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Osvaldo Delbono MD, PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentFamily & Community Medicine
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentEpidemiology & Prevention (Public Health Sciences)

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentPsychiatry & Behavioral Medicine


    Collapse Biography 
    Collapse awards and honors
    2001Section Chair, Gordon Conference on Aging, Gordon Conferences
    2005 - 2007Regular member of Skeletal Muscle Biology and Exercise Physiology Study Section, National Institute of Health
    2010 - 2012Member of the College of CSR Reviewers, National Institute of Health
    2013Fellow of the Gerontological Society of America, Gerontological Society of America, Gerontological Society of America
    2014Established Investigator in Basic Sciences Award, Wake Forest School of Medicine
    2014Team Science Award , Wake Forest School of Medicine
    2015Regular Member of Cellular Mechanisms of Aging and Development Study Section, National Institute of Health

    Collapse Research 
    Collapse research activities and funding
    R01AG13934-20     (Osvaldo Delbono)Aug 1, 2013 - Jul 30, 2019
    NIH/National Institute on Aging
    Troponin T and Muscle Excitation-Contraction Coupling
    Role Description: The proposed studies seek to define a non-canonical role for TnT3 as a regulator of Cav1.1 gene expression and a tool to ameliorate or prevent muscle weakness with aging.
    Role: Principal Investigator
    R01AG057013     (DELBONO, OSVALDO)Sep 1, 2017 - May 31, 2022
    NIH
    The Role of the Sympathetic Nervous System in the Onset and Development of Sarcopenia
    Role: Principal Investigator
    P30AG21332     (Steve Kritchevsky)Jul 1, 2018 - Jun 30, 2023
    NIH/ National Institute on Aging
    Assessment of Autophagy Flux in Single Muscle Biopsies from Young and Older Adults
    Role: Investigator. Co-leader of the Integrative Biology Core
    R01AG059416     (Steve Cummings)Jul 1, 2018 - Jun 30, 2023
    NIH/National Institute on Aging
    Study of Muscle and Mobility with Aging (SOMMA)
    Role Description: The goal of this study is to understand the role of muscle in loss of human mobility with aging.
    Role: Investigator
    R01AG057013-02S1     (Osvaldo Delbono)Sep 7, 2018 - May 31, 2023
    NIH/National Institute on Aging
    The Role of the Sympathetic Nervous System in the Onset and Development of Sarcopenia
    Role Description: This project examines the role of the SNS in muscle motor denervation and sarcopenia with aging.
    Role: Principal Investigator
    U01AG060897     (DING, JINGZHONG)Sep 30, 2018 - May 31, 2023
    NIH
    Aging Biomarkers: Integrating Omic Profiles with Mechanistic Measures
    Role: Co-Principal Investigator
    U01AG060897-01     (Delbono, Ding (contact), Molina)Sep 30, 2018 - May 31, 2023
    NIH/National Institute on Aging
    Aging Biomarkers: Integrating Omic Profiles with Mechanistic Measures
    Role Description: The proposed study will generate a panel of biomarkers reflecting a comprehensive battery of aging pathways.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Beeri MS, Leugrans SE, Delbono O, Bennett DA, Buchman AS. Sarcopenia is associated with incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline. J Am Geriatr Soc. 2021 May 05. PMID: 33954985.
      Citations:    
    2. Delbono O, Rodrigues ACZ, Bonilla HJ, Messi ML. The emerging role of the sympathetic nervous system in skeletal muscle motor innervation and sarcopenia. Ageing Res Rev. 2021 05; 67:101305. PMID: 33610815.
      Citations:    
    3. Buchman AS, Leurgans SE, Wang T, Schnaider-Beeri M, Agarwal P, Dawe RJ, Delbono O, Bennett DA. Motor function is the primary driver of the associations of sarcopenia and physical frailty with adverse health outcomes in community-dwelling older adults. PLoS One. 2021; 16(2):e0245680. PMID: 33529220.
      Citations:    
    4. Rodrigues ACZ, Wang ZM, Messi ML, Bonilla HJ, Liu L, Freeman WM, Delbono O. Heart and neural crest derivative 2-induced preservation of sympathetic neurons attenuates sarcopenia with aging. J Cachexia Sarcopenia Muscle. 2021 Feb; 12(1):91-108. PMID: 33258279.
      Citations:    
    5. Wang ZM, Messi ML, Grinevich V, Budygin E, Delbono O. Postganglionic sympathetic neurons, but not locus coeruleus optostimulation, activates neuromuscular transmission in the adult mouse in vivo. Mol Cell Neurosci. 2020 12; 109:103563. PMID: 33039519.
      Citations:    
    6. Bonilla HJ, Messi ML, Sadieva KA, Hamilton CA, Buchman AS, Delbono O. Semiautomatic morphometric analysis of skeletal muscle obtained by needle biopsy in older adults. Geroscience. 2020 12; 42(6):1431-1443. PMID: 32946050.
