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Clinical and Translational Science Institute

Keywords
Last Name

Osvaldo Delbono, M.D., Ph.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine - Gerontology
Address
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    Collapse Biography 
    Collapse awards and honors
    2001Section Chair, Gordon Conference on Aging, Gordon Conferences
    2005 - 2007Regular member of Skeletal Muscle Biology and Exercise Physiology Study Section, National Institute of Health
    2010 - 2012Member of the College of CSR Reviewers, National Institute of Health
    2013Fellow of the Gerontological Society of America, Gerontological Society of America, Gerontological Society of America
    2014Established Investigator in Basic Sciences Award, Wake Forest School of Medicine
    2014Team Science Award , Wake Forest School of Medicine
    2015Regular Member of Cellular Mechanisms of Aging and Development Study Section, National Institute of Health

    Collapse Research 
    Collapse research activities and funding
    R01AG13934-20     (Osvaldo Delbono)Aug 1, 2013 - Jul 30, 2019
    NIH/National Institute on Aging
    Troponin T and Muscle Excitation-Contraction Coupling
    Role Description: The proposed studies seek to define a non-canonical role for TnT3 as a regulator of Cav1.1 gene expression and a tool to ameliorate or prevent muscle weakness with aging.
    Role: Principal Investigator

    R01AG057013     (DELBONO, OSVALDO)Sep 1, 2017 - May 31, 2022
    NIH/NIA
    The Role of the Sympathetic Nervous System in the Onset and Development of Sarcopenia
    Role: Principal Investigator

    P30AG21332     (Steve Kritchevsky)Jul 1, 2018 - Jun 30, 2023
    NIH/ National Institute on Aging
    Assessment of Autophagy Flux in Single Muscle Biopsies from Young and Older Adults
    Role: Investigator. Co-leader of the Integrative Biology Core

    R01AG059416     (Steve Cummings)Jul 1, 2018 - Jun 30, 2023
    NIH/National Institute on Aging
    Study of Muscle and Mobility with Aging (SOMMA)
    Role Description: The goal of this study is to understand the role of muscle in loss of human mobility with aging.
    Role: Investigator

    R01AG057013-02S1     (Osvaldo Delbono)Sep 7, 2018 - May 31, 2023
    NIH/National Institute on Aging
    The Role of the Sympathetic Nervous System in the Onset and Development of Sarcopenia
    Role Description: This project examines the role of the SNS in muscle motor denervation and sarcopenia with aging.
    Role: Principal Investigator

    U01AG060897-01     (Delbono, Ding (contact), Molina)Sep 30, 2018 - May 31, 2023
    NIH/National Institute on Aging
    Aging Biomarkers: Integrating Omic Profiles with Mechanistic Measures
    Role Description: The proposed study will generate a panel of biomarkers reflecting a comprehensive battery of aging pathways.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rodrigues ACZ, Messi ML, Wang ZM, Abba MC, Pereyra A, Birbrair A, Zhang T, O'Meara M, Kwan P, Lopez EIS, Willis MS, Mintz A, Files DC, Furdui C, Oppenheim RW, Delbono O. The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability. Acta Physiologica. 2018; (e13195):1-28.
    2. Prazeres PHDM, Turquetti AOM, Azevedo PO, Barreto RSN, Miglino MA, Mintz A, Delbono O, Birbrair A. Perivascular cell av integrins as a target to treat skeletal muscle fibrosis. Int J Biochem Cell Biol. 2018 Jun; 99:109-113. PMID: 29627438.
      View in: PubMed
    3. Nunez Lopez YO, Messi ML, Pratley RE, Zhang T, Delbono O. Troponin T3 associates with DNA consensus sequence that overlaps with p53 binding motifs. Exp Gerontol. 2018 Jul 15; 108:35-40. PMID: 29596868.
      View in: PubMed
    4. Wang ZM, Leng X, Messi ML, Choi SJ, Marsh AP, Nicklas B, Delbono O. Relationship of Physical Function to Single Muscle Fiber Contractility in Older Adults: Effects of Resistance Training with and without Caloric Restriction. J Gerontol A Biol Sci Med Sci. 2018 Mar 13. PMID: 29546320.
