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Last Name

Barry I. Freedman, M.D.

TitleSection Chief
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine - Nephrology
Address
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentInstitute for Regenerative Medicine

    TitleSection Chief
    InstitutionWake Forest School of Medicine
    DepartmentInternal Medicine-Nephrology

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentSurgical Sciences-Urology


    Collapse Research 
    Collapse research activities and funding
    R01HL056266     (FREEDMAN, BARRY IRA)Jul 1, 1997 - Jun 30, 2003
    NIH/NHLBI
    GENETIC ANALYSIS OF HUMAN HYPERTENSIVE ESRD
    Role: Principal Investigator

    U01DK057298     (FREEDMAN, BARRY IRA)Sep 30, 1999 - Aug 31, 2009
    NIH/NIDDK
    Continuation of the FIND Study
    Role: Principal Investigator

    R01DK070941     (FREEDMAN, BARRY IRA)Apr 1, 2005 - Apr 30, 2016
    NIH/NIDDK
    An Integrative Genomic Approach to APOL1-Associated Nephropathy.
    Role: Principal Investigator

    R01DK071891     (FREEDMAN, BARRY IRA)Jul 1, 2005 - Jun 30, 2017
    NIH/NIDDK
    Subclinical CVD in African American Type 2 Diabetics
    Role: Principal Investigator

    R01DK084149     (FREEDMAN, BARRY IRA)Sep 1, 2009 - Aug 31, 2014
    NIH/NIDDK
    Natural History of MYH9-Associated Nephropathy
    Role: Principal Investigator

    R01NS075107     (FREEDMAN, BARRY IRA)Jun 1, 2011 - Apr 30, 2016
    NIH/NINDS
    Cerebrovascular Disease and Cognitive Performance in African Americans
    Role: Principal Investigator

    R01MD009055     (DIVERS, JASMIN)Jul 10, 2014 - Apr 30, 2019
    NIH/NIMHD
    Genetic Determinants of Renal Transplant Survival from African American Donors
    Role: Co-Principal Investigator

    U01DK116041     (FREEDMAN, BARRY IRA)Sep 25, 2017 - May 31, 2022
    NIH/NIDDK
    Wake Forest APOLLO Scientific and Data Research Center
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Grams ME, Surapaneni A, Ballew SH, Appel LJ, Boerwinkle E, Boulware LE, Chen TK, Coresh J, Cushman M, Divers J, Gutiérrez OM, Irvin MR, Ix JH, Kopp JB, Kuller LH, Langefeld CD, Lipkowitz MS, Mukamal KJ, Musani SK, Naik RP, Pajewski NM, Peralta CA, Tin A, Wassel CL, Wilson JG, Winkler CA, Young BA, Zakai NA, Freedman BI. APOL1 Kidney Risk Variants and Cardiovascular Disease: An Individual Participant Data Meta-Analysis. J Am Soc Nephrol. 2019 Aug 05. PMID: 31383730.
      View in: PubMed
    2. Beddhu S, Shen J, Cheung AK, Kimmel PL, Chertow GM, Wei G, Boucher RE, Chonchol M, Arman F, Campbell RC, Contreras G, Dwyer JP, Freedman BI, Ix JH, Kirchner K, Papademetriou V, Pisoni R, Rocco MV, Whelton PK, Greene T. Implications of Early Decline in eGFR due to Intensive BP Control for Cardiovascular Outcomes in SPRINT. J Am Soc Nephrol. 2019 Aug; 30(8):1523-1533. PMID: 31324734.
      View in: PubMed
    3. Huo Y, Terry JG, Wang J, Nair S, Lasko TA, Freedman BI, Carr JJ, Landman BA. Fully automatic liver attenuation estimation combing CNN segmentation and morphological operations. Med Phys. 2019 Aug; 46(8):3508-3519. PMID: 31228267.
      View in: PubMed
    4. Murea M, Ma L, Freedman BI. APOL1 and Mortality in Patients on Dialysis. Cardiorenal Med. 2019; 9(4):261-264. PMID: 31185465.
      View in: PubMed
    5. de Vries PS, Brown MR, Bentley AR, Sung YJ, Winkler TW, Ntalla I, Schwander K, Kraja AT, Guo X, Franceschini N, Cheng CY, Sim X, Vojinovic D, Huffman JE, Musani SK, Li C, Feitosa MF, Richard MA, Noordam R, Aschard H, Bartz TM, Bielak LF, Deng X, Dorajoo R, Lohman KK, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Evangelou E, Graff M, Alver M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Goel A, Hagemeijer Y, Harris SE, Hartwig FP, He M, Horimoto ARVR, Hsu FC, Jackson AU, Kasturiratne A, Komulainen P, Kühnel B, Laguzzi F, Lee JH, Luan J, Lyytikäinen LP, Matoba N, Nolte IM, Pietzner M, Riaz M, Said MA, Scott RA, Sofer T, Stancáková A, Takeuchi F, Tayo BO, van der Most PJ, Varga TV, Wang Y, Ware EB, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Amin N, Amini M, Arking DE, Aung T, Ballantyne C, Boerwinkle E, Broeckel U, Campbell A, Canouil M, Charumathi S, Chen YI, Connell JM, de Faire U, de Las Fuentes L, de Mutsert R, de Silva HJ, Ding J, Dominiczak AF, Duan Q, Eaton CB, Eppinga RN, Faul JD, Fisher V, Forrester T, Franco OH, Friedlander Y, Ghanbari M, Giulianini F, Grabe HJ, Grove ML, Gu CC, Harris TB, Heikkinen S, Heng CK, Hirata M, Hixson JE, Howard BV, Ikram MA, Jacobs DR, Johnson C, Jonas JB, Kammerer CM, Katsuya T, Khor CC, Kilpeläinen TO, Koh WP, Koistinen HA, Kolcic I, Kooperberg C, Krieger JE, Kritchevsky SB, Kubo M, Kuusisto J, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lemaitre RN, Li Y, Liang J, Liu J, Liu K, Loh M, Louie T, Mägi R, Manichaikul AW, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mohlke KL, Mosley TH, Mukamal KJ, Nalls MA, Nauck M, Nelson CP, Sotoodehnia N, O'Connell JR, Palmer ND, Pazoki R, Pedersen NL, Peters A, Peyser PA, Polasek O, Poulter N, Raffel LJ, Raitakari OT, Reiner AP, Rice TK, Rich SS, Robino A, Robinson JG, Rose LM, Rudan I, Schmidt CO, Schreiner PJ, Scott WR, Sever P, Shi Y, Sidney S, Sims M, Smith BH, Smith JA, Snieder H, Starr JM, Strauch K, Tan N, Taylor KD, Teo YY, Tham YC, Uitterlinden AG, van Heemst D, Vuckovic D, Waldenberger M, Wang L, Wang Y, Wang Z, Wei WB, Williams C, Wilson G, Wojczynski MK, Yao J, Yu B, Yu C, Yuan JM, Zhao W, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Deary IJ, Esko T, Farrall M, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Kamatani Y, Kato N, Kooner JS, Laakso M, Leander K, Lehtimäki T, Magnusson PKE, Penninx B, Pereira AC, Rauramaa R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wang YX, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Zheng W, Elliott P, North KE, Bouchard C, Evans MK, Gudnason V, Liu CT, Liu Y, Psaty BM, Ridker PM, van Dam RM, Kardia SLR, Zhu X, Rotimi CN, Mook-Kanamori DO, Fornage M, Kelly TN, Fox ER, Hayward C, van Duijn CM, Tai ES, Wong TY, Liu J, Rotter JI, Gauderman WJ, Province MA, Munroe PB, Rice K, Chasman DI, Cupples LA, Rao DC, Morrison AC. Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. Am J Epidemiol. 2019 Jun 01; 188(6):1033-1054. PMID: 30698716.
      View in: PubMed
    6. Kruzel-Davila E, Divers J, Russell GB, Kra-Oz Z, Cohen MS, Langefeld CD, Ma L, Lyles DS, Hicks PJ, Skorecki KL, Freedman BI. JC Viruria Is Associated With Reduced Risk of Diabetic Kidney Disease. J Clin Endocrinol Metab. 2019 Jun 01; 104(6):2286-2294. PMID: 30715336.