      Citations:    
    7. Deal AL, Bass CE, Grinevich VP, Delbono O, Bonin KD, Weiner JL, Budygin EA. Bidirectional Control of Alcohol-drinking Behaviors Through Locus Coeruleus Optoactivation. Neuroscience. 2020 09 01; 443:84-92. PMID: 32707291.
      Citations:    
    8. Wang ZM, Rodrigues ACZ, Messi ML, Delbono O. Aging Blunts Sympathetic Neuron Regulation of Motoneurons Synaptic Vesicle Release Mediated by ß1- and a2B-Adrenergic Receptors in Geriatric Mice. J Gerontol A Biol Sci Med Sci. 2020 07 13; 75(8):1473-1480. PMID: 31956900.
      Citations:    
    9. Wang ZM, Leng X, Messi ML, Choi SJ, Marsh AP, Nicklas B, Delbono O. Relationship of Physical Function to Single Muscle Fiber Contractility in Older Adults: Effects of Resistance Training With and Without Caloric Restriction. J Gerontol A Biol Sci Med Sci. 2019 02 15; 74(3):412-419. PMID: 29546320.
      Citations:    
    10. Rodrigues AZC, Wang ZM, Messi ML, Delbono O. Sympathomimetics regulate neuromuscular junction transmission through TRPV1, P/Q- and N-type Ca2+ channels. Mol Cell Neurosci. 2019 03; 95:59-70. PMID: 30763691.
      Citations:    
    11. Rodrigues ACZ, Messi ML, Wang ZM, Abba MC, Pereyra A, Birbrair A, Zhang T, O'Meara M, Kwan P, Lopez EIS, Willis MS, Mintz A, Files DC, Furdui C, Oppenheim RW, Delbono O. The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability. Acta Physiol (Oxf). 2019 03; 225(3):e13195. PMID: 30269419.
      Citations:    
    12. Rodrigues ACZ, Messi ML, Wang ZM, Abba MC, Pereyra A, Birbrair A, Zhang T, O'Meara M, Kwan P, Lopez EIS, Willis MS, Mintz A, Files DC, Furdui C, Oppenheim RW, Delbono O. The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability. Acta Physiologica. 2018; (e13195):1-28.
    13. Nunez Lopez YO, Messi ML, Pratley RE, Zhang T, Delbono O. Troponin T3 associates with DNA consensus sequence that overlaps with p53 binding motifs. Exp Gerontol. 2018 07 15; 108:35-40. PMID: 29596868.
      Citations:    
    14. Pereyra AS, Wang ZM, Messi ML, Zhang T, Wu H, Register TC, Forbes E, Devarie-Baez NO, Files DC, Abba MC, Furdui C, Delbono O. BDA-410 Treatment Reduces Body Weight and Fat Content by Enhancing Lipolysis in Sedentary Senescent Mice. J Gerontol A Biol Sci Med Sci. 2017 Aug 01; 72(8):1045-1053. PMID: 27789616.
      Citations:    
    15. Birbrair A, Borges IDT, Gilson Sena IF, Almeida GG, da Silva Meirelles L, Gonçalves R, Mintz A, Delbono O. How Plastic Are Pericytes? Stem Cells Dev. 2017 07 15; 26(14):1013-1019. PMID: 28490256.
      Citations:    
    16. Dias Moura Prazeres PH, Sena IFG, Borges IDT, de Azevedo PO, Andreotti JP, de Paiva AE, de Almeida VM, de Paula Guerra DA, Pinheiro Dos Santos GS, Mintz A, Delbono O, Birbrair A. Pericytes are heterogeneous in their origin within the same tissue. Dev Biol. 2017 07 01; 427(1):6-11. PMID: 28479340.
      Citations:    
    17. Xu Z, Feng X, Dong J, Wang ZM, Lee J, Furdui C, Files DC, Beavers KM, Kritchevsky S, Milligan C, Jin JP, Delbono O, Zhang T. Cardiac troponin T and fast skeletal muscle denervation in ageing. J Cachexia Sarcopenia Muscle. 2017 Oct; 8(5):808-823. PMID: 28419739.
      Citations:    
    18. Birbrair A, Sattiraju A, Zhu D, Zulato G, Batista I, Nguyen VT, Messi ML, Solingapuram Sai KK, Marini FC, Delbono O, Mintz A. Novel Peripherally Derived Neural-Like Stem Cells as Therapeutic Carriers for Treating Glioblastomas. Stem Cells Transl Med. 2017 02; 6(2):471-481. PMID: 28191774.
      Citations:    
    19. Files DC, Ilaiwy A, Parry TL, Gibbs KW, Liu C, Bain JR, Delbono O, Muehlbauer MJ, Willis MS. Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism. Metabolomics. 2016 Aug; 12(8). PMID: 28217037.