      View in: PubMed
    5. Pereyra AS, Wang ZM, Messi ML, Zhang T, Wu H, Register TC, Forbes E, Devarie-Baez NO, Files DC, Abba MC, Furdui C, Delbono O. BDA-410 Treatment Reduces Body Weight and Fat Content by Enhancing Lipolysis in Sedentary Senescent Mice. J Gerontol A Biol Sci Med Sci. 2017 Aug 01; 72(8):1045-1053. PMID: 27789616.
      View in: PubMed
    6. Birbrair A, Borges IDT, Gilson Sena IF, Almeida GG, da Silva Meirelles L, Gonçalves R, Mintz A, Delbono O. How Plastic Are Pericytes? Stem Cells Dev. 2017 07 15; 26(14):1013-1019. PMID: 28490256.
      View in: PubMed
    7. Dias Moura Prazeres PH, Sena IFG, Borges IDT, de Azevedo PO, Andreotti JP, de Paiva AE, de Almeida VM, de Paula Guerra DA, Pinheiro Dos Santos GS, Mintz A, Delbono O, Birbrair A. Pericytes are heterogeneous in their origin within the same tissue. Dev Biol. 2017 07 01; 427(1):6-11. PMID: 28479340.
      View in: PubMed
    8. Xu Z, Feng X, Dong J, Wang ZM, Lee J, Furdui C, Files DC, Beavers KM, Kritchevsky S, Milligan C, Jin JP, Delbono O, Zhang T. Cardiac troponin T and fast skeletal muscle denervation in ageing. J Cachexia Sarcopenia Muscle. 2017 Oct; 8(5):808-823. PMID: 28419739.
      View in: PubMed
    9. Birbrair A, Sattiraju A, Zhu D, Zulato G, Batista I, Nguyen VT, Messi ML, Solingapuram Sai KK, Marini FC, Delbono O, Mintz A. Novel Peripherally Derived Neural-Like Stem Cells as Therapeutic Carriers for Treating Glioblastomas. Stem Cells Transl Med. 2017 Feb; 6(2):471-481. PMID: 28191774.
      View in: PubMed
    10. Files DC, Ilaiwy A, Parry TL, Gibbs KW, Liu C, Bain JR, Delbono O, Muehlbauer MJ, Willis MS. Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism. Metabolomics. 2016 Aug; 12(8). PMID: 28217037.
      View in: PubMed
    11. Pereyra AS, Mykhaylyk O, Lockhart EF, Taylor JR, Delbono O, Goya RG, Plank C, Hereñu CB. Magnetofection Enhances Adenoviral Vector-based Gene Delivery in Skeletal Muscle Cells. J Nanomed Nanotechnol. 2016 Apr; 7(2). PMID: 27274908.
      View in: PubMed
    12. Zhang T, Pereyra AS, Wang ZM, Birbrair A, Reisz JA, Files DC, Purcell L, Feng X, Messi ML, Feng H, Chalovich J, Jin JP, Furdui C, Delbono O. Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice. Aging Cell. 2016 06; 15(3):488-98. PMID: 26892246.
      View in: PubMed
    13. Messi ML, Li T, Wang ZM, Marsh AP, Nicklas B, Delbono O. Resistance Training Enhances Skeletal Muscle Innervation Without Modifying the Number of Satellite Cells or their Myofiber Association in Obese Older Adults. J Gerontol A Biol Sci Med Sci. 2016 10; 71(10):1273-80. PMID: 26447161.
      View in: PubMed
    14. Choi SJ, Files DC, Zhang T, Wang ZM, Messi ML, Gregory H, Stone J, Lyles MF, Dhar S, Marsh AP, Nicklas BJ, Delbono O. Intramyocellular Lipid and Impaired Myofiber Contraction in Normal Weight and Obese Older Adults. J Gerontol A Biol Sci Med Sci. 2016 Apr; 71(4):557-64. PMID: 26405061; PMCID: PMC5014190 [Available on 04/01/17].
    15. Birbrair A, Delbono O. Pericytes are Essential for Skeletal Muscle Formation. Stem Cell Rev. 2015 Aug; 11(4):547-8. PMID: 25896402.
