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Chia-Chi Chuang Key, Ph.D.

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine - Molecular Medicine
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    Collapse Research 
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    K01DK117069     (KEY, CHIA-CHI CHUANG)Sep 1, 2018 - Aug 31, 2022
    NIH
    Role of Hepatic GDPD3 in Mechanisms of Lipid Metabolism
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gibbs KW, Chuang Key CC, Belfield L, Krall J, Purcell L, Liu C, Files DC. Aging Influences the Metabolic and Inflammatory Phenotype in an Experimental Mouse Model of Acute Lung Injury. J Gerontol A Biol Sci Med Sci. 2021 Apr 30; 76(5):770-777. PMID: 32997738.
      View in: PubMed
    2. Ruggiero AD, Key CC, Kavanagh K. Adipose Tissue Macrophage Polarization in Healthy and Unhealthy Obesity. Front Nutr. 2021; 8:625331. PMID: 33681276.
      View in: PubMed
    3. Key CC, Bishop AC, Wang X, Zhao Q, Chen GY, Quinn MA, Zhu X, Zhang Q, Parks JS. Human GDPD3 overexpression promotes liver steatosis by increasing lysophosphatidic acid production and fatty acid uptake. J Lipid Res. 2020 07; 61(7):1075-1086. PMID: 32430316.
      View in: PubMed
    4. Wang Z, Zhao Q, Nie Y, Yu Y, Misra BB, Zabalawi M, Chou JW, Key CC, Molina AJ, Quinn MA, Fessler MB, Parks JS, McCall CE, Zhu X. Solute Carrier Family 37 Member 2 (SLC37A2) Negatively Regulates Murine Macrophage Inflammation by Controlling Glycolysis. iScience. 2020 May 22; 23(5):101125. PMID: 32428862.
      View in: PubMed
    5. Bashore AC, Liu M, Key CC, Boudyguina E, Wang X, Carroll CM, Sawyer JK, Mullick AE, Lee RG, Macauley SL, Parks JS. Targeted Deletion of Hepatocyte Abca1 Increases Plasma HDL (High-Density Lipoprotein) Reverse Cholesterol Transport via the LDL (Low-Density Lipoprotein) Receptor. Arterioscler Thromb Vasc Biol. 2019 09; 39(9):1747-1761. PMID: 31167565.
      View in: PubMed
    6. Sharma NK, Chuang Key CC, Civelek M, Wabitsch M, Comeau ME, Langefeld CD, Parks JS, Das SK. Genetic Regulation of Enoyl-CoA Hydratase Domain-Containing 3 in Adipose Tissue Determines Insulin Sensitivity in African Americans and Europeans. Diabetes. 2019 07; 68(7):1508-1522. PMID: 31010960.
      View in: PubMed
    7. Liu M, Chuang Key CC, Weckerle A, Boudyguina E, Sawyer JK, Gebre AK, Spoo W, Makwana O, Parks JS. Feeding of tobacco blend or nicotine induced weight loss associated with decreased adipocyte size and increased physical activity in male mice. Food Chem Toxicol. 2018 Mar; 113:287-295. PMID: 29421645.
      View in: PubMed
    8. Cuffe H, Liu M, Key CC, Boudyguina E, Sawyer JK, Weckerle A, Bashore A, Fried SK, Chung S, Parks JS. Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity. Arterioscler Thromb Vasc Biol. 2018 04; 38(4):733-743. PMID: 29348118.
      View in: PubMed
    9. Shen L, Yang Y, Ou T, Key CC, Tong SH, Sequeira RC, Nelson JM, Nie Y, Wang Z, Boudyguina E, Shewale SV, Zhu X. Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy. J Lipid Res. 2017 09; 58(9):1808-1821. PMID: 28729463.
      View in: PubMed
    10. Key CC, Liu M, Kurtz CL, Chung S, Boudyguina E, Dinh TA, Bashore A, Phelan PE, Freedman BI, Osborne TF, Zhu X, Ma L, Sethupathy P, Biddinger SB, Parks JS. Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis. Cell Rep. 2017 06 06; 19(10):2116-2129. PMID: 28591582.