      View in: PubMed
    7. Wuttke M, Li Y, Li M, Sieber KB, Feitosa MF, Gorski M, Tin A, Wang L, Chu AY, Hoppmann A, Kirsten H, Giri A, Chai JF, Sveinbjornsson G, Tayo BO, Nutile T, Fuchsberger C, Marten J, Cocca M, Ghasemi S, Xu Y, Horn K, Noce D, van der Most PJ, Sedaghat S, Yu Z, Akiyama M, Afaq S, Ahluwalia TS, Almgren P, Amin N, Ärnlöv J, Bakker SJL, Bansal N, Baptista D, Bergmann S, Biggs ML, Biino G, Boehnke M, Boerwinkle E, Boissel M, Bottinger EP, Boutin TS, Brenner H, Brumat M, Burkhardt R, Butterworth AS, Campana E, Campbell A, Campbell H, Canouil M, Carroll RJ, Catamo E, Chambers JC, Chee ML, Chee ML, Chen X, Cheng CY, Cheng Y, Christensen K, Cifkova R, Ciullo M, Concas MP, Cook JP, Coresh J, Corre T, Sala CF, Cusi D, Danesh J, Daw EW, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Degenhardt F, Delgado G, Demirkan A, Di Angelantonio E, Dittrich K, Divers J, Dorajoo R, Eckardt KU, Ehret G, Elliott P, Endlich K, Evans MK, Felix JF, Foo VHX, Franco OH, Franke A, Freedman BI, Freitag-Wolf S, Friedlander Y, Froguel P, Gansevoort RT, Gao H, Gasparini P, Gaziano JM, Giedraitis V, Gieger C, Girotto G, Giulianini F, Gögele M, Gordon SD, Gudbjartsson DF, Gudnason V, Haller T, Hamet P, Harris TB, Hartman CA, Hayward C, Hellwege JN, Heng CK, Hicks AA, Hofer E, Huang W, Hutri-Kähönen N, Hwang SJ, Ikram MA, Indridason OS, Ingelsson E, Ising M, Jaddoe VWV, Jakobsdottir J, Jonas JB, Joshi PK, Josyula NS, Jung B, Kähönen M, Kamatani Y, Kammerer CM, Kanai M, Kastarinen M, Kerr SM, Khor CC, Kiess W, Kleber ME, Koenig W, Kooner JS, Körner A, Kovacs P, Kraja AT, Krajcoviechova A, Kramer H, Krämer BK, Kronenberg F, Kubo M, Kühnel B, Kuokkanen M, Kuusisto J, La Bianca M, Laakso M, Lange LA, Langefeld CD, Lee JJ, Lehne B, Lehtimäki T, Lieb W, Lim SC, Lind L, Lindgren CM, Liu J, Liu J, Loeffler M, Loos RJF, Lucae S, Lukas MA, Lyytikäinen LP, Mägi R, Magnusson PKE, Mahajan A, Martin NG, Martins J, März W, Mascalzoni D, Matsuda K, Meisinger C, Meitinger T, Melander O, Metspalu A, Mikaelsdottir EK, Milaneschi Y, Miliku K, Mishra PP, Mohlke KL, Mononen N, Montgomery GW, Mook-Kanamori DO, Mychaleckyj JC, Nadkarni GN, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Noordam R, O'Connell J, O'Donoghue ML, Olafsson I, Oldehinkel AJ, Orho-Melander M, Ouwehand WH, Padmanabhan S, Palmer ND, Palsson R, Penninx BWJH, Perls T, Perola M, Pirastu M, Pirastu N, Pistis G, Podgornaia AI, Polasek O, Ponte B, Porteous DJ, Poulain T, Pramstaller PP, Preuss MH, Prins BP, Province MA, Rabelink TJ, Raffield LM, Raitakari OT, Reilly DF, Rettig R, Rheinberger M, Rice KM, Ridker PM, Rivadeneira F, Rizzi F, Roberts DJ, Robino A, Rossing P, Rudan I, Rueedi R, Ruggiero D, Ryan KA, Saba Y, Sabanayagam C, Salomaa V, Salvi E, Saum KU, Schmidt H, Schmidt R, Schöttker B, Schulz CA, Schupf N, Shaffer CM, Shi Y, Smith AV, Smith BH, Soranzo N, Spracklen CN, Strauch K, Stringham HM, Stumvoll M, Svensson PO, Szymczak S, Tai ES, Tajuddin SM, Tan NYQ, Taylor KD, Teren A, Tham YC, Thiery J, Thio CHL, Thomsen H, Thorleifsson G, Toniolo D, Tönjes A, Tremblay J, Tzoulaki I, Uitterlinden AG, Vaccargiu S, van Dam RM, van der Harst P, van Duijn CM, Velez Edward DR, Verweij N, Vogelezang S, Völker U, Vollenweider P, Waeber G, Waldenberger M, Wallentin L, Wang YX, Wang C, Waterworth DM, Bin Wei W, White H, Whitfield JB, Wild SH, Wilson JF, Wojczynski MK, Wong C, Wong TY, Xu L, Yang Q, Yasuda M, Yerges-Armstrong LM, Zhang W, Zonderman AB, Rotter JI, Bochud M, Psaty BM, Vitart V, Wilson JG, Dehghan A, Parsa A, Chasman DI, Ho K, Morris AP, Devuyst O, Akilesh S, Pendergrass SA, Sim X, Böger CA, Okada Y, Edwards TL, Snieder H, Stefansson K, Hung AM, Heid IM, Scholz M, Teumer A, Köttgen A, Pattaro C. A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nat Genet. 2019 06; 51(6):957-972. PMID: 31152163.
      View in: PubMed
    8. Liu M, Frej C, Langefeld CD, Divers J, Bowden DW, Carr JJ, Gebre AK, Xu J, Larsson B, Dahlbäck B, Freedman BI, Parks JS. Plasma apoM and S1P levels are inversely associated with mortality in African Americans with type 2 diabetes mellitus. J Lipid Res. 2019 Aug; 60(8):1425-1431. PMID: 31133557.
      View in: PubMed
    9. Guan M, Keaton JM, Dimitrov L, Hicks PJ, Xu J, Palmer ND, Ma L, Das SK, Chen YI, Coresh J, Fornage M, Franceschini N, Kramer H, Langefeld CD, Mychaleckyj JC, Parekh RS, Post WS, Rasmussen-Torvik LJ, Rich SS, Rotter JI, Sedor JR, Thornley-Brown D, Tin A, Wilson JG, Freedman BI, Bowden DW, Ng MCY. Genome-wide association study identifies novel loci for type 2 diabetes-attributed end-stage kidney disease in African Americans. Hum Genomics. 2019 May 15; 13(1):21. PMID: 31092297.
      View in: PubMed
    10. Freedman BI, Spainhour M, Hicks PJ, Turner J, Robertson J, Langefeld CD, Murea M, Divers J. Nephropathy Progression in African Americans With a Family History of ESKD: Implications for Clinical Trials in APOL1-Associated Nephropathy. Am J Kidney Dis. 2019 Aug; 74(2):284-286. PMID: 31076172.
