed phosphatidylserine in a mouse glioma model. Molecules. 2013 Nov 26; 18(12):14613-28. PMID: 24287994.
      Citations:    
    24. Hallac RR, Zhou H, Pidikiti R, Song K, Stojadinovic S, Zhao D, Solberg T, Peschke P, Mason RP. Correlations of noninvasive BOLD and TOLD MRI with pO2 and relevance to tumor radiation response. Magn Reson Med. 2014 May; 71(5):1863-73. PMID: 23813468.
      Citations:    
    25. Zhou H, Chen M, Zhao D. Longitudinal MRI evaluation of intracranial development and vascular characteristics of breast cancer brain metastases in a mouse model. PLoS One. 2013; 8(4):e62238. PMID: 23638013.
      Citations:    
    26. Tumati V, Mathur S, Song K, Hsieh JT, Zhao D, Takahashi M, Dobin T, Gandee L, Solberg TD, Habib AA, Saha D. Development of a locally advanced orthotopic prostate tumor model in rats for assessment of combined modality therapy. Int J Oncol. 2013 May; 42(5):1613-9. PMID: 23525451.
      Citations:    
    27. Zhao D, Stafford JH, Zhou H, Thorpe PE. Near-infrared Optical Imaging of Exposed Phosphatidylserine in a Mouse Glioma Model. Transl Oncol. 2011 Dec; 4(6):355-64. PMID: 22191000.
      Citations:    
    28. Saha D, Dunn H, Zhou H, Harada H, Hiraoka M, Mason RP, Zhao D. In vivo bioluminescence imaging of tumor hypoxia dynamics of breast cancer brain metastasis in a mouse model. J Vis Exp. 2011 Oct 03; (56). PMID: 21989061.
      Citations:    
    29. Zhao D, Chang CH, Kim JG, Liu H, Mason RP. In vivo near-infrared spectroscopy and magnetic resonance imaging monitoring of tumor response to combretastatin A-4-phosphate correlated with therapeutic outcome. Int J Radiat Oncol Biol Phys. 2011 Jun 01; 80(2):574-81. PMID: 21345614.
      Citations:    
    30. Mason RP, Zhao D, Liu L, Trawick ML, Pinney KG. A perspective on vascular disrupting agents that interact with tubulin: preclinical tumor imaging and biological assessment. Integr Biol (Camb). 2011 Apr; 3(4):375-87. PMID: 21321746.
      Citations:    
    31. Hatanpaa KJ, Burma S, Zhao D, Habib AA. Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance. Neoplasia. 2010 Sep; 12(9):675-84. PMID: 20824044.
      Citations:    
    32. Mason RP, Zhao D, Pacheco-Torres J, Cui W, Kodibagkar VD, Gulaka PK, Hao G, Thorpe P, Hahn EW, Peschke P. Multimodality imaging of hypoxia in preclinical settings. Q J Nucl Med Mol Imaging. 2010 Jun; 54(3):259-80. PMID: 20639813.
      Citations:    
    33. Zhou H, Luby-Phelps K, Mickey BE, Habib AA, Mason RP, Zhao D. Dynamic near-infrared optical imaging of 2-deoxyglucose uptake by intracranial glioma of athymic mice. PLoS One. 2009 Nov 30; 4(11):e8051. PMID: 19956682.
      Citations:    
    34. Zhao D, Jiang L, Hahn EW, Mason RP. Comparison of 1H blood oxygen level-dependent (BOLD) and 19F MRI to investigate tumor oxygenation. Magn Reson Med. 2009 Aug; 62(2):357-64. PMID: 19526495.
      Citations:    
    35. Park S, Zhao D, Hatanpaa KJ, Mickey BE, Saha D, Boothman DA, Story MD, Wong ET, Burma S, Georgescu MM, Rangnekar VM, Chauncey SS, Habib AA. RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN. Cancer Res. 2009 May 15; 69(10):4107-11. PMID: 19435890.
      Citations:    
    36. Park S, Hatanpaa KJ, Xie Y, Mickey BE, Madden CJ, Raisanen JM, Ramnarain DB, Xiao G, Saha D, Boothman DA, Zhao D, Bachoo RM, Pieper RO, Habib AA. The receptor interacting protein 1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma. Cancer Res. 2009 Apr 01; 69(7):2809-16. PMID: 19339267.
      Citations:    
    37. Kwon CH, Zhao D, Chen J, Alcantara S, Li Y, Burns DK, Mason RP, Lee EY, Wu H, Parada LF. Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res. 2008 May 01; 68(9):3286-94. PMID: 18451155.
      Citations:    
    38. Jennewein M, Lewis MA, Zhao D, Tsyganov E, Slavine N, He J, Watkins L, Kodibagkar VD, O'Kelly S, Kulkarni P, Antich PP, Hermanne A, Rösch F, Mason RP, Thorpe PE. Vascular imaging of solid tumors in rats with a radioactive arsenic-labeled antibody that binds exposed phosphatidylserine. Clin Cancer Res. 2008 Mar 01; 14(5):1377-85. PMID: 18316558.
      Citations:    
    39. Zhao D, Richer E, Antich PP, Mason RP. Antivascular effects of combretastatin A4 phosphate in breast cancer xenograft assessed using dynamic bioluminescence imaging and confirmed by MRI. FASEB J. 2008 Jul; 22(7):2445-51. PMID: 18263704.