      View in: PubMed
    11. Collins B, Hoffman J, Martinez K, Grace M, Lila MA, Cockrell C, Nadimpalli A, Chang E, Chuang CC, Zhong W, Mackert J, Shen W, Cooney P, Hopkins R, McIntosh M. A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice. J Nutr Biochem. 2016 05; 31:150-65. PMID: 27133434.
      View in: PubMed
    12. Baldwin J, Collins B, Wolf PG, Martinez K, Shen W, Chuang CC, Zhong W, Cooney P, Cockrell C, Chang E, Gaskins HR, McIntosh MK. Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice. J Nutr Biochem. 2016 Jan; 27:123-35. PMID: 26423887.
      View in: PubMed
    13. Ding J, Reynolds LM, Zeller T, Müller C, Lohman K, Nicklas BJ, Kritchevsky SB, Huang Z, de la Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR, Post W, Tracy RP, Wild PS, Blankenberg S, Hoeschele I, Herrington D, McCall CE, Liu Y. Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease. Diabetes. 2015 Oct; 64(10):3464-74. PMID: 26153245.
      View in: PubMed
    14. Shen W, Baldwin J, Collins B, Hixson L, Lee KT, Herberg T, Starnes J, Cooney P, Chuang CC, Hopkins R, Reid T, Gupta S, McIntosh M. Low level of trans-10, cis-12 conjugated linoleic acid decreases adiposity and increases browning independent of inflammatory signaling in overweight Sv129 mice. J Nutr Biochem. 2015 Jun; 26(6):616-25. PMID: 25801353.
      View in: PubMed
    15. Liu M, Allegood J, Zhu X, Seo J, Gebre AK, Boudyguina E, Cheng D, Chuang CC, Shelness GS, Spiegel S, Parks JS. Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles. J Biol Chem. 2015 Mar 20; 290(12):7861-70. PMID: 25627684.
      View in: PubMed
    16. Huang Y, DiDonato JA, Levison BS, Schmitt D, Li L, Wu Y, Buffa J, Kim T, Gerstenecker GS, Gu X, Kadiyala CS, Wang Z, Culley MK, Hazen JE, Didonato AJ, Fu X, Berisha SZ, Peng D, Nguyen TT, Liang S, Chuang CC, Cho L, Plow EF, Fox PL, Gogonea V, Tang WH, Parks JS, Fisher EA, Smith JD, Hazen SL. An abundant dysfunctional apolipoprotein A1 in human atheroma. Nat Med. 2014 Feb; 20(2):193-203. PMID: 24464187.
      View in: PubMed
    17. Zhu X, Chung S, Bi X, Chuang CC, Brown AL, Liu M, Seo J, Cuffe H, Gebre AK, Boudyguina E, Parks JS. Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF diet-induced or genetically obese mouse models. J Lipid Res. 2013 Oct; 54(10):2708-17. PMID: 23894207.
      View in: PubMed
    18. Shen W, Martinez K, Chuang CC, McIntosh M. The phospholipase C inhibitor U73122 attenuates trans-10, cis-12 conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes. J Nutr. 2013 May; 143(5):584-90. PMID: 23468551.
      View in: PubMed
    19. Shen W, Chuang CC, Martinez K, Reid T, Brown JM, Xi L, Hixson L, Hopkins R, Starnes J, McIntosh M. Conjugated linoleic acid reduces adiposity and increases markers of browning and inflammation in white adipose tissue of mice. J Lipid Res. 2013 Apr; 54(4):909-22. PMID: 23401602.
      View in: PubMed
    20. Martinez K, Shyamasundar S, Kennedy A, Chuang CC, Marsh A, Kincaid J, Reid T, McIntosh M. Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes. J Lipid Res. 2013 Mar; 54(3):662-70. PMID: 23264678.