      View in: PubMed
    11. Sung YJ, de Las Fuentes L, Winkler TW, Chasman DI, Bentley AR, Kraja AT, Ntalla I, Warren HR, Guo X, Schwander K, Manning AK, Brown MR, Aschard H, Feitosa MF, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Kilpeläinen TO, Richard MA, Aslibekyan S, Bartz TM, Dorajoo R, Li C, Liu Y, Rankinen T, Smith AV, Tajuddin SM, Tayo BO, Zhao W, Zhou Y, Matoba N, Sofer T, Alver M, Amini M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Giulianini F, Goel A, Harris SE, Hartwig FP, He M, Horimoto ARVR, Hsu FC, Jackson AU, Kammerer CM, Kasturiratne A, Komulainen P, Kühnel B, Leander K, Lee WJ, Lin KH, Luan J, Lyytikäinen LP, McKenzie CA, Nelson CP, Noordam R, Scott RA, Sheu WHH, Stancáková A, Takeuchi F, van der Most PJ, Varga TV, Waken RJ, Wang H, Wang Y, Ware EB, Weiss S, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Alfred T, Amin N, Arking DE, Aung T, Barr RG, Bielak LF, Boerwinkle E, Bottinger EP, Braund PS, Brody JA, Broeckel U, Cade B, Campbell A, Canouil M, Chakravarti A, Cocca M, Collins FS, Connell JM, de Mutsert R, de Silva HJ, Dörr M, Duan Q, Eaton CB, Ehret G, Evangelou E, Faul JD, Forouhi NG, Franco OH, Friedlander Y, Gao H, Gigante B, Gu CC, Gupta P, Hagenaars SP, Harris TB, He J, Heikkinen S, Heng CK, Hofman A, Howard BV, Hunt SC, Irvin MR, Jia Y, Katsuya T, Kaufman J, Kerrison ND, Khor CC, Koh WP, Koistinen HA, Kooperberg CB, Krieger JE, Kubo M, Kutalik Z, Kuusisto J, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Lee JH, Lehne B, Levy D, Lewis CE, Li Y, Lim SH, Liu CT, Liu J, Liu J, Liu Y, Loh M, Lohman KK, Louie T, Mägi R, Matsuda K, Meitinger T, Metspalu A, Milani L, Momozawa Y, Mosley TH, Nalls MA, Nasri U, O'Connell JR, Ogunniyi A, Palmas WR, Palmer ND, Pankow JS, Pedersen NL, Peters A, Peyser PA, Polasek O, Porteous D, Raitakari OT, Renström F, Rice TK, Ridker PM, Robino A, Robinson JG, Rose LM, Rudan I, Sabanayagam C, Salako BL, Sandow K, Schmidt CO, Schreiner PJ, Scott WR, Sever P, Sims M, Sitlani CM, Smith BH, Smith JA, Snieder H, Starr JM, Strauch K, Tang H, Taylor KD, Teo YY, Tham YC, Uitterlinden AG, Waldenberger M, Wang L, Wang YX, Wei WB, Wilson G, Wojczynski MK, Xiang YB, Yao J, Yuan JM, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Chen YI, Weir DR, de Faire U, Deary IJ, Esko T, Farrall M, Forrester T, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Hung YJ, Jonas JB, Kato N, Kooner JS, Laakso M, Lehtimäki T, Liang KW, Magnusson PKE, Oldehinkel AJ, Pereira AC, Perls T, Rauramaa R, Redline S, Rettig R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wareham NJ, Watkins H, Wickremasinghe AR, Wu T, Kamatani Y, Laurie CC, Bouchard C, Cooper RS, Evans MK, Gudnason V, Hixson J, Kardia SLR, Kritchevsky SB, Psaty BM, van Dam RM, Arnett DK, Mook-Kanamori DO, Fornage M, Fox ER, Hayward C, van Duijn CM, Tai ES, Wong TY, Loos RJF, Reiner AP, Rotimi CN, Bierut LJ, Zhu X, Cupples LA, Province MA, Rotter JI, Franks PW, Rice K, Elliott P, Caulfield MJ, Gauderman WJ, Munroe PB, Rao DC, Morrison AC. A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Hum Mol Genet. 2019 Apr 10. PMID: 31127295.
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    12. Murea M, Geary RL, Edwards MS, Moossavi S, Davis RP, Goldman MP, Hurie J, Williams TK, Velazquez-Ramirez G, Robinson TW, Bagwell B, Tuttle AB, Callahan KE, Rocco MV, Houston DK, Pajewski NM, Divers J, Freedman BI, Williamson JD. A randomized pilot study comparing graft-first to fistula-first strategies in older patients with incident end-stage kidney disease: Clinical rationale and study design. Contemp Clin Trials Commun. 2019 Jun; 14:100357. PMID: 31016270.
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    13. Jotwani VK, Lee AK, Estrella MM, Katz R, Garimella PS, Malhotra R, Rifkin DE, Ambrosius W, Freedman BI, Cheung AK, Raphael KL, Drawz P, Neyra JA, Oparil S, Punzi H, Shlipak MG, Ix JH. Urinary Biomarkers of Tubular Damage Are Associated with Mortality but Not Cardiovascular Risk among Systolic Blood Pressure Intervention Trial Participants with Chronic Kidney Disease. Am J Nephrol. 2019; 49(5):346-355. PMID: 30939472.
      View in: PubMed
    14. Bentley AR, Sung YJ, Brown MR, Winkler TW, Kraja AT, Ntalla I, Schwander K, Chasman DI, Lim E, Deng X, Guo X, Liu J, Lu Y, Cheng CY, Sim X, Vojinovic D, Huffman JE, Musani SK, Li C, Feitosa MF, Richard MA, Noordam R, Baker J, Chen G, Aschard H, Bartz TM, Ding J, Dorajoo R, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Zhao W, Graff M, Alver M, Boissel M, Chai JF, Chen X, Divers J, Evangelou E, Gao C, Goel A, Hagemeijer Y, Harris SE, Hartwig FP, He M, Horimoto ARVR, Hsu FC, Hung YJ, Jackson AU, Kasturiratne A, Komulainen P, Kühnel B, Leander K, Lin KH, Luan J, Lyytikäinen LP, Matoba N, Nolte IM, Pietzner M, Prins B, Riaz M, Robino A, Said MA, Schupf N, Scott RA, Sofer T, Stancáková A, Takeuchi F, Tayo BO, van der Most PJ, Varga TV, Wang TD, Wang Y, Ware EB, Wen W, Xiang YB, Yanek LR, Zhang W, Zhao JH, Adeyemo A, Afaq S, Amin N, Amini M, Arking DE, Arzumanyan Z, Aung T, Ballantyne C, Barr RG, Bielak LF, Boerwinkle E, Bottinger EP, Broeckel U, Brown M, Cade BE, Campbell A, Canouil M, Charumathi S, Chen YI, Christensen K, Concas MP, Connell JM, de Las Fuentes L, de Silva HJ, de Vries PS, Doumatey A, Duan Q, Eaton CB, Eppinga RN, Faul JD, Floyd JS, Forouhi NG, Forrester T, Friedlander Y, Gandin I, Gao H, Ghanbari M, Gharib SA, Gigante B, Giulianini F, Grabe HJ, Gu CC, Harris TB, Heikkinen S, Heng CK, Hirata M, Hixson JE, Ikram MA, Jia Y, Joehanes R, Johnson C, Jonas JB, Justice AE, Katsuya T, Khor CC, Kilpeläinen TO, Koh WP, Kolcic I, Kooperberg C, Krieger JE, Kritchevsky SB, Kubo M, Kuusisto J, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lewis CE, Li Y, Liang J, Lin S, Liu CT, Liu J, Liu K, Loh M, Lohman KK, Louie T, Luzzi A, Mägi R, Mahajan A, Manichaikul AW, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mohlke KL, Momozawa Y, Morris AP, Murray AD, Nalls MA, Nauck M, Nelson CP, North KE, O'Connell JR, Palmer ND, Papanicolau GJ, Pedersen NL, Peters A, Peyser PA, Polasek O, Poulter N, Raitakari OT, Reiner AP, Renström F, Rice TK, Rich SS, Robinson JG, Rose LM, Rosendaal FR, Rudan I, Schmidt CO, Schreiner PJ, Scott WR, Sever P, Shi Y, Sidney S, Sims M, Smith JA, Snieder H, Starr JM, Strauch K, Stringham HM, Tan NYQ, Tang H, Taylor KD, Teo YY, Tham YC, Tiemeier H, Turner ST, Uitterlinden AG, van Heemst D, Waldenberger M, Wang H, Wang L, Wang L, Wei WB, Williams CA, Wilson G, Wojczynski MK, Yao J, Young K, Yu C, Yuan JM, Zhou J, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Cooper RS, de Faire U, Deary IJ, Elliott P, Esko T, Farrall M, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Juang JJ, Kamatani Y, Kammerer CM, Kato N, Kooner JS, Laakso M, Laurie CC, Lee IT, Lehtimäki T, Magnusson PKE, Oldehinkel AJ, Penninx BWJH, Pereira AC, Rauramaa R, Redline S, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wang JS, Wang YX, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Wu T, Zeggini E, Zheng W, Bouchard C, Evans MK, Gudnason V, Kardia SLR, Liu Y, Psaty BM, Ridker PM, van Dam RM, Mook-Kanamori DO, Fornage M, Province MA, Kelly TN, Fox ER, Hayward C, van Duijn CM, Tai ES, Wong TY, Loos RJF, Franceschini N, Rotter JI, Zhu X, Bierut LJ, Gauderman WJ, Rice K, Munroe PB, Morrison AC, Rao DC, Rotimi CN, Cupples LA. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nat Genet. 2019 04; 51(4):636-648. PMID: 30926973.
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    15. Robinson TW, Freedman BI. The Impact of APOL1 on Chronic Kidney Disease and Hypertension. Adv Chronic Kidney Dis. 2019 Mar; 26(2):131-136. PMID: 31023447.
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    16. Ma L, Divers J, Freedman BI. Mechanisms of Injury in APOL1-associated Kidney Disease. Transplantation. 2019 03; 103(3):487-492. PMID: 30371607.