      View in: PubMed
    16. Zhang T, Taylor J, Jiang Y, Pereyra AS, Messi ML, Wang ZM, Hereñú C, Delbono O. Troponin T3 regulates nuclear localization of the calcium channel Cavß1a subunit in skeletal muscle. Exp Cell Res. 2015 Aug 15; 336(2):276-86. PMID: 25981458; PMCID: PMC4522384.
    17. Nicklas BJ, Chmelo E, Delbono O, Carr JJ, Lyles MF, Marsh AP. Effects of resistance training with and without caloric restriction on physical function and mobility in overweight and obese older adults: a randomized controlled trial. Am J Clin Nutr. 2015 May; 101(5):991-9. PMID: 25762810; PMCID: PMC4409692.
    18. Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O. Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Sci Transl Med. 2015 Mar 11; 7(278):278ra32. PMID: 25761888; PMCID: PMC4820823.
    19. Lopez RJ, Mosca B, Treves S, Maj M, Bergamelli L, Calderon JC, Bentzinger CF, Romanino K, Hall MN, Rüegg MA, Delbono O, Caputo C, Zorzato F. Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex. Biochem J. 2015 Feb 15; 466(1):123-35. PMID: 25431931; PMCID: PMC4843809.
    20. Zhang T, Birbrair A, Wang ZM, Messi ML, Marsh AP, Leng I, Nicklas BJ, Delbono O. Improved knee extensor strength with resistance training associates with muscle specific miRNAs in older adults. Exp Gerontol. 2015 Feb; 62:7-13. PMID: 25560803; PMCID: PMC4314447.
    21. Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O. Pericytes at the intersection between tissue regeneration and pathology. Clin Sci (Lond). 2015 Jan; 128(2):81-93. PMID: 25236972.
      View in: PubMed
    22. Birbrair A, Zhang T, Files DC, Mannava S, Smith T, Wang ZM, Messi ML, Mintz A, Delbono O. Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner. Stem Cell Res Ther. 2014 Nov 06; 5(6):122. PMID: 25376879; PMCID: PMC4445991.
    23. Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O. Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle. Front Aging Neurosci. 2014; 6:245. PMID: 25278877; PMCID: PMC4166895.
    24. Taylor J, Pereyra A, Zhang T, Messi ML, Wang ZM, Hereñú C, Kuan PF, Delbono O. The Cavß1a subunit regulates gene expression and suppresses myogenin in muscle progenitor cells. J Cell Biol. 2014 Jun 23; 205(6):829-46. PMID: 24934157; PMCID: PMC4068134.
    25. Birbrair A, Zhang T, Wang ZM, Messi ML, Olson JD, Mintz A, Delbono O. Type-2 pericytes participate in normal and tumoral angiogenesis. Am J Physiol Cell Physiol. 2014 Jul 01; 307(1):C25-38. PMID: 24788248; PMCID: PMC4080181.
    26. Files DC, Xiao K, Zhang T, Liu C, Qian J, Zhao W, Morris PE, Delbono O, Feng X. The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury. PLoS One. 2014; 9(1):e87587. PMID: 24498144; PMCID: PMC3909200.
    27. Zhang T, Choi SJ, Wang ZM, Birbrair A, Messi ML, Jin JP, Marsh AP, Nicklas B, Delbono O. Human slow troponin T (TNNT1) pre-mRNA alternative splicing is an indicator of skeletal muscle response to resistance exercise in older adults. J Gerontol A Biol Sci Med Sci. 2014 Dec; 69(12):1437-47. PMID: 24368775; PMCID: PMC4296115.
    28. Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O. Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle. Am J Physiol Cell Physiol. 2013 Dec 01; 305(11):C1098-113. PMID: 24067916; PMCID: PMC3882385.
    29. Birbrair A, Zhang T, Wang ZM, Messi ML, Enikolopov GN, Mintz A, Delbono O. Role of pericytes in skeletal muscle regeneration and fat accumulation. Stem Cells Dev. 2013 Aug 15; 22(16):2298-314. PMID: 23517218; PMCID: PMC3730538.
    30. Zhang T, Birbrair A, Delbono O. Nonmyofilament-associated troponin T3 nuclear and nucleolar localization sequence and leucine zipper domain mediate muscle cell apoptosis. Cytoskeleton (Hoboken). 2013 Mar; 70(3):134-47. PMID: 23378072; PMCID: PMC3667714.
