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Hollis, Thomas

One or more keywords matched the following items that are connected to Hollis, Thomas

Item Type	Name
Academic Article	Essential amino acid residues in the single-stranded DNA-binding protein of bacteriophage T7. Identification of the dimer interface.
Academic Article	The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis.
Academic Article	Crystallization of protein-DNA complexes.
Academic Article	A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus.
Academic Article	Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
Academic Article	Small molecule induction of MSH2-dependent cell death suggests a vital role of mismatch repair proteins in cell death.
Academic Article	Structural and mutational analysis of Escherichia coli AlkB provides insight into substrate specificity and DNA damage searching.
Academic Article	The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity.
Academic Article	The transcription factor AmrZ utilizes multiple DNA binding modes to recognize activator and repressor sequences of Pseudomonas aeruginosa virulence genes.
Academic Article	Crystallization of Pseudomonas aeruginosa AmrZ protein: development of a comprehensive method for obtaining and optimization of protein-DNA crystals.
Academic Article	The molecular mechanism of DNA damage recognition by MutS homologs and its consequences for cell death response.
Academic Article	The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.
Academic Article	Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome.
Academic Article	DNA damage recognition and repair by 3-methyladenine DNA glycosylase I (TAG).
Academic Article	Cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonuclease.
Academic Article	The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease.
Academic Article	Lesion bypass of N2-ethylguanine by human DNA polymerase iota.
Academic Article	DNA binding induces active site conformational change in the human TREX2 3'-exonuclease.
Academic Article	The structure of the mammalian RNase H2 complex provides insight into RNA.NA hybrid processing to prevent immune dysfunction.
Academic Article	AmrZ beta-sheet residues are essential for DNA binding and transcriptional control of Pseudomonas aeruginosa virulence genes.
Academic Article	Dominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome.
Academic Article	Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease.
Concept	DNA, Bacterial
Concept	DNA Damage
Concept	DNA-Directed DNA Polymerase
Concept	DNA Polymerase III
Concept	MutS DNA Mismatch-Binding Protein
Concept	DNA
Concept	DNA Glycosylases
Concept	DNA Primers
Concept	DNA Mismatch Repair
Concept	DNA Adducts
Concept	DNA Mutational Analysis
Concept	Sequence Analysis, DNA
Concept	DNA-Binding Proteins
Concept	DNA Replication
Concept	DNA Repair
Concept	DNA, Single-Stranded
Academic Article	The Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers.
Academic Article	Cationic antimicrobial peptides promote microbial mutagenesis and pathoadaptation in chronic infections.
Academic Article	Crystal structure of RNA-DNA duplex provides insight into conformational changes induced by RNase H binding.
Academic Article	Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.
Academic Article	Solid-State Nanopore Analysis of Diverse DNA Base Modifications Using a Modular Enzymatic Labeling Process.
Grant	Structure and Regulation of the TREX1 Exonuclease

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