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    282. Bowden DW, Cox AJ, Freedman BI, Hugenschimdt CE, Wagenknecht LE, Herrington D, Agarwal S, Register TC, Maldjian JA, Ng MC, Hsu FC, Langefeld CD, Williamson JD, Carr JJ. Review of the Diabetes Heart Study (DHS) family of studies: a comprehensively examined sample for genetic and epidemiological studies of type 2 diabetes and its complications. Rev Diabet Stud. 2010; 7(3):188-201. PMID: 21409311.
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    284. Palmer ND, Hester JM, An SS, Adeyemo A, Rotimi C, Langefeld CD, Freedman BI, Ng MC, Bowden DW. Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant. Diabetes. 2011 Feb; 60(2):662-8. PMID: 20980453.
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    285. Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Register TC, Xu J, Langefeld CD, Freedman BI. Ethnic differences in the relationship between pericardial adipose tissue and coronary artery calcified plaque: African-American-diabetes heart study. J Clin Endocrinol Metab. 2010 Dec; 95(12):5382-9. PMID: 20810573.
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    286. Freedman BI, Kopp JB, Langefeld CD, Genovese G, Friedman DJ, Nelson GW, Winkler CA, Bowden DW, Pollak MR. The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans. J Am Soc Nephrol. 2010 Sep; 21(9):1422-6. PMID: 20688934.
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    287. Lewis JP, Palmer ND, Ellington JB, Divers J, Ng MC, Lu L, Langefeld CD, Freedman BI, Bowden DW. Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans. Genomics. 2010 Oct; 96(4):211-9. PMID: 20650312.
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    288. Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke B, Winkler CA, Kopp JB, Pays E, Pollak MR. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science. 2010 Aug 13; 329(5993):841-5. PMID: 20647424.
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    289. Bostrom MA, Lu L, Chou J, Hicks PJ, Xu J, Langefeld CD, Bowden DW, Freedman BI. Candidate genes for non-diabetic ESRD in African Americans: a genome-wide association study using pooled DNA. Hum Genet. 2010 Aug; 128(2):195-204. PMID: 20532800.
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    290. Freedman BI, Edberg JC, Comeau ME, Murea M, Bowden DW, Divers J, Alarcón GS, Brown EE, McGwin G, Kopp JB, Winkler CA, Nelson GW, Illei G, Petri M, Ramsey-Goldman R, Reveille JD, Vilá LM, Langefeld CD, Kimberly RP. The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans. Am J Nephrol. 2010; 32(1):66-72. PMID: 20523037.
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    291. Tang SC, Leung VT, Chan LY, Wong SS, Chu DW, Leung JC, Ho YW, Lai KN, Ma L, Elbein SC, Bowden DW, Hicks PJ, Comeau ME, Langefeld CD, Freedman BI. The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes. Nephrol Dial Transplant. 2010 Dec; 25(12):3931-4. PMID: 20519229.
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    292. Buckalew VM, Freedman BI. Reappraisal of the impact of race on survival in patients on dialysis. Am J Kidney Dis. 2010 Jun; 55(6):1102-10. PMID: 20137840.
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    293. Burdon KP, Rudock ME, Lehtinen AB, Langefeld CD, Bowden DW, Register TC, Liu Y, Freedman BI, Carr JJ, Hedrick CC, Rich SS. Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study. Mediators Inflamm. 2010; 2010:170153. PMID: 20592751.
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    294. Chen Y, Lipkowitz MS, Salem RM, Fung MM, Bhatnagar V, Mahata M, Nievergelt CM, Rao F, Mahata SK, Schork NJ, Hicks PJ, Bowden DW, Freedman BI, Brophy VH, O'Connor DT. Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis. Am J Nephrol. 2010; 32(1):23-30. PMID: 20484896.
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    296. Murea M, Freedman BI. Essential hypertension and risk of nephropathy: a reappraisal. Curr Opin Nephrol Hypertens. 2010 May; 19(3):235-41. PMID: 20051853.
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    298. Freedman BI, Shihabi ZK, Andries L, Cardona CY, Peacock TP, Byers JR, Russell GB, Stratta RJ, Bleyer AJ. Relationship between assays of glycemia in diabetic subjects with advanced chronic kidney disease. Am J Nephrol. 2010; 31(5):375-9. PMID: 20299782.
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    299. Bleyer AJ, Reddy SV, Sujata L, Russell GB, Akinnifesi D, Bleyer AJ, Hire D, Shihabi Z, Knovich MA, Daeihagh P, Calles J, Freedman BI. Sickle cell trait and development of microvascular complications in diabetes mellitus. Clin J Am Soc Nephrol. 2010 Jun; 5(6):1015-20. PMID: 20299376.
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    301. Sedor JR, Freedman BI. Genetics and the kidney: promise, potential, and challenges. Introduction. Semin Nephrol. 2010 Mar; 30(2):99-100. PMID: 20347639.
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    302. Freedman BI, Parekh RS, Kao WH. Genetic basis of nondiabetic end-stage renal disease. Semin Nephrol. 2010 Mar; 30(2):101-10. PMID: 20347640.
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    303. Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Ding J, Xu J, Langefeld CD, Freedman BI. Regional adipose tissue associations with calcified atherosclerotic plaque: African American-diabetes heart study. Obesity (Silver Spring). 2010 Oct; 18(10):2004-9. PMID: 20186134.
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    304. Maeda S, Kobayashi MA, Araki S, Babazono T, Freedman BI, Bostrom MA, Cooke JN, Toyoda M, Umezono T, Tarnow L, Hansen T, Gaede P, Jorsal A, Ng DP, Ikeda M, Yanagimoto T, Tsunoda T, Unoki H, Kawai K, Imanishi M, Suzuki D, Shin HD, Park KS, Kashiwagi A, Iwamoto Y, Kaku K, Kawamori R, Parving HH, Bowden DW, Pedersen O, Nakamura Y. A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes. PLoS Genet. 2010 Feb 12; 6(2):e1000842. PMID: 20168990.
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    305. Leak TS, Langefeld CD, Keene KL, Gallagher CJ, Lu L, Mychaleckyj JC, Rich SS, Freedman BI, Bowden DW, Sale MM. Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy. BMC Med Genet. 2010 Feb 08; 11:22. PMID: 20144192.
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    306. Nelson GW, Freedman BI, Bowden DW, Langefeld CD, An P, Hicks PJ, Bostrom MA, Johnson RC, Kopp JB, Winkler CA. Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15. Hum Mol Genet. 2010 May 01; 19(9):1805-15. PMID: 20124285.
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    307. Reeves-Daniel AM, Iskandar SS, Bowden DW, Bostrom MA, Hicks PJ, Comeau ME, Langefeld CD, Freedman BI. Is collapsing C1q nephropathy another MYH9-associated kidney disease? A case report. Am J Kidney Dis. 2010 May; 55(5):e21-4. PMID: 20116156.
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    308. Freedman BI, Wagenknecht LE, Hairston KG, Bowden DW, Carr JJ, Hightower RC, Gordon EJ, Xu J, Langefeld CD, Divers J. Vitamin d, adiposity, and calcified atherosclerotic plaque in african-americans. J Clin Endocrinol Metab. 2010 Mar; 95(3):1076-83. PMID: 20061416.
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    309. Freedman BI, Shenoy RN, Planer JA, Clay KD, Shihabi ZK, Burkart JM, Cardona CY, Andries L, Peacock TP, Sabio H, Byers JR, Russell GB, Bleyer AJ. Comparison of glycated albumin and hemoglobin A1c concentrations in diabetic subjects on peritoneal and hemodialysis. Perit Dial Int. 2010 Jan-Feb; 30(1):72-9. PMID: 20056983.
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    310. Núñez M, Saran AM, Freedman BI. Gene-gene and gene-environment interactions in HIV-associated nephropathy: A focus on the MYH9 nephropathy susceptibility gene. Adv Chronic Kidney Dis. 2010 Jan; 17(1):44-51. PMID: 20005488.
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    311. Divers J, Freedman BI. Susceptibility genes in common complex kidney disease. Curr Opin Nephrol Hypertens. 2010 Jan; 19(1):79-84. PMID: 19838113.
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    312. McDonough CW, Bostrom MA, Lu L, Hicks PJ, Langefeld CD, Divers J, Mychaleckyj JC, Freedman BI, Bowden DW. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. Hum Genet. 2009 Dec; 126(6):805-17. PMID: 19690890.
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    313. Malhotra A, Igo RP, Thameem F, Kao WH, Abboud HE, Adler SG, Arar NH, Bowden DW, Duggirala R, Freedman BI, Goddard KA, Ipp E, Iyengar SK, Kimmel PL, Knowler WC, Kohn O, Leehey D, Meoni LA, Nelson RG, Nicholas SB, Parekh RS, Rich SS, Chen YD, Saad MF, Scavini M, Schelling JR, Sedor JR, Shah VO, Taylor KD, Thornley-Brown D, Zager PG, Horvath A, Hanson RL. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group. Diabetes Metab Res Rev. 2009 Nov; 25(8):740-7. PMID: 19795399.