    31. Mosca B, Delbono O, Laura Messi M, Bergamelli L, Wang ZM, Vukcevic M, Lopez R, Treves S, Nishi M, Takeshima H, Paolini C, Martini M, Rispoli G, Protasi F, Zorzato F. Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice. Nat Commun. 2013; 4:1541. PMID: 23443569; PMCID: PMC4856057.
    32. Yasuda T, Delbono O, Wang ZM, Messi ML, Girard T, Urwyler A, Treves S, Zorzato F. JP-45/JSRP1 variants affect skeletal muscle excitation-contraction coupling by decreasing the sensitivity of the dihydropyridine receptor. Hum Mutat. 2013 Jan; 34(1):184-90. PMID: 22927026; PMCID: PMC3519957.
    33. Birbrair A, Zhang T, Wang ZM, Messi ML, Enikolopov GN, Mintz A, Delbono O. Skeletal muscle pericyte subtypes differ in their differentiation potential. Stem Cell Res. 2013 Jan; 10(1):67-84. PMID: 23128780; PMCID: PMC3781014.
    34. Birbrair A, Zhang T, Wang ZM, Messi ML, Enikolopov GN, Mintz A, Delbono O. Skeletal muscle neural progenitor cells exhibit properties of NG2-glia. Exp Cell Res. 2013 Jan 01; 319(1):45-63. PMID: 22999866; PMCID: PMC3597239.
    35. Kute T, Stehle JR, Ornelles D, Walker N, Delbono O, Vaughn JP. Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cells. Oncoimmunology. 2012 09 01; 1(6):810-821. PMID: 23162748.
      View in: PubMed
    36. Choi SJ, Shively CA, Register TC, Feng X, Stehle J, High K, Ip E, Kritchevsky SB, Nicklas B, Delbono O. Force-generation capacity of single vastus lateralis muscle fibers and physical function decline with age in African green vervet monkeys. J Gerontol A Biol Sci Med Sci. 2013 Mar; 68(3):258-67. PMID: 22923428; PMCID: PMC3566711.
    37. Dardevet D, Savary-Auzeloux I, Remond D, Mosoni L, Marzetti E, Buford TW, Bernabei R, Dionne IJ, Buford TW, Marzetti E, Manini TM, Buehring B, Kirchner E, Calabrese L, Manini TM, Clark BC, Fonseca HM, Delbono O, Taylor JR, Aubertin-Leheudre M, Barbat-Artigas S, Pion CH, Thornell LE, Gustafsson T, Cederholm T, Ulfhake B. Commentaries on Viewpoint: Muscle atrophy is not always sarcopenia. J Appl Physiol (1985). 2012 Aug 15; 113(4):680-4. PMID: 22896680.
      View in: PubMed
    38. Feng X, Zhang T, Xu Z, Choi SJ, Qian J, Furdui CM, Register TC, Delbono O. Myosin heavy chain isoform expression in the Vastus Lateralis muscle of aging African green vervet monkeys. Exp Gerontol. 2012 Aug; 47(8):601-7. PMID: 22617406; PMCID: PMC3389286.
    39. Files DC, D'Alessio FR, Johnston LF, Kesari P, Aggarwal NR, Garibaldi BT, Mock JR, Simmers JL, DeGorordo A, Murdoch J, Willis MS, Patterson C, Tankersley CG, Messi ML, Liu C, Delbono O, Furlow JD, Bodine SC, Cohn RD, King LS, Crow MT. A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting. Am J Respir Crit Care Med. 2012 Apr 15; 185(8):825-34. PMID: 22312013; PMCID: PMC3360571.
    40. Delbono O, Messi ML, Wang ZM, Treves S, Mosca B, Bergamelli L, Nishi M, Takeshima H, Shi H, Xue B, Zorzato F. Endogenously determined restriction of food intake overcomes excitation-contraction uncoupling in JP45KO mice with aging. Exp Gerontol. 2012 Apr; 47(4):304-16. PMID: 22297108; PMCID: PMC3307889.
    41. Wang ZM, Tang S, Messi ML, Yang JJ, Delbono O. Residual sarcoplasmic reticulum Ca2+ concentration after Ca2+ release in skeletal myofibers from young adult and old mice. Pflugers Arch. 2012 Apr; 463(4):615-24. PMID: 22249494; PMCID: PMC3319114.