      Citations:    
    20. Pereyra AS, Mykhaylyk O, Lockhart EF, Taylor JR, Delbono O, Goya RG, Plank C, Hereñu CB. Magnetofection Enhances Adenoviral Vector-based Gene Delivery in Skeletal Muscle Cells. J Nanomed Nanotechnol. 2016 Apr; 7(2). PMID: 27274908.
      Citations:    
    21. Zhang T, Pereyra AS, Wang ZM, Birbrair A, Reisz JA, Files DC, Purcell L, Feng X, Messi ML, Feng H, Chalovich J, Jin JP, Furdui C, Delbono O. Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice. Aging Cell. 2016 06; 15(3):488-98. PMID: 26892246.
      Citations:    
    22. Messi ML, Li T, Wang ZM, Marsh AP, Nicklas B, Delbono O. Resistance Training Enhances Skeletal Muscle Innervation Without Modifying the Number of Satellite Cells or their Myofiber Association in Obese Older Adults. J Gerontol A Biol Sci Med Sci. 2016 10; 71(10):1273-80. PMID: 26447161.
      Citations:    
    23. Choi SJ, Files DC, Zhang T, Wang ZM, Messi ML, Gregory H, Stone J, Lyles MF, Dhar S, Marsh AP, Nicklas BJ, Delbono O. Intramyocellular Lipid and Impaired Myofiber Contraction in Normal Weight and Obese Older Adults. J Gerontol A Biol Sci Med Sci. 2016 Apr; 71(4):557-64. PMID: 26405061.
      Citations:    
    24. Birbrair A, Delbono O. Pericytes are Essential for Skeletal Muscle Formation. Stem Cell Rev Rep. 2015 Aug; 11(4):547-8. PMID: 25896402.
      Citations:    
    25. Zhang T, Taylor J, Jiang Y, Pereyra AS, Messi ML, Wang ZM, Hereñú C, Delbono O. Troponin T3 regulates nuclear localization of the calcium channel Cavß1a subunit in skeletal muscle. Exp Cell Res. 2015 Aug 15; 336(2):276-86. PMID: 25981458.
      Citations:    
    26. Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O. Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Sci Transl Med. 2015 Mar 11; 7(278):278ra32. PMID: 25761888.
      Citations:    
    27. Nicklas BJ, Chmelo E, Delbono O, Carr JJ, Lyles MF, Marsh AP. Effects of resistance training with and without caloric restriction on physical function and mobility in overweight and obese older adults: a randomized controlled trial. Am J Clin Nutr. 2015 May; 101(5):991-9. PMID: 25762810.
      Citations:    
    28. Lopez RJ, Mosca B, Treves S, Maj M, Bergamelli L, Calderon JC, Bentzinger CF, Romanino K, Hall MN, Rüegg MA, Delbono O, Caputo C, Zorzato F. Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex. Biochem J. 2015 Feb 15; 466(1):123-35. PMID: 25431931.
      Citations:    
    29. Zhang T, Birbrair A, Wang ZM, Messi ML, Marsh AP, Leng I, Nicklas BJ, Delbono O. Improved knee extensor strength with resistance training associates with muscle specific miRNAs in older adults. Exp Gerontol. 2015 Feb; 62:7-13. PMID: 25560803.
      Citations:    
    30. Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O. Pericytes at the intersection between tissue regeneration and pathology. Clin Sci (Lond). 2015 Jan; 128(2):81-93. PMID: 25236972.
      Citations:    
    31. Birbrair A, Zhang T, Files DC, Mannava S, Smith T, Wang ZM, Messi ML, Mintz A, Delbono O. Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner. Stem Cell Res Ther. 2014 Nov 06; 5(6):122. PMID: 25376879.
      Citations:    
    32. Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O. Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle. Front Aging Neurosci. 2014; 6:245. PMID: 25278877.
      Citations:    
    33. Taylor J, Pereyra A, Zhang T, Messi ML, Wang ZM, Hereñú C, Kuan PF, Delbono O. The Cavß1a subunit regulates gene expression and suppresses myogenin in muscle progenitor cells. J Cell Biol. 2014 Jun 23; 205(6):829-46. PMID: 24934157.
      Citations:    
    34. Birbrair A, Zhang T, Wang ZM, Messi ML, Olson JD, Mintz A, Delbono O. Type-2 pericytes participate in normal and tumoral angiogenesis. . 2014 Jul 01; 307(1):C25-38. PMID: 24788248.
      Citations:    
    35. Files DC, Xiao K, Zhang T, Liu C, Qian J, Zhao W, Morris PE, Delbono O, Feng X. The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury. PLoS One. 2014; 9(1):e87587. PMID: 24498144.
      Citations:    
    36. Zhang T, Choi SJ, Wang ZM, Birbrair A, Messi ML, Jin JP, Marsh AP, Nicklas B, Delbono O. Human slow troponin T (TNNT1) pre-mRNA alternative splicing is an indicator of skeletal muscle response to resistance exercise in older adults. J Gerontol A Biol Sci Med Sci. 2014 Dec; 69(12):1437-47. PMID: 24368775.