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    316. Song EY, McClellan WM, McClellan A, Gadi R, Hadley AC, Krisher J, Clay M, Freedman BI. Effect of community characteristics on familial clustering of end-stage renal disease. Am J Nephrol. 2009; 30(6):499-504. PMID: 19797894.
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    318. Moossavi S, Freedman BI. Treating anemia with erythropoiesis-stimulating agents: effects on quality of life. Arch Intern Med. 2009 Jun 22; 169(12):1100-1. PMID: 19546408.
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    320. McClellan WM, Satko SG, Gladstone E, Krisher JO, Narva AS, Freedman BI. Individuals with a family history of ESRD are a high-risk population for CKD: implications for targeted surveillance and intervention activities. Am J Kidney Dis. 2009 Mar; 53(3 Suppl 3):S100-6. PMID: 19231753.
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    321. Freedman BI, Hicks PJ, Bostrom MA, Cunningham ME, Liu Y, Divers J, Kopp JB, Winkler CA, Nelson GW, Langefeld CD, Bowden DW. Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans. Kidney Int. 2009 Apr; 75(7):736-45. PMID: 19177153.
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    323. Young TA, Patel TS, Camacho F, Clark A, Freedman BI, Kaur M, Fountain J, Williams LL, Yosipovitch G, Fleischer AB. A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients. J Dermatolog Treat. 2009; 20(2):76-81. PMID: 18821119.
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    324. Lehtinen AB, Daniel KR, Shah SA, Nelson MR, Ziegler JT, Freedman BI, Carr JJ, Herrington DM, Langefeld CD, Bowden DW. Relationship between genetic variants in myocardial sodium and potassium channel genes and QT interval duration in diabetics: the Diabetes Heart Study. Ann Noninvasive Electrocardiol. 2009 Jan; 14(1):72-9. PMID: 19149796.
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    325. Friedman DJ, Talbert ME, Bowden DW, Freedman BI, Mukanya Y, Enjyoji K, Robson SC. Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease. Diabetes. 2009 Apr; 58(4):999-1006. PMID: 19095759.
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    326. Bostrom MA, Freedman BI, Langefeld CD, Liu L, Hicks PJ, Bowden DW. Association of adiponectin gene polymorphisms with type 2 diabetes in an African American population enriched for nephropathy. Diabetes. 2009 Feb; 58(2):499-504. PMID: 19056609.
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    327. Hawfield A, Freedman BI. Pre-eclampsia: the pivotal role of the placenta in its pathophysiology and markers for early detection. Ther Adv Cardiovasc Dis. 2009 Feb; 3(1):65-73. PMID: 19124387.
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    328. Freedman BI, Sedor JR. Hypertension-associated kidney disease: perhaps no more. J Am Soc Nephrol. 2008 Nov; 19(11):2047-51. PMID: 18923054.
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    329. McKimmie RL, Daniel KR, Carr JJ, Bowden DW, Freedman BI, Register TC, Hsu FC, Lohman KK, Weinberg RB, Wagenknecht LE. Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type 2 diabetes: the Diabetes Heart Study. Am J Gastroenterol. 2008 Dec; 103(12):3029-35. PMID: 18853970.
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    330. Zhang D, Freedman BI, Flekac M, Santos E, Hicks PJ, Bowden DW, Efendic S, Brismar K, Gu HF. Evaluation of genetic association and expression reduction of TRPC1 in the development of diabetic nephropathy. Am J Nephrol. 2009; 29(3):244-51. PMID: 18802326.
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    333. Arar NH, Freedman BI, Adler SG, Iyengar SK, Chew EY, Davis MD, Satko SG, Bowden DW, Duggirala R, Elston RC, Guo X, Hanson RL, Igo RP, Ipp E, Kimmel PL, Knowler WC, Molineros J, Nelson RG, Pahl MV, Quade SR, Rasooly RS, Rotter JI, Saad MF, Scavini M, Schelling JR, Sedor JR, Shah VO, Zager PG, Abboud HE. Heritability of the severity of diabetic retinopathy: the FIND-Eye study. Invest Ophthalmol Vis Sci. 2008 Sep; 49(9):3839-45. PMID: 18765632.
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    335. Keene KL, Mychaleckyj JC, Leak TS, Smith SG, Perlegas PS, Divers J, Langefeld CD, Freedman BI, Bowden DW, Sale MM. Exploration of the utility of ancestry informative markers for genetic association studies of African Americans with type 2 diabetes and end stage renal disease. Hum Genet. 2008 Sep; 124(2):147-54. PMID: 18654799.
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    336. Hicks PJ, Staten JL, Palmer ND, Langefeld CD, Ziegler JT, Keene KL, Sale MM, Bowden DW, Freedman BI. Association analysis of the ephrin-B2 gene in African-Americans with end-stage renal disease. Am J Nephrol. 2008; 28(6):914-20. PMID: 18580054.
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    337. Leak TS, Mychaleckyj JC, Smith SG, Keene KL, Gordon CJ, Hicks PJ, Freedman BI, Bowden DW, Sale MM. Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population. Hum Genet. 2008 Aug; 124(1):63-71. PMID: 18560894.
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    338. Burdon KP, Lehtinen AB, Langefeld CD, Carr JJ, Rich SS, Freedman BI, Herrington D, Bowden DW. Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study. Diab Vasc Dis Res. 2008 Jun; 5(2):128-34. PMID: 18537101.
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    339. Lewis JP, Palmer ND, Hicks PJ, Sale MM, Langefeld CD, Freedman BI, Divers J, Bowden DW. Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes. 2008 Aug; 57(8):2220-5. PMID: 18443202.
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    342. Keene KL, Mychaleckyj JC, Smith SG, Leak TS, Perlegas PS, Langefeld CD, Herrington DM, Freedman BI, Rich SS, Bowden DW, Sale MM. Comprehensive evaluation of the estrogen receptor alpha gene reveals further evidence for association with type 2 diabetes enriched for nephropathy in an African American population. Hum Genet. 2008 May; 123(4):333-41. PMID: 18305958.
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    343. Lehtinen AB, Newton-Cheh C, Ziegler JT, Langefeld CD, Freedman BI, Daniel KR, Herrington DM, Bowden DW. Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study. Diabetes. 2008 Apr; 57(4):1108-14. PMID: 18235038.
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    344. Salem RM, Cadman PE, Chen Y, Rao F, Wen G, Hamilton BA, Rana BK, Smith DW, Stridsberg M, Ward HJ, Mahata M, Mahata SK, Bowden DW, Hicks PJ, Freedman BI, Schork NJ, O'Connor DT. Chromogranin A polymorphisms are associated with hypertensive renal disease. J Am Soc Nephrol. 2008 Mar; 19(3):600-14. PMID: 18235090.
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    345. Keene KL, Mychaleckyj JC, Smith SG, Leak TS, Perlegas PS, Langefeld CD, Freedman BI, Rich SS, Bowden DW, Sale MM. Association of the distal region of the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy. Diabetes. 2008 Apr; 57(4):1057-62. PMID: 18184924.
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    346. Moossavi S, Tuttle AB, Vachharajani TJ, Plonk G, Bettmann MA, Majekodunmi O, Russell GB, Regan JD, Freedman BI. Long-term outcomes of transposed basilic vein arteriovenous fistulae. Hemodial Int. 2008 Jan; 12(1):80-4. PMID: 18271846.
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    347. Bleyer AJ, Sedor JR, Freedman BI, O'Brien A, Russell GB, Graley J, Schelling JR. Risk factors for development and progression of diabetic kidney disease and treatment patterns among diabetic siblings of patients with diabetic kidney disease. Am J Kidney Dis. 2008 Jan; 51(1):29-37. PMID: 18155530.
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    348. Divers J, Moossavi S, Langefeld CD, Freedman BI. Genetic admixture: a tool to identify diabetic nephropathy genes in African Americans. Ethn Dis. 2008; 18(3):384-8. PMID: 18785456.
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    349. Saran AM, Hsu FC, Lohman KK, Carr JJ, Bowden DW, Wagenknecht LE, Freedman BI. Kidney volume associations with subclinical renal and cardiovascular disease: the Diabetes Heart Study. Am J Nephrol. 2008; 28(3):366-71. PMID: 18057869.