    42. Zhang T, Birbrair A, Wang ZM, Taylor J, Messi ML, Delbono O. Troponin T nuclear localization and its role in aging skeletal muscle. Age (Dordr). 2013 Apr; 35(2):353-70. PMID: 22189912; PMCID: PMC3592954.
    43. Delbono O. Expression and regulation of excitation-contraction coupling proteins in aging skeletal muscle. Curr Aging Sci. 2011 Dec; 4(3):248-59. PMID: 21529320.
      View in: PubMed
    44. Tang S, Wong HC, Wang ZM, Huang Y, Zou J, Zhuo Y, Pennati A, Gadda G, Delbono O, Yang JJ. Design and application of a class of sensors to monitor Ca2+ dynamics in high Ca2+ concentration cellular compartments. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16265-70. PMID: 21914846; PMCID: PMC3182728.
    45. Birbrair A, Wang ZM, Messi ML, Enikolopov GN, Delbono O. Nestin-GFP transgene reveals neural precursor cells in adult skeletal muscle. PLoS One. 2011 Feb 03; 6(2):e16816. PMID: 21304812; PMCID: PMC3033412.
    46. Jiménez-Moreno R, Wang ZM, Messi ML, Delbono O. Sarcoplasmic reticulum Ca2+ depletion in adult skeletal muscle fibres measured with the biosensor D1ER. Pflugers Arch. 2010 Apr; 459(5):725-35. PMID: 20069312; PMCID: PMC2864504.
    47. Delbono O. Myosin - still a good reference for skeletal muscle fibre classification? J Physiol. 2010 Jan 01; 588(Pt 1):9. PMID: 20045898; PMCID: PMC2821535.
    48. Taylor JR, Zheng Z, Wang ZM, Payne AM, Messi ML, Delbono O. Increased CaVbeta1A expression with aging contributes to skeletal muscle weakness. Aging Cell. 2009 Sep; 8(5):584-94. PMID: 19663902; PMCID: PMC2765867.
    49. Payne AM, Jimenez-Moreno R, Wang ZM, Messi ML, Delbono O. Role of Ca2+, membrane excitability, and Ca2+ stores in failing muscle contraction with aging. Exp Gerontol. 2009 Apr; 44(4):261-73. PMID: 18948183; PMCID: PMC3082867.
    50. Nicklas BJ, Leng I, Delbono O, Kitzman DW, Marsh AP, Hundley WG, Lyles MF, O'Rourke KS, Annex BH, Kraus WE. Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women. Aging Clin Exp Res. 2008 Aug; 20(4):302-9. PMID: 18852542; PMCID: PMC3665340.
    51. Jiménez-Moreno R, Wang ZM, Gerring RC, Delbono O. Sarcoplasmic reticulum Ca2+ release declines in muscle fibers from aging mice. Biophys J. 2008 Apr 15; 94(8):3178-88. PMID: 18178643; PMCID: PMC2275691.
    52. Delbono O, Xia J, Treves S, Wang ZM, Jimenez-Moreno R, Payne AM, Messi ML, Briguet A, Schaerer F, Nishi M, Takeshima H, Zorzato F. Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):20108-13. PMID: 18077436; PMCID: PMC2148430.
    53. Wang ZM, Zheng Z, Messi ML, Delbono O. Muscle fibers from senescent mice retain excitation-contraction coupling properties in culture. In Vitro Cell Dev Biol Anim. 2007 Jul-Aug; 43(7):222-34. PMID: 17712595.
      View in: PubMed
    54. Messi ML, Clark HM, Prevette DM, Oppenheim RW, Delbono O. The lack of effect of specific overexpression of IGF-1 in the central nervous system or skeletal muscle on pathophysiology in the G93A SOD-1 mouse model of ALS. Exp Neurol. 2007 Sep; 207(1):52-63. PMID: 17597610; PMCID: PMC2043146.
    55. Moreno RJ, Messi ML, Zheng Z, Wang ZM, Ye P, D'Ercole JA, Delbono O. Role of sustained overexpression of central nervous system IGF-I in the age-dependent decline of mouse excitation-contraction coupling. J Membr Biol. 2006; 212(3):147-61. PMID: 17334835.
