Item Type | Name |
Concept
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Animals
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Concept
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Behavior, Animal
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Concept
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Disease Models, Animal
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Academic Article
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Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112.
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Academic Article
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Effects of spinally administered bifunctional nociceptin/orphanin FQ peptide receptor/µ-opioid receptor ligands in mouse models of neuropathic and inflammatory pain.
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Academic Article
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Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice.
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Academic Article
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The effects of nociceptin/orphanin FQ receptor agonist Ro 64-6198 and diazepam on antinociception and remifentanil self-administration in rhesus monkeys.
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Academic Article
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Cocaine esterase: interactions with cocaine and immune responses in mice.
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Academic Article
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Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.
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Academic Article
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The role of central gastrin-releasing peptide and neuromedin B receptors in the modulation of scratching behavior in rats.
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Academic Article
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The fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination.
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Academic Article
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Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys.
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Academic Article
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Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates.
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Academic Article
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Roles of µ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates.
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Academic Article
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Antinociceptive effects of nociceptin/orphanin FQ administered intrathecally in monkeys.
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Academic Article
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Behavioral effects of a synthetic agonist selective for nociceptin/orphanin FQ peptide receptors in monkeys.
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Academic Article
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Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats.
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Academic Article
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The therapeutic potential of nociceptin/orphanin FQ receptor agonists as analgesics without abuse liability.
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Academic Article
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Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.
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Academic Article
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Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase.
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Academic Article
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Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats.
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Academic Article
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Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: behavioral and BDNF mRNA expression studies.
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Academic Article
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Effects of butorphanol on morphine-induced itch and analgesia in primates.
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Academic Article
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Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
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Academic Article
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Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats.
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Academic Article
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Effects of mu, kappa, and delta opioid receptor agonists on the function of hypothalamic-pituitary-adrenal axis in monkeys.
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Academic Article
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The spinal antinociceptive effects of endomorphins in rats: behavioral and G protein functional studies.
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Academic Article
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Most efficient cocaine hydrolase designed by virtual screening of transition states.
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Academic Article
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Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity.
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Academic Article
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Effects of cocaine esterase following its repeated administration with cocaine in mice.
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Academic Article
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PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicity.
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Academic Article
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Pharmacokinetic evidence for the long-lasting effect of nor-binaltorphimine, a potent kappa opioid receptor antagonist, in mice.
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Academic Article
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Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain.
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Academic Article
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[Dmt1]N/OFQ(1-13)-NH2: a potent nociceptin/orphanin FQ and opioid receptor universal agonist.
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Academic Article
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Seizure activity involved in the up-regulation of BDNF mRNA expression by activation of central mu opioid receptors.
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Academic Article
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Effects of intrathecally administered nociceptin/orphanin FQ in monkeys: behavioral and mass spectrometric studies.
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Academic Article
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Endogenous opioids upregulate brain-derived neurotrophic factor mRNA through delta- and micro-opioid receptors independent of antidepressant-like effects.
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Academic Article
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Differential in vivo potencies of naltrexone and 6beta-naltrexol in the monkey.
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Academic Article
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Antinociceptive, hypothermic, hypotensive, and reinforcing effects of a novel neurotensin receptor agonist, NT69L, in rhesus monkeys.
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Academic Article
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Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist.
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Academic Article
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The role of central mu opioid receptors in opioid-induced itch in primates.
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Academic Article
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Characterization of scratching responses in rats following centrally administered morphine or bombesin.
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Academic Article
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Ultra-long antagonism of kappa opioid agonist-induced diuresis by intracisternal nor-binaltorphimine in monkeys.
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Academic Article
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Effect of opioid receptor antagonists on hypothalamic-pituitary-adrenal activity in rhesus monkeys.
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Academic Article
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Studies of micro-, kappa-, and delta-opioid receptor density and G protein activation in the cortex and thalamus of monkeys.
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Academic Article
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Activation of kappa-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys.
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Academic Article
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Relative reinforcing effects of three opioids with different durations of action.
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Academic Article
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Orphanin FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors.
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Academic Article
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Gangrenous Clostridium perfringens infection and subsequent wound management in a rhesus macaque (Macaca mulatta).