      Citations:    
    40. Bourke VA, Zhao D, Gilio J, Chang CH, Jiang L, Hahn EW, Mason RP. Correlation of radiation response with tumor oxygenation in the Dunning prostate R3327-AT1 tumor. Int J Radiat Oncol Biol Phys. 2007 Mar 15; 67(4):1179-86. PMID: 17336219.
      Citations:    
    41. Zhu Y, Guignard F, Zhao D, Liu L, Burns DK, Mason RP, Messing A, Parada LF. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell. 2005 Aug; 8(2):119-30. PMID: 16098465.
      Citations:    
    42. Zhao D, Jiang L, Hahn EW, Mason RP. Continuous low-dose (metronomic) chemotherapy on rat prostate tumors evaluated using MRI in vivo and comparison with histology. Neoplasia. 2005 Jul; 7(7):678-87. PMID: 16026647.
      Citations:    
    43. Zhao D, Jiang L, Hahn EW, Mason RP. Tumor physiologic response to combretastatin A4 phosphate assessed by MRI. Int J Radiat Oncol Biol Phys. 2005 Jul 01; 62(3):872-80. PMID: 15936572.
      Citations:    
    44. Jiang L, Zhao D, Constantinescu A, Mason RP. Comparison of BOLD contrast and Gd-DTPA dynamic contrast-enhanced imaging in rat prostate tumor. Magn Reson Med. 2004 May; 51(5):953-60. PMID: 15122677.
      Citations:    
    45. Zhao D, Jiang L, Mason RP. Measuring changes in tumor oxygenation. Methods Enzymol. 2004; 386:378-418. PMID: 15120262.
      Citations:    
    46. Zhao D, Ran S, Constantinescu A, Hahn EW, Mason RP. Tumor oxygen dynamics: correlation of in vivo MRI with histological findings. Neoplasia. 2003 Jul-Aug; 5(4):308-18. PMID: 14511402.
      Citations:    
    47. Zhao D, Constantinescu A, Chang CH, Hahn EW, Mason RP. Correlation of tumor oxygen dynamics with radiation response of the dunning prostate R3327-HI tumor. Radiat Res. 2003 May; 159(5):621-31. PMID: 12710873.
      Citations:    
    48. Kim JG, Zhao D, Song Y, Constantinescu A, Mason RP, Liu H. Interplay of tumor vascular oxygenation and tumor pO2 observed using near-infrared spectroscopy, an oxygen needle electrode, and 19F MR pO2 mapping. J Biomed Opt. 2003 Jan; 8(1):53-62. PMID: 12542380.
      Citations:    
    49. Song Y, Worden KL, Jiang X, Zhao D, Constantinescu A, Liu H, Mason RP. Tumor oxygen dynamics: comparison of 19F MR EPI and frequency domain NIR spectroscopy. Adv Exp Med Biol. 2003; 530:225-36. PMID: 14562720.
      Citations:    
    50. Mason RP, Hunjan S, Constantinescu A, Song Y, Zhao D, Hahn EW, Antich PP, Peschke P. Tumor oximetry: comparison of 19F MR EPI and electrodes. Adv Exp Med Biol. 2003; 530:19-27. PMID: 14562701.
      Citations:    
    51. Zhao D, Constantinescu A, Hahn EW, Mason RP. Differential oxygen dynamics in two diverse Dunning prostate R3327 rat tumor sublines (MAT-Lu and HI) with respect to growth and respiratory challenge. Int J Radiat Oncol Biol Phys. 2002 Jul 01; 53(3):744-56. PMID: 12062621.
      Citations:    
    52. Zhao D, Constantinescu A, Hahn EW, Mason RP. Tumor oxygen dynamics with respect to growth and respiratory challenge: investigation of the Dunning prostate R3327-HI tumor. Radiat Res. 2001 Nov; 156(5 Pt 1):510-20. PMID: 11604064.
      Citations:    
    53. Zhao D, Constantinescu A, Jiang L, Hahn EW, Mason RP. Prognostic radiology: quantitative assessment of tumor oxygen dynamics by MRI. Am J Clin Oncol. 2001 Oct; 24(5):462-6. PMID: 11586097.
      Citations:    
    54. Hunjan S, Zhao D, Constantinescu A, Hahn EW, Antich PP, Mason RP. Tumor oximetry: demonstration of an enhanced dynamic mapping procedure using fluorine-19 echo planar magnetic resonance imaging in the Dunning prostate R3327-AT1 rat tumor. Int J Radiat Oncol Biol Phys. 2001 Mar 15; 49(4):1097-108. PMID: 11240252.
      Citations:    
    55. Zhao D, Tomono Y, Tsuboi K, Nose T. Immunohistochemical and ultrastructural study of clinically nonfunctioning pituitary adenomas. Neurol Med Chir (Tokyo). 2000 Sep; 40(9):453-6; discussion 456-7. PMID: 11021076.
      Citations:    
    56. Yoshii Y, Saito A, Zhao DW, Nose T. Copper/zinc superoxide dismutase, nuclear DNA content, and progression in human gliomas. J Neurooncol. 1999 Apr; 42(2):103-8. PMID: 10421066.
      Citations:    
    57. Zhao D, Tomono Y, Nose T. Expression of P27kip1 and Ki-67 in pituitary adenomas: an investigation of marker of adenoma invasiveness. Acta Neurochir (Wien). 1999; 141(2):187-92. PMID: 10189502.
      Citations:    
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