      View in: PubMed
    56. Payne AM, Messi ML, Zheng Z, Delbono O. Motor neuron targeting of IGF-1 attenuates age-related external Ca2+-dependent skeletal muscle contraction in senescent mice. Exp Gerontol. 2007 Apr; 42(4):309-19. PMID: 17174053; PMCID: PMC2063746.
    57. Anderson AA, Altafaj X, Zheng Z, Wang ZM, Delbono O, Ronjat M, Treves S, Zorzato F. The junctional SR protein JP-45 affects the functional expression of the voltage-dependent Ca2+ channel Cav1.1. J Cell Sci. 2006 May 15; 119(Pt 10):2145-55. PMID: 16638807; PMCID: PMC2802288.
    58. Payne AM, Zheng Z, Messi ML, Milligan CE, González E, Delbono O. Motor neurone targeting of IGF-1 prevents specific force decline in ageing mouse muscle. J Physiol. 2006 Jan 15; 570(Pt 2):283-94. PMID: 16293644; PMCID: PMC1464304.
    59. Wang ZM, Zheng Z, Messi ML, Delbono O. Extension and magnitude of denervation in skeletal muscle from ageing mice. J Physiol. 2005 Jun 15; 565(Pt 3):757-64. PMID: 15890702; PMCID: PMC1464566.
    60. Payne AM, Zheng Z, González E, Wang ZM, Messi ML, Delbono O. External Ca(2+)-dependent excitation--contraction coupling in a population of ageing mouse skeletal muscle fibres. J Physiol. 2004 Oct 01; 560(Pt 1):137-55. PMID: 15297570; PMCID: PMC1665204.
    61. Payne AM, Delbono O. Neurogenesis of excitation-contraction uncoupling in aging skeletal muscle. Exerc Sport Sci Rev. 2004 Jan; 32(1):36-40. PMID: 14748548.
      View in: PubMed
    62. Shan H, Messi ML, Zheng Z, Wang ZM, Delbono O. Preservation of motor neuron Ca2+ channel sensitivity to insulin-like growth factor-1 in brain motor cortex from senescent rat. J Physiol. 2003 Nov 15; 553(Pt 1):49-63. PMID: 12963799; PMCID: PMC2343486.
    63. Gonzalez E, Messi ML, Zheng Z, Delbono O. Insulin-like growth factor-1 prevents age-related decrease in specific force and intracellular Ca2+ in single intact muscle fibres from transgenic mice. J Physiol. 2003 Nov 01; 552(Pt 3):833-44. PMID: 12937290; PMCID: PMC2343464.
    64. Messi ML, Delbono O. Target-derived trophic effect on skeletal muscle innervation in senescent mice. J Neurosci. 2003 Feb 15; 23(4):1351-9. PMID: 12598623.
      View in: PubMed
    65. Delbono O. Neural control of aging skeletal muscle. Aging Cell. 2003 02; 2(1):21-9. PMID: 12882331.
      View in: PubMed
    66. Zheng Z, Wang ZM, Delbono O. Insulin-like growth factor-1 increases skeletal muscle dihydropyridine receptor alpha 1S transcriptional activity by acting on the cAMP-response element-binding protein element of the promoter region. J Biol Chem. 2002 Dec 27; 277(52):50535-42. PMID: 12407098.
      View in: PubMed
    67. Zheng Z, Wang ZM, Delbono O. Charge movement and transcription regulation of L-type calcium channel alpha(1S) in skeletal muscle cells. J Physiol. 2002 Apr 15; 540(Pt 2):397-409. PMID: 11956331; PMCID: PMC2290248.
    68. Wang ZM, Messi ML, Delbono O. Sustained overexpression of IGF-1 prevents age-dependent decrease in charge movement and intracellular Ca(2+) in mouse skeletal muscle. Biophys J. 2002 Mar; 82(3):1338-44. PMID: 11867450; PMCID: PMC1301936.
    69. Delbono O. Molecular mechanisms and therapeutics of the deficit in specific force in ageing skeletal muscle. Biogerontology. 2002; 3(5):265-70. PMID: 12237563.
      View in: PubMed
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