      Citations:    
    37. Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O. Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle. . 2013 Dec 01; 305(11):C1098-113. PMID: 24067916.
      Citations:    
    38. Birbrair A, Zhang T, Wang ZM, Messi ML, Enikolopov GN, Mintz A, Delbono O. Role of pericytes in skeletal muscle regeneration and fat accumulation. Stem Cells Dev. 2013 Aug 15; 22(16):2298-314. PMID: 23517218.
      Citations:    
    39. Zhang T, Birbrair A, Delbono O. Nonmyofilament-associated troponin T3 nuclear and nucleolar localization sequence and leucine zipper domain mediate muscle cell apoptosis. Cytoskeleton (Hoboken). 2013 Mar; 70(3):134-47. PMID: 23378072.
      Citations:    
    40. Mosca B, Delbono O, Laura Messi M, Bergamelli L, Wang ZM, Vukcevic M, Lopez R, Treves S, Nishi M, Takeshima H, Paolini C, Martini M, Rispoli G, Protasi F, Zorzato F. Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice. Nat Commun. 2013; 4:1541. PMID: 23443569.
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    41. Yasuda T, Delbono O, Wang ZM, Messi ML, Girard T, Urwyler A, Treves S, Zorzato F. JP-45/JSRP1 variants affect skeletal muscle excitation-contraction coupling by decreasing the sensitivity of the dihydropyridine receptor. Hum Mutat. 2013 Jan; 34(1):184-90. PMID: 22927026.
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    42. Birbrair A, Zhang T, Wang ZM, Messi ML, Enikolopov GN, Mintz A, Delbono O. Skeletal muscle pericyte subtypes differ in their differentiation potential. Stem Cell Res. 2013 Jan; 10(1):67-84. PMID: 23128780.
      Citations:    
    43. Birbrair A, Zhang T, Wang ZM, Messi ML, Enikolopov GN, Mintz A, Delbono O. Skeletal muscle neural progenitor cells exhibit properties of NG2-glia. Exp Cell Res. 2013 Jan 01; 319(1):45-63. PMID: 22999866.
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    44. Kute T, Stehle JR, Ornelles D, Walker N, Delbono O, Vaughn JP. Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cells. Oncoimmunology. 2012 Sep 01; 1(6):810-821. PMID: 23162748.
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    45. Choi SJ, Shively CA, Register TC, Feng X, Stehle J, High K, Ip E, Kritchevsky SB, Nicklas B, Delbono O. Force-generation capacity of single vastus lateralis muscle fibers and physical function decline with age in African green vervet monkeys. J Gerontol A Biol Sci Med Sci. 2013 Mar; 68(3):258-67. PMID: 22923428.
      Citations:    
    46. Dardevet D, Savary-Auzeloux I, Remond D, Mosoni L, Marzetti E, Buford TW, Bernabei R, Dionne IJ, Buford TW, Marzetti E, Manini TM, Buehring B, Kirchner E, Calabrese L, Manini TM, Clark BC, Fonseca HM, Delbono O, Taylor JR, Aubertin-Leheudre M, Barbat-Artigas S, Pion CH, Thornell LE, Gustafsson T, Cederholm T, Ulfhake B. Commentaries on Viewpoint: Muscle atrophy is not always sarcopenia. J Appl Physiol (1985). 2012 Aug 15; 113(4):680-4. PMID: 22896680.
      Citations:    
    47. Feng X, Zhang T, Xu Z, Choi SJ, Qian J, Furdui CM, Register TC, Delbono O. Myosin heavy chain isoform expression in the Vastus Lateralis muscle of aging African green vervet monkeys. Exp Gerontol. 2012 Aug; 47(8):601-7. PMID: 22617406.
      Citations:    
    48. Files DC, D'Alessio FR, Johnston LF, Kesari P, Aggarwal NR, Garibaldi BT, Mock JR, Simmers JL, DeGorordo A, Murdoch J, Willis MS, Patterson C, Tankersley CG, Messi ML, Liu C, Delbono O, Furlow JD, Bodine SC, Cohn RD, King LS, Crow MT. A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting. Am J Respir Crit Care Med. 2012 Apr 15; 185(8):825-34. PMID: 22312013.
      Citations:    
    49. Delbono O, Messi ML, Wang ZM, Treves S, Mosca B, Bergamelli L, Nishi M, Takeshima H, Shi H, Xue B, Zorzato F. Endogenously determined restriction of food intake overcomes excitation-contraction uncoupling in JP45KO mice with aging. Exp Gerontol. 2012 Apr; 47(4):304-16. PMID: 22297108.
      Citations:    
    50. Wang ZM, Tang S, Messi ML, Yang JJ, Delbono O. Residual sarcoplasmic reticulum Ca2+ concentration after Ca2+ release in skeletal myofibers from young adult and old mice. Pflugers Arch. 2012 Apr; 463(4):615-24. PMID: 22249494.
