OVERALL Adolescence is a critical time of development where teens increase their identification with peers, establish their independence and autonomy, and some begin experimenting with substances, including vaping products. Project MARVEL takes a multidisciplinary approach to assess the impact of youth vaping on health with projects that address vaping behavior, dependence, well-being, brain structure and function, respiratory health, and how to inform adolescents about the health harms to stem the epidemic of youth vaping.