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    350. Schelling JR, Abboud HE, Nicholas SB, Pahl MV, Sedor JR, Adler SG, Arar NH, Bowden DW, Elston RC, Freedman BI, Goddard KA, Guo X, Hanson RL, Ipp E, Iyengar SK, Jun G, Kao WH, Kasinath BS, Kimmel PL, Klag MJ, Knowler WC, Nelson RG, Parekh RS, Quade SR, Rich SS, Saad MF, Scavini M, Smith MW, Taylor K, Winkler CA, Zager PG, Shah VO. Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND). Diabetes. 2008 Jan; 57(1):235-43. PMID: 18003762.
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    351. Freedman BI, Bostrom M, Daeihagh P, Bowden DW. Genetic factors in diabetic nephropathy. Clin J Am Soc Nephrol. 2007 Nov; 2(6):1306-16. PMID: 17942768.
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    352. Moossavi S, Regan JD, Pierson ED, Kasey JM, Tuttle AB, Vachharajani TJ, Bettmann MA, Russell GB, Freedman BI. Non-surgical salvage of thrombosed arterio-venous fistulae: a case series and review of the literature. Semin Dial. 2007 Sep-Oct; 20(5):459-64. PMID: 17897255.
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    353. Carr JJ, Register TC, Hsu FC, Lohman K, Lenchik L, Bowden DW, Langefeld CD, Xu J, Rich SS, Wagenknecht LE, Freedman BI. Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the diabetes heart study. Bone. 2008 Jan; 42(1):43-52. PMID: 17964237.
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    354. Shikany JM, Lewis CE, Freedman BI, Arnett DK, Leiendecker-Foster C, Jones TL, Redden DT, Oberman A. Plasma adiponectin concentrations and correlates in African Americans in the Hypertension Genetic Epidemiology Network (HyperGEN) study. Metabolism. 2007 Aug; 56(8):1011-6. PMID: 17618943.
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    355. Leak TS, Keene KL, Langefeld CD, Gallagher CJ, Mychaleckyj JC, Freedman BI, Bowden DW, Rich SS, Sale MM. Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population. Mol Genet Metab. 2007 Sep-Oct; 92(1-2):145-50. PMID: 17618154.
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    356. Patel TS, Freedman BI, Yosipovitch G. An update on pruritus associated with CKD. Am J Kidney Dis. 2007 Jul; 50(1):11-20. PMID: 17591521.
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    357. Sale MM, Smith SG, Mychaleckyj JC, Keene KL, Langefeld CD, Leak TS, Hicks PJ, Bowden DW, Rich SS, Freedman BI. Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy. Diabetes. 2007 Oct; 56(10):2638-42. PMID: 17601994.
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    358. Yosipovitch G, Duque MI, Patel TS, Ishiuji Y, Guzman-Sanchez DA, Dawn AG, Freedman BI, Chan YH, Crumrine D, Elias PM. Skin barrier structure and function and their relationship to pruritus in end-stage renal disease. Nephrol Dial Transplant. 2007 Nov; 22(11):3268-72. PMID: 17595180.
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    360. Hadley AC, Karchmer TB, Russell GB, McBride DG, Freedman BI. The prevalence of resistant bacterial colonization in chronic hemodialysis patients. Am J Nephrol. 2007; 27(4):352-9. PMID: 17541264.
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    361. Wagenknecht LE, Langefeld CD, Freedman BI, Carr JJ, Bowden DW. A comparison of risk factors for calcified atherosclerotic plaque in the coronary, carotid, and abdominal aortic arteries: the diabetes heart study. Am J Epidemiol. 2007 Aug 01; 166(3):340-7. PMID: 17493948.
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    362. Satko SG, Sedor JR, Iyengar SK, Freedman BI. Familial clustering of chronic kidney disease. Semin Dial. 2007 May-Jun; 20(3):229-36. PMID: 17555489.
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    363. Iyengar SK, Abboud HE, Goddard KA, Saad MF, Adler SG, Arar NH, Bowden DW, Duggirala R, Elston RC, Hanson RL, Ipp E, Kao WH, Kimmel PL, Klag MJ, Knowler WC, Meoni LA, Nelson RG, Nicholas SB, Pahl MV, Parekh RS, Quade SR, Rich SS, Rotter JI, Scavini M, Schelling JR, Sedor JR, Sehgal AR, Shah VO, Smith MW, Taylor KD, Winkler CA, Zager PG, Freedman BI. Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes (FIND). Diabetes. 2007 Jun; 56(6):1577-85. PMID: 17363742.
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    364. Iyengar SK, Freedman BI, Sedor JR. Mining the genome for susceptibility to diabetic nephropathy: the role of large-scale studies and consortia. Semin Nephrol. 2007 Mar; 27(2):208-22. PMID: 17418689.
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    365. Gallagher CJ, Keene KL, Mychaleckyj JC, Langefeld CD, Hirschhorn JN, Henderson BE, Gordon CJ, Freedman BI, Rich SS, Bowden DW, Sale MM. Investigation of the estrogen receptor-alpha gene with type 2 diabetes and/or nephropathy in African-American and European-American populations. Diabetes. 2007 Mar; 56(3):675-84. PMID: 17327435.
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    366. Freedman BI, Hicks PJ, Sale MM, Pierson ED, Langefeld CD, Rich SS, Xu J, McDonough C, Janssen B, Yard BA, van der Woude FJ, Bowden DW. A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans. Nephrol Dial Transplant. 2007 Apr; 22(4):1131-5. PMID: 17205963.
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    367. North KE, Franceschini N, Borecki IB, Gu CC, Heiss G, Province MA, Arnett DK, Lewis CE, Miller MB, Myers RH, Hunt SC, Freedman BI. Genotype-by-sex interaction on fasting insulin concentration: the HyperGEN study. Diabetes. 2007 Jan; 56(1):137-42. PMID: 17192475.
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    368. Leon JM, Freedman BI, Miller MB, North KE, Hunt SC, Eckfeldt JH, Lewis CE, Kraja AT, Djoussé L, Arnett DK. Genome scan of glomerular filtration rate and albuminuria: the HyperGEN study. Nephrol Dial Transplant. 2007 Mar; 22(3):763-71. PMID: 17189282.
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    369. Lange LA, Burdon K, Langefeld CD, Liu Y, Beck SR, Rich SS, Freedman BI, Brosnihan KB, Herrington DM, Wagenknecht LE, Bowden DW. Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart Study. Ann Hum Genet. 2006 Nov; 70(Pt 6):717-25. PMID: 17044846.
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    370. Lehtinen AB, Burdon KP, Lewis JP, Langefeld CD, Ziegler JT, Rich SS, Register TC, Carr JJ, Freedman BI, Bowden DW. Association of alpha2-Heremans-Schmid glycoprotein polymorphisms with subclinical atherosclerosis. J Clin Endocrinol Metab. 2007 Jan; 92(1):345-52. PMID: 17062776.
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    371. Elbein SC, Wang X, Karim MA, Freedman BI, Bowden DW, Shuldiner AR, Brancati FL, Kao WH. Role of a proline insertion in the insulin promoter factor 1 (IPF1) gene in African Americans with type 2 diabetes. Diabetes. 2006 Oct; 55(10):2909-14. PMID: 17003361.
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    372. Liu Y, Herrington D, Burdon KP, Langefeld CD, Rich SS, Bowden DW, Freedman BI, Wagenknecht LE. A functional polymorphism in the lymphotoxin-alpha gene is associated with carotid artery wall thickness: the Diabetes Heart Study. Eur J Cardiovasc Prev Rehabil. 2006 Aug; 13(4):655-7. PMID: 16874159.
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    373. Speckman RA, McClellan WM, Volkova NV, Jurkovitz CT, Satko SG, Schoolwerth AC, Freedman BI. Obesity is associated with family history of ESRD in incident dialysis patients. Am J Kidney Dis. 2006 Jul; 48(1):50-8. PMID: 16797386.
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    374. Bowden DW, Rudock M, Ziegler J, Lehtinen AB, Xu J, Wagenknecht LE, Herrington D, Rich SS, Freedman BI, Carr JJ, Langefeld CD. Coincident linkage of type 2 diabetes, metabolic syndrome, and measures of cardiovascular disease in a genome scan of the diabetes heart study. Diabetes. 2006 Jul; 55(7):1985-94. PMID: 16804067.
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    375. Freedman BI, Bowden DW, Sale MM, Langefeld CD, Rich SS. Genetic susceptibility contributes to renal and cardiovascular complications of type 2 diabetes mellitus. Hypertension. 2006 Jul; 48(1):8-13. PMID: 16735643.