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    51. Zhang T, Birbrair A, Wang ZM, Taylor J, Messi ML, Delbono O. Troponin T nuclear localization and its role in aging skeletal muscle. Age (Dordr). 2013 Apr; 35(2):353-70. PMID: 22189912.
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    52. Delbono O. Expression and regulation of excitation-contraction coupling proteins in aging skeletal muscle. Curr Aging Sci. 2011 Dec; 4(3):248-59. PMID: 21529320.
      Citations:    
    53. Tang S, Wong HC, Wang ZM, Huang Y, Zou J, Zhuo Y, Pennati A, Gadda G, Delbono O, Yang JJ. Design and application of a class of sensors to monitor Ca2+ dynamics in high Ca2+ concentration cellular compartments. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16265-70. PMID: 21914846.
      Citations:    
    54. Birbrair A, Wang ZM, Messi ML, Enikolopov GN, Delbono O. Nestin-GFP transgene reveals neural precursor cells in adult skeletal muscle. PLoS One. 2011 Feb 03; 6(2):e16816. PMID: 21304812.
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    55. Jiménez-Moreno R, Wang ZM, Messi ML, Delbono O. Sarcoplasmic reticulum Ca2+ depletion in adult skeletal muscle fibres measured with the biosensor D1ER. Pflugers Arch. 2010 Apr; 459(5):725-35. PMID: 20069312.
      Citations:    
    56. Delbono O. Myosin - still a good reference for skeletal muscle fibre classification? J Physiol. 2010 Jan 01; 588(Pt 1):9. PMID: 20045898.
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    57. Taylor JR, Zheng Z, Wang ZM, Payne AM, Messi ML, Delbono O. Increased CaVbeta1A expression with aging contributes to skeletal muscle weakness. Aging Cell. 2009 Sep; 8(5):584-94. PMID: 19663902.
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    58. Payne AM, Jimenez-Moreno R, Wang ZM, Messi ML, Delbono O. Role of Ca2+, membrane excitability, and Ca2+ stores in failing muscle contraction with aging. Exp Gerontol. 2009 Apr; 44(4):261-73. PMID: 18948183.
      Citations:    
    59. Nicklas BJ, Leng I, Delbono O, Kitzman DW, Marsh AP, Hundley WG, Lyles MF, O'Rourke KS, Annex BH, Kraus WE. Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women. Aging Clin Exp Res. 2008 Aug; 20(4):302-9. PMID: 18852542.
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    60. Jiménez-Moreno R, Wang ZM, Gerring RC, Delbono O. Sarcoplasmic reticulum Ca2+ release declines in muscle fibers from aging mice. Biophys J. 2008 Apr 15; 94(8):3178-88. PMID: 18178643.
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    61. Delbono O, Xia J, Treves S, Wang ZM, Jimenez-Moreno R, Payne AM, Messi ML, Briguet A, Schaerer F, Nishi M, Takeshima H, Zorzato F. Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):20108-13. PMID: 18077436.
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    62. Wang ZM, Zheng Z, Messi ML, Delbono O. Muscle fibers from senescent mice retain excitation-contraction coupling properties in culture. In Vitro Cell Dev Biol Anim. 2007 Jul-Aug; 43(7):222-34. PMID: 17712595.
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    63. Messi ML, Clark HM, Prevette DM, Oppenheim RW, Delbono O. The lack of effect of specific overexpression of IGF-1 in the central nervous system or skeletal muscle on pathophysiology in the G93A SOD-1 mouse model of ALS. Exp Neurol. 2007 Sep; 207(1):52-63. PMID: 17597610.
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    64. Moreno RJ, Messi ML, Zheng Z, Wang ZM, Ye P, D'Ercole JA, Delbono O. Role of sustained overexpression of central nervous system IGF-I in the age-dependent decline of mouse excitation-contraction coupling. J Membr Biol. 2006; 212(3):147-61. PMID: 17334835.
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    65. Payne AM, Messi ML, Zheng Z, Delbono O. Motor neuron targeting of IGF-1 attenuates age-related external Ca2+-dependent skeletal muscle contraction in senescent mice. Exp Gerontol. 2007 Apr; 42(4):309-19. PMID: 17174053.
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    66. Anderson AA, Altafaj X, Zheng Z, Wang ZM, Delbono O, Ronjat M, Treves S, Zorzato F. The junctional SR protein JP-45 affects the functional expression of the voltage-dependent Ca2+ channel Cav1.1. J Cell Sci. 2006 May 15; 119(Pt 10):2145-55. PMID: 16638807.
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    67. Payne AM, Zheng Z, Messi ML, Milligan CE, González E, Delbono O. Motor neurone targeting of IGF-1 prevents specific force decline in ageing mouse muscle. J Physiol. 2006 Jan 15; 570(Pt 2):283-94. PMID: 16293644.