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Academic Article
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Comparison of the opioid receptor antagonist properties of naltrexone and 6 beta-naltrexol in morphine-naïve and morphine-dependent mice.
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Academic Article
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Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists.
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Academic Article
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Effects of the NOP agonist SCH221510 on producing and attenuating reinforcing effects as measured by drug self-administration in rats.
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Academic Article
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Neuraxial opioid-induced itch and its pharmacological antagonism.
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Academic Article
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Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates.
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Academic Article
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TC-2559, an a4ß2 nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1ß through STAT3 inhibition in cultured murine macrophages.
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Academic Article
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Central N/OFQ-NOP Receptor System in Pain Modulation.
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Academic Article
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Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice.
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Academic Article
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Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeys.
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Academic Article
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Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates.
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Academic Article
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GR89,696: a potent kappa-opioid agonist with subtype selectivity in rhesus monkeys.
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Academic Article
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Local inhibitory effects of dynorphin A-(1-17) on capsaicin-induced thermal allodynia in rhesus monkeys.
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Academic Article
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Diltiazem enhances the analgesic but not the respiratory depressant effects of morphine in rhesus monkeys.
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Academic Article
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An experimental itch model in monkeys: characterization of intrathecal morphine-induced scratching and antinociception.
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Academic Article
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Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats.
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Academic Article
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Activation of peripheral kappa opioid receptors inhibits capsaicin-induced thermal nociception in rhesus monkeys.
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Academic Article
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Local administration of delta9-tetrahydrocannabinol attenuates capsaicin-induced thermal nociception in rhesus monkeys: a peripheral cannabinoid action.
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Academic Article
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Intracisternal nor-binaltorphimine distinguishes central and peripheral kappa-opioid antinociception in rhesus monkeys.
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Academic Article
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The effects of the phyllolitorin analogue [desTrp(3), Leu(8)]phyllolitorin on scratching induced by bombesin and related peptides in rats.
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Academic Article
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Differentiation of kappa opioid agonist-induced antinociception by naltrexone apparent pA2 analysis in rhesus monkeys.
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Academic Article
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kappa-Opioid receptor binding populations in rhesus monkey brain: relationship to an assay of thermal antinociception.
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Academic Article
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The role of peripheral mu opioid receptors in the modulation of capsaicin-induced thermal nociception in rhesus monkeys.
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Academic Article
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Chronic effects of haloperidol and SCH23390 on operant and licking behaviors in the rat.
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Academic Article
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A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates.
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Academic Article
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Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys.
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Academic Article
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Pharmacological studies on the NOP and opioid receptor agonist PWT2-[Dmt1]N/OFQ(1-13).
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Academic Article
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Differential mRNA expression of neuroinflammatory modulators in the spinal cord and thalamus of type 2 diabetic monkeys.
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Academic Article
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A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates.
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Academic Article
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Effects of NOP-Related Ligands in Nonhuman Primates.
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Academic Article
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Neuromedin B Induces Acute Itch in Mice via the Activation of Peripheral Sensory Neurons.
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Academic Article
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BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates.
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Academic Article
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Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys.
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Academic Article
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Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch.
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Academic Article
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GRP receptor and AMPA receptor cooperatively regulate itch-responsive neurons in the spinal dorsal horn.
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Academic Article
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Antinociceptive, reinforcing, and pruritic effects of the G-protein signalling-biased mu opioid receptor agonist PZM21 in non-human primates.
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Academic Article
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STING controls nociception via type I interferon signalling in sensory neurons.
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Academic Article
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Functional consequences of short-term exposure to opioids versus cannabinoids in nonhuman primates.
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Academic Article
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Characterization of Early Alzheimer's Disease-Like Pathological Alterations in Non-Human Primates with Aging: A Pilot Study.
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Academic Article
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Potential therapeutic targets for the treatment of opioid abuse and pain.
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Academic Article
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IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.
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Academic Article
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[Therapeutic potentials of safe opioid analgesics targeting nociceptin/orphanin FQ peptide receptor].
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Academic Article
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Enhanced antidepressant-like effects of a delta opioid receptor agonist, SNC80, in rats under inflammatory pain.
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Academic Article
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Nociceptin Receptor-Related Agonists as Safe and Non-addictive Analgesics.
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