A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.

Descriptor ID	D050778
MeSH Number(s)	D12.776.930.608
Concept/Terms	NFATC Transcription Factors NFATC Transcription Factors Transcription Factors, NFATC NFAT Proteins Transcription Factor NF-AT NF-AT, Transcription Factor Transcription Factor NF AT Nuclear Factor of Activated T-Cells, Cytoplasmic Nuclear Factor of Activated T Cells, Cytoplasmic Nuclear Factors of Activated T-Cells Nuclear Factors of Activated T Cells NF-AT Proteins NF AT Proteins NFATC Proteins NFAT Transcription Factor 4 NFAT Transcription Factor 4 NFAT4 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 3 Protein Nuclear Factor of Activated T Cells, Cytoplasmic 3 Protein NFATC3 Transcription Factor Factor, NFATC3 Transcription Transcription Factor, NFATC3 NFATx Protein NF-AT4 Protein NF AT4 Protein NFATC3 Protein NFAT Transcription Factor 2 NFAT Transcription Factor 2 NFAT-2 Protein NFAT 2 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 1 Protein Nuclear Factor of Activated T Cells, Cytoplasmic 1 Protein NFATC1 Protein NFATC1 Transcription Factor Factor, NFATC1 Transcription Transcription Factor, NFATC1 NF-ATc1 Protein NF ATc1 Protein NFAT2 Protein NFAT Transcription Factor 3 NFAT Transcription Factor 3 NFATC4 Transcription Factor Transcription Factor, NFATC4 NFAT3 Protein NFATC4 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 4 Protein Nuclear Factor of Activated T Cells, Cytoplasmic 4 Protein NF-AT3 Protein NF AT3 Protein NFAT Transcription Factor 5 NFAT Transcription Factor 5 Nuclear Factor of Activated T-Cells 5 Protein Nuclear Factor of Activated T Cells 5 Protein OREBP Protein Osmotic Response Element Binding Protein NFATL1 Protein Tonicity-Responsive Enhancer-Binding Protein Tonicity Responsive Enhancer Binding Protein NFAT5 Protein NFATz Protein TonEBP Protein NFAT Transcription Factor 1 NFAT Transcription Factor 1 NFATC2 Transcription Factor Factor, NFATC2 Transcription Transcription Factor, NFATC2 NFAT1 Protein NFATC2 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 2 Protein Nuclear Factor of Activated T Cells, Cytoplasmic 2 Protein NFAT-1 Protein NFAT 1 Protein

Below are MeSH descriptors whose meaning is more general than "NFATC Transcription Factors".

Below are MeSH descriptors whose meaning is related to "NFATC Transcription Factors".

Below are MeSH descriptors whose meaning is more specific than "NFATC Transcription Factors".