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Gmeiner, William

One or more keywords matched the following items that are connected to Gmeiner, William

Item Type	Name
Academic Article	Intramolecular binding of a proximal PPII helix to an SH3 domain in the fusion protein SH3Hck : PPIIhGAP.
Academic Article	The structure and dynamics of the U4/U6 snRNP: implications for pre-mRNA splicing and use as a model system to investigate the RNA-mediated effects of (5F)Ura.
Academic Article	Effect of 5-FU substitution and mutation on Sm protein binding to human U4 snRNA.
Academic Article	A linear 23-residue peptide reveals a propensity to form an unusual native-like conformation.
Academic Article	Three-dimensional structure of the Hck SH2 domain in solution.
Academic Article	Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry.
Academic Article	Solution structure of the human Hck SH3 domain and identification of its ligand binding site.
Academic Article	Structure of the Sm binding site from human U4 snRNA derived from a 3 ns PME molecular dynamics simulation.
Academic Article	Molecular dynamics simulation of the human U2B" protein complex with U2 snRNA hairpin IV in aqueous solution.
Academic Article	Implications of SH3 domain structure and dynamics for protein regulation and drug design.
Academic Article	Improved 3D gd-HCACO and gd-(H)CACO-TOCSY experiments for isotopically enriched proteins dissolved in H2O.
Academic Article	A 3D NOESY-(HCACO)NH experiment for the measurement of NOEs involving 1H alpha in 13C/15N-labeled proteins dissolved in H2O.
Academic Article	Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase.
Academic Article	Self-association and backbone dynamics of the hck SH2 domain in the free and phosphopeptide-complexed forms.
Academic Article	Comparison of SH3 and SH2 domain dynamics when expressed alone or in an SH(3+2) construct: the role of protein dynamics in functional regulation.
Academic Article	Hydrogen exchange shows peptide binding stabilizes motions in Hck SH2.
Academic Article	Dynamics of the Hck-SH3 domain: comparison of experiment with multiple molecular dynamics simulations.
Academic Article	Antineoplastic activity of a novel multimeric gemcitabine-monophosphate prodrug against thyroid cancer cells in vitro.
Concept	BRCA1 Protein
Concept	Protein Structure, Tertiary
Concept	Protein Kinase Inhibitors
Concept	Protein Denaturation
Concept	Protein Structure, Secondary
Concept	Protein-Tyrosine Kinases
Concept	Protein Binding
Concept	Protein Folding
Concept	Fas Ligand Protein
Concept	Protein Conformation
Academic Article	Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway.
Academic Article	Importance of long-time simulations for rare event sampling in zinc finger proteins.
Academic Article	Binding Site Configurations Probe the Structure and Dynamics of the Zinc Finger of NEMO (NF-?B Essential Modulator).
Grant	IMPACT OF 5FU ON THE STRUCTURE OF THE U4/U6 COMPLEX
Grant	DNA-DIRECTED EFFECTS OF FdUMP(N)
Academic Article	All-atom molecular dynamics comparison of disease-associated zinc fingers.
Grant	Aptamer-Based Radiopharmaceuticals for the Targeted Alpha Particle Therapy of Prostate Cancer
Academic Article	Thymineless Death by the Fluoropyrimidine Polymer F10 Involves Replication Fork Collapse and Is Enhanced by Chk1 Inhibition.
Academic Article	Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells.

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