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    376. Warnock DG, Freedman BI, Guay-Woodford L, Bleyer AJ. Recent progress in inherited kidney diseases. Adv Chronic Kidney Dis. 2006 Apr; 13(2):95. PMID: 16580608.
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    377. Freedman BI. Genetic factors in common complex renal and cardiovascular diseases. Adv Chronic Kidney Dis. 2006 Apr; 13(2):105-9. PMID: 16580610.
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    378. Sale MM, Woods J, Freedman BI. Genetic determinants of the metabolic syndrome. Curr Hypertens Rep. 2006 Apr; 8(1):16-22. PMID: 16600155.
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    379. Burdon KP, Bento JL, Langefeld CD, Campbell JK, Carr JJ, Wagenknecht LM, Herrington DM, Freedman BI, Rich SS, Bowden DW. Association of protein tyrosine phosphatase-N1 polymorphisms with coronary calcified plaque in the Diabetes Heart Study. Diabetes. 2006 Mar; 55(3):651-8. PMID: 16505227.
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    380. Burdon KP, Langefeld CD, Beck SR, Wagenknecht LE, Carr JJ, Rich SS, Freedman BI, Herrington D, Bowden DW. Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS). Am Heart J. 2006 Mar; 151(3):706-11. PMID: 16504636.
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    381. An P, Freedman BI, Rich SS, Mandel SA, Arnett DK, Myers RH, Chen YD, Hunt SC, Rao DC. Quantitative trait loci on chromosome 8q24 for pancreatic beta-cell function and 7q11 for insulin sensitivity in obese nondiabetic white and black families: evidence from genome-wide linkage scans in the NHLBI Hypertension Genetic Epidemiology Network (HyperGEN) study. Diabetes. 2006 Feb; 55(2):551-8. PMID: 16443794.
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    382. Bento JL, Bowden DW, Mychaleckyj JC, Hirakawa S, Rich SS, Freedman BI, Segade F. Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes. BMC Med Genet. 2005 Dec 07; 6:42. PMID: 16336637.
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    383. Liu Y, Freedman BI. Genetics of progressive renal failure in diabetic kidney disease. Kidney Int Suppl. 2005 Dec; (99):S94-7. PMID: 16336585.
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    384. Freedman BI, Wagenknecht LE, Bowden DW. Trends in racial disparities in care. N Engl J Med. 2005 Nov 10; 353(19):2081-5; author reply 2081-5. PMID: 16285158.
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    385. Bowden DW, Lange LA, Langefeld CD, Brosnihan KB, Freedman BI, Carr JJ, Wagenknecht LE, Herrington DM. The relationship between C-reactive protein and subclinical cardiovascular disease in the Diabetes Heart Study (DHS). Am Heart J. 2005 Nov; 150(5):1032-8. PMID: 16290992.
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    386. Sale MM, Freedman BI. Genetic determinants of albuminuria and renal disease in diabetes mellitus. Nephrol Dial Transplant. 2006 Jan; 21(1):13-6. PMID: 16234290.
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    387. Freedman BI, Volkova NV, Satko SG, Krisher J, Jurkovitz C, Soucie JM, McClellan WM. Population-based screening for family history of end-stage renal disease among incident dialysis patients. Am J Nephrol. 2005 Nov-Dec; 25(6):529-35. PMID: 16179780.
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    388. Hsu FC, Zaccaro DJ, Lange LA, Arnett DK, Langefeld CD, Wagenknecht LE, Herrington DM, Beck SR, Freedman BI, Bowden DW, Rich SS. The impact of pedigree structure on heritability estimates for pulse pressure in three studies. Hum Hered. 2005; 60(2):63-72. PMID: 16155398.
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    389. Gallagher CJ, Gordon CJ, Langefeld CD, Mychaleckyj JC, Freedman BI, Rich SS, Bowden DW, Sale MM. Association of the mu-opioid receptor gene with type 2 diabetes mellitus in an African American population. Mol Genet Metab. 2006 Jan; 87(1):54-60. PMID: 16140553.
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    390. Liu Y, Burdon KP, Langefeld CD, Beck SR, Wagenknecht LE, Rich SS, Bowden DW, Freedman BI. P-selectin gene haplotype associations with albuminuria in the Diabetes Heart Study. Kidney Int. 2005 Aug; 68(2):741-6. PMID: 16014051.
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    391. Dusel JA, Burdon KP, Hicks PJ, Hawkins GA, Bowden DW, Freedman BI. Identification of podocin (NPHS2) gene mutations in African Americans with nondiabetic end-stage renal disease. Kidney Int. 2005 Jul; 68(1):256-62. PMID: 15954915.
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    392. Agarwal M, Selvan V, Freedman BI, Liu Y, Wagenknecht LE. The relationship between albuminuria and hormone therapy in postmenopausal women. Am J Kidney Dis. 2005 Jun; 45(6):1019-25. PMID: 15957130.
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    393. Freedman BI, Langefeld CD, Lohman KK, Bowden DW, Carr JJ, Rich SS, Wagenknecht LE. Relationship between albuminuria and cardiovascular disease in Type 2 diabetes. J Am Soc Nephrol. 2005 Jul; 16(7):2156-61. PMID: 15872076.
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    394. Satko SG, Freedman BI. The familial clustering of renal disease and related phenotypes. Med Clin North Am. 2005 May; 89(3):447-56. PMID: 15755461.
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    395. Satko SG, Freedman BI, Moossavi S. Genetic factors in end-stage renal disease. Kidney Int Suppl. 2005 Apr; (94):S46-9. PMID: 15752239.
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    396. Bagwell AM, Bento JL, Mychaleckyj JC, Freedman BI, Langefeld CD, Bowden DW. Genetic analysis of HNF4A polymorphisms in Caucasian-American type 2 diabetes. Diabetes. 2005 Apr; 54(4):1185-90. PMID: 15793260.
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    397. Li PK, Weening JJ, Dirks J, Lui SL, Szeto CC, Tang S, Atkins RC, Mitch WE, Chow KM, D'Amico G, Freedman BI, Harris DC, Hooi LS, Jong PE, Kincaid-Smith P, Lai KN, Lee E, Li FK, Lin SY, Lo WK, Mani MK, Mathew T, Murakami M, Qian JQ, Ramirez S, Reiser T, Tomino Y, Tong MK, Tsang WK, Tungsanga K, Wang H, Wong AK, Wong KM, Yang WC, de Zeeuw D, Yu AW, Remuzzi G. A report with consensus statements of the International Society of Nephrology 2004 Consensus Workshop on Prevention of Progression of Renal Disease, Hong Kong, June 29, 2004. Kidney Int Suppl. 2005 Apr; (94):S2-7. PMID: 15752234.
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    398. Liu Y, Burdon KP, Langefeld CD, Beck SR, Wagenknecht LE, Rich SS, Bowden DW, Freedman BI. T-786C polymorphism of the endothelial nitric oxide synthase gene is associated with albuminuria in the diabetes heart study. J Am Soc Nephrol. 2005 Apr; 16(4):1085-90. PMID: 15743995.
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    399. An P, Freedman BI, Hanis CL, Chen YD, Weder AB, Schork NJ, Boerwinkle E, Province MA, Hsiung CA, Wu X, Quertermous T, Rao DC. Genome-wide linkage scans for fasting glucose, insulin, and insulin resistance in the National Heart, Lung, and Blood Institute Family Blood Pressure Program: evidence of linkages to chromosome 7q36 and 19q13 from meta-analysis. Diabetes. 2005 Mar; 54(3):909-14. PMID: 15734873.
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    400. Duque MI, Yosipovitch G, Fleischer AB, Willard J, Freedman BI. Lack of efficacy of tacrolimus ointment 0.1% for treatment of hemodialysis-related pruritus: a randomized, double-blind, vehicle-controlled study. J Am Acad Dermatol. 2005 Mar; 52(3 Pt 1):519-21. PMID: 15761435.
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    401. Freedman BI, Bowden DW, Rich SS, Valis CJ, Sale MM, Hicks PJ, Langefeld CD. A genome scan for all-cause end-stage renal disease in African Americans. Nephrol Dial Transplant. 2005 Apr; 20(4):712-8. PMID: 15701670.
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    402. Hsu FC, Lenchik L, Nicklas BJ, Lohman K, Register TC, Mychaleckyj J, Langefeld CD, Freedman BI, Bowden DW, Carr JJ. Heritability of body composition measured by DXA in the diabetes heart study. Obes Res. 2005 Feb; 13(2):312-9. PMID: 15800289.
