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overview Current Projects: Mitochondrial Ultrastructural Remodeling and Inter-Organelles Crosstalk: We aim to identify the molecular determinants, and signaling events associated with mitochondrial contact sites and mitochondrial membranes architecture. Protein Quality Control: Our research aims to identify the molecular determinants of the mitochondrial protein quality control mechanisms and delineate the associated molecular events that lead to disease onset. Calcium signaling and mitochondrial ionic homeostasis: We aim to identify the new regulators and regulatory events associated with mitochondrial calcium-sensing/flux and their role in animal physiology using protein biochemistry, high-end imaging-based approaches, and genetic manipulations. Cardiac Physiology & Metabolism: We aim to characterize the molecular regulators and events involved in cardiac physiology and metabolism using mouse genetics and physiology-based in vivo methods.
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