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    68. Wang ZM, Zheng Z, Messi ML, Delbono O. Extension and magnitude of denervation in skeletal muscle from ageing mice. J Physiol. 2005 Jun 15; 565(Pt 3):757-64. PMID: 15890702.
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    69. Payne AM, Zheng Z, González E, Wang ZM, Messi ML, Delbono O. External Ca(2+)-dependent excitation--contraction coupling in a population of ageing mouse skeletal muscle fibres. J Physiol. 2004 Oct 01; 560(Pt 1):137-55. PMID: 15297570.
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    70. Zheng Z, Wang ZM, Delbono O. Ca(2+) calmodulin kinase and calcineurin mediate IGF-1-induced skeletal muscle dihydropyridine receptor alpha(1S) transcription. J Membr Biol. 2004 Jan 15; 197(2):101-12. PMID: 15014912.
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    71. Payne AM, Delbono O. Neurogenesis of excitation-contraction uncoupling in aging skeletal muscle. Exerc Sport Sci Rev. 2004 Jan; 32(1):36-40. PMID: 14748548.
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    72. Shan H, Messi ML, Zheng Z, Wang ZM, Delbono O. Preservation of motor neuron Ca2+ channel sensitivity to insulin-like growth factor-1 in brain motor cortex from senescent rat. J Physiol. 2003 Nov 15; 553(Pt 1):49-63. PMID: 12963799.
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    73. Gonzalez E, Messi ML, Zheng Z, Delbono O. Insulin-like growth factor-1 prevents age-related decrease in specific force and intracellular Ca2+ in single intact muscle fibres from transgenic mice. J Physiol. 2003 Nov 01; 552(Pt 3):833-44. PMID: 12937290.
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    74. Messi ML, Delbono O. Target-derived trophic effect on skeletal muscle innervation in senescent mice. J Neurosci. 2003 Feb 15; 23(4):1351-9. PMID: 12598623.
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    75. Delbono O. Neural control of aging skeletal muscle. Aging Cell. 2003 02; 2(1):21-9. PMID: 12882331.
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    76. Zheng Z, Wang ZM, Delbono O. Insulin-like growth factor-1 increases skeletal muscle dihydropyridine receptor alpha 1S transcriptional activity by acting on the cAMP-response element-binding protein element of the promoter region. J Biol Chem. 2002 Dec 27; 277(52):50535-42. PMID: 12407098.
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    77. Zheng Z, Wang ZM, Delbono O. Charge movement and transcription regulation of L-type calcium channel alpha(1S) in skeletal muscle cells. J Physiol. 2002 Apr 15; 540(Pt 2):397-409. PMID: 11956331.
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    78. Wang ZM, Messi ML, Delbono O. Sustained overexpression of IGF-1 prevents age-dependent decrease in charge movement and intracellular Ca(2+) in mouse skeletal muscle. Biophys J. 2002 Mar; 82(3):1338-44. PMID: 11867450.
      Citations:    
    79. Delbono O. Molecular mechanisms and therapeutics of the deficit in specific force in ageing skeletal muscle. Biogerontology. 2002; 3(5):265-70. PMID: 12237563.
      Citations:    
    80. González E, Delbono O. Recovery from fatigue in fast and slow single intact skeletal muscle fibers from aging mouse. Muscle Nerve. 2001 Sep; 24(9):1219-24. PMID: 11494276.
      Citations:    
    81. González E, Delbono O. Age-dependent fatigue in single intact fast- and slow fibers from mouse EDL and soleus skeletal muscles. Mech Ageing Dev. 2001 Jul 31; 122(10):1019-32. PMID: 11389921.
      Citations:    
    82. Zheng Z, Messi ML, Delbono O. Age-dependent IGF-1 regulation of gene transcription of Ca2+ channels in skeletal muscle. Mech Ageing Dev. 2001 Apr 15; 122(4):373-84. PMID: 11240160.
      Citations:    
    83. González E, Messi ML, Delbono O. The specific force of single intact extensor digitorum longus and soleus mouse muscle fibers declines with aging. J Membr Biol. 2000 Dec 01; 178(3):175-83. PMID: 11148759.
      Citations:    
    84. Wang ZM, Messi ML, Delbono O. L-Type Ca(2+) channel charge movement and intracellular Ca(2+) in skeletal muscle fibers from aging mice. Biophys J. 2000 Apr; 78(4):1947-54. PMID: 10733973.
      Citations:    
    85. Delbono O. Regulation of excitation contraction coupling by insulin-like growth factor-1 in aging skeletal muscle. J Nutr Health Aging. 2000; 4(3):162-4. PMID: 10936903.
      Citations:    
    86. Wang ZM, Messi ML, Delbono O. Patch-clamp recording of charge movement, Ca2+ current, and Ca2+ transients in adult skeletal muscle fibers. Biophys J. 1999 Nov; 77(5):2709-16. PMID: 10545370.
