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Hollis, Thomas
One or more keywords matched the following items that are connected to
Hollis, Thomas
Item Type
Name
Academic Article
Essential amino acid residues in the single-stranded DNA-binding protein of bacteriophage T7. Identification of the dimer interface.
Academic Article
The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis.
Academic Article
Crystallization of protein-DNA complexes.
Academic Article
A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus.
Academic Article
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
Academic Article
Small molecule induction of MSH2-dependent cell death suggests a vital role of mismatch repair proteins in cell death.
Academic Article
Structural and mutational analysis of Escherichia coli AlkB provides insight into substrate specificity and DNA damage searching.
Academic Article
The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity.
Academic Article
The transcription factor AmrZ utilizes multiple DNA binding modes to recognize activator and repressor sequences of Pseudomonas aeruginosa virulence genes.
Academic Article
Crystallization of Pseudomonas aeruginosa AmrZ protein: development of a comprehensive method for obtaining and optimization of protein-DNA crystals.
Academic Article
The molecular mechanism of DNA damage recognition by MutS homologs and its consequences for cell death response.
Academic Article
The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.
Academic Article
Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome.
Academic Article
DNA damage recognition and repair by 3-methyladenine DNA glycosylase I (TAG).
Academic Article
Cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonuclease.
Academic Article
The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease.
Academic Article
Lesion bypass of N2-ethylguanine by human DNA polymerase iota.
Academic Article
DNA binding induces active site conformational change in the human TREX2 3'-exonuclease.
Academic Article
The structure of the mammalian RNase H2 complex provides insight into RNA.NA hybrid processing to prevent immune dysfunction.
Academic Article
AmrZ beta-sheet residues are essential for DNA binding and transcriptional control of Pseudomonas aeruginosa virulence genes.
Academic Article
Dominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome.
Academic Article
Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease.
Concept
DNA, Bacterial
Concept
DNA Damage
Concept
DNA-Directed DNA Polymerase
Concept
DNA Polymerase III
Concept
MutS DNA Mismatch-Binding Protein
Concept
DNA
Concept
DNA Glycosylases
Concept
DNA Primers
Concept
DNA Mismatch Repair
Concept
DNA Adducts
Concept
DNA Mutational Analysis
Concept
Sequence Analysis, DNA
Concept
DNA-Binding Proteins
Concept
DNA Replication
Concept
DNA Repair
Concept
DNA, Single-Stranded
Academic Article
The Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers.
Academic Article
Cationic antimicrobial peptides promote microbial mutagenesis and pathoadaptation in chronic infections.
Academic Article
Crystal structure of RNA-DNA duplex provides insight into conformational changes induced by RNase H binding.
Academic Article
Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.
Academic Article
Solid-State Nanopore Analysis of Diverse DNA Base Modifications Using a Modular Enzymatic Labeling Process.
Grant
Structure and Regulation of the TREX1 Exonuclease
Search Criteria
DNA