      View in: PubMed
    21. Chuang CC, Shen W, Chen H, Xie G, Jia W, Chung S, McIntosh MK. Differential effects of grape powder and its extract on glucose tolerance and chronic inflammation in high-fat-fed obese mice. J Agric Food Chem. 2012 Dec 26; 60(51):12458-68. PMID: 23210691.
      View in: PubMed
    22. Chuang CC, McIntosh MK. Potential mechanisms by which polyphenol-rich grapes prevent obesity-mediated inflammation and metabolic diseases. Annu Rev Nutr. 2011 Aug 21; 31:155-76. PMID: 21548775.
      View in: PubMed
    23. Overman A, Chuang CC, McIntosh M. Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media. Int J Obes (Lond). 2011 Sep; 35(9):1165-72. PMID: 21224828.
      View in: PubMed
    24. Chuang CC, Martinez K, Xie G, Kennedy A, Bumrungpert A, Overman A, Jia W, McIntosh MK. Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-{alpha}-mediated inflammation and insulin resistance in primary human adipocytes. Am J Clin Nutr. 2010 Dec; 92(6):1511-21. PMID: 20943792.
      View in: PubMed
    25. Chuang CC, Bumrungpert A, Kennedy A, Overman A, West T, Dawson B, McIntosh MK. Grape powder extract attenuates tumor necrosis factor a-mediated inflammation and insulin resistance in primary cultures of human adipocytes. J Nutr Biochem. 2011 Jan; 22(1):89-94. PMID: 20382011.
      View in: PubMed
    26. Bumrungpert A, Kalpravidh RW, Chuang CC, Overman A, Martinez K, Kennedy A, McIntosh M. Xanthones from mangosteen inhibit inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. J Nutr. 2010 Apr; 140(4):842-7. PMID: 20181789.
      View in: PubMed
    27. Overman A, Bumrungpert A, Kennedy A, Martinez K, Chuang CC, West T, Dawson B, Jia W, McIntosh M. Polyphenol-rich grape powder extract (GPE) attenuates inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. Int J Obes (Lond). 2010 May; 34(5):800-8. PMID: 20101247.
      View in: PubMed
    28. Yang RS, Tzeng HP, Ho FM, Chuang CC, Chen BL, Huang CF, Chen YW, Chen RM, Liu SH. Titanium implants alter endothelial function and vasoconstriction via a protein kinase C-regulated pathway. Acta Biomater. 2009 Oct; 5(8):3258-64. PMID: 19446049.
      View in: PubMed
    29. Bumrungpert A, Kalpravidh RW, Chitchumroonchokchai C, Chuang CC, West T, Kennedy A, McIntosh M. Xanthones from mangosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes. J Nutr. 2009 Jun; 139(6):1185-91. PMID: 19403722.
      View in: PubMed
    30. Kennedy A, Martinez K, Chuang CC, LaPoint K, McIntosh M. Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: mechanisms of action and implications. J Nutr. 2009 Jan; 139(1):1-4. PMID: 19056664.
      View in: PubMed
    31. Kennedy A, Overman A, Lapoint K, Hopkins R, West T, Chuang CC, Martinez K, Bell D, McIntosh M. Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol. J Lipid Res. 2009 Feb; 50(2):225-32. PMID: 18776171.
      View in: PubMed
    32. Chuang CC, Yang RS, Tsai KS, Ho FM, Liu SH. Hyperglycemia enhances adipogenic induction of lipid accumulation: involvement of extracellular signal-regulated protein kinase 1/2, phosphoinositide 3-kinase/Akt, and peroxisome proliferator-activated receptor gamma signaling. Endocrinology. 2007 Sep; 148(9):4267-75. PMID: 17540722.
      View in: PubMed
    33. Chao KC, Chao KF, Chuang CC, Liu SH. Blockade of interleukin 6 accelerates acinar cell apoptosis and attenuates experimental acute pancreatitis in vivo. Br J Surg. 2006 Mar; 93(3):332-8. PMID: 16392107.
      View in: PubMed
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