      Citations:    
    87. Renganathan M, Wang ZM, Messi ML, Delbono O. Calcium regulates L-type Ca2+ channel expression in rat skeletal muscle cells. Pflugers Arch. 1999 Oct; 438(5):649-55. PMID: 10555562.
      Citations:    
    88. Wang ZM, Messi ML, Renganathan M, Delbono O. Insulin-like growth factor-1 enhances rat skeletal muscle charge movement and L-type Ca2+ channel gene expression. J Physiol. 1999 Apr 15; 516 ( Pt 2):331-41. PMID: 10087334.
      Citations:    
    89. Renganathan M, Messi ML, Delbono O. Overexpression of IGF-1 exclusively in skeletal muscle prevents age-related decline in the number of dihydropyridine receptors. J Biol Chem. 1998 Oct 30; 273(44):28845-51. PMID: 9786885.
      Citations:    
    90. Mayhew M, Renganathan M, Delbono O. Effectiveness of caloric restriction in preventing age-related changes in rat skeletal muscle. Biochem Biophys Res Commun. 1998 Oct 09; 251(1):95-9. PMID: 9790913.
      Citations:    
    91. Renganathan M, Delbono O. Caloric restriction prevents age-related decline in skeletal muscle dihydropyridine receptor and ryanodine receptor expression. FEBS Lett. 1998 Sep 04; 434(3):346-50. PMID: 9742952.
      Citations:    
    92. Molinari EJ, Delbono O, Messi ML, Renganathan M, Arneric SP, Sullivan JP, Gopalakrishnan M. Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands. Eur J Pharmacol. 1998 Apr 17; 347(1):131-9. PMID: 9650859.
      Citations:    
    93. Renganathan M, Messi ML, Schwartz R, Delbono O. Overexpression of hIGF-1 exclusively in skeletal muscle increases the number of dihydropyridine receptors in adult transgenic mice. FEBS Lett. 1997 Nov 03; 417(1):13-6. PMID: 9395065.
      Citations:    
    94. Delbono O, Renganathan M, Messi ML. Regulation of mouse skeletal muscle L-type Ca2+ channel by activation of the insulin-like growth factor-1 receptor. J Neurosci. 1997 Sep 15; 17(18):6918-28. PMID: 9278527.
      Citations:    
    95. Messi ML, Renganathan M, Grigorenko E, Delbono O. Activation of alpha7 nicotinic acetylcholine receptor promotes survival of spinal cord motoneurons. FEBS Lett. 1997 Jul 07; 411(1):32-8. PMID: 9247137.
      Citations:    
    96. Renganathan M, Sonntag WE, Delbono O. L-type Ca2+ channel-insulin-like growth factor-1 receptor signaling impairment in aging rat skeletal muscle. Biochem Biophys Res Commun. 1997 Jun 27; 235(3):784-9. PMID: 9207239.
      Citations:    
    97. Renganathan M, Messi ML, Delbono O. Dihydropyridine receptor-ryanodine receptor uncoupling in aged skeletal muscle. J Membr Biol. 1997 Jun 01; 157(3):247-53. PMID: 9178612.
      Citations:    
    98. Delbono O, Renganathan M, Messi ML. Excitation-Ca2+ release-contraction coupling in single aged human skeletal muscle fiber. Muscle Nerve Suppl. 1997; 5:S88-92. PMID: 9331393.
      Citations:    
    99. Delbono O, Gopalakrishnan M, Renganathan M, Monteggia LM, Messi ML, Sullivan JP. Activation of the recombinant human alpha 7 nicotinic acetylcholine receptor significantly raises intracellular free calcium. J Pharmacol Exp Ther. 1997 Jan; 280(1):428-38. PMID: 8996225.
      Citations:    
    100. Delbono O, Meissner G. Sarcoplasmic reticulum Ca2+ release in rat slow- and fast-twitch muscles. J Membr Biol. 1996 May; 151(2):123-30. PMID: 8661500.
      Citations:    
    101. Delbono O, O'Rourke KS, Ettinger WH. Excitation-calcium release uncoupling in aged single human skeletal muscle fibers. J Membr Biol. 1995 Dec; 148(3):211-22. PMID: 8747553.
      Citations:    
    102. Delbono O. Ca2+ modulation of sarcoplasmic reticulum Ca2+ release in rat skeletal muscle fibers. J Membr Biol. 1995 Jul; 146(1):91-9. PMID: 7563040.
      Citations:    
    103. Delbono O, Chu A. Ca2+ release channels in rat denervated skeletal muscles. Exp Physiol. 1995 Jul; 80(4):561-74. PMID: 7576596.
      Citations:    
    104. Mosier DR, Baldelli P, Delbono O, Smith RG, Alexianu ME, Appel SH, Stefani E. Amyotrophic lateral sclerosis immunoglobulins increase Ca2+ currents in a motoneuron cell line. Ann Neurol. 1995 Jan; 37(1):102-9. PMID: 7818241.