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    403. Wheeler GL, Shi R, Beck SR, Langefeld CD, Lenchik L, Wagenknecht LE, Freedman BI, Rich SS, Bowden DW, Chen MY, Carr JJ. Pericardial and visceral adipose tissues measured volumetrically with computed tomography are highly associated in type 2 diabetic families. Invest Radiol. 2005 Feb; 40(2):97-101. PMID: 15654254.
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    404. Gonzalez E, Kulkarni H, Bolivar H, Mangano A, Sanchez R, Catano G, Nibbs RJ, Freedman BI, Quinones MP, Bamshad MJ, Murthy KK, Rovin BH, Bradley W, Clark RA, Anderson SA, O'connell RJ, Agan BK, Ahuja SS, Bologna R, Sen L, Dolan MJ, Ahuja SK. The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. Science. 2005 Mar 04; 307(5714):1434-40. PMID: 15637236.
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    405. Knowler WC, Coresh J, Elston RC, Freedman BI, Iyengar SK, Kimmel PL, Olson JM, Plaetke R, Sedor JR, Seldin MF. The Family Investigation of Nephropathy and Diabetes (FIND): design and methods. J Diabetes Complications. 2005 Jan-Feb; 19(1):1-9. PMID: 15642484.
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    406. Karim MA, Wang X, Zhang Z, Bowden DW, Freedman BI, Elbein SC. Association of an insulin gene promoter insertion polymorphism with type 2 diabetes and diabetic nephropathy in African Americans. Mol Genet Metab. 2004 Dec; 83(4):344-6. PMID: 15589123.
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    407. Avery CL, Freedman BI, Heiss G, Kraja A, Rice T, Arnett D, Miller MB, Pankow JS, Lewis CE, Myers RH, Hunt SC, Almasy L, North KE. Linkage analysis of diabetes status among hypertensive families: the Hypertension Genetic Epidemiology Network study. Diabetes. 2004 Dec; 53(12):3307-12. PMID: 15561964.
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    408. Bento JL, Palmer ND, Mychaleckyj JC, Lange LA, Langefeld CD, Rich SS, Freedman BI, Bowden DW. Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes. Diabetes. 2004 Nov; 53(11):3007-12. PMID: 15504984.
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    409. Freedman BI, Langefeld CD, Rich SS, Valis CJ, Sale MM, Williams AH, Brown WM, Beck SR, Hicks PJ, Bowden DW. A genome scan for ESRD in black families enriched for nondiabetic nephropathy. J Am Soc Nephrol. 2004 Oct; 15(10):2719-27. PMID: 15466277.
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    410. Bowden DW, Colicigno CJ, Langefeld CD, Sale MM, Williams A, Anderson PJ, Rich SS, Freedman BI. A genome scan for diabetic nephropathy in African Americans. Kidney Int. 2004 Oct; 66(4):1517-26. PMID: 15458446.
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    411. Freedman BI, Hsu FC, Langefeld CD, Bowden DW, Moossavi S, Dryman BN, Carr JJ. Renal artery calcified plaque associations with subclinical renal and cardiovascular disease. Kidney Int. 2004 Jun; 65(6):2262-7. PMID: 15149339.
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    412. Satko SG, Freedman BI. The importance of family history on the development of renal disease. Curr Opin Nephrol Hypertens. 2004 May; 13(3):337-41. PMID: 15073494.
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    413. Langefeld CD, Beck SR, Bowden DW, Rich SS, Wagenknecht LE, Freedman BI. Heritability of GFR and albuminuria in Caucasians with type 2 diabetes mellitus. Am J Kidney Dis. 2004 May; 43(5):796-800. PMID: 15112169.
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    414. Wagenknecht LE, Langefeld CD, Carr JJ, Riley W, Freedman BI, Moossavi S, Bowden DW. Race-specific relationships between coronary and carotid artery calcification and carotid intimal medial thickness. Stroke. 2004 May; 35(5):e97-9. PMID: 15073382.
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    415. Sale MM, Freedman BI, Langefeld CD, Williams AH, Hicks PJ, Colicigno CJ, Beck SR, Brown WM, Rich SS, Bowden DW. A genome-wide scan for type 2 diabetes in African-American families reveals evidence for a locus on chromosome 6q. Diabetes. 2004 Mar; 53(3):830-7. PMID: 14988270.
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    416. Bagwell AM, Bailly A, Mychaleckyj JC, Freedman BI, Bowden DW. Comparative genomic analysis of the HNF-4alpha transcription factor gene. Mol Genet Metab. 2004 Feb; 81(2):112-21. PMID: 14741192.
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    417. Bolton WK, Cattran DC, Williams ME, Adler SG, Appel GB, Cartwright K, Foiles PG, Freedman BI, Raskin P, Ratner RE, Spinowitz BS, Whittier FC, Wuerth JP. Randomized trial of an inhibitor of formation of advanced glycation end products in diabetic nephropathy. Am J Nephrol. 2004 Jan-Feb; 24(1):32-40. PMID: 14685005.
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    418. Freedman BI, Beck SR, Rich SS, Heiss G, Lewis CE, Turner S, Province MA, Schwander KL, Arnett DK, Mellen BG. A genome-wide scan for urinary albumin excretion in hypertensive families. Hypertension. 2003 Sep; 42(3):291-6. PMID: 12925555.
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    419. Bensen JT, Langefeld CD, Hawkins GA, Green LE, Mychaleckyj JC, Brewer CS, Kiger DS, Binford SM, Colicigno CJ, Allred DC, Freedman BI, Bowden DW. Nucleotide variation, haplotype structure, and association with end-stage renal disease of the human interleukin-1 gene cluster. Genomics. 2003 Aug; 82(2):194-217. PMID: 12837270.
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    420. Freedman BI. Susceptibility genes for hypertension and renal failure. J Am Soc Nephrol. 2003 Jul; 14(7 Suppl 2):S192-4. PMID: 12819327.
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    421. Hirakawa S, Lange EM, Colicigno CJ, Freedman BI, Rich SS, Bowden DW. Evaluation of genetic variation and association in the matrix metalloproteinase 9 (MMP9) gene in ESRD patients. Am J Kidney Dis. 2003 Jul; 42(1):133-42. PMID: 12830465.
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    422. Bensen JT, Langefeld CD, Li L, McCall CE, Cousart SL, Dryman BN, Freedman BI, Bowden DW. Association of an IL-1A 3'UTR polymorphism with end-stage renal disease and IL-1 alpha expression. Kidney Int. 2003 Apr; 63(4):1211-9. PMID: 12631337.
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    423. Fan ZJ, Lackland DT, Kenderes B, Krisher J, Freedman BI. Impact of birth weight on familial aggregation of end-stage renal disease. Am J Nephrol. 2003 Mar-Apr; 23(2):117-20. PMID: 12481151.
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    424. Freedman BI, Rich SS, Yu H, Roh BH, Bowden DW. Linkage heterogeneity of end-stage renal disease on human chromosome 10. Kidney Int. 2002 Sep; 62(3):770-4. PMID: 12164858.
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    425. Satko SG, Langefeld CD, Daeihagh P, Bowden DW, Rich SS, Freedman BI. Nephropathy in siblings of African Americans with overt type 2 diabetic nephropathy. Am J Kidney Dis. 2002 Sep; 40(3):489-94. PMID: 12200799.
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    426. Lange LA, Bowden DW, Langefeld CD, Wagenknecht LE, Carr JJ, Rich SS, Riley WA, Freedman BI. Heritability of carotid artery intima-medial thickness in type 2 diabetes. Stroke. 2002 Jul; 33(7):1876-81. PMID: 12105369.
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    427. Yu H, Song Q, Freedman BI, Chao J, Chao L, Rich SS, Bowden DW. Association of the tissue kallikrein gene promoter with ESRD and hypertension. Kidney Int. 2002 Mar; 61(3):1030-9. PMID: 11849458.
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    428. Cherr GS, Hansen KJ, Craven TE, Edwards MS, Ligush J, Levy PJ, Freedman BI, Dean RH. Surgical management of atherosclerotic renovascular disease. J Vasc Surg. 2002 Feb; 35(2):236-45. PMID: 11854720.
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    429. Freedman BI. End-stage renal failure in African Americans: insights in kidney disease susceptibility. Nephrol Dial Transplant. 2002 Feb; 17(2):198-200. PMID: 11812863.
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    430. Gitter J, Langefeld CD, Rich SS, Pedley CF, Bowden DW, Freedman BI. Prevalence of nephropathy in black patients with type 2 diabetes mellitus. Am J Nephrol. 2002 Jan-Feb; 22(1):35-41. PMID: 11919401.
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