      Citations:    
    105. Kimura F, Smith RG, Delbono O, Nyormoi O, Schneider T, Nastainczyk W, Hofmann F, Stefani E, Appel SH. Amyotrophic lateral sclerosis patient antibodies label Ca2+ channel alpha 1 subunit. Ann Neurol. 1994 Feb; 35(2):164-71. PMID: 8109897.
      Citations:    
    106. Llinás R, Sugimori M, Cherksey BD, Smith RG, Delbono O, Stefani E, Appel S. IgG from amyotrophic lateral sclerosis patients increases current through P-type calcium channels in mammalian cerebellar Purkinje cells and in isolated channel protein in lipid bilayer. Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11743-7. PMID: 8265620.
      Citations:    
    107. Delbono O, Kotsias BA. Effect of aminophylline-Ca2+ blocker interaction on membrane potential of rat diaphragm fibers. J Appl Physiol (1985). 1993 Jun; 74(6):2745-9. PMID: 8365976.
      Citations:    
    108. Delbono O, Stefani E. Calcium transients in single mammalian skeletal muscle fibres. J Physiol. 1993 Apr; 463:689-707. PMID: 8246201.
      Citations:    
    109. Delbono O, Magnelli V, Sawada T, Smith RG, Appel SH, Stefani E. Fab fragments from amyotrophic lateral sclerosis IgG affect calcium channels of skeletal muscle. Am J Physiol. 1993 Mar; 264(3 Pt 1):C537-43. PMID: 8384783.
      Citations:    
    110. Magnelli V, Sawada T, Delbono O, Smith RG, Appel SH, Stefani E. The action of amyotrophic lateral sclerosis immunoglobulins on mammalian single skeletal muscle Ca2+ channels. J Physiol. 1993 Feb; 461:103-18. PMID: 8394422.
      Citations:    
    111. Delbono O, Stefani E. Calcium current inactivation in denervated rat skeletal muscle fibres. J Physiol. 1993 Jan; 460:173-83. PMID: 8387584.
      Citations:    
    112. Delbono O. Calcium current activation and charge movement in denervated mammalian skeletal muscle fibres. J Physiol. 1992; 451:187-203. PMID: 1328616.
      Citations:    
    113. Delbono O, García J, Appel SH, Stefani E. Calcium current and charge movement of mammalian muscle: action of amyotrophic lateral sclerosis immunoglobulins. J Physiol. 1991 Dec; 444:723-42. PMID: 1668354.
      Citations:    
    114. Delbono O, García J, Appel SH, Stefani E. IgG from amyotrophic lateral sclerosis affects tubular calcium channels of skeletal muscle. Am J Physiol. 1991 Jun; 260(6 Pt 1):C1347-51. PMID: 1647668.
      Citations:    
    115. Delbono O, Kotsias BA. Calcium action potentials in innervated and denervated rat muscle fibres. Pflugers Arch. 1991 Apr; 418(3):284-91. PMID: 1649994.
      Citations:    
    116. Delbono O, Kotsias BA. Effect of aminophylline on mechanical activity of rat diaphragm bundles. J Appl Physiol (1985). 1990 Mar; 68(3):1142-9. PMID: 2341339.
      Citations:    
    117. Delbono O, Kotsias BA. Ruthenium red effect on mechanical and electrical properties of mammalian skeletal muscle. Life Sci. 1989; 45(18):1699-708. PMID: 2479803.
      Citations:    
    118. Delbono O, Kotsias BA. Hyperpolarizing effect of aminophylline, theophylline, and cAMP on rat diaphragm fibers. J Appl Physiol (1985). 1988 May; 64(5):1893-9. PMID: 2839450.
      Citations:    
    119. Delbono O, Kotsias BA. Relation between action potential duration and mechanical activity on rat diaphragm fibers. Effects of 3,4-diaminopyridine and tetraethylammonium. Pflugers Arch. 1987 Nov; 410(4-5):394-400. PMID: 3432046.
      Citations:    
    120. Delbono O, Obejero Paz CA, Muchnik S. The effect of verapamil and Ca free solution on mechanical and electrical properties in fast twitch mammalian skeletal muscle. Acta Physiol Pharmacol Latinoam. 1987; 37(4):423-35. PMID: 3274022.
      Citations:    
    121. Obejero Paz CA, Delbono O, Muchnik S. Effects of actinomycin D on contractile properties of denervated rat skeletal muscle. Exp Neurol. 1986 Dec; 94(3):509-18. PMID: 3780904.
      Citations:    
    122. Delbono O, Losavio A, Muchnik S. [Participation of calcium and parathyroid hormone in skeletal and cardiac muscular injury in chronic renal insufficiency]. Medicina (B Aires). 1984; 44(3):318-24. PMID: 6545563.
      Citations:    
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